STRINGSTRING
TLR4 TLR4 IRF7 IRF7 ENSTSYP00000034948 ENSTSYP00000034948 IL18 IL18 TYK2 TYK2 TMEM223 TMEM223 IRF3 IRF3 PIK3CB PIK3CB ENSTSYP00000034361 ENSTSYP00000034361 CREBBP CREBBP ENSTSYP00000032931 ENSTSYP00000032931 RNF135 RNF135 NLRP3 NLRP3 BAX BAX MAPK1 MAPK1 CUNH7orf31 CUNH7orf31 IL6 IL6 AKT1 AKT1 CASP8 CASP8 LOC103254808 LOC103254808 ENSTSYP00000030184 ENSTSYP00000030184 PIK3CD PIK3CD KLK15 KLK15 TRIM65 TRIM65 LOC103261014 LOC103261014 ICAM1 ICAM1 TRIM47 TRIM47 LOC103274909 LOC103274909 MAPK3 MAPK3 MX1 MX1 TNFRSF1A TNFRSF1A KLK13 KLK13 TNF TNF BAK1 BAK1 IKBKE IKBKE ENSTSYP00000027026 ENSTSYP00000027026 LOC103251709 LOC103251709 IKBKG IKBKG RAB11A RAB11A DNAJB13 DNAJB13 NXF3 NXF3 DNAJB1 DNAJB1 KPNA5 KPNA5 PIK3R3 PIK3R3 ENSTSYP00000025304 ENSTSYP00000025304 LOC103249528 LOC103249528 RAE1 RAE1 LOC103274121 LOC103274121 ENSTSYP00000024872 ENSTSYP00000024872 RELA RELA PRSS2 PRSS2 APAF1 APAF1 CALCOCO2 CALCOCO2 TRADD TRADD LOC103255326 LOC103255326 ENSTSYP00000023156 ENSTSYP00000023156 ENSTSYP00000022473 ENSTSYP00000022473 STOML1 STOML1 KLK11 KLK11 TRAF3 TRAF3 ENSTSYP00000021855 ENSTSYP00000021855 BID BID TPSG1 TPSG1 RNASEL RNASEL PIK3R1 PIK3R1 TMPRSS4 TMPRSS4 ENSTSYP00000020800 ENSTSYP00000020800 KPNA6 KPNA6 LOC110596190 LOC110596190 NLRX1 NLRX1 ENSTSYP00000020233 ENSTSYP00000020233 KLK8 KLK8 XPO1 XPO1 TLR7 TLR7 ENSTSYP00000019285 ENSTSYP00000019285 NXF1 NXF1 TBK1 TBK1 DNAJB4 DNAJB4 MAP2K1 MAP2K1 SLC25A31 SLC25A31 TNFSF10 TNFSF10 CPSF4L CPSF4L ENSTSYP00000016922 ENSTSYP00000016922 SOCS3 SOCS3 ENSTSYP00000016704 ENSTSYP00000016704 ENSTSYP00000016703 ENSTSYP00000016703 CPSF4 CPSF4 VDAC1 VDAC1 RAB11B RAB11B TRIM25 TRIM25 AKT2 AKT2 ENSTSYP00000035030 ENSTSYP00000035030 CCND3 CCND3 PML PML IFNAR1 IFNAR1 ENSTSYP00000014268 ENSTSYP00000014268 ENSTSYP00000013967 ENSTSYP00000013967 ENSTSYP00000013843 ENSTSYP00000013843 SLC25A5 SLC25A5 IL12B IL12B EIF2S1 EIF2S1 FDPS FDPS HLA-DMA HLA-DMA LOC103271929 LOC103271929 HLA-DPA1 HLA-DPA1 EIF2AK2 EIF2AK2 ADAR ADAR CDK6 CDK6 IL1A IL1A CDK4 CDK4 PRKCB PRKCB DNAJC3 DNAJC3 AKT3 AKT3 TMPRSS11A TMPRSS11A CCL2 CCL2 TMPRSS11F TMPRSS11F JAK2 JAK2 RSAD2 RSAD2 HLA-DPB1 HLA-DPB1 LOC103267233 LOC103267233 ACTL8 ACTL8 LOC103267988 LOC103267988 IL33 IL33 OAS2 OAS2 OAS3 OAS3 LOC103257846 LOC103257846 TMPRSS11E TMPRSS11E TLR3 TLR3 NUP98 NUP98 IFNGR2 IFNGR2 LOC103265222 LOC103265222 KPNA2 KPNA2 ENSTSYP00000007331 ENSTSYP00000007331 LOC103258295 LOC103258295 IL1B IL1B PYCARD PYCARD PLG PLG MYD88 MYD88 HLA-DOB HLA-DOB NXT1 NXT1 IRF9 IRF9 RAF1 RAF1 KLK14 KLK14 ENSTSYP00000006680 ENSTSYP00000006680 FAS FAS CCL5 CCL5 ENSTSYP00000006536 ENSTSYP00000006536 PABPN1 PABPN1 JAK1 JAK1 HLA-DRA HLA-DRA ACTL7B ACTL7B KLK12 KLK12 LOC103269362 LOC103269362 IFNGR1 IFNGR1 IFIH1 IFIH1 TMPRSS11D TMPRSS11D COIL COIL HLA-DOA HLA-DOA NFKB1 NFKB1 HNRNPUL1 HNRNPUL1 CHUK CHUK PIK3CA PIK3CA SLC25A4 SLC25A4 DDX58 DDX58 PRKCA PRKCA CXCL8 CXCL8 NFKBIA NFKBIA OAS1 OAS1 IKBKB IKBKB MAVS MAVS CASP9 CASP9 NFKBIB NFKBIB ENSTSYP00000002080 ENSTSYP00000002080 LOC103256945 LOC103256945 IRAK4 IRAK4 TMPRSS2 TMPRSS2 NXT2 NXT2 IFNG IFNG PRSS37 PRSS37 TMPRSS11B TMPRSS11B EP300 EP300 IL12A IL12A CXCL10 CXCL10
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TLR4Toll-like receptor 4 isoform X1; Belongs to the Toll-like receptor family. (840 aa)
IRF7Interferon regulatory factor 7. (133 aa)
ENSTSYP00000034948annotation not available (607 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (192 aa)
TYK2Tyrosine-protein kinase. (869 aa)
TMEM223Transmembrane protein 223. (202 aa)
IRF3Interferon regulatory factor 3 isoform X2. (426 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2; Belongs to the PI3/PI4-kinase family. (1070 aa)
