STRINGSTRING
MET MET SOS2 SOS2 DDB2 DDB2 RB1 RB1 CASP9 CASP9 SOS1 SOS1 HRAS HRAS CSDE1 CSDE1 PRKCA PRKCA PLCG1 PLCG1 PIK3CA PIK3CA KRAS KRAS POLK POLK EGFR EGFR PDPK1 PDPK1 RAF1 RAF1 BRAF BRAF EGF EGF ALK ALK E2F2 E2F2 ENSTSYP00000009629 ENSTSYP00000009629 AKT3 AKT3 PRKCB PRKCB CDK4 CDK4 STAT3 STAT3 HGF HGF CDK6 CDK6 EML4 EML4 ERBB2 ERBB2 RASSF5 RASSF5 ENSTSYP00000014856 ENSTSYP00000014856 AKT2 AKT2 PLCG2 PLCG2 RARB RARB CDKN2A CDKN2A MAP2K1 MAP2K1 STAT5B STAT5B FHIT FHIT LTK LTK PIK3R1 PIK3R1 E2F3 E2F3 ENSTSYP00000021856 ENSTSYP00000021856 TGFA TGFA CCND1 CCND1 LOC103266579 LOC103266579 TP53 TP53 E2F1 E2F1 STAT5A STAT5A RXRB RXRB NRAS NRAS PIK3R3 PIK3R3 RASSF1 RASSF1 RXRG RXRG LOC103251709 LOC103251709 BAK1 BAK1 CDKN1A CDKN1A MAPK3 MAPK3 RXRA RXRA ARAF ARAF PIK3CD PIK3CD AKT1 AKT1 STK4 STK4 ENSTSYP00000031894 ENSTSYP00000031894 MAPK1 MAPK1 BAX BAX GRB2 GRB2 LOC103277171 LOC103277171 PRKCG PRKCG PIK3CB PIK3CB ENSTSYP00000035030 ENSTSYP00000035030
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
METHepatocyte growth factor receptor isoform X1. (1415 aa)
SOS2Son of sevenless homolog 2 isoform X1. (1318 aa)
DDB2DNA damage-binding protein 2 isoform X1. (415 aa)
RB1Retinoblastoma-associated protein. (929 aa)
CASP9Caspase-9; Belongs to the peptidase C14A family. (410 aa)
SOS1Son of sevenless homolog 1 isoform X2. (441 aa)
HRASGTPase HRas isoform X6. (189 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (842 aa)
PRKCAProtein kinase C. (614 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1302 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
KRASGTPase KRas isoform X1. (189 aa)
POLKDNA polymerase kappa. (804 aa)
EGFRReceptor protein-tyrosine kinase. (1180 aa)
PDPK13-phosphoinositide-dependent protein kinase 1. (554 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (668 aa)
BRAFSerine/threonine-protein kinase B-raf. (760 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1167 aa)
ALKTyrosine-protein kinase receptor. (1397 aa)
E2F2Transcription factor E2F2. (423 aa)
ENSTSYP00000009629annotation not available (58 aa)
AKT3RAC-gamma serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (419 aa)
PRKCBNon-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (531 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
STAT3Signal transducer and activator of transcription 3. (444 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (728 aa)
CDK6Cyclin-dependent kinase 6. (264 aa)
EML4Echinoderm microtubule-associated protein-like 4 isoform X1. (992 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
RASSF5Ras association domain-containing protein 5. (319 aa)
ENSTSYP00000014856annotation not available (69 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
RARBRetinoic acid receptor beta isoform X2. (448 aa)
CDKN2ACyclin-dependent kinase inhibitor 2A. (171 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1. (381 aa)
STAT5BSignal transducer and activator of transcription. (786 aa)
FHITBis(5'-adenosyl)-triphosphatase. (149 aa)
LTKTyrosine-protein kinase receptor. (780 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (612 aa)
E2F3Transcription factor E2F3. (334 aa)
ENSTSYP00000021856annotation not available (88 aa)
TGFATransforming growth factor alpha. (164 aa)
CCND1G1/S-specific cyclin-D1. (156 aa)
LOC103266579Growth arrest and DNA damage-inducible protein GADD45 alpha-like. (84 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (388 aa)
E2F1Transcription factor E2F1. (350 aa)
STAT5ASignal transducer and activator of transcription. (669 aa)
RXRBRetinoic acid receptor RXR-beta isoform X2. (533 aa)
NRASGTPase NRas. (189 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2. (461 aa)
RASSF1Ras association domain-containing protein 1 isoform X1. (344 aa)
RXRGRetinoic acid receptor RXR-gamma isoform X1. (463 aa)
LOC103251709Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (348 aa)
BAK1Bcl-2 homologous antagonist/killer. (211 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
MAPK3Mitogen-activated protein kinase. (363 aa)
RXRARetinoic acid receptor RXR-alpha. (470 aa)
ARAFSerine/threonine-protein kinase A-Raf isoform X1. (611 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1063 aa)
AKT1Non-specific serine/threonine protein kinase. (393 aa)
STK4Serine/threonine-protein kinase 4. (487 aa)
ENSTSYP00000031894annotation not available (263 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (363 aa)
BAXApoptosis regulator BAX isoform X1. (192 aa)
GRB2Growth factor receptor-bound protein 2 isoform X1. (217 aa)
LOC103277171LOW QUALITY PROTEIN: signal transducer and activator of transcription 3-like. (248 aa)
PRKCGProtein kinase C. (634 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2; Belongs to the PI3/PI4-kinase family. (1070 aa)
ENSTSYP00000035030annotation not available (263 aa)
Your Current Organism:
Carlito syrichta
NCBI taxonomy Id: 1868482
Other names: C. syrichta, Philippine tarsier, Tarsius syrichta
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