STRINGSTRING
leuB leuB MTH_140 MTH_140 guaB guaB ilvC ilvC hcp hcp mtd mtd MTH_1468 MTH_1468 MTH_1473 MTH_1473 MTH_1482 MTH_1482 ala ala MTH_1502 MTH_1502 MTH_152 MTH_152 cfbD cfbD MTH_1539 MTH_1539 MTH_1548 MTH_1548 MTH_1549 MTH_1549 MTH_155 MTH_155 MTH_1552 MTH_1552 MTH_1553 MTH_1553 MTH_1554 MTH_1554 MTH_1555 MTH_1555 MTH_1556 MTH_1556 fwdC fwdC MTH_1559 MTH_1559 MTH_156 MTH_156 nifH1 nifH1 nifD nifD nifK nifK nifE nifE MTH_1566 MTH_1566 MTH_1567 MTH_1567 MTH_157 MTH_157 MTH_1577 MTH_1577 MTH_1578 MTH_1578 MTH_1586 MTH_1586 MTH_159 MTH_159 MTH_1595 MTH_1595 sod sod MTH_1640 MTH_1640 MTH_1643 MTH_1643 MTH_1648 MTH_1648 MTH_1666 MTH_1666 MTH_1684 MTH_1684 MTH_1695 MTH_1695 cdhA cdhA cdhC cdhC MTH_1714 MTH_1714 MTH_1718 MTH_1718 MTH_1719 MTH_1719 MTH_1736 MTH_1736 MTH_1737 MTH_1737 porB porB porA porA porC porC MTH_1747 MTH_1747 MTH_175 MTH_175 mer mer MTH_1799 MTH_1799 MTH_1807 MTH_1807 MTH_1819 MTH_1819 MTH_1826 MTH_1826 MTH_184 MTH_184 MTH_1850 MTH_1850 iorA iorA iorB iorB hdrC hdrC hdrB hdrB mdh mdh MTH_192 MTH_192 MTH_193 MTH_193 MTH_194 MTH_194 MTH_220 MTH_220 MTH_221 MTH_221 hisD hisD MTH_234 MTH_234 MTH_235 MTH_235 MTH_238 MTH_238 aroE aroE fno fno MTH_277 MTH_277 MTH_278 MTH_278 MTH_280 MTH_280 MTH_287 MTH_287 MTH_341 MTH_341 MTH_345 MTH_345 gpsA gpsA MTH_398 MTH_398 gap gap hemA hemA MTH_1013 MTH_1013 MTH_1032 MTH_1032 korA korA korB korB korC korC MTH_105 MTH_105 MTH_106 MTH_106 MTH_1106 MTH_1106 mvhB mvhB mvhA mvhA mvhG mvhG MTH_399 MTH_399 MTH_401 MTH_401 MTH_405 MTH_405 MTH_417 MTH_417 fni fni msrA msrA MTH_536 MTH_536 hmgA hmgA MTH_574 MTH_574 aroB aroB egsA egsA MTH_63 MTH_63 nifH2 nifH2 MTH_652 MTH_652 MTH_691 MTH_691 vorC vorC vorB vorB vorA vorA MTH_708 MTH_708 msrB msrB MTH_725 MTH_725 MTH_745 MTH_745 MTH_756 MTH_756 MTH_757 MTH_757 MTH_772 MTH_772 asd-2 asd-2 dapB dapB MTH_807 MTH_807 MTH_822 MTH_822 MTH_836 MTH_836 argC argC MTH_847 MTH_847 MTH_853 MTH_853 MTH_854 MTH_854 MTH_875 MTH_875 MTH_895 MTH_895 MTH_897 MTH_897 fmdC fmdC MTH_919 MTH_919 MTH_926 MTH_926 MTH_927 MTH_927 MTH_933 MTH_933 MTH_935 MTH_935 serA serA nadX nadX MTH_978 MTH_978 MTH_984 MTH_984 mvhD mvhD MTH_1138 MTH_1138 MTH_1139 MTH_1139 MTH_114 MTH_114 MTH_1140 MTH_1140 hmd hmd MTH_116 MTH_116 MTH_1173 MTH_1173 MTH_120 MTH_120 comC comC pyrK pyrK pyrD pyrD MTH_1232 MTH_1232 MTH_1238 MTH_1238 MTH_1240 MTH_1240 MTH_1241 MTH_1241 frhB frhB frhG frhG frhA frhA MTH_135 MTH_135 fpaA fpaA MTH_1351 MTH_1351 MTH_1354 MTH_1354 MTH_1379 MTH_1379 hdrA hdrA cbiJ cbiJ
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
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experimentally determined
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gene neighborhood
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leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity); Belongs to the isocitrate and isopropylmalate dehydrogenases family. (329 aa)
MTH_140Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, gp:GI:g1786498 LN:ECAE000137, p()=5.8E-38, pid=25%. (396 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (484 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (333 aa)
hcp6Fe-6S prismane-containing protein; Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O. (476 aa)
mtdCoenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin dehydrogenase; Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT. (276 aa)
MTH_1468Ferredoxin; Function Code:2.08 - Energy Metabolism, Electron transport; similar to, gp:GI:g726054 LN:MTU19362, p()=5.9E-45, pid=97%. (83 aa)
MTH_1473Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:C64391 AC:C64391, p()=5.1E-46, pid=42%. (203 aa)
MTH_1482Nitrogenase iron-molybdenum cofactor biosynthesis protein NifE homolog; Function Code:2.06 - Energy Metabolism, Nitrogen metabolism; similar to, gp:GI:g1263078 LN:AVU51863, p()=2.7E-33, pid=43%. (402 aa)
alaOrnithine cyclodeaminase; Catalyzes the NAD(+)-dependent oxidative deamination of L- alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate; Belongs to the ornithine cyclodeaminase/mu-crystallin family. Archaeal alanine dehydrogenase subfamily. (339 aa)
MTH_1502Succinate dehydrogenase, flavoprotein subunit; Function Code:1.02 - Carbohydrate Metabolism, Citrate cycle (TCA cycle); similar to, sp:LN:Y033_METJA AC:Q60356, p()=2.9E-139, pid=51%. (558 aa)
MTH_152Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, gp_new:GI:e311284:g1929333 LN:BSZ93767, p()=8.6E-12, pid=27%; Belongs to the flavoredoxin family. (186 aa)
cfbDNitrogenase alpha chain (NifD) related protein; Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes both the six-electron reduction of the tetrahydroporphyrin ring system and the gamma-lactamization of the c- acetamide side chain of Ni-sirohydrochlorin a,c-diamide to yield 15,17(3)-seco-F430-17(3)-acid (seco-F430), the last intermediate in the biosynthesis of the coenzyme F430; Belongs to the NifD/NifK/NifE/N [...] (359 aa)
MTH_1539Anaerobic ribonucleoside-triphosphate reductase; Function Code:4.01 - Nucleotide Metabolism, Purine metabolism; similar to, pir:LN:H64403 AC:H64403, p()=2.5E-200, pid=51%. (776 aa)
MTH_1548NADP-reducing hydrogenase, subunit A; Function Code:2.01 - Energy Metabolism, Oxidative phosphorylation; similar to, pir:LN:A57150 AC:A57150, p()=1.2E-23, pid=34%. (149 aa)
MTH_1549NADP-reducing hydrogenase, subunit C; Function Code:2.01 - Energy Metabolism, Oxidative phosphorylation; similar to, pir:LN:C57150 AC:C57150, p()=1.2E-133, pid=38%. (630 aa)
MTH_155Rubredoxin; Rubredoxin is a small nonheme, iron protein lacking acid- labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule (By similarity). (63 aa)
MTH_1552Formate dehydrogenase, alpha subunit homolog; Function Code:2.02 - Energy Metabolism, Methane metabolism; similar to, pir:LN:S57430 AC:S57430, p()=0, pid=72%. (865 aa)
MTH_1553Tungsten formylmethanofuran dehydrogenase, subunit H; Function Code:2.02 - Energy Metabolism, Methane metabolism; similar to, pir:LN:S57452 AC:S57452, p()=6.5E-78, pid=80%. (166 aa)
MTH_1554Tungsten formylmethanofuran dehydrogenase, subunit F; Function Code:2.02 - Energy Metabolism, Methane metabolism; similar to, pir:LN:S57453 AC:S57453, p()=2.9E-169, pid=87%. (336 aa)
MTH_1555Tungsten formylmethanofuran dehydrogenase, subunit G; Function Code:2.02 - Energy Metabolism, Methane metabolism; similar to, pir:LN:S57454 AC:S57454, p()=2.9E-36, pid=81%. (82 aa)
