STRINGSTRING
CREBBP CREBBP PRKACB PRKACB MED13L MED13L NCOA2 NCOA2 MYH1 MYH1 MYH8 MYH8 MYH15 MYH15 EP300 EP300 RHEB RHEB SLCO1C1 SLCO1C1 PFKFB2 PFKFB2 SLC16A2 SLC16A2 DIO2 DIO2 CASP9 CASP9 SLC16A10 SLC16A10 HRAS HRAS CSDE1 CSDE1 ATP1A4 ATP1A4 PRKCA PRKCA PLCG1 PLCG1 PIK3CA PIK3CA MED14 MED14 KRAS KRAS LOC103251060 LOC103251060 PFKM PFKM SIN3A SIN3A PLCE1 PLCE1 NCOR1 NCOR1 NCOA3 NCOA3 TBC1D4 TBC1D4 ESR1 ESR1 MYH3 MYH3 ACTL7B ACTL7B KAT2B KAT2B PDPK1 PDPK1 MED13 MED13 PLCD4 PLCD4 RAF1 RAF1 RCAN2 RCAN2 HDAC3 HDAC3 THRB THRB PLCB4 PLCB4 LOC103259463 LOC103259463 HDAC2 HDAC2 ACTL8 ACTL8 CCDC170 CCDC170 GATA4 GATA4 PLCB1 PLCB1 ATP1B1 ATP1B1 NCOA1 NCOA1 MYH6 MYH6 ATP2A1 ATP2A1 AKT3 AKT3 CTNNB1 CTNNB1 SLC2A1 SLC2A1 PRKCB PRKCB GPSM3 GPSM3 MTOR MTOR NOTCH3 NOTCH3 NOTCH2 NOTCH2 MED12L MED12L ATP2A2 ATP2A2 PRKACA PRKACA ENSTSYP00000013967 ENSTSYP00000013967 MED16 MED16 ENSTSYP00000014856 ENSTSYP00000014856 AKT2 AKT2 ATP1A2 ATP1A2 HIF1A HIF1A PLCG2 PLCG2 GSK3B GSK3B RCAN3 RCAN3 ENSTSYP00000016704 ENSTSYP00000016704 LOC103250564 LOC103250564 PLCD3 PLCD3 ENSTSYP00000017776 ENSTSYP00000017776 THRA THRA MAP2K1 MAP2K1 MED24 MED24 ENSTSYP00000019285 ENSTSYP00000019285 PLCB3 PLCB3 ENSTSYP00000020233 ENSTSYP00000020233 PIK3R1 PIK3R1 PFKL PFKL ATP1B2 ATP1B2 ENSTSYP00000021856 ENSTSYP00000021856 ITGAV ITGAV TSC2 TSC2 CCND1 CCND1 LOC103250373 LOC103250373 ENSTSYP00000023135 ENSTSYP00000023135 MED4 MED4 MYH4 MYH4 TP53 TP53 SLC9A1 SLC9A1 RXRB RXRB KAT2A KAT2A MED12 MED12 NRAS NRAS ATP1B4 ATP1B4 PIK3R3 PIK3R3 LOC103262420 LOC103262420 HDAC1 HDAC1 PFKP PFKP BMP4 BMP4 PLCB2 PLCB2 RXRG RXRG LOC103251709 LOC103251709 ENSTSYP00000027441 ENSTSYP00000027441 MAPK3 MAPK3 RXRA RXRA RHEBL1 RHEBL1 ENSTSYP00000028505 ENSTSYP00000028505 RCAN1 RCAN1 MED17 MED17 PIK3CD PIK3CD ENSTSYP00000030184 ENSTSYP00000030184 LOC103272783 LOC103272783 MYC MYC AKT1 AKT1 LOC103252147 LOC103252147 WNT4 WNT4 PLCD1 PLCD1 MAPK1 MAPK1 MED1 MED1 ATP1A1 ATP1A1 DIO1 DIO1 NOTCH1 NOTCH1 SRC SRC PRKCG PRKCG SIN3B SIN3B LOC103270389 LOC103270389 ATP1A3 ATP1A3 MED30 MED30 ATP2A3 ATP2A3 NOTCH4 NOTCH4 FXYD2 FXYD2 MYH7 MYH7 PIK3CB PIK3CB LOC103262367 LOC103262367
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CREBBPCREB-binding protein isoform X1. (2433 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (398 aa)
MED13LMediator of RNA polymerase II transcription subunit 13; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (2197 aa)
NCOA2Nuclear receptor coactivator. (1483 aa)
MYH1Myosin-1 isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1940 aa)
MYH8Myosin-8; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1937 aa)
MYH15Myosin-15; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1933 aa)
EP300Histone acetyltransferase p300. (2174 aa)
RHEBGTP-binding protein Rheb. (184 aa)
SLCO1C1Solute carrier organic anion transporter family member. (730 aa)
PFKFB26-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 2 isoform X1. (525 aa)
SLC16A2Monocarboxylate transporter 8. (535 aa)
DIO2Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine). (88 aa)
CASP9Caspase-9; Belongs to the peptidase C14A family. (410 aa)
SLC16A10Monocarboxylate transporter 10. (241 aa)
HRASGTPase HRas isoform X6. (189 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (842 aa)
ATP1A4Sodium/potassium-transporting ATPase subunit alpha. (1029 aa)
PRKCAProtein kinase C. (614 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1302 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MED14Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1437 aa)
KRASGTPase KRas isoform X1. (189 aa)
LOC103251060Protein eyes shut homolog. (297 aa)
PFKMATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (851 aa)
