STRINGSTRING
GRB2 GRB2 SRC SRC ATF4 ATF4 LOC103257967 LOC103257967 LOC103268605 LOC103268605 REM1 REM1 ENSTSYP00000033656 ENSTSYP00000033656 PTK2B PTK2B ENSTSYP00000034769 ENSTSYP00000034769 MAPK11 MAPK11 ADCY2 ADCY2 PRKACB PRKACB ENSTSYP00000000627 ENSTSYP00000000627 SOS2 SOS2 MAPK14 MAPK14 MMP2 MMP2 PLD1 PLD1 MMP14 MMP14 ITPR2 ITPR2 MAP3K4 MAP3K4 PLA2G4B PLA2G4B SOS1 SOS1 HRAS HRAS CSDE1 CSDE1 PRKCA PRKCA LOC103250483 LOC103250483 KRAS KRAS MAP2K3 MAP2K3 MAPK10 MAPK10 EGFR EGFR PTX3 PTX3 CGA CGA PLA2G4F PLA2G4F PLA2G4D PLA2G4D RAF1 RAF1 PRKCD PRKCD ELK1 ELK1 PLCB4 PLCB4 ADCY9 ADCY9 PLCB1 PLCB1 PTRHD1 PTRHD1 ADCY3 ADCY3 LOC103249868 LOC103249868 MAP3K1 MAP3K1 HBEGF HBEGF ADCY8 ADCY8 PRKCB PRKCB FSHB FSHB LOC103256992 LOC103256992 PRKACA PRKACA PLA2G4C PLA2G4C EFCAB3 EFCAB3 CAMK2A CAMK2A ADCY4 ADCY4 GNRH2 GNRH2 MAP3K2 MAP3K2 GNRHR GNRHR GNRH1 GNRH1 CAMK2G CAMK2G MAP2K7 MAP2K7 MAP2K4 MAP2K4 CACNA1C CACNA1C CAMK2D CAMK2D MAPK12 MAPK12 MAP2K1 MAP2K1 LOC103250483-2 LOC103250483-2 PLD2 PLD2 PLCB3 PLCB3 CALML4 CALML4 LOC110594926 LOC110594926 LOC103263091 LOC103263091 LOC103268450 LOC103268450 ADCY6 ADCY6 JMJD7 JMJD7 MAP3K3 MAP3K3 CACNA1S CACNA1S MAP2K6 MAP2K6 LOC103255950 LOC103255950 LHB LHB ENSTSYP00000024401 ENSTSYP00000024401 NRAS NRAS LOC103249516 LOC103249516 ADCY7 ADCY7 PVALEF PVALEF LOC103261438 LOC103261438 MAPK8 MAPK8 PLCB2 PLCB2 LOC103255823 LOC103255823 MAPK13 MAPK13 LOC103251709 LOC103251709 LOC103253123 LOC103253123 ITPR3 ITPR3 ARSI ARSI CAMK2B CAMK2B MAPK3 MAPK3 ENSTSYP00000028505 ENSTSYP00000028505 PLA2G4A PLA2G4A CALML6 CALML6 CACNA1D CACNA1D ENSTSYP00000030193 ENSTSYP00000030193 EGR1 EGR1 ADCY5 ADCY5 ENSTSYP00000030893 ENSTSYP00000030893 MAPK9 MAPK9 CALM3 CALM3 ENSTSYP00000031441 ENSTSYP00000031441 CDC42 CDC42 RRAD RRAD GEM GEM CACNA1F CACNA1F MAPK1 MAPK1 MAPK7 MAPK7 ENSTSYP00000032829 ENSTSYP00000032829
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GRB2Growth factor receptor-bound protein 2 isoform X1. (217 aa)
SRCTyrosine-protein kinase. (542 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4 isoform X2. (352 aa)
LOC103257967Calmodulin-like; Belongs to the calmodulin family. (147 aa)
LOC103268605Calmodulin isoform X1; Belongs to the calmodulin family. (149 aa)
REM1GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (331 aa)
ENSTSYP00000033656annotation not available (345 aa)
PTK2BProtein-tyrosine kinase 2-beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
ENSTSYP00000034769annotation not available (133 aa)
MAPK11Mitogen-activated protein kinase. (255 aa)
ADCY2Adenylate cyclase type 2. (955 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (398 aa)
ENSTSYP00000000627annotation not available (167 aa)
SOS2Son of sevenless homolog 2 isoform X1. (1318 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MMP272 kDa type IV collagenase. (662 aa)
PLD1Phospholipase. (1075 aa)
MMP14Matrix metalloproteinase-14 isoform X1. (582 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
MAP3K4Mitogen-activated protein kinase kinase kinase 4 isoform X1. (1602 aa)
PLA2G4BPhospholipase A2. (781 aa)
SOS1Son of sevenless homolog 1 isoform X2. (441 aa)
HRASGTPase HRas isoform X6. (189 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (842 aa)
PRKCAProtein kinase C. (614 aa)
LOC103250483calmodulin-A-like isoform X1; Belongs to the calmodulin family. (150 aa)
KRASGTPase KRas isoform X1. (189 aa)
MAP2K3Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
MAPK10Mitogen-activated protein kinase. (473 aa)
EGFRReceptor protein-tyrosine kinase. (1180 aa)
PTX3Pentraxin 3. (317 aa)
CGAGlycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. (120 aa)
PLA2G4FPhospholipase A2. (849 aa)
PLA2G4DPhospholipase A2. (806 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (668 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (674 aa)
ELK1ETS domain-containing protein Elk-1 isoform X1. (430 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1135 aa)
PTRHD1Putative peptidyl-tRNA hydrolase PTRHD1. (140 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
LOC103249868Cytosolic phospholipase A2 epsilon. (452 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1346 aa)
HBEGFProheparin-binding EGF-like growth factor. (209 aa)
