STRINGSTRING
SDC4 SDC4 LOC110595060 LOC110595060 ENSTSYP00000034769 ENSTSYP00000034769 PIK3CB PIK3CB CAV3 CAV3 LOC103268605 LOC103268605 LOC103257967 LOC103257967 LOC103269085 LOC103269085 PDGFA PDGFA SRC SRC MAPK7 MAPK7 RAC2 RAC2 ENSTSYP00000032485 ENSTSYP00000032485 CAV1 CAV1 LOC103269084 LOC103269084 NQO1 NQO1 MEF2C MEF2C ENSTSYP00000031842 ENSTSYP00000031842 ENSTSYP00000031304 ENSTSYP00000031304 CALM3 CALM3 MAPK9 MAPK9 AKT1 AKT1 MAP3K7 MAP3K7 ENSTSYP00000030439 ENSTSYP00000030439 ENSTSYP00000030184 ENSTSYP00000030184 GSTA5 GSTA5 PIK3CD PIK3CD FOS FOS PDGFB PDGFB ENSTSYP00000029618 ENSTSYP00000029618 ITGA2B ITGA2B LOC103257595 LOC103257595 CALML6 CALML6 SDC1 SDC1 CYBA CYBA ENSTSYP00000028205 ENSTSYP00000028205 ICAM1 ICAM1 ENSTSYP00000027808 ENSTSYP00000027808 NOXA1 NOXA1 TNFRSF1A TNFRSF1A ACVR2B ACVR2B SDC2 SDC2 TNF TNF DUSP1 DUSP1 RHOA-2 RHOA-2 HMOX1 HMOX1 MAPK13 MAPK13 MAPK11 MAPK11 IKBKG IKBKG ENSTSYP00000026316 ENSTSYP00000026316 MAPK8 MAPK8 LOC103261438 LOC103261438 BMP4 BMP4 NOS3 NOS3 ENSTSYP00000025711 ENSTSYP00000025711 ACVR1 ACVR1 PIK3R3 PIK3R3 GSTP1 GSTP1 PTK2 PTK2 PVALEF PVALEF KEAP1 KEAP1 TXN2 TXN2 HSP90AB1 HSP90AB1 ENSTSYP00000024721 ENSTSYP00000024721 MGST2 MGST2 RHOA RHOA GSTM3 GSTM3 RELA RELA LOC103269077 LOC103269077 LOC103260062 LOC103260062 BMPR2 BMPR2 SUMO3 SUMO3 LOC103263043 LOC103263043 LOC103255950 LOC103255950 MAP2K6 MAP2K6 LOC103260063 LOC103260063 TP53 TP53 ENSTSYP00000023190 ENSTSYP00000023190 ASS1 ASS1 ENSTSYP00000022730 ENSTSYP00000022730 PIAS4 PIAS4 ENSTSYP00000022518 ENSTSYP00000022518 ENSTSYP00000022482 ENSTSYP00000022482 LOC103273612 LOC103273612 PRKCZ PRKCZ LOC103266009 LOC103266009 ITGAV ITGAV VCAM1 VCAM1 PIK3R1 PIK3R1 PRKAA1 PRKAA1 PECAM1 PECAM1 CALML4 CALML4 ENSTSYP00000020233 ENSTSYP00000020233 BMPR1A BMPR1A MEF2A MEF2A ENSTSYP00000019705 ENSTSYP00000019705 ENSTSYP00000019285 ENSTSYP00000019285 LOC103250483-2 LOC103250483-2 VEGFA VEGFA NCF1 NCF1 ENSTSYP00000018913 ENSTSYP00000018913 ENSTSYP00000018856 ENSTSYP00000018856 ENSTSYP00000018500 ENSTSYP00000018500 LOC103260055 LOC103260055 LOC103260052 LOC103260052 ENSTSYP00000018036 ENSTSYP00000018036 ENSTSYP00000017625 ENSTSYP00000017625 MAPK12 MAPK12 ENSTSYP00000017365 ENSTSYP00000017365 MAP2K5 MAP2K5 ENSTSYP00000017214 ENSTSYP00000017214 LOC103250564 LOC103250564 ENSTSYP00000016704 ENSTSYP00000016704 RAC1 RAC1 RHOC RHOC LOC103269581 LOC103269581 SUMO2 SUMO2 AKT2 AKT2 MAP2K4 MAP2K4 MAP2K7 MAP2K7 ENSTSYP00000013967 ENSTSYP00000013967 SQSTM1 SQSTM1 RAC3 RAC3 SELE SELE HSP90B1 HSP90B1 NPPC NPPC IL1A IL1A HSP90AA1 HSP90AA1 PRKAA2 PRKAA2 EDN1 EDN1 CTNNB1 CTNNB1 AKT3 AKT3 CCL2 CCL2 IL1R1 IL1R1 CDH5 CDH5 ACTL8 ACTL8 IL1R2 IL1R2 LOC103271334 LOC103271334 CAV2 CAV2 IL1B IL1B ARHGEF2 ARHGEF2 LOC103255107 LOC103255107 LOC103263427 LOC103263427 ACVR2A ACVR2A NOX1 NOX1 ACTL7B ACTL7B MAPK10 MAPK10 MGST3 MGST3 NFKB1 NFKB1 GSTA4 GSTA4 LOC103250483 LOC103250483 CHUK CHUK KDR KDR PIK3CA PIK3CA IKBKB IKBKB LOC103268588 LOC103268588 CTSL CTSL NCF2 NCF2 PLAT PLAT BMPR1B BMPR1B LOC103271335 LOC103271335 ENSTSYP00000002295 ENSTSYP00000002295 TXNDC8 TXNDC8 LOC103260057 LOC103260057 GSTO2 GSTO2 GSTO1 GSTO1 MMP9 MMP9 IFNG IFNG MMP2 MMP2 TXNDC2 TXNDC2 MAPK14 MAPK14 GPC1 GPC1 MAP3K5 MAP3K5 NFE2L2 NFE2L2 GSTT4 GSTT4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SDC4Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (201 aa)
LOC110595060Small ubiquitin-related modifier. (117 aa)