ENSTSYP00000034361annotation not available (66 aa)
CREBBPCREB-binding protein isoform X1. (2433 aa)
ENSTSYP00000032931annotation not available (296 aa)
RNF135E3 ubiquitin-protein ligase RNF135. (401 aa)
NLRP3NACHT, LRR and PYD domains-containing protein 3 isoform X1. (1037 aa)
BAXApoptosis regulator BAX isoform X1. (192 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (363 aa)
CUNH7orf31Uncharacterized protein C7orf31 homolog. (589 aa)
IL6Interleukin-6. (209 aa)
AKT1Non-specific serine/threonine protein kinase. (393 aa)
CASP8Caspase-8; Belongs to the peptidase C14A family. (521 aa)
LOC103254808Importin subunit alpha-5. (182 aa)
ENSTSYP00000030184annotation not available (260 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1063 aa)
KLK15LOW QUALITY PROTEIN: kallikrein-15. (191 aa)
TRIM65Tripartite motif-containing protein 65. (381 aa)
LOC103261014Cationic trypsin-3; Belongs to the peptidase S1 family. (248 aa)
ICAM1Intercellular adhesion molecule 1. (281 aa)
TRIM47Tripartite motif-containing protein 47. (467 aa)
LOC103274909Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
MAPK3Mitogen-activated protein kinase. (363 aa)
MX1Interferon-induced GTP-binding protein Mx1-like; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (620 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A. (183 aa)
KLK13Kallikrein-13; Belongs to the peptidase S1 family. (270 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (232 aa)
BAK1Bcl-2 homologous antagonist/killer. (211 aa)
IKBKEInhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1. (718 aa)
ENSTSYP00000027026annotation not available (105 aa)
LOC103251709Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (348 aa)
IKBKGNF-kappa-B essential modulator. (460 aa)
RAB11ARas-related protein Rab-11A. (262 aa)
DNAJB13dnaJ homolog subfamily B member 13. (308 aa)
NXF3LOW QUALITY PROTEIN: nuclear RNA export factor 3. (532 aa)
DNAJB1dnaJ homolog subfamily B member 1 isoform X1. (340 aa)
KPNA5Importin subunit alpha; Functions in nuclear protein import. (539 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2. (461 aa)
ENSTSYP00000025304annotation not available (193 aa)
LOC103249528Interferon alpha/beta receptor 2-like. (236 aa)
RAE1mRNA export factor. (521 aa)
LOC103274121Nuclear RNA export factor 2-like. (402 aa)
ENSTSYP00000024872annotation not available (524 aa)
RELATranscription factor p65. (519 aa)
PRSS2Trypsin-2; Belongs to the peptidase S1 family. (247 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1246 aa)
CALCOCO2Calcium-binding and coiled-coil domain-containing protein 2 isoform X1. (469 aa)
TRADDTumor necrosis factor receptor type 1-associated DEATH domain protein isoform X2. (310 aa)
LOC103255326Cytochrome c 2; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (96 aa)
ENSTSYP00000023156annotation not available (245 aa)
ENSTSYP00000022473annotation not available (276 aa)
STOML1Stomatin-like protein 1 isoform X1. (398 aa)
KLK11Kallikrein related peptidase 11. (250 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
ENSTSYP00000021855annotation not available (300 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (193 aa)
TPSG1LOW QUALITY PROTEIN: tryptase gamma. (290 aa)
RNASEL2-5A-dependent ribonuclease. (738 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (612 aa)
TMPRSS4Transmembrane protease serine 4 isoform X1; Belongs to the peptidase S1 family. (435 aa)
ENSTSYP00000020800annotation not available (283 aa)
KPNA6Importin subunit alpha; Functions in nuclear protein import. (542 aa)
LOC110596190Cytochrome c, somatic-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (108 aa)
NLRX1NLR family member X1. (974 aa)
