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thiG thiG BN69_0042 BN69_0042 BN69_0102 BN69_0102 BN69_0267 BN69_0267 thiC thiC BN69_0358 BN69_0358 thiL thiL BN69_0508 BN69_0508 BN69_0530 BN69_0530 BN69_0531 BN69_0531 BN69_0762 BN69_0762 BN69_0837 BN69_0837 BN69_0838 BN69_0838 BN69_0895 BN69_0895 BN69_0992 BN69_0992 pdxJ pdxJ gloB gloB aroE aroE cyc cyc BN69_1178 BN69_1178 gph gph BN69_1360 BN69_1360 BN69_1361 BN69_1361 BN69_1363 BN69_1363 BN69_1364 BN69_1364 BN69_1392 BN69_1392 BN69_1791 BN69_1791 glpK glpK BN69_1943 BN69_1943 BN69_2025 BN69_2025 pdxH pdxH BN69_2082 BN69_2082 pdxA pdxA BN69_2236 BN69_2236 BN69_2242 BN69_2242 BN69_2275 BN69_2275 BN69_2290 BN69_2290 dxs dxs BN69_2415 BN69_2415 mxaF mxaF BN69_2571 BN69_2571 BN69_2572 BN69_2572 BN69_2573 BN69_2573 BN69_2574 BN69_2574 BN69_2576 BN69_2576 BN69_2577 BN69_2577 BN69_2578 BN69_2578 BN69_2579 BN69_2579 BN69_2685 BN69_2685 BN69_2720 BN69_2720 BN69_2735 BN69_2735 BN69_2737 BN69_2737 BN69_2756 BN69_2756 cysQ cysQ BN69_2823 BN69_2823 BN69_2878 BN69_2878 BN69_2931 BN69_2931 BN69_3030 BN69_3030 BN69_3035 BN69_3035 BN69_3036 BN69_3036 BN69_3037 BN69_3037 BN69_3138 BN69_3138 lldD lldD BN69_3477 BN69_3477 BN69_3568 BN69_3568 BN69_3574 BN69_3574 BN69_3658 BN69_3658
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
thiGThiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (264 aa)
BN69_0042Glyoxalase/bleomycin resistance protein/dioxygenase. (137 aa)
BN69_0102Fructose-1,6-bisphosphatase, class II; Belongs to the FBPase class 2 family. (329 aa)
BN69_0267ATPase associated with various cellular activities AAA_3. (334 aa)
thiCPhosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (611 aa)
BN69_0358Beta-lactamase domain protein. (309 aa)
thiLThiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (316 aa)
BN69_0508Phosphomethylpyrimidine kinase. (267 aa)
BN69_0530Inositol monophosphatase. (272 aa)
BN69_0531Inositol monophosphatase family protein. (86 aa)
BN69_0762Zinc-binding alcohol dehydrogenase family protein. (329 aa)
BN69_0837FAD linked oxidase domain protein. (405 aa)
BN69_0838D-lactate dehydrogenase (Cytochrome). (497 aa)
BN69_0895Isocitrate dehydrogenase; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (403 aa)
BN69_0992Fumarylacetoacetate (FAA) hydrolase. (337 aa)
pdxJPyridoxine 5'-phosphate synthase (PNP synthase); Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. (263 aa)
gloBHydroxyacylglutathione hydrolase; Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl- glutathione to form glutathione and D-lactic acid. (258 aa)
aroEShikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (280 aa)
cycCytochrome P450. (463 aa)
BN69_1178Aminotransferase class V. (397 aa)
gphPhosphoglycolate phosphatase; Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress. Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. (234 aa)
BN69_1360Rhodanese domain protein. (188 aa)
BN69_1361Extracellular solute-binding protein family 3. (300 aa)
BN69_1363PQQ-dependent dehydrogenase, methanol/ethanol family. (613 aa)
BN69_1364Putative metallo-beta-lactamase family protein. (307 aa)
BN69_1392Monooxygenase FAD-binding. (548 aa)
BN69_1791Rhodanese domain protein. (112 aa)
glpKGlycerol kinase (glycerol 3-phosphotransferase); Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family. (498 aa)
BN69_1943Cytochrome P450. (452 aa)
BN69_2025FAD linked oxidase domain protein. (474 aa)
pdxHPyridoxine/pyridoxamine 5'-phosphate oxidase (PNP/PMP oxidase); Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (204 aa)
BN69_2082Oxidoreductase, NAD-binding. (316 aa)
pdxA4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). (333 aa)
BN69_2236Rhodanese domain protein. (113 aa)
BN69_2242Conserved hypothetical protein. (66 aa)
BN69_2275N-acetylmuramyl-L-alanine amidase, negative regulator of AmpC, AmpD; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). (456 aa)
BN69_2290Thiamine monophosphate synthase. (203 aa)
dxs1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (642 aa)
BN69_2415Fumarylacetoacetate (FAA) hydrolase. (235 aa)
mxaFMethanol dehydrogenase MxaF. (624 aa)
BN69_2571Extracellular solute-binding protein family 3. (301 aa)
BN69_2572Cytochrome c class I; Electron acceptor for MDH. Acts in methanol oxidation. (193 aa)
BN69_2573Methanol dehydrogenase beta subunit; Catalyzes the oxidation of primary alcohols including methanol. (96 aa)
BN69_2574ATPase associated with various cellular activities AAA_3. (343 aa)
BN69_2576MxaA protein, putative. (298 aa)
BN69_2577Von Willebrand factor type A. (333 aa)
BN69_2578Conserved hypothetical protein. (202 aa)
BN69_2579Von Willebrand factor type A. (334 aa)
BN69_2685Nitroreductase-like protein. (551 aa)
BN69_2720Enterobactin synthetase component B (Isochorismatase). (295 aa)
BN69_2735Ethanolamine ammonia-lyase light chain; Belongs to the EutC family. (261 aa)
BN69_2737Choline/ethanolamine kinase. (296 aa)
BN69_2756Glyoxalase/bleomycin resistance protein/dioxygenase. (151 aa)
cysQ3'(2'),5'-bisphosphate nucleotidase; Converts adenosine-3',5'-bisphosphate (PAP) to AMP. Belongs to the inositol monophosphatase superfamily. CysQ family. (285 aa)
BN69_2823Transcriptional coactivator/pterin dehydratase. (125 aa)
BN69_2878Ornithine cyclodeaminase. (355 aa)
BN69_2931Glyoxalase/bleomycin resistance protein/dioxygenase. (146 aa)
BN69_3030Putative myo-inositol-1-phosphate synthase protein. (357 aa)
BN69_3035Putative periplasmic binding protein, involved in methanol oxidation. (269 aa)
BN69_3036Putative pqq dehydrogenase /Methanol dehydrogenase large subunit homolog. (223 aa)
BN69_3037Putative pqq dehydrogenase protein. (390 aa)
BN69_3138Undecaprenyl diphosphate synthase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. (259 aa)
lldDL-lactate dehydrogenase [cytochrome]. (377 aa)
BN69_3477L-lactate dehydrogenase. (425 aa)
BN69_3568Inositol monophosphatase. (263 aa)
BN69_3574Histidinol-phosphate phosphatase. (273 aa)
BN69_3658Alcohol dehydrogenase GroES domain protein. (389 aa)
Your Current Organism:
Methylocystis sp. SC2
NCBI taxonomy Id: 187303
Other names: M. sp. SC2
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