MTH_1556Tungsten formylmethanofuran dehydrogenase, subunit D; Function Code:2.02 - Energy Metabolism, Methane metabolism; similar to, pir:LN:S57455 AC:S57455, p()=1.7E-63, pid=89%. (130 aa)
fwdCTungsten formylmethanofuran dehydrogenase, subunit C; Catalyzes the reversible oxidation of CO(2) and methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). Can only oxidize formylmethanofuran. This enzyme is oxygen-labile. Belongs to the FwdC/FmdC family. (270 aa)
MTH_1559Tungsten formylmethanofuran dehydrogenase, subunit B; Function Code:2.02 - Energy Metabolism, Methane metabolism; similar to, pir:LN:S57458 AC:S57458, p()=1.1E-208, pid=86%. (437 aa)
MTH_156Rubredoxin; Rubredoxin is a small nonheme, iron protein lacking acid- labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule. (53 aa)
nifH1Nitrogenase NifH subunit; The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein. (299 aa)
nifDNitrogenase NifD subunit; This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation. (469 aa)
nifKNitrogenase molybdenum-iron protein, NifK subunit; This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation; Belongs to the NifD/NifK/NifE/NifN family. (459 aa)
nifENitrogenase iron-molybdenum cofactor biosynthesis protein NifE; This protein may play a role in the biosynthesis of the prosthetic group of nitrogenase (FeMo cofactor); Belongs to the NifD/NifK/NifE/NifN family. (478 aa)
MTH_1566Nitrogenase molybdenum-iron protein, NifN subunit; Function Code:2.06 - Energy Metabolism, Nitrogen metabolism; similar to, gp:GI:e303924:g1854559, p()=7.1E-159, pid=66%; Belongs to the NifD/NifK/NifE/NifN family. (448 aa)
MTH_1567Catalytic subunit of nitrate reductase (flp); Function Code:2.06 - Energy Metabolism, Nitrogen metabolism; similar to, gp:GI:e303919:g1854561, p()=7.1E-72, pid=19%. (666 aa)
MTH_157Flavoprotein A homolog (III); Function Code:13.07 - Other, Unclassified; similar to, pir:LN:S66533 AC:S66533, p()=4.1E-60, pid=68%. (385 aa)
MTH_1577Unknown; Function Code:14.00 - Unknown; similar to, sp:LN:YRUB_CLOPA AC:P23171, p()=0.000041, pid=21%. (92 aa)
MTH_1578Unknown; Function Code:14.00 - Unknown; similar to, pir:LN:A64392 AC:A64392, p()=0.016, pid=08%. (151 aa)
MTH_1586Pyruvate formate-lyase activating enzyme; Function Code:2.08 - Energy Metabolism, Electron transport; similar to, pir:LN:B64453 AC:B64453, p()=7.4E-38, pid=37%. (233 aa)
MTH_159Alkyl hydroperoxide reductase; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. (226 aa)
MTH_1595Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:B64435 AC:B64435, p()=4E-23, pid=28%. (173 aa)
sodSuperoxide dismutase (Fe/Mn); Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the iron/manganese superoxide dismutase family. (205 aa)
MTH_1640Chorismate mutase; Function Code:5.14 - L-Amino Acid Metabolism, Phenylalanine--tyrosine and tryptophan biosynthesis; similar to, pir:LN:D64376 AC:D64376, p()=2.9E-82, pid=38%. (449 aa)
MTH_1643Pyruvate formate-lyase activating enzyme related protein; Function Code:2.08 - Energy Metabolism, Electron transport; similar to, sp:LN:PFLA_HAEIN AC:P43751, p()=0.00000034, pid=13%. (390 aa)
