(54 nodes) Basal cell carcinoma network (Carlito syrichta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	WNT2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
	DDB2	DNA damage-binding protein 2 isoform X1. (415 aa)
	FZD6	Frizzled-6 isoform X1; Belongs to the G-protein coupled receptor Fz/Smo family. (703 aa)
	PTCH1	Protein patched homolog 1. (1318 aa)
	POLK	DNA polymerase kappa. (804 aa)
	HHIP	Hedgehog-interacting protein. (700 aa)
	FZD3	Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family. (603 aa)
	DVL3	Segment polarity protein dishevelled homolog DVL-3 isoform X1. (685 aa)
	GLI3	LOW QUALITY PROTEIN: transcriptional activator GLI3. (1533 aa)
	WNT16	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
	TCF7	Transcription factor 7 isoform X1. (400 aa)
	FZD9	Frizzled-9; Belongs to the G-protein coupled receptor Fz/Smo family. (365 aa)
	CTNNB1	Catenin beta-1 isoform X1. (783 aa)
	WNT7A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (297 aa)
	WNT3	Wnt family member 3. (239 aa)
	SHH	Sonic hedgehog signaling molecule. (368 aa)
	WNT7B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
	GSK3B	Glycogen synthase kinase-3 beta; Belongs to the protein kinase superfamily. (403 aa)
	TCF7L1	Transcription factor 7-like 1. (499 aa)
	AXIN2	Axin-2. (649 aa)
	WNT9B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (335 aa)
	LOC103250886	Segment polarity protein dishevelled homolog DVL-1-like. (373 aa)
	KIF27	Kinesin-like protein KIF27 isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1400 aa)
	SUFU	Suppressor of fused homolog. (511 aa)
	KIF7	Kinesin-like protein KIF7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1200 aa)
	FZD4	Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (507 aa)
	LOC103266579	Growth arrest and DNA damage-inducible protein GADD45 alpha-like. (84 aa)
	WNT6	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (366 aa)
	WNT9A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (364 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (388 aa)
	LEF1	Lymphoid enhancer-binding factor 1 isoform X2. (399 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
	WNT8A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (356 aa)
	APC	Adenomatous polyposis coli protein isoform X2. (2844 aa)
	PTCH2	Protein patched homolog 2. (1207 aa)
	GLI1	LOW QUALITY PROTEIN: zinc finger protein GLI1. (1105 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (387 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	BMP4	Bone morphogenetic protein 4 isoform X1. (409 aa)
	WNT3A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	BAK1	Bcl-2 homologous antagonist/killer. (211 aa)
	CDKN1A	Cyclin-dependent kinase inhibitor 1. (164 aa)
	TCF7L2	Transcription factor 7-like 2 isoform X1. (565 aa)
	WNT10A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (397 aa)
	AXIN1	Axin-1. (574 aa)
	WNT5B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa)
	DVL2	Segment polarity protein dishevelled homolog DVL-2 isoform X1. (736 aa)
	WNT4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	SMO	Smoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
	BAX	Apoptosis regulator BAX isoform X1. (192 aa)
	WNT2B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (330 aa)
	WNT10B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
	BMP2	Bone morphogenetic protein 2. (398 aa)
	LOC103268188	Zinc finger protein GLI2. (760 aa)

Your Current Organism:

Carlito syrichta

NCBI taxonomy Id: 1868482
Other names: C. syrichta, Philippine tarsier, Tarsius syrichta

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APC	AXIN1	ENSTSYP00000024747	ENSTSYP00000028314	Adenomatous polyposis coli protein isoform X2.	Axin-1.	0.999
APC	AXIN2	ENSTSYP00000024747	ENSTSYP00000017909	Adenomatous polyposis coli protein isoform X2.	Axin-2.	0.993
APC	CTNNB1	ENSTSYP00000024747	ENSTSYP00000010210	Adenomatous polyposis coli protein isoform X2.	Catenin beta-1 isoform X1.	0.999
APC	DVL2	ENSTSYP00000024747	ENSTSYP00000030749	Adenomatous polyposis coli protein isoform X2.	Segment polarity protein dishevelled homolog DVL-2 isoform X1.	0.917
APC	DVL3	ENSTSYP00000024747	ENSTSYP00000008405	Adenomatous polyposis coli protein isoform X2.	Segment polarity protein dishevelled homolog DVL-3 isoform X1.	0.914
APC	FZD3	ENSTSYP00000024747	ENSTSYP00000007982	Adenomatous polyposis coli protein isoform X2.	Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family.	0.543
APC	FZD4	ENSTSYP00000024747	ENSTSYP00000022751	Adenomatous polyposis coli protein isoform X2.	Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family.	0.543
APC	FZD6	ENSTSYP00000024747	ENSTSYP00000002576	Adenomatous polyposis coli protein isoform X2.	Frizzled-6 isoform X1; Belongs to the G-protein coupled receptor Fz/Smo family.	0.534
APC	FZD9	ENSTSYP00000024747	ENSTSYP00000009934	Adenomatous polyposis coli protein isoform X2.	Frizzled-9; Belongs to the G-protein coupled receptor Fz/Smo family.	0.543
APC	GSK3B	ENSTSYP00000024747	ENSTSYP00000015538	Adenomatous polyposis coli protein isoform X2.	Glycogen synthase kinase-3 beta; Belongs to the protein kinase superfamily.	0.995
APC	LEF1	ENSTSYP00000024747	ENSTSYP00000024050	Adenomatous polyposis coli protein isoform X2.	Lymphoid enhancer-binding factor 1 isoform X2.	0.892
APC	LOC103250886	ENSTSYP00000024747	ENSTSYP00000021283	Adenomatous polyposis coli protein isoform X2.	Segment polarity protein dishevelled homolog DVL-1-like.	0.933
APC	SMO	ENSTSYP00000024747	ENSTSYP00000031831	Adenomatous polyposis coli protein isoform X2.	Smoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family.	0.420
APC	TCF7	ENSTSYP00000024747	ENSTSYP00000009642	Adenomatous polyposis coli protein isoform X2.	Transcription factor 7 isoform X1.	0.892
APC	TCF7L1	ENSTSYP00000024747	ENSTSYP00000016099	Adenomatous polyposis coli protein isoform X2.	Transcription factor 7-like 1.	0.892
APC	TCF7L2	ENSTSYP00000024747	ENSTSYP00000027423	Adenomatous polyposis coli protein isoform X2.	Transcription factor 7-like 2 isoform X1.	0.892
APC	TP53	ENSTSYP00000024747	ENSTSYP00000023752	Adenomatous polyposis coli protein isoform X2.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.471
APC	WNT1	ENSTSYP00000024747	ENSTSYP00000025394	Adenomatous polyposis coli protein isoform X2.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.703
APC	WNT10A	ENSTSYP00000024747	ENSTSYP00000028133	Adenomatous polyposis coli protein isoform X2.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.411
APC	WNT10B	ENSTSYP00000024747	ENSTSYP00000033749	Adenomatous polyposis coli protein isoform X2.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.411