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CD80 CD80 RELCH RELCH LOC103271953 LOC103271953 LTB LTB MMP3 MMP3 ENSTSYP00000006691 ENSTSYP00000006691 HLA-DOB HLA-DOB IL1B IL1B ATP6V0A2 ATP6V0A2 CXCL1 CXCL1 CSF2 CSF2 LOC103267988 LOC103267988 TNFSF13B TNFSF13B HLA-DPB1 HLA-DPB1 CTLA4 CTLA4 ATP6V1B2 ATP6V1B2 CCL2 CCL2 ANGPT1 ANGPT1 ITGAL ITGAL IL17A IL17A IL15 IL15 IL1A IL1A CXCL5 CXCL5 ATP6V1B1 ATP6V1B1 MMP1 MMP1 HLA-DPA1 HLA-DPA1 LOC103271929 LOC103271929 HLA-DMA HLA-DMA ATP6V1H ATP6V1H ATP6V1C2 ATP6V1C2 ATP6V1A ATP6V1A ENSTSYP00000013843 ENSTSYP00000013843 ENSTSYP00000014000 ENSTSYP00000014000 ENSTSYP00000014082 ENSTSYP00000014082 TNFRSF11A TNFRSF11A LOC103264991 LOC103264991 CD28 CD28 ENSTSYP00000015122 ENSTSYP00000015122 ENSTSYP00000015488 ENSTSYP00000015488 TNFSF13 TNFSF13 ATP6V1G2 ATP6V1G2 LOC103270920 LOC103270920 LOC103268380 LOC103268380 IL23A IL23A ENSTSYP00000016884 ENSTSYP00000016884 LOC103271195 LOC103271195 LOC103259075 LOC103259075 ACP5 ACP5 ENSTSYP00000017520 ENSTSYP00000017520 ATP6AP1 ATP6AP1 ITGB2 ITGB2 ATP6V0E2 ATP6V0E2 ATP6V1D ATP6V1D VEGFA VEGFA ATP6V0B ATP6V0B TEK TEK IL11 IL11 ATP6V0D2 ATP6V0D2 ATP6V0D1 ATP6V0D1 ENSTSYP00000023511 ENSTSYP00000023511 TNFSF11 TNFSF11 LOC103254497 LOC103254497 PTH PTH ATP6V1G1 ATP6V1G1 ATP6V0C ATP6V0C LOC103258166 LOC103258166 ENSTSYP00000027060 ENSTSYP00000027060 TNF TNF CSF1 CSF1 ICAM1 ICAM1 ATP6V1E1 ATP6V1E1 CD86 CD86 LOC103269764 LOC103269764 FOS FOS TGFB3 TGFB3 TGFB1 TGFB1 TGFB2 TGFB2 IL6 IL6 ATP6V1C1 ATP6V1C1 ATP6V0A1 ATP6V0A1 ENSTSYP00000033599 ENSTSYP00000033599 ATP6V1F ATP6V1F IFNG IFNG LOC103256945 LOC103256945 CCL20 CCL20 HLA-DRA HLA-DRA CTSL CTSL TLR4 TLR4 MMP10 MMP10 CXCL8 CXCL8 HLA-DOA HLA-DOA CCL5 CCL5 IL18 IL18 ATP6V1G3 ATP6V1G3 CTSK CTSK ATP6V0A4 ATP6V0A4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CD80T-lymphocyte activation antigen CD80. (232 aa)
RELCHlisH domain and HEAT repeat-containing protein KIAA1468 homolog isoform X2. (721 aa)
LOC103271953Vascular endothelial growth factor receptor 1-like. (713 aa)
LTBLymphotoxin-beta isoform X1; Belongs to the tumor necrosis factor family. (243 aa)
MMP3Stromelysin-1. (477 aa)
ENSTSYP00000006691annotation not available (107 aa)
HLA-DOBHLA class II histocompatibility antigen, DO beta chain isoform X1. (273 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (267 aa)
ATP6V0A2V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (817 aa)
CXCL1C-X-C motif chemokine. (107 aa)
CSF2Granulocyte-macrophage colony-stimulating factor. (144 aa)
LOC103267988LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DRB1-9 beta chain-like. (256 aa)
TNFSF13BTumor necrosis factor ligand superfamily member 13B isoform X2; Belongs to the tumor necrosis factor family. (305 aa)
HLA-DPB1HLA class II histocompatibility antigen, DP beta 1 chain-like isoform X2. (258 aa)
CTLA4Cytotoxic T-lymphocyte protein 4 isoform X1. (223 aa)
ATP6V1B2Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (526 aa)
CCL2C-C motif chemokine. (99 aa)
ANGPT1Angiopoietin-1 isoform X1. (498 aa)
ITGALIntegrin alpha-L; Belongs to the integrin alpha chain family. (1167 aa)
IL17Ainterleukin-17A. (152 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (273 aa)
CXCL5C-X-C motif chemokine. (123 aa)
ATP6V1B1Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (506 aa)
MMP1Interstitial collagenase. (468 aa)
HLA-DPA1HLA class II histocompatibility antigen, DP alpha 1 chain-like; Belongs to the MHC class II family. (260 aa)
LOC103271929HLA class II histocompatibility antigen, DM beta chain isoform X5. (263 aa)
HLA-DMAHLA class II histocompatibility antigen, DM alpha chain isoform X3; Belongs to the MHC class II family. (261 aa)
ATP6V1HV-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (453 aa)
ATP6V1C2V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (437 aa)
ATP6V1AV-type proton ATPase catalytic subunit A. (615 aa)
ENSTSYP00000013843annotation not available (133 aa)
ENSTSYP00000014000annotation not available (196 aa)
ENSTSYP00000014082annotation not available (103 aa)
TNFRSF11ATumor necrosis factor receptor superfamily member 11A. (238 aa)
