Your Input: | |
| | BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (180 aa) |
| | FGF16 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (198 aa) |
| | BRCA2 | LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein. (3391 aa) |
| | SOS2 | Son of sevenless homolog 2 isoform X1. (1318 aa) |
| | SP1 | Transcription factor Sp1. (668 aa) |
| | DDB2 | DNA damage-binding protein 2 isoform X1. (415 aa) |
| | RB1 | Retinoblastoma-associated protein. (929 aa) |
| | IGF1R | Tyrosine-protein kinase receptor. (1335 aa) |
| | NCOA7 | Nuclear receptor coactivator 7 isoform X1. (943 aa) |
| | FZD6 | Frizzled-6 isoform X1; Belongs to the G-protein coupled receptor Fz/Smo family. (703 aa) |
| | JAG1 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1214 aa) |
| | SOS1 | Son of sevenless homolog 1 isoform X2. (441 aa) |
| | HRAS | GTPase HRas isoform X6. (189 aa) |
| | CSDE1 | Cold shock domain-containing protein E1 isoform X1. (842 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | KIT | Mast/stem cell growth factor receptor Kit; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (953 aa) |
| | KRAS | GTPase KRas isoform X1. (189 aa) |
| | POLK | DNA polymerase kappa. (804 aa) |
| | LOC103251060 | Protein eyes shut homolog. (297 aa) |
| | DLL1 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (741 aa) |
| | NCOA3 | Nuclear receptor coactivator. (1416 aa) |
| | CSNK1A1 | Casein kinase I isoform X2. (324 aa) |
| | EGFR | Receptor protein-tyrosine kinase. (1180 aa) |
| | ESR1 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (589 aa) |
| | WNT2 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa) |
| | RAF1 | RAF proto-oncogene serine/threonine-protein kinase isoform X1. (668 aa) |
| | GALK2 | N-acetylgalactosamine kinase isoform X1. (458 aa) |
| | CEP152 | Centrosomal protein of 152 kDa. (1704 aa) |
| | FZD3 | Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family. (603 aa) |
| | LRP6 | Low-density lipoprotein receptor-related protein 6. (1603 aa) |
| | DVL3 | Segment polarity protein dishevelled homolog DVL-3 isoform X1. (685 aa) |
| | BRAF | Serine/threonine-protein kinase B-raf. (760 aa) |
| | EGF | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1167 aa) |
| | CCDC170 | Coiled-coil domain-containing protein 170. (717 aa) |
| | E2F2 | Transcription factor E2F2. (423 aa) |
| | WNT16 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa) |
| | NCOA1 | Nuclear receptor coactivator. (1441 aa) |
| | TCF7 | Transcription factor 7 isoform X1. (400 aa) |
| | FZD9 | Frizzled-9; Belongs to the G-protein coupled receptor Fz/Smo family. (365 aa) |
| | AKT3 | RAC-gamma serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (419 aa) |
| | CTNNB1 | Catenin beta-1 isoform X1. (783 aa) |
| | SHC1 | SHC-transforming protein 1 isoform X1. (474 aa) |
| | CDK4 | Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa) |
| | GPSM3 | G-protein-signaling modulator 3. (158 aa) |
| | DLL4 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa) |
| | WNT7A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (297 aa) |
| | MTOR | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa) |
| | NOTCH3 | Neurogenic locus notch homolog protein 3. (2169 aa) |
| | NOTCH2 | Neurogenic locus notch homolog protein 2. (2211 aa) |
| | CDK6 | Cyclin-dependent kinase 6. (264 aa) |
| | FGF5 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (268 aa) |
| | SHC4 | SHC-transforming protein 4. (629 aa) |
| | WNT3 | Wnt family member 3. (239 aa) |
| | ERBB2 | Receptor protein-tyrosine kinase. (1255 aa) |
| | LOC103255477 | Transcription factor Sp1-like. (259 aa) |
| | FGF6 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa) |
| | ENSTSYP00000014979 | annotation not available (200 aa) |
| | WNT7B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa) |
| | FGF3 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (172 aa) |
| | GSK3B | Glycogen synthase kinase-3 beta; Belongs to the protein kinase superfamily. (403 aa) |
| | TCF7L1 | Transcription factor 7-like 1. (499 aa) |
| | FGF7 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa) |
| | AXIN2 | Axin-2. (649 aa) |
| | ESR2 | Estrogen receptor beta isoform X1. (530 aa) |
| | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1. (381 aa) |
| | LOC103276437 | Vascular endothelial growth factor receptor 3-like. (295 aa) |
| | FGF1 | Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa) |
| | RPS6KB1 | Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa) |
