STRINGSTRING
STAT6 STAT6 SOS2 SOS2 MAPK14 MAPK14 EP300 EP300 LOC103256403 LOC103256403 DDB2 DDB2 RB1 RB1 MMP9 MMP9 TGFBR2 TGFBR2 IRAK4 IRAK4 ATF2 ATF2 CCNA2 CCNA2 CASP9 CASP9 MAVS MAVS ATF6B ATF6B IKBKB IKBKB SOS1 SOS1 TLR4 TLR4 HRAS HRAS CSDE1 CSDE1 CASP12 CASP12 DDX3X DDX3X NFKBIA NFKBIA CXCL8 CXCL8 PRKCA PRKCA CREB3L4 CREB3L4 DDX58 DDX58 PIK3CA PIK3CA CHUK CHUK KRAS KRAS CCNE1 CCNE1 NFKB1 NFKB1 NFATC2 NFATC2 CREB5 CREB5 MAP2K3 MAP2K3 IFIH1 IFIH1 CCNA1 CCNA1 MAPK10 MAPK10 YWHAZ YWHAZ CREB1 CREB1 JAK1 JAK1 VDAC3 VDAC3 FAS FAS ENSTSYP00000006680 ENSTSYP00000006680 RAF1 RAF1 ELK1 ELK1 MYD88 MYD88 TAB2 TAB2 LOC103258295 LOC103258295 CREB3 CREB3 ENSTSYP00000007331 ENSTSYP00000007331 DDB1 DDB1 TLR3 TLR3 CREB3L1 CREB3L1 LOC103257846 LOC103257846 BRAF BRAF SMAD4 SMAD4 E2F2 E2F2 MAP3K1 MAP3K1 JAK2 JAK2 CASP10 CASP10 AKT3 AKT3 CREB3L2 CREB3L2 PRKCB PRKCB STAT3 STAT3 MAP2K7 MAP2K7 ENSTSYP00000014268 ENSTSYP00000014268 IFNAR1 IFNAR1 MAP2K4 MAP2K4 ENSTSYP00000014599 ENSTSYP00000014599 LOC103262174 LOC103262174 ENSTSYP00000014856 ENSTSYP00000014856 AKT2 AKT2 ENSTSYP00000015946 ENSTSYP00000015946 TRAF6 TRAF6 NFATC4 NFATC4 MAPK12 MAPK12 ATP6AP1 ATP6AP1 BIRC5 BIRC5 MAP2K1 MAP2K1 TBK1 TBK1 STAT5B STAT5B PCNA PCNA ENSTSYP00000019167 ENSTSYP00000019167 LOC110596190 LOC110596190 PIK3R1 PIK3R1 BID BID E2F3 E2F3 ENSTSYP00000021856 ENSTSYP00000021856 TRAF3 TRAF3 YWHAB YWHAB HSPG2 HSPG2 LOC103255989 LOC103255989 TIRAP TIRAP CCNE2 CCNE2 LOC103255326 LOC103255326 NFATC1 NFATC1 ENSTSYP00000023511 ENSTSYP00000023511 TP53 TP53 MAP2K6 MAP2K6 E2F1 E2F1 STAT5A STAT5A APAF1 APAF1 ENSTSYP00000024257 ENSTSYP00000024257 RELA RELA YWHAQ YWHAQ NRAS NRAS PIK3R3 PIK3R3 EGR2 EGR2 MAPK8 MAPK8 IKBKG IKBKG MAPK11 MAPK11 MAPK13 MAPK13 LOC103251709 LOC103251709 ENSTSYP00000027026 ENSTSYP00000027026 IKBKE IKBKE CDKN1A CDKN1A TNF TNF MAPK3 MAPK3 LOC103274909 LOC103274909 ARAF ARAF FOS FOS PIK3CD PIK3CD TMED7 TMED7 SMAD3 SMAD3 TGFB3 TGFB3 CASP8 CASP8 MYC MYC MAP3K7 MAP3K7 TGFB1 TGFB1 ENSTSYP00000030893 ENSTSYP00000030893 AKT1 AKT1 IRAK1 IRAK1 MAPK9 MAPK9 CREB3L3 CREB3L3 TGFB2 TGFB2 IL6 IL6 TAB1 TAB1 SLC10A1 SLC10A1 ENSTSYP00000031894 ENSTSYP00000031894 CUNH7orf31 CUNH7orf31 MAPK1 MAPK1 BAX BAX EGR3 EGR3 NFATC3 NFATC3 CREBBP CREBBP GRB2 GRB2 LOC103277171 LOC103277171 SRC SRC PRKCG PRKCG ATF4 ATF4 CDK2 CDK2 ENSTSYP00000033656 ENSTSYP00000033656 PIK3CB PIK3CB IRF3 IRF3 PTK2B PTK2B TGFBR1 TGFBR1 TYK2 TYK2 IRF7 IRF7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
STAT6Signal transducer and activator of transcription. (847 aa)
SOS2Son of sevenless homolog 2 isoform X1. (1318 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
EP300Histone acetyltransferase p300. (2174 aa)
LOC103256403Signal transducer and activator of transcription 4. (281 aa)
DDB2DNA damage-binding protein 2 isoform X1. (415 aa)
RB1Retinoblastoma-associated protein. (929 aa)
MMP9Matrix metalloproteinase-9. (710 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (558 aa)
IRAK4Interleukin-1 receptor-associated kinase 4. (460 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (507 aa)
CCNA2cyclin-A2; Belongs to the cyclin family. (430 aa)
CASP9Caspase-9; Belongs to the peptidase C14A family. (410 aa)
MAVSMitochondrial antiviral-signaling protein. (521 aa)
ATF6BCyclic AMP-dependent transcription factor ATF-6 beta isoform X3. (700 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (756 aa)
SOS1Son of sevenless homolog 1 isoform X2. (441 aa)
TLR4Toll-like receptor 4 isoform X1; Belongs to the Toll-like receptor family. (840 aa)
HRASGTPase HRas isoform X6. (189 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (842 aa)
CASP12Caspase-12-like; Belongs to the peptidase C14A family. (341 aa)
DDX3XATP-dependent RNA helicase DDX3X isoform X1; Belongs to the DEAD box helicase family. (725 aa)
NFKBIANF-kappa-B inhibitor alpha. (282 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (95 aa)
PRKCAProtein kinase C. (614 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4. (393 aa)
