STRINGSTRING
ERG ERG SOS2 SOS2 EP300 EP300 SRD5A2 SRD5A2 RB1 RB1 MMP9 MMP9 TMPRSS2 TMPRSS2 IGF1R IGF1R PLAT PLAT CASP9 CASP9 ETV5 ETV5 IKBKB IKBKB SOS1 SOS1 MMP10 MMP10 HRAS HRAS CSDE1 CSDE1 NFKBIA NFKBIA CREB3L4 CREB3L4 PIK3CA PIK3CA CHUK CHUK KRAS KRAS PDGFRA PDGFRA CCNE1 CCNE1 NFKB1 NFKB1 CREB5 CREB5 EGFR EGFR PDPK1 PDPK1 CREB1 CREB1 MMP3 MMP3 RAF1 RAF1 CREB3 CREB3 PLAU PLAU IL1R2 IL1R2 CREB3L1 CREB3L1 BRAF BRAF EGF EGF LOC103260890 LOC103260890 AR AR E2F2 E2F2 FGFR2 FGFR2 TCF7 TCF7 LOC103251683 LOC103251683 AKT3 AKT3 CTNNB1 CTNNB1 PDGFC PDGFC CREB3L2 CREB3L2 HSP90AA1 HSP90AA1 PDGFD PDGFD MTOR MTOR HSP90B1 HSP90B1 ERBB2 ERBB2 ENSTSYP00000014856 ENSTSYP00000014856 AKT2 AKT2 GSK3B GSK3B TCF7L1 TCF7L1 MAP2K1 MAP2K1 LOC103267910 LOC103267910 ENSTSYP00000019705 ENSTSYP00000019705 PIK3R1 PIK3R1 E2F3 E2F3 ENSTSYP00000021856 ENSTSYP00000021856 TGFA TGFA FGFR1 FGFR1 ENSTSYP00000022518 ENSTSYP00000022518 CCND1 CCND1 LOC103250373 LOC103250373 CCNE2 CCNE2 ENSTSYP00000023190 ENSTSYP00000023190 INSRR INSRR ZEB1 ZEB1 TP53 TP53 E2F1 E2F1 LEF1 LEF1 SPINT1 SPINT1 RELA RELA HSP90AB1 HSP90AB1 NRAS NRAS GSTP1 GSTP1 PIK3R3 PIK3R3 IKBKG IKBKG LOC103251709 LOC103251709 CDKN1A CDKN1A TCF7L2 TCF7L2 ENSTSYP00000027808 ENSTSYP00000027808 MAPK3 MAPK3 CDKN1B CDKN1B PDGFRB PDGFRB IGF1 IGF1 ARAF ARAF PDGFB PDGFB PIK3CD PIK3CD ENSTSYP00000030439 ENSTSYP00000030439 ENSTSYP00000030893 ENSTSYP00000030893 AKT1 AKT1 CREB3L3 CREB3L3 PTEN PTEN ENSTSYP00000031842 ENSTSYP00000031842 MAPK1 MAPK1 CREBBP CREBBP GRB2 GRB2 PDGFA PDGFA ATF4 ATF4 CDK2 CDK2 ENSTSYP00000033656 ENSTSYP00000033656 PIK3CB PIK3CB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ERGTranscriptional regulator ERG isoform X1. (485 aa)
SOS2Son of sevenless homolog 2 isoform X1. (1318 aa)
EP300Histone acetyltransferase p300. (2174 aa)
SRD5A23-oxo-5-alpha-steroid 4-dehydrogenase 2. (254 aa)
RB1Retinoblastoma-associated protein. (929 aa)
MMP9Matrix metalloproteinase-9. (710 aa)
TMPRSS2Transmembrane protease serine 2; Belongs to the peptidase S1 family. (523 aa)
IGF1RTyrosine-protein kinase receptor. (1335 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (563 aa)
CASP9Caspase-9; Belongs to the peptidase C14A family. (410 aa)
ETV5ETS translocation variant 5. (435 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (756 aa)
SOS1Son of sevenless homolog 1 isoform X2. (441 aa)
MMP10Matrix metallopeptidase 10. (467 aa)
HRASGTPase HRas isoform X6. (189 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (842 aa)
NFKBIANF-kappa-B inhibitor alpha. (282 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4. (393 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (744 aa)
KRASGTPase KRas isoform X1. (189 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1088 aa)
CCNE1G1/S-specific cyclin-E1. (410 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (964 aa)
CREB5Cyclic AMP-responsive element-binding protein 5 isoform X1. (508 aa)
EGFRReceptor protein-tyrosine kinase. (1180 aa)
PDPK13-phosphoinositide-dependent protein kinase 1. (554 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
MMP3Stromelysin-1. (477 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (668 aa)
CREB3Cyclic AMP-responsive element-binding protein 3 isoform X2. (371 aa)
PLAUUrokinase-type plasminogen activator isoform X1. (433 aa)
IL1R2Interleukin-1 receptor type 2. (387 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (520 aa)
BRAFSerine/threonine-protein kinase B-raf. (760 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1167 aa)
LOC103260890ETS translocation variant 5 isoform X1. (448 aa)
ARAndrogen receptor. (887 aa)
E2F2Transcription factor E2F2. (423 aa)
FGFR2Fibroblast growth factor receptor 2 isoform X1. (615 aa)
TCF7Transcription factor 7 isoform X1. (400 aa)
LOC103251683Insulin-like; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (99 aa)
