STRINGSTRING
BRCA1 BRCA1 FGF16 FGF16 BRCA2 BRCA2 SOS2 SOS2 SP1 SP1 DDB2 DDB2 RB1 RB1 IGF1R IGF1R NCOA7 NCOA7 FZD6 FZD6 JAG1 JAG1 SOS1 SOS1 HRAS HRAS CSDE1 CSDE1 PIK3CA PIK3CA KIT KIT KRAS KRAS POLK POLK LOC103251060 LOC103251060 DLL1 DLL1 NCOA3 NCOA3 CSNK1A1 CSNK1A1 EGFR EGFR ESR1 ESR1 WNT2 WNT2 RAF1 RAF1 GALK2 GALK2 CEP152 CEP152 FZD3 FZD3 LRP6 LRP6 DVL3 DVL3 BRAF BRAF EGF EGF CCDC170 CCDC170 E2F2 E2F2 WNT16 WNT16 NCOA1 NCOA1 TCF7 TCF7 FZD9 FZD9 AKT3 AKT3 CTNNB1 CTNNB1 SHC1 SHC1 CDK4 CDK4 GPSM3 GPSM3 DLL4 DLL4 WNT7A WNT7A MTOR MTOR NOTCH3 NOTCH3 NOTCH2 NOTCH2 CDK6 CDK6 FGF5 FGF5 SHC4 SHC4 WNT3 WNT3 ERBB2 ERBB2 LOC103255477 LOC103255477 FGF6 FGF6 AKT2 AKT2 ENSTSYP00000014979 ENSTSYP00000014979 WNT7B WNT7B FGF3 FGF3 GSK3B GSK3B TCF7L1 TCF7L1 FGF7 FGF7 AXIN2 AXIN2 ESR2 ESR2 MAP2K1 MAP2K1 LOC103276437 LOC103276437 FGF1 FGF1 RPS6KB1 RPS6KB1 FGF20 FGF20 FGF20-2 FGF20-2 WNT9B WNT9B FGF17 FGF17 PIK3R1 PIK3R1 LOC103250886 LOC103250886 FGF10 FGF10 E2F3 E2F3 FGF9 FGF9 FGFR1 FGFR1 CCND1 CCND1 FZD4 FZD4 PGR PGR LOC103266579 LOC103266579 WNT6 WNT6 WNT9A WNT9A TP53 TP53 E2F1 E2F1 LEF1 LEF1 WNT5A WNT5A FGF21 FGF21 SHC3 SHC3 WNT8A WNT8A APC APC NRAS NRAS WNT11 WNT11 TNFSF11 TNFSF11 WNT1 WNT1 PIK3R3 PIK3R3 FGF18 FGF18 LOC103252213 LOC103252213 ENSTSYP00000033658 ENSTSYP00000033658 WNT10B WNT10B NOTCH4 NOTCH4 PIK3CB PIK3CB ENSTSYP00000035030 ENSTSYP00000035030 LOC103251709 LOC103251709 HEY1 HEY1 BAK1 BAK1 CDKN1A CDKN1A TCF7L2 TCF7L2 LRP5 LRP5 MAPK3 MAPK3 WNT10A WNT10A WNT3A WNT3A AXIN1 AXIN1 HES1 HES1 WNT5B WNT5B IGF1 IGF1 ARAF ARAF FOS FOS PIK3CD PIK3CD MYC MYC DVL2 DVL2 AKT1 AKT1 RPS6KB2 RPS6KB2 PTEN PTEN WNT4 WNT4 JAG2 JAG2 MAPK1 MAPK1 BAX BAX WNT2B WNT2B HEYL HEYL GRB2 GRB2 NOTCH1 NOTCH1 ENSTSYP00000033115 ENSTSYP00000033115
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (180 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (198 aa)
BRCA2LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein. (3391 aa)
SOS2Son of sevenless homolog 2 isoform X1. (1318 aa)
SP1Transcription factor Sp1. (668 aa)
DDB2DNA damage-binding protein 2 isoform X1. (415 aa)
RB1Retinoblastoma-associated protein. (929 aa)
IGF1RTyrosine-protein kinase receptor. (1335 aa)
NCOA7Nuclear receptor coactivator 7 isoform X1. (943 aa)
FZD6Frizzled-6 isoform X1; Belongs to the G-protein coupled receptor Fz/Smo family. (703 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1214 aa)
SOS1Son of sevenless homolog 1 isoform X2. (441 aa)
HRASGTPase HRas isoform X6. (189 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (842 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
KITMast/stem cell growth factor receptor Kit; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (953 aa)
KRASGTPase KRas isoform X1. (189 aa)
POLKDNA polymerase kappa. (804 aa)
LOC103251060Protein eyes shut homolog. (297 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (741 aa)
NCOA3Nuclear receptor coactivator. (1416 aa)
CSNK1A1Casein kinase I isoform X2. (324 aa)
EGFRReceptor protein-tyrosine kinase. (1180 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (589 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (668 aa)
GALK2N-acetylgalactosamine kinase isoform X1. (458 aa)
CEP152Centrosomal protein of 152 kDa. (1704 aa)
FZD3Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family. (603 aa)
LRP6Low-density lipoprotein receptor-related protein 6. (1603 aa)
DVL3Segment polarity protein dishevelled homolog DVL-3 isoform X1. (685 aa)
BRAFSerine/threonine-protein kinase B-raf. (760 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1167 aa)
CCDC170Coiled-coil domain-containing protein 170. (717 aa)
E2F2Transcription factor E2F2. (423 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
NCOA1Nuclear receptor coactivator. (1441 aa)
TCF7Transcription factor 7 isoform X1. (400 aa)
FZD9Frizzled-9; Belongs to the G-protein coupled receptor Fz/Smo family. (365 aa)
AKT3RAC-gamma serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (419 aa)
CTNNB1Catenin beta-1 isoform X1. (783 aa)
SHC1SHC-transforming protein 1 isoform X1. (474 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
GPSM3G-protein-signaling modulator 3. (158 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (297 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
NOTCH3Neurogenic locus notch homolog protein 3. (2169 aa)
NOTCH2Neurogenic locus notch homolog protein 2. (2211 aa)
CDK6Cyclin-dependent kinase 6. (264 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (268 aa)