ADCY8Adenylate cyclase type 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (931 aa)
PRKCBNon-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (531 aa)
FSHBFollitropin subunit beta. (129 aa)
LOC103256992Inositol 1,4,5-trisphosphate receptor type 1. (1004 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (343 aa)
PLA2G4CCytosolic phospholipase A2 gamma. (520 aa)
EFCAB3EF-hand calcium-binding domain-containing protein 3. (460 aa)
CAMK2ACalcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1; Belongs to the protein kinase superfamily. (489 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
GNRH2Progonadoliberin-2. (117 aa)
MAP3K2Mitogen-activated protein kinase kinase kinase 2. (531 aa)
GNRHRGonadotropin-releasing hormone receptor isoform X1. (328 aa)
GNRH1Gonadoliberin; Stimulates the secretion of gonadotropins. Belongs to the GnRH family. (91 aa)
CAMK2GCalcium/calmodulin-dependent protein kinase type II subunit gamma. (566 aa)
MAP2K7Dual specificity mitogen-activated protein kinase kinase 7. (414 aa)
MAP2K4Dual specificity mitogen-activated protein kinase kinase 4 isoform X1; Belongs to the protein kinase superfamily. (387 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2045 aa)
CAMK2DCalcium/calmodulin-dependent protein kinase type II subunit delta isoform X4. (533 aa)
MAPK12Mitogen-activated protein kinase. (277 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1. (381 aa)
LOC103250483-2Calmodulin-2/4-like isoform X2; Belongs to the calmodulin family. (141 aa)
PLD2Phospholipase. (934 aa)
PLCB3Phosphoinositide phospholipase C. (828 aa)
CALML4LOW QUALITY PROTEIN: calmodulin-like protein 4. (192 aa)
LOC110594926ETS domain-containing protein Elk-3-like. (73 aa)
LOC103263091Adenylate cyclase type 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (293 aa)
LOC103268450Gonadotropin-releasing hormone II receptor. (377 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
JMJD7jmjC domain-containing protein 7. (308 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3. (528 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1868 aa)
MAP2K6LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (352 aa)
LOC103255950Calmodulin-like; Belongs to the calmodulin family. (131 aa)
LHBLutropin subunit beta. (141 aa)
ENSTSYP00000024401annotation not available (186 aa)
NRASGTPase NRas. (189 aa)
LOC103249516Inositol 1,4,5-trisphosphate receptor type 1. (389 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1071 aa)
PVALEFParvalbumin like EF-hand containing. (134 aa)
LOC103261438Calmodulin-like; Belongs to the calmodulin family. (130 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1094 aa)
LOC103255823Guanine nucleotide-binding protein G(S) subunit alpha isoform X2. (361 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
LOC103251709Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (348 aa)
LOC103253123Adenylate cyclase type 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (327 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2677 aa)
ARSIArylsulfatase I. (535 aa)
CAMK2BCalcium/calmodulin-dependent protein kinase type II subunit beta. (666 aa)
MAPK3Mitogen-activated protein kinase. (363 aa)
ENSTSYP00000028505annotation not available (242 aa)
PLA2G4APhospholipase A2. (749 aa)
CALML6Calmodulin-like protein 6. (164 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2028 aa)
ENSTSYP00000030193annotation not available (164 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (543 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (915 aa)
ENSTSYP00000030893annotation not available (343 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
CALM3Calmodulin 3. (128 aa)
ENSTSYP00000031441annotation not available (131 aa)
CDC42Cell division control protein 42 homolog. (191 aa)
RRADGTP-binding protein RAD. (275 aa)
GEMGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (296 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1977 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (363 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (813 aa)
ENSTSYP00000032829annotation not available (586 aa)
Your Current Organism:
Carlito syrichta
NCBI taxonomy Id: 1868482
Other names: C. syrichta, Philippine tarsier, Tarsius syrichta
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