ENSTSYP00000034769annotation not available (133 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2; Belongs to the PI3/PI4-kinase family. (1070 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
LOC103268605Calmodulin isoform X1; Belongs to the calmodulin family. (149 aa)
LOC103257967Calmodulin-like; Belongs to the calmodulin family. (147 aa)
LOC103269085Glutathione S-transferase. (218 aa)
PDGFAPlatelet-derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (202 aa)
SRCTyrosine-protein kinase. (542 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (813 aa)
RAC2Ras-related C3 botulinum toxin substrate 2 isoform X1. (192 aa)
ENSTSYP00000032485annotation not available (93 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
LOC103269084Glutathione S-transferase. (203 aa)
NQO1NAD(P)H dehydrogenase [quinone] 1 isoform X1. (274 aa)
MEF2CMyocyte-specific enhancer factor 2C isoform X1. (483 aa)
ENSTSYP00000031842annotation not available (607 aa)
ENSTSYP00000031304annotation not available (72 aa)
CALM3Calmodulin 3. (128 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
AKT1Non-specific serine/threonine protein kinase. (393 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
ENSTSYP00000030439annotation not available (315 aa)
ENSTSYP00000030184annotation not available (260 aa)
GSTA5Glutathione S-transferase A1-like. (222 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1063 aa)
FOSProto-oncogene c-Fos. (379 aa)
PDGFBPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (229 aa)
ENSTSYP00000029618annotation not available (173 aa)
ITGA2BIntegrin alpha-IIb; Belongs to the integrin alpha chain family. (851 aa)
LOC103257595Thioredoxin; Belongs to the thioredoxin family. (98 aa)
CALML6Calmodulin-like protein 6. (164 aa)
SDC1Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (394 aa)
CYBACytochrome b-245 light chain. (176 aa)
ENSTSYP00000028205annotation not available (105 aa)
ICAM1Intercellular adhesion molecule 1. (281 aa)
ENSTSYP00000027808annotation not available (611 aa)
NOXA1NADPH oxidase activator 1. (384 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A. (183 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (531 aa)
SDC2Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (181 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (232 aa)
DUSP1Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (332 aa)
RHOA-2Transforming protein RhoA isoform X1. (193 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (288 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
MAPK11Mitogen-activated protein kinase. (255 aa)
IKBKGNF-kappa-B essential modulator. (460 aa)
ENSTSYP00000026316annotation not available (161 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
LOC103261438Calmodulin-like; Belongs to the calmodulin family. (130 aa)
BMP4Bone morphogenetic protein 4 isoform X1. (409 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1209 aa)
ENSTSYP00000025711annotation not available (74 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2. (461 aa)
GSTP1LOW QUALITY PROTEIN: glutathione S-transferase P; Belongs to the GST superfamily. (184 aa)
PTK2Focal adhesion kinase 1 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1096 aa)
PVALEFParvalbumin like EF-hand containing. (134 aa)
KEAP1Kelch-like ECH-associated protein 1. (621 aa)
TXN2Thioredoxin, mitochondrial. (166 aa)
HSP90AB1Heat shock protein HSP 90-beta isoform X1. (723 aa)
