STRINGSTRING
TGFBR1 TGFBR1 PIK3CB PIK3CB PMAIP1 PMAIP1 GRB2 GRB2 BAX BAX RAC2 RAC2 MAPK1 MAPK1 CUNH7orf31 CUNH7orf31 TGFB2 TGFB2 RPS6KB2 RPS6KB2 MAPK9 MAPK9 AKT1 AKT1 TGFB1 TGFB1 MYC MYC EPGN EPGN TGFB3 TGFB3 SMAD3 SMAD3 PIK3CD PIK3CD FOS FOS ENSTSYP00000029618 ENSTSYP00000029618 ARAF ARAF RALB RALB AXIN1 AXIN1 LOC103274909 LOC103274909 MAPK3 MAPK3 TCF7L2 TCF7L2 CDKN1A CDKN1A BAK1 BAK1 ENSTSYP00000027026 ENSTSYP00000027026 RHOA-2 RHOA-2 LOC103251709 LOC103251709 MAPK8 MAPK8 PIK3R3 PIK3R3 MSH6 MSH6 NRAS NRAS RALGDS RALGDS APC APC RHOA RHOA LEF1 LEF1 SOS2 SOS2 TP53 TP53 LOC103255326 LOC103255326 LOC103266579 LOC103266579 ENSTSYP00000022986 ENSTSYP00000022986 CCND1 CCND1 ENSTSYP00000022482 ENSTSYP00000022482 TGFA TGFA ENSTSYP00000021856 ENSTSYP00000021856 PIK3R1 PIK3R1 RALA RALA LOC110596190 LOC110596190 RPS6KB1 RPS6KB1 ENSTSYP00000018500 ENSTSYP00000018500 MAP2K1 MAP2K1 AXIN2 AXIN2 BIRC5 BIRC5 ENSTSYP00000017214 ENSTSYP00000017214 RAC1 RAC1 RHOC RHOC TCF7L1 TCF7L1 GSK3B GSK3B AKT2 AKT2 ENSTSYP00000014856 ENSTSYP00000014856 ENSTSYP00000014268 ENSTSYP00000014268 RAC3 RAC3 MTOR MTOR BCL2L11 BCL2L11 CTNNB1 CTNNB1 AKT3 AKT3 TCF7 TCF7 AREG AREG MSH2 MSH2 SMAD4 SMAD4 EGF EGF BRAF BRAF LOC103257846 LOC103257846 ENSTSYP00000007331 ENSTSYP00000007331 RAF1 RAF1 EGFR EGFR MAPK10 MAPK10 MSH3 MSH3 MLH1 MLH1 SMAD2 SMAD2 EREG EREG POLK POLK KRAS KRAS PIK3CA PIK3CA CSDE1 CSDE1 HRAS HRAS SOS1 SOS1 CASP9 CASP9 APPL1 APPL1 ENSTSYP00000002295 ENSTSYP00000002295 TGFBR2 TGFBR2 DDB2 DDB2 DCC DCC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (487 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2; Belongs to the PI3/PI4-kinase family. (1070 aa)
PMAIP1Phorbol-12-myristate-13-acetate-induced protein 1. (54 aa)
GRB2Growth factor receptor-bound protein 2 isoform X1. (217 aa)
BAXApoptosis regulator BAX isoform X1. (192 aa)
RAC2Ras-related C3 botulinum toxin substrate 2 isoform X1. (192 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (363 aa)
CUNH7orf31Uncharacterized protein C7orf31 homolog. (589 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
RPS6KB2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
AKT1Non-specific serine/threonine protein kinase. (393 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (344 aa)
MYCMyc proto-oncogene protein. (376 aa)
EPGNEpigen isoform X1. (153 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1063 aa)
FOSProto-oncogene c-Fos. (379 aa)
ENSTSYP00000029618annotation not available (173 aa)
ARAFSerine/threonine-protein kinase A-Raf isoform X1. (611 aa)
RALBRas-related protein Ral-B. (212 aa)
AXIN1Axin-1. (574 aa)
LOC103274909Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
MAPK3Mitogen-activated protein kinase. (363 aa)
TCF7L2Transcription factor 7-like 2 isoform X1. (565 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
BAK1Bcl-2 homologous antagonist/killer. (211 aa)
ENSTSYP00000027026annotation not available (105 aa)
RHOA-2Transforming protein RhoA isoform X1. (193 aa)
LOC103251709Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (348 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2. (461 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1300 aa)
NRASGTPase NRas. (189 aa)
RALGDSRal guanine nucleotide dissociation stimulator. (920 aa)
APCAdenomatous polyposis coli protein isoform X2. (2844 aa)
