(38 nodes) Respiratory electron transport chain network (Methylocystis sp. SC2)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

Your Input:
	nuoK	NADH-quinone oxidoreductase subunit K (NADH dehydrogenase I subunit K); NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 4L family. (103 aa)
	nuoL	Proton-translocating NADH-quinone oxidoreductase subunit L (NADH dehydrogenase I subunit L). (677 aa)
	BN69_3416	Cytochrome-c3 hydrogenase/quinone oxidoreductase. (606 aa)
	BN69_3053	Cytochrome c oxidase subunit III. (296 aa)
	BN69_3049	Cytochrome c oxidase, subunit I; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B. (553 aa)
	BN69_3013	Cytochrome c oxidase, subunit I; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B. (636 aa)
	BN69_2246	Cytochrome bd ubiquinol oxidase subunit I. (524 aa)
	BN69_2247	Cytochrome d ubiquinol oxidase, subunit II. (379 aa)
	BN69_2303	Thiosulfate reductase cytochrome b subunit. (207 aa)
	BN69_2336	Ni/Fe-hydrogenase, b-type cytochrome subunit. (239 aa)
	hupB	Uptake hydrogenase large subunit; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (623 aa)
	BN69_2339	Nickel-dependent hydrogenase large subunit. (483 aa)
	BN69_2349	HyaB-Ni,Fe-hydrogenase I large subunit. (361 aa)
	coxN	Cytochrome c oxidase subunit 1; Belongs to the heme-copper respiratory oxidase family. (588 aa)
	BN69_2437	Cytochrome c oxidase subunit III. (236 aa)
	BN69_2438	Cytochrome C oxidase subunit III. (242 aa)
	ctaE	Cytochrome c oxidase subunit 3. (213 aa)
	ctaD	Cytochrome c oxidase subunit 1; Belongs to the heme-copper respiratory oxidase family. (537 aa)
	BN69_2869	Putative NADH-ubiquinone oxidoreductase chain 49kDa. (512 aa)
	BN69_2872	NADH dehydrogenase. (317 aa)
	BN69_2871	Putative hydrogenase-4 component E. (220 aa)
	BN69_2870	NADH/Ubiquinone/plastoquinone (Complex I). (482 aa)
	BN69_3012	Putative cytochrome c oxidase subunit III protein. (198 aa)
	BN69_2873	NADH/Ubiquinone/plastoquinone (Complex I). (665 aa)
	nuoM	Proton-translocating NADH-quinone oxidoreductase subunit M (NADH dehydrogenase I subunit M). (502 aa)
	nuoN	NADH-quinone oxidoreductase subunit N (NADH dehydrogenase I subunit N); NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 2 family. (477 aa)
	BN69_1450	NAD-dependent formate dehydrogenase, alpha subunit. (968 aa)
	cydB	Cytochrome d oxidase subunit II. (381 aa)
	cydA	Cytochrome bd-I oxidase subunit I. (530 aa)
	BN69_1189	Cytochrome c oxidase, subunit I; Belongs to the heme-copper respiratory oxidase family. (827 aa)
	BN69_0978	Cytochrome c oxidase, subunit I; Belongs to the heme-copper respiratory oxidase family. (850 aa)
	BN69_0845	Nickel-dependent hydrogenase large subunit. (430 aa)
	BN69_0803	Transglutaminase family protein cysteine peptidase BTLCP. (207 aa)
	BN69_0643	Electron-transferring-flavoprotein dehydrogenase; Accepts electrons from ETF and reduces ubiquinone. (558 aa)
	BN69_0332	Putative Cytochrome b561. (369 aa)
	BN69_0098	Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. (412 aa)
	nuoG	NADH-quinone oxidoreductase subunit G (NADH dehydrogenase I subunit G); NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. Belongs to the complex I 75 kDa subunit family. (686 aa)
	nuoE	NADH-quinone oxidoreductase subunit E (NADH dehydrogenase I subunit E). (204 aa)

Your Current Organism:

Methylocystis sp. SC2

NCBI taxonomy Id: 187303
Other names: M. sp. SC2

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BN69_0098	BN69_0978	BN69_0098	BN69_0978	Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.	Cytochrome c oxidase, subunit I; Belongs to the heme-copper respiratory oxidase family.	0.922
BN69_0098	BN69_1189	BN69_0098	BN69_1189	Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.	Cytochrome c oxidase, subunit I; Belongs to the heme-copper respiratory oxidase family.	0.918
BN69_0098	BN69_2246	BN69_0098	BN69_2246	Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.	Cytochrome bd ubiquinol oxidase subunit I.	0.478
BN69_0098	BN69_2437	BN69_0098	BN69_2437	Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.	Cytochrome c oxidase subunit III.	0.904
BN69_0098	BN69_2438	BN69_0098	BN69_2438	Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.	Cytochrome C oxidase subunit III.	0.905
BN69_0098	BN69_3012	BN69_0098	BN69_3012	Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.	Putative cytochrome c oxidase subunit III protein.	0.904
BN69_0098	BN69_3013	BN69_0098	BN69_3013	Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.	Cytochrome c oxidase, subunit I; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.	0.935
BN69_0098	BN69_3049	BN69_0098	BN69_3049	Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.	Cytochrome c oxidase, subunit I; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.	0.972
BN69_0098	BN69_3053	BN69_0098	BN69_3053	Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.	Cytochrome c oxidase subunit III.	0.973
BN69_0098	coxN	BN69_0098	BN69_2436	Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.	Cytochrome c oxidase subunit 1; Belongs to the heme-copper respiratory oxidase family.	0.927
BN69_0098	ctaD	BN69_0098	BN69_2692	Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.	Cytochrome c oxidase subunit 1; Belongs to the heme-copper respiratory oxidase family.	0.917
BN69_0098	ctaE	BN69_0098	BN69_2691	Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.	Cytochrome c oxidase subunit 3.	0.905
BN69_0098	cydA	BN69_0098	BN69_1287	Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.	Cytochrome bd-I oxidase subunit I.	0.478
BN69_0098	nuoE	BN69_0098	BN69_1746	Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.	NADH-quinone oxidoreductase subunit E (NADH dehydrogenase I subunit E).	0.769
BN69_0098	nuoG	BN69_0098	BN69_1744	Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.	NADH-quinone oxidoreductase subunit G (NADH dehydrogenase I subunit G); NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. Belongs to the complex I 75 kDa subunit family.	0.908
BN69_0098	nuoK	BN69_0098	BN69_1740	Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.	NADH-quinone oxidoreductase subunit K (NADH dehydrogenase I subunit K); NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 4L family.	0.640
BN69_0098	nuoL	BN69_0098	BN69_1739	Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.	Proton-translocating NADH-quinone oxidoreductase subunit L (NADH dehydrogenase I subunit L).	0.697
BN69_0098	nuoM	BN69_0098	BN69_1738	Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.	Proton-translocating NADH-quinone oxidoreductase subunit M (NADH dehydrogenase I subunit M).	0.996
BN69_0098	nuoN	BN69_0098	BN69_1737	Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.	NADH-quinone oxidoreductase subunit N (NADH dehydrogenase I subunit N); NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 2 family.	0.950
BN69_0845	BN69_1450	BN69_0845	BN69_1450	Nickel-dependent hydrogenase large subunit.	NAD-dependent formate dehydrogenase, alpha subunit.	0.715