ENSTSYP00000024721annotation not available (128 aa)
MGST2Microsomal glutathione S-transferase 2 isoform X1. (147 aa)
RHOATransforming protein RhoA isoform X7. (81 aa)
GSTM3Glutathione S-transferase. (224 aa)
RELATranscription factor p65. (519 aa)
LOC103269077Glutathione S-transferase Mu 2 isoform X1. (238 aa)
LOC103260062Glutathione S-transferase A3-like; Belongs to the GST superfamily. (218 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1035 aa)
SUMO3Small ubiquitin-related modifier. (96 aa)
LOC103263043Argininosuccinate synthase-like. (152 aa)
LOC103255950Calmodulin-like; Belongs to the calmodulin family. (131 aa)
MAP2K6LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (352 aa)
LOC103260063Glutathione S-transferase alpha-4-like. (222 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (388 aa)
ENSTSYP00000023190annotation not available (646 aa)
ASS1Argininosuccinate synthase. (97 aa)
ENSTSYP00000022730annotation not available (121 aa)
PIAS4E3 SUMO-protein ligase PIAS4. (444 aa)
ENSTSYP00000022518annotation not available (698 aa)
ENSTSYP00000022482annotation not available (178 aa)
LOC103273612Small ubiquitin-related modifier. (110 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (558 aa)
LOC103266009Thioredoxin; Belongs to the thioredoxin family. (106 aa)
ITGAVIntegrin alpha-V; Belongs to the integrin alpha chain family. (1041 aa)
VCAM1Vascular cell adhesion protein 1 isoform X1. (739 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (612 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
PECAM1Platelet endothelial cell adhesion molecule. (737 aa)
CALML4LOW QUALITY PROTEIN: calmodulin-like protein 4. (192 aa)
ENSTSYP00000020233annotation not available (371 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
MEF2AMyocyte-specific enhancer factor 2A isoform X1. (498 aa)
ENSTSYP00000019705annotation not available (218 aa)
ENSTSYP00000019285annotation not available (346 aa)
LOC103250483-2Calmodulin-2/4-like isoform X2; Belongs to the calmodulin family. (141 aa)
VEGFAVascular endothelial growth factor A isoform X2; Belongs to the PDGF/VEGF growth factor family. (186 aa)
NCF1LOW QUALITY PROTEIN: neutrophil cytosol factor 1. (232 aa)
ENSTSYP00000018913annotation not available (131 aa)
ENSTSYP00000018856annotation not available (161 aa)
ENSTSYP00000018500annotation not available (73 aa)
LOC103260055Glutathione S-transferase. (222 aa)
LOC103260052Glutathione S-transferase A3 isoform X1; Belongs to the GST superfamily. (222 aa)
ENSTSYP00000018036annotation not available (141 aa)
ENSTSYP00000017625annotation not available (109 aa)
MAPK12Mitogen-activated protein kinase. (277 aa)
ENSTSYP00000017365annotation not available (56 aa)
MAP2K5Dual specificity mitogen-activated protein kinase kinase 5 isoform X1; Belongs to the protein kinase superfamily. (448 aa)
ENSTSYP00000017214annotation not available (178 aa)
LOC103250564Integrin beta; Belongs to the integrin beta chain family. (418 aa)
ENSTSYP00000016704annotation not available (357 aa)
RAC1Ras-related C3 botulinum toxin substrate 1. (212 aa)
RHOCRho-related GTP-binding protein RhoC isoform X2. (193 aa)
LOC103269581Small ubiquitin-related modifier 2-like. (114 aa)
SUMO2Small ubiquitin-related modifier 2. (95 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
MAP2K4Dual specificity mitogen-activated protein kinase kinase 4 isoform X1; Belongs to the protein kinase superfamily. (387 aa)