LOC103264991Vascular endothelial growth factor receptor 1 isoform X2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (431 aa)
CD28T-cell-specific surface glycoprotein CD28 isoform X2. (221 aa)
ENSTSYP00000015122annotation not available (382 aa)
ENSTSYP00000015488annotation not available (117 aa)
TNFSF13Tumor necrosis factor ligand superfamily member 13 isoform X1; Belongs to the tumor necrosis factor family. (252 aa)
ATP6V1G2V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (158 aa)
LOC103270920V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (137 aa)
LOC103268380V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (81 aa)
IL23AInterleukin-23 subunit alpha. (189 aa)
ENSTSYP00000016884annotation not available (66 aa)
LOC103271195C-C motif chemokine. (91 aa)
LOC103259075V-type proton ATPase subunit d 1-like. (120 aa)
ACP5Tartrate-resistant acid phosphatase type 5. (325 aa)
ENSTSYP00000017520annotation not available (335 aa)
ATP6AP1V-type proton ATPase subunit S1. (470 aa)
ITGB2Integrin beta. (769 aa)
ATP6V0E2V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (81 aa)
ATP6V1DV-type proton ATPase subunit D. (247 aa)
VEGFAVascular endothelial growth factor A isoform X2; Belongs to the PDGF/VEGF growth factor family. (186 aa)
ATP6V0BV-type proton ATPase 21 kDa proteolipid subunit isoform X1; Belongs to the V-ATPase proteolipid subunit family. (236 aa)
TEKAngiopoietin-1 receptor isoform X1. (1125 aa)
IL11Interleukin-11. (120 aa)
ATP6V0D2V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (350 aa)
ATP6V0D1V-type proton ATPase subunit d 1. (265 aa)
ENSTSYP00000023511annotation not available (453 aa)
TNFSF11Tumor necrosis factor ligand superfamily member 11; Belongs to the tumor necrosis factor family. (250 aa)
LOC103254497lisH domain and HEAT repeat-containing protein KIAA1468-like. (391 aa)
PTHParathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (115 aa)
ATP6V1G1V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
ATP6V0CV-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (155 aa)
LOC103258166V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (153 aa)
ENSTSYP00000027060annotation not available (204 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (232 aa)
CSF1Macrophage colony-stimulating factor 1. (244 aa)
ICAM1Intercellular adhesion molecule 1. (281 aa)
ATP6V1E1V-type proton ATPase subunit E 1. (215 aa)
CD86T-lymphocyte activation antigen CD86. (273 aa)
LOC103269764Stromal cell-derived factor 1-like; Belongs to the intercrine alpha (chemokine CxC) family. (119 aa)
FOSProto-oncogene c-Fos. (379 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (344 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
IL6Interleukin-6. (209 aa)
ATP6V1C1V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (382 aa)
ATP6V0A1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (837 aa)
ENSTSYP00000033599annotation not available (81 aa)
ATP6V1FV-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (143 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (165 aa)
LOC103256945SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like. (256 aa)
CCL20C-C motif chemokine. (96 aa)
HLA-DRAHLA class II histocompatibility antigen, DR alpha chain; Belongs to the MHC class II family. (254 aa)
CTSLCathepsin L1-like; Belongs to the peptidase C1 family. (242 aa)
TLR4Toll-like receptor 4 isoform X1; Belongs to the Toll-like receptor family. (840 aa)
MMP10Matrix metallopeptidase 10. (467 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (95 aa)
HLA-DOAHLA class II histocompatibility antigen, DO alpha chain; Belongs to the MHC class II family. (250 aa)
CCL5C-C motif chemokine. (91 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (192 aa)
ATP6V1G3V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (114 aa)
CTSKCathepsin K isoform X1; Belongs to the peptidase C1 family. (329 aa)
ATP6V0A4V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (840 aa)
Your Current Organism:
Carlito syrichta
NCBI taxonomy Id: 1868482
Other names: C. syrichta, Philippine tarsier, Tarsius syrichta
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