STRINGSTRING
CSDE1 CSDE1 ENSTSYP00000035030 ENSTSYP00000035030 PIK3CB PIK3CB PDGFA PDGFA ENSTSYP00000033115 ENSTSYP00000033115 MITF MITF BAX BAX MAPK1 MAPK1 PTEN PTEN AKT1 AKT1 LOC103268676 LOC103268676 PIK3CD PIK3CD PDGFB PDGFB ARAF ARAF IGF1 IGF1 PDGFRB PDGFRB MAPK3 MAPK3 CDKN1A CDKN1A BAK1 BAK1 LOC103251709 LOC103251709 FGF18 FGF18 PIK3R3 PIK3R3 NRAS NRAS FGF21 FGF21 E2F1 E2F1 TP53 TP53 LOC103266579 LOC103266579 LOC103250373 LOC103250373 CCND1 CCND1 FGFR1 FGFR1 FGF9 FGF9 ENSTSYP00000021856 ENSTSYP00000021856 E2F3 E2F3 FGF10 FGF10 PIK3R1 PIK3R1 CDH1 CDH1 FGF17 FGF17 FGF20-2 FGF20-2 FGF20 FGF20 FGF1 FGF1 MAP2K1 MAP2K1 CDKN2A CDKN2A FGF7 FGF7 FGF3 FGF3 AKT2 AKT2 ENSTSYP00000014856 ENSTSYP00000014856 FGF6 FGF6 FGF5 FGF5 CDK6 CDK6 HGF HGF PDGFD PDGFD CDK4 CDK4 PDGFC PDGFC AKT3 AKT3 E2F2 E2F2 EGF EGF BRAF BRAF GALK2 GALK2 RAF1 RAF1 EGFR EGFR PDGFRA PDGFRA POLK POLK KRAS KRAS PIK3CA PIK3CA HRAS HRAS IGF1R IGF1R RB1 RB1 DDB2 DDB2 MET MET FGF16 FGF16
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CSDE1Cold shock domain-containing protein E1 isoform X1. (842 aa)
ENSTSYP00000035030annotation not available (263 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2; Belongs to the PI3/PI4-kinase family. (1070 aa)
PDGFAPlatelet-derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (202 aa)
ENSTSYP00000033115annotation not available (96 aa)
MITFMicrophthalmia-associated transcription factor isoform X1. (419 aa)
BAXApoptosis regulator BAX isoform X1. (192 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (363 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
AKT1Non-specific serine/threonine protein kinase. (393 aa)
LOC103268676Cadherin-1-like. (413 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1063 aa)
PDGFBPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (229 aa)
ARAFSerine/threonine-protein kinase A-Raf isoform X1. (611 aa)
IGF1Insulin-like growth factor I isoform X1. (209 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1105 aa)
MAPK3Mitogen-activated protein kinase. (363 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
BAK1Bcl-2 homologous antagonist/killer. (211 aa)
LOC103251709Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (348 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (184 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2. (461 aa)
NRASGTPase NRas. (189 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
E2F1Transcription factor E2F1. (350 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (388 aa)
LOC103266579Growth arrest and DNA damage-inducible protein GADD45 alpha-like. (84 aa)
LOC103250373E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (426 aa)
CCND1G1/S-specific cyclin-D1. (156 aa)
FGFR1Fibroblast growth factor receptor. (832 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (146 aa)
ENSTSYP00000021856annotation not available (88 aa)
E2F3Transcription factor E2F3. (334 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (612 aa)
CDH1Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. (443 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (205 aa)
FGF20-2Fibroblast growth factor 20. (75 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (115 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1. (381 aa)
CDKN2ACyclin-dependent kinase inhibitor 2A. (171 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (172 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ENSTSYP00000014856annotation not available (69 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (268 aa)
CDK6Cyclin-dependent kinase 6. (264 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (728 aa)
PDGFDPlatelet-derived growth factor D. (370 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
PDGFCPlatelet-derived growth factor C isoform X1; Belongs to the PDGF/VEGF growth factor family. (345 aa)
AKT3RAC-gamma serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (419 aa)
E2F2Transcription factor E2F2. (423 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1167 aa)
BRAFSerine/threonine-protein kinase B-raf. (760 aa)
GALK2N-acetylgalactosamine kinase isoform X1. (458 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (668 aa)
EGFRReceptor protein-tyrosine kinase. (1180 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1088 aa)
POLKDNA polymerase kappa. (804 aa)
KRASGTPase KRas isoform X1. (189 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
HRASGTPase HRas isoform X6. (189 aa)
IGF1RTyrosine-protein kinase receptor. (1335 aa)
RB1Retinoblastoma-associated protein. (929 aa)
DDB2DNA damage-binding protein 2 isoform X1. (415 aa)
METHepatocyte growth factor receptor isoform X1. (1415 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (198 aa)
Your Current Organism:
Carlito syrichta
NCBI taxonomy Id: 1868482
Other names: C. syrichta, Philippine tarsier, Tarsius syrichta
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