ENSTSYP00000020233annotation not available (371 aa)
KLK8Kallikrein-8 isoform X1; Belongs to the peptidase S1 family. (283 aa)
XPO1Exportin-1. (1071 aa)
TLR7Toll-like receptor 7; Belongs to the Toll-like receptor family. (1050 aa)
ENSTSYP00000019285annotation not available (346 aa)
NXF1Nuclear RNA export factor 1. (618 aa)
TBK1Serine/threonine-protein kinase TBK1. (729 aa)
DNAJB4dnaJ homolog subfamily B member 4. (337 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1. (381 aa)
SLC25A31ADP/ATP translocase 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (299 aa)
TNFSF10Tumor necrosis factor ligand superfamily member 10 isoform X2. (101 aa)
CPSF4LCleavage and polyadenylation specific factor 4 like. (158 aa)
ENSTSYP00000016922annotation not available (291 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
ENSTSYP00000016704annotation not available (357 aa)
ENSTSYP00000016703annotation not available (259 aa)
CPSF4Cleavage and polyadenylation specificity factor subunit 4 isoform X2. (244 aa)
VDAC1Voltage-dependent anion-selective channel protein 1 isoform X2. (297 aa)
RAB11BRas-related protein Rab-11B. (218 aa)
TRIM25E3 ubiquitin/ISG15 ligase TRIM25. (619 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ENSTSYP00000035030annotation not available (263 aa)
CCND3G1/S-specific cyclin-D3 isoform X1; Belongs to the cyclin family. (292 aa)
PMLProtein PML. (885 aa)
IFNAR1Interferon alpha/beta receptor 1. (561 aa)
ENSTSYP00000014268annotation not available (236 aa)
ENSTSYP00000013967annotation not available (167 aa)
ENSTSYP00000013843annotation not available (133 aa)
SLC25A5LOW QUALITY PROTEIN: ADP/ATP translocase 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (326 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit 1. (315 aa)
FDPSFarnesyl pyrophosphate synthase isoform X1. (248 aa)
HLA-DMAHLA class II histocompatibility antigen, DM alpha chain isoform X3; Belongs to the MHC class II family. (261 aa)
LOC103271929HLA class II histocompatibility antigen, DM beta chain isoform X5. (263 aa)
HLA-DPA1HLA class II histocompatibility antigen, DP alpha 1 chain-like; Belongs to the MHC class II family. (260 aa)
EIF2AK2Interferon-induced, double-stranded RNA-activated protein kinase isoform X2. (532 aa)
ADARDouble-stranded RNA-specific adenosine deaminase. (930 aa)
CDK6Cyclin-dependent kinase 6. (264 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (273 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
PRKCBNon-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (531 aa)
DNAJC3dnaJ homolog subfamily C member 3. (450 aa)
AKT3RAC-gamma serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (419 aa)
TMPRSS11ATransmembrane protease serine 11A-like; Belongs to the peptidase S1 family. (420 aa)
CCL2C-C motif chemokine. (99 aa)
TMPRSS11FTransmembrane protease serine; Belongs to the peptidase S1 family. (438 aa)
JAK2Tyrosine-protein kinase. (1131 aa)
RSAD2Radical S-adenosyl methionine domain-containing protein 2. (362 aa)
HLA-DPB1HLA class II histocompatibility antigen, DP beta 1 chain-like isoform X2. (258 aa)
LOC103267233Caspase-1-like; Belongs to the peptidase C14A family. (291 aa)
ACTL8LOW QUALITY PROTEIN: actin-like protein 8; Belongs to the actin family. (366 aa)
LOC103267988LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DRB1-9 beta chain-like. (256 aa)
IL33Interleukin-33-like. (231 aa)
OAS22'-5'-oligoadenylate synthase 2-like. (710 aa)
OAS32'-5'-oligoadenylate synthase 3. (1082 aa)
LOC103257846Caspase-3; Belongs to the peptidase C14A family. (277 aa)
TMPRSS11ETransmembrane protease serine; Belongs to the peptidase S1 family. (422 aa)
TLR3Toll-like receptor 3; Belongs to the Toll-like receptor family. (905 aa)