MAP2K7Dual specificity mitogen-activated protein kinase kinase 7. (414 aa)
ENSTSYP00000013967annotation not available (167 aa)
SQSTM1Sequestosome-1 isoform X2. (370 aa)
RAC3Ras-related C3 botulinum toxin substrate 3. (192 aa)
SELEE-selectin. (611 aa)
HSP90B1Endoplasmin isoform X1. (804 aa)
NPPCC-type natriuretic peptide. (129 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (273 aa)
HSP90AA1Heat shock protein HSP 90-alpha. (813 aa)
PRKAA2Non-specific serine/threonine protein kinase. (529 aa)
EDN1Endothelin-1. (202 aa)
CTNNB1Catenin beta-1 isoform X1. (783 aa)
AKT3RAC-gamma serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (419 aa)
CCL2C-C motif chemokine. (99 aa)
IL1R1Interleukin-1 receptor type 1. (573 aa)
CDH5Cadherin-5; Cadherins are calcium-dependent cell adhesion proteins. (786 aa)
ACTL8LOW QUALITY PROTEIN: actin-like protein 8; Belongs to the actin family. (366 aa)
IL1R2Interleukin-1 receptor type 2. (387 aa)
LOC103271334Glutathione S-transferase theta-2B-like isoform X1; Belongs to the GST superfamily. (243 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (267 aa)
ARHGEF2Rho guanine nucleotide exchange factor 2 isoform X1. (1013 aa)
LOC103255107Microsomal glutathione S-transferase 1. (155 aa)
LOC103263427Glutathione S-transferase. (189 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
NOX1NADPH oxidase 1 isoform X1. (564 aa)
ACTL7BLOW QUALITY PROTEIN: actin-like protein 7B; Belongs to the actin family. (366 aa)
MAPK10Mitogen-activated protein kinase. (473 aa)
MGST3Microsomal glutathione S-transferase 3 isoform X1. (152 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (964 aa)
GSTA4Glutathione S-transferase A4 isoform X1; Belongs to the GST superfamily. (222 aa)
LOC103250483calmodulin-A-like isoform X1; Belongs to the calmodulin family. (150 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (744 aa)
KDRVascular endothelial growth factor receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (756 aa)
LOC103268588Thioredoxin. (105 aa)
CTSLCathepsin L1-like; Belongs to the peptidase C1 family. (242 aa)
NCF2Neutrophil cytosol factor 2. (526 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (563 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (480 aa)
LOC103271335Glutathione S-transferase theta-1 isoform X1. (240 aa)
ENSTSYP00000002295annotation not available (173 aa)
TXNDC8Thioredoxin; Belongs to the thioredoxin family. (129 aa)
LOC103260057Glutathione S-transferase A3-like. (223 aa)
GSTO2Glutathione S-transferase omega-2 isoform X1; Belongs to the GST superfamily. (250 aa)
GSTO1Glutathione S-transferase omega-1 isoform X1; Belongs to the GST superfamily. (241 aa)
MMP9Matrix metalloproteinase-9. (710 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (165 aa)
MMP272 kDa type IV collagenase. (662 aa)
TXNDC2Thioredoxin domain-containing protein 2. (506 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
GPC1Glypican-1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (558 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1329 aa)
NFE2L2Nuclear factor erythroid 2-related factor 2 isoform X1. (591 aa)
GSTT4Glutathione S-transferase theta-4; Belongs to the GST superfamily. (241 aa)
Your Current Organism:
Carlito syrichta
NCBI taxonomy Id: 1868482
Other names: C. syrichta, Philippine tarsier, Tarsius syrichta
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