STRINGSTRING
PIK3CA PIK3CA SEPT8 SEPT8 ELMO2 ELMO2 PXN PXN ACTL7B ACTL7B GAB1 GAB1 CAV2 CAV2 CEP152 CEP152 FN1 FN1 ARHGAP10 ARHGAP10 ITGB1 ITGB1 ARHGEF26 ARHGEF26 ACTL8 ACTL8 ARPC5L ARPC5L CTNNA2 CTNNA2 LPXN LPXN DNM3 DNM3 CTNNB1 CTNNB1 SHC1 SHC1 BCAR1 BCAR1 SEPT3 SEPT3 HCLS1 HCLS1 WASF1 WASF1 SHC4 SHC4 ARPC5 ARPC5 ENSTSYP00000013967 ENSTSYP00000013967 ENSTSYP00000014812 ENSTSYP00000014812 RHOC RHOC ENSTSYP00000016210 ENSTSYP00000016210 VCL VCL ENSTSYP00000000627 ENSTSYP00000000627 MET MET ARPC2 ARPC2 CLTCL1 CLTCL1 SEPT14 SEPT14 CD2AP CD2AP ENSTSYP00000002295 ENSTSYP00000002295 ARPC3 ARPC3 LOC103254094 LOC103254094 SEPTIN10 SEPTIN10 ARPC1A ARPC1A SEPT2 SEPT2 ENSTSYP00000016704 ENSTSYP00000016704 TMEM250 TMEM250 ARPC1B ARPC1B RHOG RHOG WASL WASL ENSTSYP00000018500 ENSTSYP00000018500 ENSTSYP00000019285 ENSTSYP00000019285 DNM1 DNM1 SEPTIN12 SEPTIN12 ENSTSYP00000019960 ENSTSYP00000019960 ENSTSYP00000020233 ENSTSYP00000020233 CDH1 CDH1 CTNNA1 CTNNA1 PIK3R1 PIK3R1 CLTC CLTC ENSTSYP00000021791 ENSTSYP00000021791 ENSTSYP00000021813 ENSTSYP00000021813 SEPT1 SEPT1 ENSTSYP00000022482 ENSTSYP00000022482 ENSTSYP00000022556 ENSTSYP00000022556 CLTA CLTA LOC103267969 LOC103267969 ILK ILK ENSTSYP00000024401 ENSTSYP00000024401 SHC3 SHC3 RHOA RHOA LOC103267245 LOC103267245 ELMO3 ELMO3 PTK2 PTK2 PIK3R3 PIK3R3 SEPT6 SEPT6 ENSTSYP00000026316 ENSTSYP00000026316 ENSTSYP00000026390 ENSTSYP00000026390 RHOA-2 RHOA-2 ENSTSYP00000027281 ENSTSYP00000027281 ENSTSYP00000027501 ENSTSYP00000027501 LOC103273849 LOC103273849 ENSTSYP00000028924 ENSTSYP00000028924 DNM2 DNM2 ENSTSYP00000029374 ENSTSYP00000029374 SEPT11 SEPT11 PIK3CD PIK3CD CBL CBL ENSTSYP00000030184 ENSTSYP00000030184 ENSTSYP00000030193 ENSTSYP00000030193 LOC103268676 LOC103268676 ITGA5 ITGA5 SEPT9 SEPT9 ENSTSYP00000031155 ENSTSYP00000031155 ENSTSYP00000031441 ENSTSYP00000031441 GOLGA2 GOLGA2 CDC42 CDC42 CTNNA3 CTNNA3 ENSTSYP00000031672 ENSTSYP00000031672 CAV1 CAV1 SRC SRC CRK CRK CAV3 CAV3 MAD2L2 MAD2L2 ENSTSYP00000033992 ENSTSYP00000033992 ARPC4 ARPC4 PIK3CB PIK3CB WASF2 WASF2 CRKL CRKL SLC25A1 SLC25A1 ENSTSYP00000034959 ENSTSYP00000034959
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
SEPT8Septin-8 isoform X3; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (477 aa)
ELMO2Engulfment and cell motility protein 2 isoform X2. (720 aa)
PXNLOW QUALITY PROTEIN: paxillin. (1079 aa)
ACTL7BLOW QUALITY PROTEIN: actin-like protein 7B; Belongs to the actin family. (366 aa)
GAB1GRB2-associated-binding protein 1 isoform X1. (700 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
CEP152Centrosomal protein of 152 kDa. (1704 aa)
FN1Fibronectin isoform X2. (2450 aa)
ARHGAP10Rho GTPase-activating protein 10 isoform X1. (786 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
ARHGEF26Rho guanine nucleotide exchange factor 26. (868 aa)
ACTL8LOW QUALITY PROTEIN: actin-like protein 8; Belongs to the actin family. (366 aa)
ARPC5LActin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (153 aa)
CTNNA2Catenin alpha-2 isoform X1. (555 aa)
LPXNLeupaxin; Belongs to the paxillin family. (391 aa)
DNM3Dynamin-3 isoform X1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (790 aa)
CTNNB1Catenin beta-1 isoform X1. (783 aa)
SHC1SHC-transforming protein 1 isoform X1. (474 aa)
BCAR1Breast cancer anti-estrogen resistance protein 1. (871 aa)
SEPT3Neuronal-specific septin-3 isoform X1; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (358 aa)
HCLS1Hematopoietic lineage cell-specific protein. (469 aa)
WASF1wiskott-Aldrich syndrome protein family member 1. (560 aa)
SHC4SHC-transforming protein 4. (629 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (151 aa)
ENSTSYP00000013967annotation not available (167 aa)
ENSTSYP00000014812annotation not available (288 aa)
RHOCRho-related GTP-binding protein RhoC isoform X2. (193 aa)
ENSTSYP00000016210annotation not available (141 aa)
VCLVinculin. (1122 aa)
ENSTSYP00000000627annotation not available (167 aa)
METHepatocyte growth factor receptor isoform X1. (1415 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (300 aa)
CLTCL1Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1640 aa)
SEPT14Septin-14; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (432 aa)
CD2APCD2-associated protein. (638 aa)
ENSTSYP00000002295annotation not available (173 aa)
ARPC3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa)