DDX58Probable ATP-dependent RNA helicase DDX58. (926 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (744 aa)
KRASGTPase KRas isoform X1. (189 aa)
CCNE1G1/S-specific cyclin-E1. (410 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (964 aa)
NFATC2Nuclear factor of activated T-cells, cytoplasmic 2 isoform X1. (921 aa)
CREB5Cyclic AMP-responsive element-binding protein 5 isoform X1. (508 aa)
MAP2K3Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
IFIH1Interferon-induced helicase C domain-containing protein 1. (1025 aa)
CCNA1cyclin-A1; Belongs to the cyclin family. (455 aa)
MAPK10Mitogen-activated protein kinase. (473 aa)
YWHAZ14-3-3 protein zeta/delta; Belongs to the 14-3-3 family. (254 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
JAK1Tyrosine-protein kinase. (1140 aa)
VDAC3Voltage-dependent anion-selective channel protein 3 isoform X1. (284 aa)
FASTumor necrosis factor receptor superfamily member 6. (333 aa)
ENSTSYP00000006680annotation not available (255 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (668 aa)
ELK1ETS domain-containing protein Elk-1 isoform X1. (430 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (321 aa)
TAB2TGF-beta-activated kinase 1 and MAP3K7-binding protein 2. (693 aa)
LOC103258295LOW QUALITY PROTEIN: signal transducer and activator of transcription 2-like. (451 aa)
CREB3Cyclic AMP-responsive element-binding protein 3 isoform X2. (371 aa)
ENSTSYP00000007331annotation not available (100 aa)
DDB1DNA damage-binding protein 1. (1138 aa)
TLR3Toll-like receptor 3; Belongs to the Toll-like receptor family. (905 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (520 aa)
LOC103257846Caspase-3; Belongs to the peptidase C14A family. (277 aa)
BRAFSerine/threonine-protein kinase B-raf. (760 aa)
SMAD4Mothers against decapentaplegic homolog. (551 aa)
E2F2Transcription factor E2F2. (423 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1346 aa)
JAK2Tyrosine-protein kinase. (1131 aa)
CASP10Caspase-10; Belongs to the peptidase C14A family. (471 aa)
AKT3RAC-gamma serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (419 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2. (520 aa)
PRKCBNon-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (531 aa)
STAT3Signal transducer and activator of transcription 3. (444 aa)
MAP2K7Dual specificity mitogen-activated protein kinase kinase 7. (414 aa)
ENSTSYP00000014268annotation not available (236 aa)
IFNAR1Interferon alpha/beta receptor 1. (561 aa)
MAP2K4Dual specificity mitogen-activated protein kinase kinase 4 isoform X1; Belongs to the protein kinase superfamily. (387 aa)
ENSTSYP00000014599annotation not available (238 aa)
LOC103262174ATP-dependent RNA helicase DDX3X-like; Belongs to the DEAD box helicase family. (608 aa)
ENSTSYP00000014856annotation not available (69 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ENSTSYP00000015946annotation not available (229 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (512 aa)
NFATC4Nuclear factor of activated T-cells, cytoplasmic 4 isoform X1. (930 aa)
MAPK12Mitogen-activated protein kinase. (277 aa)
ATP6AP1V-type proton ATPase subunit S1. (470 aa)
BIRC5Baculoviral IAP repeat-containing protein 5 isoform X1. (142 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1. (381 aa)
TBK1Serine/threonine-protein kinase TBK1. (729 aa)
STAT5BSignal transducer and activator of transcription. (786 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
ENSTSYP00000019167annotation not available (267 aa)
LOC110596190Cytochrome c, somatic-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (108 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (612 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (193 aa)
E2F3Transcription factor E2F3. (334 aa)
ENSTSYP00000021856annotation not available (88 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
YWHAB14-3-3 protein beta/alpha isoform X1; Belongs to the 14-3-3 family. (246 aa)
