STRINGSTRING
EGF EGF MMP2 MMP2 RB1 RB1 MMP9 MMP9 THBS1 THBS1 HRAS HRAS CSDE1 CSDE1 CXCL8 CXCL8 KRAS KRAS UPK3A UPK3A EGFR EGFR RAF1 RAF1 BRAF BRAF E2F2 E2F2 HBEGF HBEGF CDK4 CDK4 MMP1 MMP1 RPS6KA5 RPS6KA5 DAPK1 DAPK1 ERBB2 ERBB2 CDKN2A CDKN2A MAP2K1 MAP2K1 VEGFA VEGFA CDH1 CDH1 E2F3 E2F3 CCND1 CCND1 LOC103250373 LOC103250373 TP53 TP53 E2F1 E2F1 NRAS NRAS FGFR3 FGFR3 RASSF1 RASSF1 LOC103251709 LOC103251709 CDKN1A CDKN1A DAPK2 DAPK2 MAPK3 MAPK3 ARAF ARAF LOC103268676 LOC103268676 MYC MYC MAPK1 MAPK1 SRC SRC ENSTSYP00000035030 ENSTSYP00000035030
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1167 aa)
MMP272 kDa type IV collagenase. (662 aa)
RB1Retinoblastoma-associated protein. (929 aa)
MMP9Matrix metalloproteinase-9. (710 aa)
THBS1Thrombospondin-1. (1178 aa)
HRASGTPase HRas isoform X6. (189 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (842 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (95 aa)
KRASGTPase KRas isoform X1. (189 aa)
UPK3AUroplakin-3a isoform X1. (287 aa)
EGFRReceptor protein-tyrosine kinase. (1180 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (668 aa)
BRAFSerine/threonine-protein kinase B-raf. (760 aa)
E2F2Transcription factor E2F2. (423 aa)
HBEGFProheparin-binding EGF-like growth factor. (209 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
MMP1Interstitial collagenase. (468 aa)
RPS6KA5Non-specific serine/threonine protein kinase. (594 aa)
DAPK1Death-associated protein kinase 1 isoform X2. (1430 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
CDKN2ACyclin-dependent kinase inhibitor 2A. (171 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1. (381 aa)
VEGFAVascular endothelial growth factor A isoform X2; Belongs to the PDGF/VEGF growth factor family. (186 aa)
CDH1Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. (443 aa)
E2F3Transcription factor E2F3. (334 aa)
CCND1G1/S-specific cyclin-D1. (156 aa)
LOC103250373E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (426 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (388 aa)
E2F1Transcription factor E2F1. (350 aa)
NRASGTPase NRas. (189 aa)
FGFR3Fibroblast growth factor receptor. (745 aa)
RASSF1Ras association domain-containing protein 1 isoform X1. (344 aa)
LOC103251709Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (348 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
DAPK2Death-associated protein kinase 2 isoform X1; Belongs to the protein kinase superfamily. (488 aa)
MAPK3Mitogen-activated protein kinase. (363 aa)
ARAFSerine/threonine-protein kinase A-Raf isoform X1. (611 aa)
LOC103268676Cadherin-1-like. (413 aa)
MYCMyc proto-oncogene protein. (376 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (363 aa)
SRCTyrosine-protein kinase. (542 aa)
ENSTSYP00000035030annotation not available (263 aa)
Your Current Organism:
Carlito syrichta
NCBI taxonomy Id: 1868482
Other names: C. syrichta, Philippine tarsier, Tarsius syrichta
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