| | FGF20 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (115 aa) |
| | FGF20-2 | Fibroblast growth factor 20. (75 aa) |
| | WNT9B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (335 aa) |
| | FGF17 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (205 aa) |
| | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (612 aa) |
| | LOC103250886 | Segment polarity protein dishevelled homolog DVL-1-like. (373 aa) |
| | FGF10 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa) |
| | E2F3 | Transcription factor E2F3. (334 aa) |
| | FGF9 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (146 aa) |
| | FGFR1 | Fibroblast growth factor receptor. (832 aa) |
| | CCND1 | G1/S-specific cyclin-D1. (156 aa) |
| | FZD4 | Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (507 aa) |
| | PGR | Progesterone receptor. (338 aa) |
| | LOC103266579 | Growth arrest and DNA damage-inducible protein GADD45 alpha-like. (84 aa) |
| | WNT6 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (366 aa) |
| | WNT9A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (364 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (388 aa) |
| | E2F1 | Transcription factor E2F1. (350 aa) |
| | LEF1 | Lymphoid enhancer-binding factor 1 isoform X2. (399 aa) |
| | WNT5A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa) |
| | FGF21 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa) |
| | SHC3 | SHC-transforming protein 3. (107 aa) |
| | WNT8A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (356 aa) |
| | APC | Adenomatous polyposis coli protein isoform X2. (2844 aa) |
| | NRAS | GTPase NRas. (189 aa) |
| | WNT11 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (387 aa) |
| | TNFSF11 | Tumor necrosis factor ligand superfamily member 11; Belongs to the tumor necrosis factor family. (250 aa) |
| | WNT1 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa) |
| | PIK3R3 | Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2. (461 aa) |
| | FGF18 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (184 aa) |
| | LOC103252213 | Breast cancer type 1 susceptibility protein-like. (97 aa) |
| | ENSTSYP00000033658 | annotation not available (79 aa) |
| | WNT10B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa) |
| | NOTCH4 | Neurogenic locus notch homolog protein 4. (1999 aa) |
| | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2; Belongs to the PI3/PI4-kinase family. (1070 aa) |
| | ENSTSYP00000035030 | annotation not available (263 aa) |
| | LOC103251709 | Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (348 aa) |
| | HEY1 | Hairy/enhancer-of-split related with YRPW motif protein 1 isoform X2. (304 aa) |
| | BAK1 | Bcl-2 homologous antagonist/killer. (211 aa) |
| | CDKN1A | Cyclin-dependent kinase inhibitor 1. (164 aa) |
| | TCF7L2 | Transcription factor 7-like 2 isoform X1. (565 aa) |
| | LRP5 | Low-density lipoprotein receptor-related protein 5. (1615 aa) |
| | MAPK3 | Mitogen-activated protein kinase. (363 aa) |
| | WNT10A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (397 aa) |
| | WNT3A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa) |
| | AXIN1 | Axin-1. (574 aa) |
| | HES1 | Transcription factor HES-1. (272 aa) |
| | WNT5B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa) |
| | IGF1 | Insulin-like growth factor I isoform X1. (209 aa) |
| | ARAF | Serine/threonine-protein kinase A-Raf isoform X1. (611 aa) |
| | FOS | Proto-oncogene c-Fos. (379 aa) |
| | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1063 aa) |
| | MYC | Myc proto-oncogene protein. (376 aa) |
| | DVL2 | Segment polarity protein dishevelled homolog DVL-2 isoform X1. (736 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase. (393 aa) |
| | RPS6KB2 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa) |
| | PTEN | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa) |
| | WNT4 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa) |
| | JAG2 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1101 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (363 aa) |
| | BAX | Apoptosis regulator BAX isoform X1. (192 aa) |
| | WNT2B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (330 aa) |
| | HEYL | Hairy/enhancer-of-split related with YRPW motif-like protein isoform X1. (328 aa) |
| | GRB2 | Growth factor receptor-bound protein 2 isoform X1. (217 aa) |
| | NOTCH1 | Neurogenic locus notch homolog protein 1. (2339 aa) |
| | ENSTSYP00000033115 | annotation not available (96 aa) |
