(15 nodes) Nickel cation binding network (Methanothermobacter thermautotrophicus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Predicted Interactions

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Your Input:
	mvhA	Methyl viologen-reducing hydrogenase, alpha subunit; Part of a complex that provides reducing equivalents for heterodisulfide reductase. (472 aa)
	hypA	Hydrogenase expression/formation protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. (125 aa)
	MTH_782	Hydrogenase expression/formation protein HypB; Function Code:2.02 - Energy Metabolism, Methane metabolism; similar to, pir:LN:B64355 AC:B64355, p()=6.3E-64, pid=58%. (217 aa)
	MTH_739	Conserved protein; Transcriptional regulator; Belongs to the transcriptional regulatory CopG/NikR family. (140 aa)
	cdhC	Carbon monoxide dehydrogenase, alpha subunit; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex); Belongs to the CdhC family. (460 aa)
	cdhA	Carbon monoxide dehydrogenase, alpha subunit; Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. (780 aa)
	MTH_1672	Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, sp:LN:Y120_METJA AC:Q57584, p()=8.8E-90, pid=65%. (236 aa)
	cbiX	Conserved protein; Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel- containing tetrapyrrole coenzyme F430, the prosthetic group of methyl- coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation (Potential). Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni-sirohydrochlorin (Potential). (128 aa)
	frhA	Coenzyme F420-reducing hydrogenase, alpha subunit; Reduces the physiological low-potential two-electron acceptor coenzyme F420, and the artificial one-electron acceptor methylviologen; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (408 aa)
	frhG	Coenzyme F420-reducing hydrogenase, gamma subunit; Reduces the physiological low-potential two-electron acceptor coenzyme F420, and the artificial one-electron acceptor methylviologen; Belongs to the FrhG family. (275 aa)
	frhB	Coenzyme F420-reducing hydrogenase, beta subunit; Reduces the physiological low-potential two-electron acceptor coenzyme F420, and the artificial one-electron acceptor methylviologen; Belongs to the FrhB family. (281 aa)
	MTH_398	Formate hydrogenlyase, subunit 5; Function Code:2.02 - Energy Metabolism, Methane metabolism; similar to, pir:LN:C64364 AC:C64364, p()=8.5E-92, pid=46%. (370 aa)
	MTH_603	Conserved protein; Transcriptional regulator; Belongs to the transcriptional regulatory CopG/NikR family. (127 aa)
	MTH_1238	Formate hydrogenlyase, subunit 5; Function Code:2.02 - Energy Metabolism, Methane metabolism; similar to, pir:LN:B64428 AC:B64428, p()=2E-99, pid=47%. (381 aa)
	MTH_1109	Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:B64473 AC:B64473, p()=2.2E-45, pid=27%; Belongs to the LarC family. (418 aa)

Your Current Organism:

Methanothermobacter thermautotrophicus

NCBI taxonomy Id: 187420
Other names: M. thermautotrophicus str. Delta H, Methanobacterium thermoautotrophicum str. Delta H, Methanobacterium thermoautotrophicum str. deltaH, Methanothermobacter thermautotrophicus str. Delta H, Methanothermobacter thermautotrophicus str. deltaH