SHC4SHC-transforming protein 4. (629 aa)
WNT3Wnt family member 3. (239 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
LOC103255477Transcription factor Sp1-like. (259 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ENSTSYP00000014979annotation not available (200 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (172 aa)
GSK3BGlycogen synthase kinase-3 beta; Belongs to the protein kinase superfamily. (403 aa)
TCF7L1Transcription factor 7-like 1. (499 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
AXIN2Axin-2. (649 aa)
ESR2Estrogen receptor beta isoform X1. (530 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1. (381 aa)
LOC103276437Vascular endothelial growth factor receptor 3-like. (295 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (115 aa)
FGF20-2Fibroblast growth factor 20. (75 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (335 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (205 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (612 aa)
LOC103250886Segment polarity protein dishevelled homolog DVL-1-like. (373 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
E2F3Transcription factor E2F3. (334 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (146 aa)
FGFR1Fibroblast growth factor receptor. (832 aa)
CCND1G1/S-specific cyclin-D1. (156 aa)
FZD4Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (507 aa)
PGRProgesterone receptor. (338 aa)
LOC103266579Growth arrest and DNA damage-inducible protein GADD45 alpha-like. (84 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (366 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (364 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (388 aa)
E2F1Transcription factor E2F1. (350 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X2. (399 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
SHC3SHC-transforming protein 3. (107 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (356 aa)
APCAdenomatous polyposis coli protein isoform X2. (2844 aa)
NRASGTPase NRas. (189 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (387 aa)
TNFSF11Tumor necrosis factor ligand superfamily member 11; Belongs to the tumor necrosis factor family. (250 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2. (461 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (184 aa)
LOC103252213Breast cancer type 1 susceptibility protein-like. (97 aa)
ENSTSYP00000033658annotation not available (79 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
NOTCH4Neurogenic locus notch homolog protein 4. (1999 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2; Belongs to the PI3/PI4-kinase family. (1070 aa)
ENSTSYP00000035030annotation not available (263 aa)
LOC103251709Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (348 aa)
HEY1Hairy/enhancer-of-split related with YRPW motif protein 1 isoform X2. (304 aa)
BAK1Bcl-2 homologous antagonist/killer. (211 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
TCF7L2Transcription factor 7-like 2 isoform X1. (565 aa)
LRP5Low-density lipoprotein receptor-related protein 5. (1615 aa)
MAPK3Mitogen-activated protein kinase. (363 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (397 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
AXIN1Axin-1. (574 aa)
HES1Transcription factor HES-1. (272 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa)
IGF1Insulin-like growth factor I isoform X1. (209 aa)
ARAFSerine/threonine-protein kinase A-Raf isoform X1. (611 aa)
FOSProto-oncogene c-Fos. (379 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1063 aa)
MYCMyc proto-oncogene protein. (376 aa)
DVL2Segment polarity protein dishevelled homolog DVL-2 isoform X1. (736 aa)
AKT1Non-specific serine/threonine protein kinase. (393 aa)
RPS6KB2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1101 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (363 aa)
BAXApoptosis regulator BAX isoform X1. (192 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (330 aa)
HEYLHairy/enhancer-of-split related with YRPW motif-like protein isoform X1. (328 aa)
GRB2Growth factor receptor-bound protein 2 isoform X1. (217 aa)
NOTCH1Neurogenic locus notch homolog protein 1. (2339 aa)
ENSTSYP00000033115annotation not available (96 aa)
Your Current Organism:
Carlito syrichta
NCBI taxonomy Id: 1868482
Other names: C. syrichta, Philippine tarsier, Tarsius syrichta
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