RHOATransforming protein RhoA isoform X7. (81 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X2. (399 aa)
SOS2Son of sevenless homolog 2 isoform X1. (1318 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (388 aa)
LOC103255326Cytochrome c 2; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (96 aa)
LOC103266579Growth arrest and DNA damage-inducible protein GADD45 alpha-like. (84 aa)
ENSTSYP00000022986annotation not available (803 aa)
CCND1G1/S-specific cyclin-D1. (156 aa)
ENSTSYP00000022482annotation not available (178 aa)
TGFATransforming growth factor alpha. (164 aa)
ENSTSYP00000021856annotation not available (88 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (612 aa)
RALARas-related protein Ral-A. (206 aa)
LOC110596190Cytochrome c, somatic-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (108 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
ENSTSYP00000018500annotation not available (73 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1. (381 aa)
AXIN2Axin-2. (649 aa)
BIRC5Baculoviral IAP repeat-containing protein 5 isoform X1. (142 aa)
ENSTSYP00000017214annotation not available (178 aa)
RAC1Ras-related C3 botulinum toxin substrate 1. (212 aa)
RHOCRho-related GTP-binding protein RhoC isoform X2. (193 aa)
TCF7L1Transcription factor 7-like 1. (499 aa)
GSK3BGlycogen synthase kinase-3 beta; Belongs to the protein kinase superfamily. (403 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ENSTSYP00000014856annotation not available (69 aa)
ENSTSYP00000014268annotation not available (236 aa)
RAC3Ras-related C3 botulinum toxin substrate 3. (192 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
BCL2L11Bcl-2-like protein 11 isoform X1. (200 aa)
CTNNB1Catenin beta-1 isoform X1. (783 aa)
AKT3RAC-gamma serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (419 aa)
TCF7Transcription factor 7 isoform X1. (400 aa)
AREGAmphiregulin isoform X1. (270 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (925 aa)
SMAD4Mothers against decapentaplegic homolog. (551 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1167 aa)
BRAFSerine/threonine-protein kinase B-raf. (760 aa)
LOC103257846Caspase-3; Belongs to the peptidase C14A family. (277 aa)
ENSTSYP00000007331annotation not available (100 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (668 aa)
EGFRReceptor protein-tyrosine kinase. (1180 aa)
MAPK10Mitogen-activated protein kinase. (473 aa)
MSH3DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1122 aa)
MLH1DNA mismatch repair protein Mlh1 isoform X1. (757 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
EREGProepiregulin. (167 aa)
POLKDNA polymerase kappa. (804 aa)
KRASGTPase KRas isoform X1. (189 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (842 aa)
HRASGTPase HRas isoform X6. (189 aa)
SOS1Son of sevenless homolog 1 isoform X2. (441 aa)
CASP9Caspase-9; Belongs to the peptidase C14A family. (410 aa)
APPL1DCC-interacting protein 13-alpha. (708 aa)
ENSTSYP00000002295annotation not available (173 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (558 aa)
DDB2DNA damage-binding protein 2 isoform X1. (415 aa)
DCCNetrin receptor DCC. (877 aa)
Your Current Organism:
Carlito syrichta
NCBI taxonomy Id: 1868482
Other names: C. syrichta, Philippine tarsier, Tarsius syrichta
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