MTH_1648Dihydrolipoamide dehydrogenase; Function Code:1.01 - Carbohydrate Metabolism, Glycolysis--Gluconeogenesis; similar to, pir:LN:D64379 AC:D64379, p()=8.1E-48, pid=31%. (431 aa)
MTH_1666Glutamate synthase (NADPH), alpha subunit related protein; Function Code:5.01 - L-Amino Acid Metabolism, Alanine--aspartate and glutamate metabolism; similar to, pir:LN:F64468 AC:F64468, p()=2E-51, pid=25%; Belongs to the glutamate synthase family. (383 aa)
MTH_1684Conserved protein (contains ferredoxin domain); Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:G64509 AC:G64509, p()=7.1E-72, pid=71%. (431 aa)
MTH_1695RNase L inhibitor; Function Code:10.10 - Metabolism of Macromolecules, RNA degradation; similar to, sp:LN:Y719_METJA AC:Q58129, p()=1.6E-163, pid=50%. (623 aa)
cdhACarbon monoxide dehydrogenase, alpha subunit; Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. (780 aa)
cdhCCarbon monoxide dehydrogenase, alpha subunit; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex); Belongs to the CdhC family. (460 aa)
MTH_1714Formate hydrogenlyase, iron-sulfur subunit 2; Function Code:2.02 - Energy Metabolism, Methane metabolism; similar to, pir:LN:D64319 AC:D64319, p()=4.6E-29, pid=37%. (160 aa)
MTH_1718Bacteriochlorophyll synthase 43 kDa subunit; Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3- diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di- O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains. (381 aa)
MTH_1719Unknown (contains ferredoxin domain); Function Code:14.00 - Unknown; similar to, gp:GI:g945400, p()=0.00077, pid=18%. (74 aa)
MTH_1736Formate hydrogenlyase, iron-sulfur subunit 2; Function Code:2.02 - Energy Metabolism, Methane metabolism; similar to, pir:LN:D64319 AC:D64319, p()=1.1E-27, pid=34%. (143 aa)
MTH_1737Formate hydrogenlyase, iron-sulfur subunit I; Function Code:2.02 - Energy Metabolism, Methane metabolism; similar to, pir:LN:B64333 AC:B64333, p()=5E-32, pid=42%. (167 aa)
porBPyruvate oxidoreductase, beta subunit; Function Code:2.08 - Energy Metabolism, Electron transport; similar to, pir:LN:C64333 AC:C64333, p()=4.6E-109, pid=66%. (288 aa)
porAPyruvate oxidoreductase, alpha subunit; Function Code:2.08 - Energy Metabolism, Electron transport; similar to, pir:LN:D64333 AC:D64333, p()=2.3E-114, pid=58%. (383 aa)
porCPyruvate oxidoreductase, gamma subunit; Function Code:2.08 - Energy Metabolism, Electron transport; similar to, pir:LN:F64333 AC:F64333, p()=3.7E-52, pid=42%. (261 aa)
MTH_1747Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, sp:LN:Y7SR_METFE AC:P21336, p()=9.9E-43, pid=36%. (264 aa)
MTH_175Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:F64383 AC:F64383, p()=1.4E-41, pid=27%. (398 aa)
merCoenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase; Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT. (321 aa)
MTH_1799Unknown; Function Code:14.00 - Unknown; similar to, pir:LN:S55234 AC:S55234, p()=0.19, pid=13%. (86 aa)
MTH_1807Phytoene dehydrogenase; Function Code:9.14 - Metabolism of Cofactors and Vitamins, Terpenoid biosynthesis (isomeric hydrocarbon ((C5H8)n); similar to, sp:LN:CRTJ_MYXXA AC:P54979, p()=4.7E-68, pid=31%. (514 aa)