LOC103254094Dedicator of cytokinesis protein 1-like; Belongs to the DOCK family. (696 aa)
SEPTIN10Septin-10 isoform X1; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (537 aa)
ARPC1AActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (370 aa)
SEPT2Septin-2; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (361 aa)
ENSTSYP00000016704annotation not available (357 aa)
TMEM250Protein C9orf69 homolog. (139 aa)
ARPC1BActin-related protein 2/3 complex subunit 1B. (303 aa)
RHOGRho-related GTP-binding protein RhoG. (191 aa)
WASLNeural Wiskott-Aldrich syndrome protein. (504 aa)
ENSTSYP00000018500annotation not available (73 aa)
ENSTSYP00000019285annotation not available (346 aa)
DNM1Dynamin-1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (816 aa)
SEPTIN12Septin-12; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (358 aa)
ENSTSYP00000019960annotation not available (172 aa)
ENSTSYP00000020233annotation not available (371 aa)
CDH1Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. (443 aa)
CTNNA1Catenin alpha-1 isoform X1. (908 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (612 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1675 aa)
ENSTSYP00000021791annotation not available (63 aa)
ENSTSYP00000021813annotation not available (294 aa)
SEPT1Septin-1; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (403 aa)
ENSTSYP00000022482annotation not available (178 aa)
ENSTSYP00000022556annotation not available (410 aa)
CLTAClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (236 aa)
LOC103267969Catenin alpha-2-like. (235 aa)
ILKIntegrin-linked protein kinase isoform X2. (465 aa)
ENSTSYP00000024401annotation not available (186 aa)
SHC3SHC-transforming protein 3. (107 aa)
RHOATransforming protein RhoA isoform X7. (81 aa)
LOC103267245Engulfment and cell motility protein 1-like isoform X1. (247 aa)
ELMO3Engulfment and cell motility protein 3 isoform X1. (707 aa)
PTK2Focal adhesion kinase 1 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1096 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2. (461 aa)
SEPT6Septin-6 isoform X3; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (434 aa)
ENSTSYP00000026316annotation not available (161 aa)
ENSTSYP00000026390annotation not available (153 aa)
RHOA-2Transforming protein RhoA isoform X1. (193 aa)
ENSTSYP00000027281annotation not available (67 aa)
ENSTSYP00000027501annotation not available (135 aa)
LOC103273849Engulfment and cell motility protein 1 isoform X3. (260 aa)
ENSTSYP00000028924annotation not available (322 aa)
DNM2Dynamin-2 isoform X2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (715 aa)
ENSTSYP00000029374annotation not available (77 aa)
SEPT11Septin-11 isoform X1; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (432 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1063 aa)
CBLE3 ubiquitin-protein ligase CBL. (898 aa)
ENSTSYP00000030184annotation not available (260 aa)
ENSTSYP00000030193annotation not available (164 aa)
LOC103268676Cadherin-1-like. (413 aa)
ITGA5Integrin alpha-5; Belongs to the integrin alpha chain family. (1053 aa)
SEPT9Septin-9 isoform X1; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (560 aa)
ENSTSYP00000031155annotation not available (169 aa)
ENSTSYP00000031441annotation not available (131 aa)
GOLGA2Golgin subfamily A member 2. (999 aa)
CDC42Cell division control protein 42 homolog. (191 aa)
CTNNA3Catenin alpha-3. (184 aa)
ENSTSYP00000031672annotation not available (349 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
SRCTyrosine-protein kinase. (542 aa)
CRKAdapter molecule crk isoform X1. (304 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
MAD2L2Mitotic spindle assembly checkpoint protein MAD2B. (223 aa)
ENSTSYP00000033992annotation not available (46 aa)
ARPC4Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (211 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2; Belongs to the PI3/PI4-kinase family. (1070 aa)
WASF2wiskott-Aldrich syndrome protein family member 2 isoform X1. (497 aa)
CRKLCrk-like protein. (303 aa)
SLC25A1Tricarboxylate transport protein, mitochondrial isoform X1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (208 aa)
ENSTSYP00000034959annotation not available (168 aa)
Your Current Organism:
Carlito syrichta
NCBI taxonomy Id: 1868482
Other names: C. syrichta, Philippine tarsier, Tarsius syrichta
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