HSPG2Basement membrane-specific heparan sulfate proteoglycan core protein. (4355 aa)
LOC103255989Signal transducer and activator of transcription 4. (261 aa)
TIRAPToll/interleukin-1 receptor domain-containing adapter protein isoform X1. (228 aa)
CCNE2G1/S-specific cyclin-E2 isoform X1; Belongs to the cyclin family. (404 aa)
LOC103255326Cytochrome c 2; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (96 aa)
NFATC1Nuclear factor of activated T-cells, cytoplasmic 1. (905 aa)
ENSTSYP00000023511annotation not available (453 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (388 aa)
MAP2K6LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (352 aa)
E2F1Transcription factor E2F1. (350 aa)
STAT5ASignal transducer and activator of transcription. (669 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1246 aa)
ENSTSYP00000024257annotation not available (242 aa)
RELATranscription factor p65. (519 aa)
YWHAQ14-3-3 protein theta; Belongs to the 14-3-3 family. (245 aa)
NRASGTPase NRas. (189 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2. (461 aa)
EGR2E3 SUMO-protein ligase EGR2 isoform X1. (472 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
IKBKGNF-kappa-B essential modulator. (460 aa)
MAPK11Mitogen-activated protein kinase. (255 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
LOC103251709Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (348 aa)
ENSTSYP00000027026annotation not available (105 aa)
IKBKEInhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1. (718 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (232 aa)
MAPK3Mitogen-activated protein kinase. (363 aa)
LOC103274909Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
ARAFSerine/threonine-protein kinase A-Raf isoform X1. (611 aa)
FOSProto-oncogene c-Fos. (379 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1063 aa)
TMED7Transmembrane emp24 domain-containing protein 7. (229 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
CASP8Caspase-8; Belongs to the peptidase C14A family. (521 aa)
MYCMyc proto-oncogene protein. (376 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (344 aa)
ENSTSYP00000030893annotation not available (343 aa)
AKT1Non-specific serine/threonine protein kinase. (393 aa)
IRAK1Interleukin-1 receptor-associated kinase 1. (618 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
CREB3L3LOW QUALITY PROTEIN: cyclic AMP-responsive element-binding protein 3-like protein 3. (330 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
IL6Interleukin-6. (209 aa)
TAB1TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X2. (504 aa)
SLC10A1LOW QUALITY PROTEIN: sodium/bile acid cotransporter. (345 aa)
ENSTSYP00000031894annotation not available (263 aa)
CUNH7orf31Uncharacterized protein C7orf31 homolog. (589 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (363 aa)
BAXApoptosis regulator BAX isoform X1. (192 aa)
EGR3Early growth response protein 3. (387 aa)
NFATC3Nuclear factor of activated T-cells, cytoplasmic 3 isoform X1. (1073 aa)
CREBBPCREB-binding protein isoform X1. (2433 aa)
GRB2Growth factor receptor-bound protein 2 isoform X1. (217 aa)
LOC103277171LOW QUALITY PROTEIN: signal transducer and activator of transcription 3-like. (248 aa)
SRCTyrosine-protein kinase. (542 aa)
PRKCGProtein kinase C. (634 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4 isoform X2. (352 aa)
CDK2Cyclin-dependent kinase 2 isoform X1; Belongs to the protein kinase superfamily. (346 aa)
ENSTSYP00000033656annotation not available (345 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2; Belongs to the PI3/PI4-kinase family. (1070 aa)
IRF3Interferon regulatory factor 3 isoform X2. (426 aa)
PTK2BProtein-tyrosine kinase 2-beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (487 aa)
TYK2Tyrosine-protein kinase. (869 aa)
IRF7Interferon regulatory factor 7. (133 aa)
Your Current Organism:
Carlito syrichta
NCBI taxonomy Id: 1868482
Other names: C. syrichta, Philippine tarsier, Tarsius syrichta
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