NUP98Nuclear pore complex protein Nup98-Nup96 isoform X1. (1559 aa)
IFNGR2Interferon gamma receptor 2. (317 aa)
LOC103265222Interferon-induced GTP-binding protein Mx2-like; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (423 aa)
KPNA2Importin subunit alpha; Functions in nuclear protein import. (458 aa)
ENSTSYP00000007331annotation not available (100 aa)
LOC103258295LOW QUALITY PROTEIN: signal transducer and activator of transcription 2-like. (451 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (267 aa)
PYCARDApoptosis-associated speck-like protein containing a CARD isoform X1. (194 aa)
PLGPlasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (810 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (321 aa)
HLA-DOBHLA class II histocompatibility antigen, DO beta chain isoform X1. (273 aa)
NXT1NTF2-related export protein 1. (140 aa)
IRF9Interferon regulatory factor 9. (398 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (668 aa)
KLK14Kallikrein-14; Belongs to the peptidase S1 family. (267 aa)
ENSTSYP00000006680annotation not available (255 aa)
FASTumor necrosis factor receptor superfamily member 6. (333 aa)
CCL5C-C motif chemokine. (91 aa)
ENSTSYP00000006536annotation not available (309 aa)
PABPN1Polyadenylate-binding protein 2. (333 aa)
JAK1Tyrosine-protein kinase. (1140 aa)
HLA-DRAHLA class II histocompatibility antigen, DR alpha chain; Belongs to the MHC class II family. (254 aa)
ACTL7BLOW QUALITY PROTEIN: actin-like protein 7B; Belongs to the actin family. (366 aa)
KLK12Kallikrein-12; Belongs to the peptidase S1 family. (250 aa)
LOC103269362Interferon alpha/beta receptor 2. (278 aa)
IFNGR1Interferon gamma receptor 1. (478 aa)
IFIH1Interferon-induced helicase C domain-containing protein 1. (1025 aa)
TMPRSS11DTransmembrane protease serine 11D; Belongs to the peptidase S1 family. (312 aa)
COILCoilin. (536 aa)
HLA-DOAHLA class II histocompatibility antigen, DO alpha chain; Belongs to the MHC class II family. (250 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (964 aa)
HNRNPUL1Heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X1. (858 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (744 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
SLC25A4ADP/ATP translocase 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
DDX58Probable ATP-dependent RNA helicase DDX58. (926 aa)
PRKCAProtein kinase C. (614 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (95 aa)
NFKBIANF-kappa-B inhibitor alpha. (282 aa)
OAS12'-5'-oligoadenylate synthase 1 isoform X1. (349 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (756 aa)
MAVSMitochondrial antiviral-signaling protein. (521 aa)
CASP9Caspase-9; Belongs to the peptidase C14A family. (410 aa)
NFKBIBNF-kappa-B inhibitor beta isoform X2. (343 aa)
ENSTSYP00000002080annotation not available (296 aa)
LOC103256945SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like. (256 aa)
IRAK4Interleukin-1 receptor-associated kinase 4. (460 aa)
TMPRSS2Transmembrane protease serine 2; Belongs to the peptidase S1 family. (523 aa)
NXT2NTF2-related export protein 2 isoform X1. (142 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (165 aa)
PRSS37Probable inactive serine protease 37 isoform X1. (235 aa)
TMPRSS11BTransmembrane protease serine 11B; Belongs to the peptidase S1 family. (417 aa)
EP300Histone acetyltransferase p300. (2174 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (233 aa)
CXCL10C-X-C motif chemokine. (98 aa)
Your Current Organism:
Carlito syrichta
NCBI taxonomy Id: 1868482
Other names: C. syrichta, Philippine tarsier, Tarsius syrichta
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