STRINGSTRING
PIK3CB PIK3CB LOC103277171 LOC103277171 PPP3CB PPP3CB NFATC3 NFATC3 MAPK1 MAPK1 ENSTSYP00000031894 ENSTSYP00000031894 PRKCQ PRKCQ PTEN PTEN RPS6KB2 RPS6KB2 AKT1 AKT1 TMED7 TMED7 PIK3CD PIK3CD FOS FOS PDCD1 PDCD1 MAPK3 MAPK3 CSNK2B CSNK2B LOC103251709 LOC103251709 MAPK14 MAPK14 CD3E CD3E RASGRP1 RASGRP1 IFNG IFNG NFKBIB NFKBIB PTPN11 PTPN11 IKBKB IKBKB NFKBIE NFKBIE TLR4 TLR4 HRAS HRAS CSDE1 CSDE1 PPP3CC PPP3CC NFKBIA NFKBIA PLCG1 PLCG1 PIK3CA PIK3CA CHUK CHUK KRAS KRAS NFKB1 NFKB1 NFATC2 NFATC2 BATF BATF MAP2K3 MAP2K3 IFNGR1 IFNGR1 EGFR EGFR JAK1 JAK1 ENSTSYP00000006680 ENSTSYP00000006680 RAF1 RAF1 MYD88 MYD88 IFNGR2 IFNGR2 EGF EGF ALK ALK CD274 CD274 JAK2 JAK2 AKT3 AKT3 CSNK2A2 CSNK2A2 ZAP70 ZAP70 STAT3 STAT3 MTOR MTOR PPP3R1 PPP3R1 EML4 EML4 AKT2 AKT2 PTPN6 PTPN6 CD28 CD28 HIF1A HIF1A TRAF6 TRAF6 CD3D CD3D MAPK12 MAPK12 LOC103255929 LOC103255929 LY6G5B LY6G5B CSNK2A1 CSNK2A1 ENSTSYP00000017967 ENSTSYP00000017967 MAP2K1 MAP2K1 BATF2 BATF2 RPS6KB1 RPS6KB1 LTK LTK PIK3R1 PIK3R1 ENSTSYP00000020999 ENSTSYP00000020999 LCK LCK CD247 CD247 TIRAP TIRAP NFATC1 NFATC1 MAP3K3 MAP3K3 PPP3CA PPP3CA MAP2K6 MAP2K6 RELA RELA ENSTSYP00000024458 ENSTSYP00000024458 BATF3 BATF3 NRAS NRAS PIK3R3 PIK3R3 LAT LAT IKBKG IKBKG MAPK11 MAPK11 MAPK13 MAPK13
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2; Belongs to the PI3/PI4-kinase family. (1070 aa)
LOC103277171LOW QUALITY PROTEIN: signal transducer and activator of transcription 3-like. (248 aa)
PPP3CBSerine/threonine-protein phosphatase. (525 aa)
NFATC3Nuclear factor of activated T-cells, cytoplasmic 3 isoform X1. (1073 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (363 aa)
ENSTSYP00000031894annotation not available (263 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
RPS6KB2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
AKT1Non-specific serine/threonine protein kinase. (393 aa)
TMED7Transmembrane emp24 domain-containing protein 7. (229 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1063 aa)
FOSProto-oncogene c-Fos. (379 aa)
PDCD1Programmed cell death protein 1. (288 aa)
MAPK3Mitogen-activated protein kinase. (363 aa)
CSNK2BCasein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (235 aa)
LOC103251709Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (348 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
CD3ET-cell surface glycoprotein CD3 epsilon chain. (178 aa)
RASGRP1RAS guanyl-releasing protein 1 isoform X1. (792 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (165 aa)
NFKBIBNF-kappa-B inhibitor beta isoform X2. (343 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type 11. (532 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (756 aa)
NFKBIENF-kappa-B inhibitor epsilon. (412 aa)
TLR4Toll-like receptor 4 isoform X1; Belongs to the Toll-like receptor family. (840 aa)
HRASGTPase HRas isoform X6. (189 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (842 aa)
PPP3CCSerine/threonine-protein phosphatase. (514 aa)
NFKBIANF-kappa-B inhibitor alpha. (282 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1302 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (744 aa)
KRASGTPase KRas isoform X1. (189 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (964 aa)
NFATC2Nuclear factor of activated T-cells, cytoplasmic 2 isoform X1. (921 aa)
BATFBasic leucine zipper transcriptional factor ATF-like. (125 aa)
MAP2K3Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
IFNGR1Interferon gamma receptor 1. (478 aa)
EGFRReceptor protein-tyrosine kinase. (1180 aa)
JAK1Tyrosine-protein kinase. (1140 aa)
ENSTSYP00000006680annotation not available (255 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (668 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (321 aa)
IFNGR2Interferon gamma receptor 2. (317 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1167 aa)
ALKTyrosine-protein kinase receptor. (1397 aa)
CD274Programmed cell death 1 ligand 1. (246 aa)
JAK2Tyrosine-protein kinase. (1131 aa)
AKT3RAC-gamma serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (419 aa)
CSNK2A2Casein kinase II subunit alpha' isoform X2; Belongs to the protein kinase superfamily. (352 aa)
ZAP70Tyrosine-protein kinase ZAP-70. (556 aa)
STAT3Signal transducer and activator of transcription 3. (444 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
PPP3R1Calcineurin subunit B type 1. (169 aa)
EML4Echinoderm microtubule-associated protein-like 4 isoform X1. (992 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type 6. (402 aa)
CD28T-cell-specific surface glycoprotein CD28 isoform X2. (221 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform X1. (842 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (512 aa)
CD3DT-cell surface glycoprotein CD3 delta chain isoform X1. (171 aa)
MAPK12Mitogen-activated protein kinase. (277 aa)
LOC103255929Toll-like receptor 9 isoform X2. (1029 aa)
LY6G5BLymphocyte antigen 6 complex locus protein G5b. (195 aa)
CSNK2A1Casein kinase II subunit alpha; Belongs to the protein kinase superfamily. (391 aa)
ENSTSYP00000017967annotation not available (148 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1. (381 aa)
BATF2Basic leucine zipper transcriptional factor ATF-like 2. (245 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
LTKTyrosine-protein kinase receptor. (780 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (612 aa)
ENSTSYP00000020999annotation not available (63 aa)
LCKTyrosine-protein kinase. (524 aa)
CD247CD247 molecule. (145 aa)
TIRAPToll/interleukin-1 receptor domain-containing adapter protein isoform X1. (228 aa)
NFATC1Nuclear factor of activated T-cells, cytoplasmic 1. (905 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3. (528 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
MAP2K6LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (352 aa)
RELATranscription factor p65. (519 aa)
ENSTSYP00000024458annotation not available (182 aa)
BATF3Basic leucine zipper transcriptional factor ATF-like 3. (97 aa)
NRASGTPase NRas. (189 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2. (461 aa)
LATLinker for activation of T cells. (258 aa)
IKBKGNF-kappa-B essential modulator. (460 aa)
MAPK11Mitogen-activated protein kinase. (255 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
Your Current Organism:
Carlito syrichta
NCBI taxonomy Id: 1868482
Other names: C. syrichta, Philippine tarsier, Tarsius syrichta
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.