SIN3APaired amphipathic helix protein Sin3a. (1274 aa)
PLCE1Phosphoinositide phospholipase C. (2303 aa)
NCOR1Nuclear receptor corepressor 1 isoform X8. (2437 aa)
NCOA3Nuclear receptor coactivator. (1416 aa)
TBC1D4TBC1 domain family member 4 isoform X1. (1297 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (589 aa)
MYH3Myosin-3; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1951 aa)
ACTL7BLOW QUALITY PROTEIN: actin-like protein 7B; Belongs to the actin family. (366 aa)
KAT2BHistone acetyltransferase KAT2B. (731 aa)
PDPK13-phosphoinositide-dependent protein kinase 1. (554 aa)
MED13Mediator of RNA polymerase II transcription subunit 13; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (2158 aa)
PLCD4Phosphoinositide phospholipase C. (799 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (668 aa)
RCAN2Calcipressin-2 isoform X1. (243 aa)
HDAC3Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (428 aa)
THRBThyroid hormone receptor beta isoform X1. (476 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
LOC103259463Mediator of RNA polymerase II transcription subunit 30-like isoform X1. (162 aa)
HDAC2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (458 aa)
ACTL8LOW QUALITY PROTEIN: actin-like protein 8; Belongs to the actin family. (366 aa)
CCDC170Coiled-coil domain-containing protein 170. (717 aa)
GATA4Transcription factor GATA-4. (234 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1135 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (303 aa)
NCOA1Nuclear receptor coactivator. (1441 aa)
MYH6Myosin-6; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1939 aa)
ATP2A1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1007 aa)
AKT3RAC-gamma serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (419 aa)
CTNNB1Catenin beta-1 isoform X1. (783 aa)
SLC2A1Solute carrier family 2, facilitated glucose transporter member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (460 aa)
PRKCBNon-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (531 aa)
GPSM3G-protein-signaling modulator 3. (158 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
NOTCH3Neurogenic locus notch homolog protein 3. (2169 aa)
NOTCH2Neurogenic locus notch homolog protein 2. (2211 aa)
MED12LMediator of RNA polymerase II transcription subunit 12-like protein. (2103 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1049 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (343 aa)
ENSTSYP00000013967annotation not available (167 aa)
MED16Mediator of RNA polymerase II transcription subunit 16; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (223 aa)
ENSTSYP00000014856annotation not available (69 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1035 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform X1. (842 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
GSK3BGlycogen synthase kinase-3 beta; Belongs to the protein kinase superfamily. (403 aa)
RCAN3Calcipressin-3 isoform X2. (241 aa)
ENSTSYP00000016704annotation not available (357 aa)
LOC103250564Integrin beta; Belongs to the integrin beta chain family. (418 aa)
PLCD3Phosphoinositide phospholipase C. (595 aa)
ENSTSYP00000017776annotation not available (292 aa)
THRAThyroid hormone receptor alpha. (513 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1. (381 aa)
MED24Mediator of RNA polymerase II transcription subunit 24 isoform X2. (1013 aa)
ENSTSYP00000019285annotation not available (346 aa)
PLCB3Phosphoinositide phospholipase C. (828 aa)
ENSTSYP00000020233annotation not available (371 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (612 aa)
PFKLATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (774 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
ENSTSYP00000021856annotation not available (88 aa)
ITGAVIntegrin alpha-V; Belongs to the integrin alpha chain family. (1041 aa)
TSC2LOW QUALITY PROTEIN: tuberin. (1728 aa)
CCND1G1/S-specific cyclin-D1. (156 aa)
LOC103250373E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (426 aa)
ENSTSYP00000023135annotation not available (201 aa)
MED4Mediator of RNA polymerase II transcription subunit 4; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (270 aa)
MYH4Myosin-4; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1937 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (388 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (811 aa)
RXRBRetinoic acid receptor RXR-beta isoform X2. (533 aa)
KAT2AHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (798 aa)
MED12Mediator of RNA polymerase II transcription subunit 12 isoform X1. (2127 aa)
NRASGTPase NRas. (189 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (352 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2. (461 aa)
LOC103262420Mediator of RNA polymerase II transcription subunit 27 isoform X1. (160 aa)
HDAC1Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (482 aa)
PFKPATP-dependent 6-phosphofructokinase, platelet type. (742 aa)
BMP4Bone morphogenetic protein 4 isoform X1. (409 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1094 aa)
RXRGRetinoic acid receptor RXR-gamma isoform X1. (463 aa)
LOC103251709Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (348 aa)
ENSTSYP00000027441annotation not available (357 aa)
MAPK3Mitogen-activated protein kinase. (363 aa)
RXRARetinoic acid receptor RXR-alpha. (470 aa)
RHEBL1GTPase RhebL1. (183 aa)
ENSTSYP00000028505annotation not available (242 aa)
RCAN1Calcipressin-1 isoform X2. (251 aa)
MED17Mediator of RNA polymerase II transcription subunit 17; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (567 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1063 aa)
ENSTSYP00000030184annotation not available (260 aa)
LOC103272783LOW QUALITY PROTEIN: GTP-binding protein Rheb-like. (178 aa)
MYCMyc proto-oncogene protein. (376 aa)
AKT1Non-specific serine/threonine protein kinase. (393 aa)
LOC103252147Myosin-2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1939 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
PLCD1Phosphoinositide phospholipase C. (777 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (363 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1579 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (1025 aa)
DIO1Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine). (249 aa)
NOTCH1Neurogenic locus notch homolog protein 1. (2339 aa)
SRCTyrosine-protein kinase. (542 aa)
PRKCGProtein kinase C. (634 aa)
SIN3BPaired amphipathic helix protein Sin3b. (1117 aa)
LOC103270389LOW QUALITY PROTEIN: GTP-binding protein Rheb-like. (188 aa)
ATP1A3Sodium/potassium-transporting ATPase subunit alpha. (1036 aa)
MED30Mediator of RNA polymerase II transcription subunit 30 isoform X1. (177 aa)
ATP2A3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1028 aa)
NOTCH4Neurogenic locus notch homolog protein 4. (1999 aa)
FXYD2FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (66 aa)
MYH7Myosin-7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1935 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2; Belongs to the PI3/PI4-kinase family. (1070 aa)
LOC103262367Mediator of RNA polymerase II transcription subunit 27-like. (145 aa)
Your Current Organism:
Carlito syrichta
NCBI taxonomy Id: 1868482
Other names: C. syrichta, Philippine tarsier, Tarsius syrichta
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