AKT3RAC-gamma serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (419 aa)
CTNNB1Catenin beta-1 isoform X1. (783 aa)
PDGFCPlatelet-derived growth factor C isoform X1; Belongs to the PDGF/VEGF growth factor family. (345 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2. (520 aa)
HSP90AA1Heat shock protein HSP 90-alpha. (813 aa)
PDGFDPlatelet-derived growth factor D. (370 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
HSP90B1Endoplasmin isoform X1. (804 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
ENSTSYP00000014856annotation not available (69 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
GSK3BGlycogen synthase kinase-3 beta; Belongs to the protein kinase superfamily. (403 aa)
TCF7L1Transcription factor 7-like 1. (499 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1. (381 aa)
LOC103267910Fibroblast growth factor receptor 2-like. (208 aa)
ENSTSYP00000019705annotation not available (218 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (612 aa)
E2F3Transcription factor E2F3. (334 aa)
ENSTSYP00000021856annotation not available (88 aa)
TGFATransforming growth factor alpha. (164 aa)
FGFR1Fibroblast growth factor receptor. (832 aa)
ENSTSYP00000022518annotation not available (698 aa)
CCND1G1/S-specific cyclin-D1. (156 aa)
LOC103250373E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (426 aa)
CCNE2G1/S-specific cyclin-E2 isoform X1; Belongs to the cyclin family. (404 aa)
ENSTSYP00000023190annotation not available (646 aa)
INSRRTyrosine-protein kinase receptor. (1284 aa)
ZEB1Zinc finger E-box-binding homeobox 1. (1105 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (388 aa)
E2F1Transcription factor E2F1. (350 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X2. (399 aa)
SPINT1Kunitz-type protease inhibitor 1. (515 aa)
RELATranscription factor p65. (519 aa)
HSP90AB1Heat shock protein HSP 90-beta isoform X1. (723 aa)
NRASGTPase NRas. (189 aa)
GSTP1LOW QUALITY PROTEIN: glutathione S-transferase P; Belongs to the GST superfamily. (184 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2. (461 aa)
IKBKGNF-kappa-B essential modulator. (460 aa)
LOC103251709Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (348 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
TCF7L2Transcription factor 7-like 2 isoform X1. (565 aa)
ENSTSYP00000027808annotation not available (611 aa)
MAPK3Mitogen-activated protein kinase. (363 aa)
CDKN1BLOW QUALITY PROTEIN: cyclin-dependent kinase inhibitor 1B. (197 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1105 aa)
IGF1Insulin-like growth factor I isoform X1. (209 aa)
ARAFSerine/threonine-protein kinase A-Raf isoform X1. (611 aa)
PDGFBPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (229 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1063 aa)
ENSTSYP00000030439annotation not available (315 aa)
ENSTSYP00000030893annotation not available (343 aa)
AKT1Non-specific serine/threonine protein kinase. (393 aa)
CREB3L3LOW QUALITY PROTEIN: cyclic AMP-responsive element-binding protein 3-like protein 3. (330 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
ENSTSYP00000031842annotation not available (607 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (363 aa)
CREBBPCREB-binding protein isoform X1. (2433 aa)
GRB2Growth factor receptor-bound protein 2 isoform X1. (217 aa)
PDGFAPlatelet-derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (202 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4 isoform X2. (352 aa)
CDK2Cyclin-dependent kinase 2 isoform X1; Belongs to the protein kinase superfamily. (346 aa)
ENSTSYP00000033656annotation not available (345 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2; Belongs to the PI3/PI4-kinase family. (1070 aa)
Your Current Organism:
Carlito syrichta
NCBI taxonomy Id: 1868482
Other names: C. syrichta, Philippine tarsier, Tarsius syrichta
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