MTH_1819Ferredoxin; Function Code:2.08 - Energy Metabolism, Electron transport; similar to, sp:LN:FER_CLOTH AC:P00203, p()=0.000000021, pid=29%. (76 aa)
MTH_1826Unknown (contains ferredoxin domain); Function Code:14.00 - Unknown; similar to, pir:LN:A42960 AC:A42960, p()=0.0045, pid=08%. (367 aa)
MTH_184Isocitrate dehydrogenase; Function Code:1.02 - Carbohydrate Metabolism, Citrate cycle (TCA cycle); similar to, pir:LN:H64389 AC:H64389, p()=1.5E-78, pid=50%. (331 aa)
MTH_1850Fumarate reductase; Function Code:1.02 - Carbohydrate Metabolism, Citrate cycle (TCA cycle); similar to, sp:LN:Y092_METJA AC:Q57557, p()=6.9E-106, pid=43%. (492 aa)
iorAIndolepyruvate oxidoreductase, alpha subunit; Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates. (618 aa)
iorBIndolepyruvate oxidoreductase, beta subunit; Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates. (196 aa)
hdrCHeterodisulfide reductase, subunit C; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). (325 aa)
hdrBHeterodisulfide reductase, subunit B; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B); Belongs to the HdrB family. (302 aa)
mdhLactate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. (325 aa)
MTH_192Tungsten formylmethanofuran dehydrogenase, subunit C homolog; Function Code:2.02 - Energy Metabolism, Methane metabolism; similar to, pir:LN:B64446 AC:B64446, p()=0.0000024, pid=20%. (229 aa)
MTH_193Coenzyme F420-reducing hydrogenase, beta subunit homolog; Function Code:2.02 - Energy Metabolism, Methane metabolism; similar to, sp:LN:FRHB_METJA AC:Q60341, p()=3.3E-35, pid=31%. (352 aa)
MTH_194Glutamate synthase (NADPH), alpha subunit; Function Code:5.01 - L-Amino Acid Metabolism, Alanine--aspartate and glutamate metabolism; similar to, pir:LN:F64468 AC:F64468, p()=2.2E-90, pid=42%; Belongs to the glutamate synthase family. (499 aa)
MTH_220Flavoprotein A homolog (II); Function Code:13.07 - Other, Unclassified; similar to, pir:LN:D64393 AC:D64393, p()=8.2E-142, pid=62%. (410 aa)
MTH_221Unknown; Function Code:14.00 - Unknown; similar to, sp:LN:FER2_DESDN AC:P00211, p()=0.48, pid=05%. (270 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (426 aa)
MTH_234Gamma-carboxymuconolactone decarboxylase; Function Code:13.07 - Other, Unclassified; similar to, sp:LN:DC4C_ACICA AC:P20370, p()=1.2E-12, pid=28%. (125 aa)
MTH_235Riboflavin-specific deaminase; Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6- ribitylamino-4(3H)-pyrimidinone 5'-phosphate. (216 aa)
MTH_238Tungsten formylmethanofuran dehydrogenase, subunit C homolog; Function Code:2.02 - Energy Metabolism, Methane metabolism; similar to, pir:LN:B64382 AC:B64382, p()=7.3E-70, pid=31%; To M.jannaschii MJ0658. (306 aa)
aroEShikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (260 aa)
fnoConserved protein; Catalyzes the reduction of NADP(+) with F420H(2) via hydride transfer, and likely the reverse reaction, i.e. the reduction of F420 with NADPH. Probably functions in the regeneration of NADPH required in biosynthetic reactions. Is specific for reduced F420 as electron donor for the reduction of NADP; neither reduced FAD nor FMN can act as electron donor. The enzyme is also specific for NADP; NAD is not utilized as substrate; Belongs to the F420-dependent NADP reductase family. (232 aa)
