STRINGSTRING
RAC2 RAC2 CASP9 CASP9 IKBKB IKBKB PIK3CA PIK3CA CHUK CHUK KRAS KRAS POLK POLK NFKB1 NFKB1 SMAD2 SMAD2 MAPK10 MAPK10 EGFR EGFR JAK1 JAK1 RAF1 RAF1 BRAF BRAF EGF EGF SMAD4 SMAD4 E2F2 E2F2 RALBP1 RALBP1 AKT3 AKT3 CDK4 CDK4 STAT3 STAT3 MTOR MTOR CDK6 CDK6 RAC3 RAC3 BCL2L1 BCL2L1 ERBB2 ERBB2 ENSTSYP00000014856 ENSTSYP00000014856 AKT2 AKT2 RAC1 RAC1 ENSTSYP00000017214 ENSTSYP00000017214 CDKN2A CDKN2A MAP2K1 MAP2K1 VEGFA VEGFA RPS6KB1 RPS6KB1 PLD2 PLD2 RALA RALA PIK3R1 PIK3R1 E2F3 E2F3 ENSTSYP00000021856 ENSTSYP00000021856 TGFA TGFA CCND1 CCND1 LOC103266579 LOC103266579 TP53 TP53 E2F1 E2F1 ENSTSYP00000024401 ENSTSYP00000024401 RELA RELA RALGDS RALGDS PIK3R3 PIK3R3 MAPK8 MAPK8 IKBKG IKBKG BAK1 BAK1 CDKN1A CDKN1A MAPK3 MAPK3 RALB RALB ARAF ARAF ENSTSYP00000029618 ENSTSYP00000029618 PIK3CD PIK3CD SMAD3 SMAD3 TGFB3 TGFB3 ENSTSYP00000030193 ENSTSYP00000030193 TGFB1 TGFB1 AKT1 AKT1 MAPK9 MAPK9 ENSTSYP00000031441 ENSTSYP00000031441 RPS6KB2 RPS6KB2 TGFB2 TGFB2 CDC42 CDC42 ENSTSYP00000031894 ENSTSYP00000031894 MAPK1 MAPK1 BAX BAX ARHGEF6 ARHGEF6 LOC103277171 LOC103277171 PIK3CB PIK3CB TGFBR1 TGFBR1 ENSTSYP00000035030 ENSTSYP00000035030 BRCA2 BRCA2 ENSTSYP00000000627 ENSTSYP00000000627 RAD51 RAD51 DDB2 DDB2 RB1 RB1 PLD1 PLD1 TGFBR2 TGFBR2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RAC2Ras-related C3 botulinum toxin substrate 2 isoform X1. (192 aa)
CASP9Caspase-9; Belongs to the peptidase C14A family. (410 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (756 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (744 aa)
KRASGTPase KRas isoform X1. (189 aa)
POLKDNA polymerase kappa. (804 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (964 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
MAPK10Mitogen-activated protein kinase. (473 aa)
EGFRReceptor protein-tyrosine kinase. (1180 aa)
JAK1Tyrosine-protein kinase. (1140 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (668 aa)
BRAFSerine/threonine-protein kinase B-raf. (760 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1167 aa)
SMAD4Mothers against decapentaplegic homolog. (551 aa)
E2F2Transcription factor E2F2. (423 aa)
RALBP1ralA-binding protein 1 isoform X1. (650 aa)
AKT3RAC-gamma serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (419 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
STAT3Signal transducer and activator of transcription 3. (444 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
CDK6Cyclin-dependent kinase 6. (264 aa)
RAC3Ras-related C3 botulinum toxin substrate 3. (192 aa)
BCL2L1Bcl-2-like protein 1 isoform X1. (233 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
ENSTSYP00000014856annotation not available (69 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
RAC1Ras-related C3 botulinum toxin substrate 1. (212 aa)
ENSTSYP00000017214annotation not available (178 aa)
CDKN2ACyclin-dependent kinase inhibitor 2A. (171 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1. (381 aa)
VEGFAVascular endothelial growth factor A isoform X2; Belongs to the PDGF/VEGF growth factor family. (186 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
PLD2Phospholipase. (934 aa)
RALARas-related protein Ral-A. (206 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (612 aa)
E2F3Transcription factor E2F3. (334 aa)
ENSTSYP00000021856annotation not available (88 aa)
TGFATransforming growth factor alpha. (164 aa)
CCND1G1/S-specific cyclin-D1. (156 aa)
LOC103266579Growth arrest and DNA damage-inducible protein GADD45 alpha-like. (84 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (388 aa)
E2F1Transcription factor E2F1. (350 aa)
ENSTSYP00000024401annotation not available (186 aa)
RELATranscription factor p65. (519 aa)
RALGDSRal guanine nucleotide dissociation stimulator. (920 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2. (461 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
IKBKGNF-kappa-B essential modulator. (460 aa)
BAK1Bcl-2 homologous antagonist/killer. (211 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
MAPK3Mitogen-activated protein kinase. (363 aa)
RALBRas-related protein Ral-B. (212 aa)
ARAFSerine/threonine-protein kinase A-Raf isoform X1. (611 aa)
ENSTSYP00000029618annotation not available (173 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1063 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
ENSTSYP00000030193annotation not available (164 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (344 aa)
AKT1Non-specific serine/threonine protein kinase. (393 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
ENSTSYP00000031441annotation not available (131 aa)
RPS6KB2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
CDC42Cell division control protein 42 homolog. (191 aa)
ENSTSYP00000031894annotation not available (263 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (363 aa)
BAXApoptosis regulator BAX isoform X1. (192 aa)
ARHGEF6Rho guanine nucleotide exchange factor 6 isoform X1. (777 aa)
LOC103277171LOW QUALITY PROTEIN: signal transducer and activator of transcription 3-like. (248 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2; Belongs to the PI3/PI4-kinase family. (1070 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (487 aa)
ENSTSYP00000035030annotation not available (263 aa)
BRCA2LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein. (3391 aa)
ENSTSYP00000000627annotation not available (167 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (349 aa)
DDB2DNA damage-binding protein 2 isoform X1. (415 aa)
RB1Retinoblastoma-associated protein. (929 aa)
PLD1Phospholipase. (1075 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (558 aa)
Your Current Organism:
Carlito syrichta
NCBI taxonomy Id: 1868482
Other names: C. syrichta, Philippine tarsier, Tarsius syrichta
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