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MTH_1238	MTH_1672	MTH_1238	MTH_1672	Formate hydrogenlyase, subunit 5; Function Code:2.02 - Energy Metabolism, Methane metabolism; similar to, pir:LN:B64428 AC:B64428, p()=2E-99, pid=47%.	Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, sp:LN:Y120_METJA AC:Q57584, p()=8.8E-90, pid=65%.	0.768
MTH_1238	MTH_782	MTH_1238	MTH_782	Formate hydrogenlyase, subunit 5; Function Code:2.02 - Energy Metabolism, Methane metabolism; similar to, pir:LN:B64428 AC:B64428, p()=2E-99, pid=47%.	Hydrogenase expression/formation protein HypB; Function Code:2.02 - Energy Metabolism, Methane metabolism; similar to, pir:LN:B64355 AC:B64355, p()=6.3E-64, pid=58%.	0.930
MTH_1238	hypA	MTH_1238	MTH_783	Formate hydrogenlyase, subunit 5; Function Code:2.02 - Energy Metabolism, Methane metabolism; similar to, pir:LN:B64428 AC:B64428, p()=2E-99, pid=47%.	Hydrogenase expression/formation protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.	0.840
MTH_1238	mvhA	MTH_1238	MTH_1134	Formate hydrogenlyase, subunit 5; Function Code:2.02 - Energy Metabolism, Methane metabolism; similar to, pir:LN:B64428 AC:B64428, p()=2E-99, pid=47%.	Methyl viologen-reducing hydrogenase, alpha subunit; Part of a complex that provides reducing equivalents for heterodisulfide reductase.	0.542
MTH_1672	MTH_1238	MTH_1672	MTH_1238	Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, sp:LN:Y120_METJA AC:Q57584, p()=8.8E-90, pid=65%.	Formate hydrogenlyase, subunit 5; Function Code:2.02 - Energy Metabolism, Methane metabolism; similar to, pir:LN:B64428 AC:B64428, p()=2E-99, pid=47%.	0.768
MTH_1672	MTH_398	MTH_1672	MTH_398	Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, sp:LN:Y120_METJA AC:Q57584, p()=8.8E-90, pid=65%.	Formate hydrogenlyase, subunit 5; Function Code:2.02 - Energy Metabolism, Methane metabolism; similar to, pir:LN:C64364 AC:C64364, p()=8.5E-92, pid=46%.	0.768
MTH_1672	hypA	MTH_1672	MTH_783	Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, sp:LN:Y120_METJA AC:Q57584, p()=8.8E-90, pid=65%.	Hydrogenase expression/formation protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.	0.887
MTH_398	MTH_1672	MTH_398	MTH_1672	Formate hydrogenlyase, subunit 5; Function Code:2.02 - Energy Metabolism, Methane metabolism; similar to, pir:LN:C64364 AC:C64364, p()=8.5E-92, pid=46%.	Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, sp:LN:Y120_METJA AC:Q57584, p()=8.8E-90, pid=65%.	0.768
MTH_398	MTH_782	MTH_398	MTH_782	Formate hydrogenlyase, subunit 5; Function Code:2.02 - Energy Metabolism, Methane metabolism; similar to, pir:LN:C64364 AC:C64364, p()=8.5E-92, pid=46%.	Hydrogenase expression/formation protein HypB; Function Code:2.02 - Energy Metabolism, Methane metabolism; similar to, pir:LN:B64355 AC:B64355, p()=6.3E-64, pid=58%.	0.865
MTH_398	hypA	MTH_398	MTH_783	Formate hydrogenlyase, subunit 5; Function Code:2.02 - Energy Metabolism, Methane metabolism; similar to, pir:LN:C64364 AC:C64364, p()=8.5E-92, pid=46%.	Hydrogenase expression/formation protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.	0.729
MTH_398	mvhA	MTH_398	MTH_1134	Formate hydrogenlyase, subunit 5; Function Code:2.02 - Energy Metabolism, Methane metabolism; similar to, pir:LN:C64364 AC:C64364, p()=8.5E-92, pid=46%.	Methyl viologen-reducing hydrogenase, alpha subunit; Part of a complex that provides reducing equivalents for heterodisulfide reductase.	0.548
MTH_782	MTH_1238	MTH_782	MTH_1238	Hydrogenase expression/formation protein HypB; Function Code:2.02 - Energy Metabolism, Methane metabolism; similar to, pir:LN:B64355 AC:B64355, p()=6.3E-64, pid=58%.	Formate hydrogenlyase, subunit 5; Function Code:2.02 - Energy Metabolism, Methane metabolism; similar to, pir:LN:B64428 AC:B64428, p()=2E-99, pid=47%.	0.930
MTH_782	MTH_398	MTH_782	MTH_398	Hydrogenase expression/formation protein HypB; Function Code:2.02 - Energy Metabolism, Methane metabolism; similar to, pir:LN:B64355 AC:B64355, p()=6.3E-64, pid=58%.	Formate hydrogenlyase, subunit 5; Function Code:2.02 - Energy Metabolism, Methane metabolism; similar to, pir:LN:C64364 AC:C64364, p()=8.5E-92, pid=46%.	0.865
MTH_782	cdhC	MTH_782	MTH_1710	Hydrogenase expression/formation protein HypB; Function Code:2.02 - Energy Metabolism, Methane metabolism; similar to, pir:LN:B64355 AC:B64355, p()=6.3E-64, pid=58%.	Carbon monoxide dehydrogenase, alpha subunit; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex); Belongs to the CdhC family.	0.525
MTH_782	frhA	MTH_782	MTH_1300	Hydrogenase expression/formation protein HypB; Function Code:2.02 - Energy Metabolism, Methane metabolism; similar to, pir:LN:B64355 AC:B64355, p()=6.3E-64, pid=58%.	Coenzyme F420-reducing hydrogenase, alpha subunit; Reduces the physiological low-potential two-electron acceptor coenzyme F420, and the artificial one-electron acceptor methylviologen; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.	0.999
MTH_782	hypA	MTH_782	MTH_783	Hydrogenase expression/formation protein HypB; Function Code:2.02 - Energy Metabolism, Methane metabolism; similar to, pir:LN:B64355 AC:B64355, p()=6.3E-64, pid=58%.	Hydrogenase expression/formation protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.	0.999
MTH_782	mvhA	MTH_782	MTH_1134	Hydrogenase expression/formation protein HypB; Function Code:2.02 - Energy Metabolism, Methane metabolism; similar to, pir:LN:B64355 AC:B64355, p()=6.3E-64, pid=58%.	Methyl viologen-reducing hydrogenase, alpha subunit; Part of a complex that provides reducing equivalents for heterodisulfide reductase.	0.999
cdhA	cdhC	MTH_1708	MTH_1710	Carbon monoxide dehydrogenase, alpha subunit; Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase.	Carbon monoxide dehydrogenase, alpha subunit; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex); Belongs to the CdhC family.	0.999
cdhC	MTH_782	MTH_1710	MTH_782	Carbon monoxide dehydrogenase, alpha subunit; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex); Belongs to the CdhC family.	Hydrogenase expression/formation protein HypB; Function Code:2.02 - Energy Metabolism, Methane metabolism; similar to, pir:LN:B64355 AC:B64355, p()=6.3E-64, pid=58%.	0.525
cdhC	cdhA	MTH_1710	MTH_1708	Carbon monoxide dehydrogenase, alpha subunit; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex); Belongs to the CdhC family.	Carbon monoxide dehydrogenase, alpha subunit; Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase.	0.999

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