MTH_277Bacteriochlorophyll synthase 43 kDa subunit; Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3- diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di- O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains. (397 aa)
MTH_278Ferredoxin; Function Code:2.08 - Energy Metabolism, Electron transport; similar to, sp:LN:FER1_RHORU AC:P00194, p()=0.000000056, pid=50%. (56 aa)
MTH_280Coenzyme F420-reducing hydrogenase, beta subunit homolog; Function Code:2.02 - Energy Metabolism, Methane metabolism; similar to, pir:LN:F64408 AC:F64408, p()=4.3E-223, pid=55%. (689 aa)
MTH_287Anaerobic ribonucleoside-triphosphate reductase activating protein; Function Code:4.01 - Nucleotide Metabolism, Purine metabolism; similar to, sp:LN:NRDG_BPT4 AC:P07075, p()=3.1E-16, pid=22%. (237 aa)
MTH_341Coenzyme F420-reducing hydrogenase, beta subunit homolog; Function Code:2.02 - Energy Metabolism, Methane metabolism; similar to, pir:LN:D35620 AC:D35620, p()=1.8E-21, pid=19%. (406 aa)
MTH_345Pyruvate formate-lyase 2 activating enzyme; Function Code:1.08 - Carbohydrate Metabolism, Pyruvate and acetyl-CoA metabolism; similar to, gp:GI:g1787045 LN:ECAE000184, p()=2.7E-31, pid=28%. (288 aa)
gpsAGlycerol-3-phosphate dehydrogenase (NAD); Function Code:8.01 - Metabolism of Complex Lipids, Glycerolipid metabolism; similar to, sp:LN:GPDA_BACSU AC:P46919, p()=3.5E-31, pid=30%; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (321 aa)
MTH_398Formate hydrogenlyase, subunit 5; Function Code:2.02 - Energy Metabolism, Methane metabolism; similar to, pir:LN:C64364 AC:C64364, p()=8.5E-92, pid=46%. (370 aa)
gapGlyceraldehyde 3-phosphate dehydrogenase; Function Code:1.01 - Carbohydrate Metabolism, Glycolysis--Gluconeogenesis; similar to, pir:LN:S02804 AC:S02804, p()=7.6E-139, pid=76%. (337 aa)
hemAglutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (402 aa)
MTH_1013Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, gp:GI:e288126:g1752671, p()=1E-13, pid=25%. (206 aa)
MTH_1032Ferredoxin (putative 2-oxoglutarate oxidoreductase, delat subunit); Function Code:2.08 - Energy Metabolism, Electron transport; similar to, sp:LN:FER3_METJA AC:Q57610, p()=1.6E-17, pid=45%. (69 aa)
korA2-oxoglutarate oxidoreductase, alpha subunit; Function Code:2.08 - Energy Metabolism, Electron transport; similar to, pir:LN:E64334 AC:E64334, p()=3.6E-116, pid=57%. (378 aa)
korB2-oxoglutarate oxidoreductase, beta subunit; Function Code:2.08 - Energy Metabolism, Electron transport; similar to, pir:LN:A64367 AC:A64367, p()=2.1E-88, pid=54%. (286 aa)
korC2-oxoglutarate oxidoreductase, gamma subunit; Function Code:2.08 - Energy Metabolism, Electron transport; similar to, pir:LN:H64366 AC:H64366, p()=4.2E-51, pid=54%. (189 aa)
MTH_105Glutamate synthase (NADPH), alpha subunit; Function Code:5.01 - L-Amino Acid Metabolism, Alanine--aspartate and glutamate metabolism; similar to, pir:LN:F64468 AC:F64468, p()=7E-77, pid=33%; Belongs to the glutamate synthase family. (622 aa)
MTH_106Tungsten formylmethanofuran dehydrogenase, subunit C homolog; Function Code:2.02 - Energy Metabolism, Methane metabolism; similar to, pir:LN:B64446 AC:B64446, p()=4E-12, pid=32%. (222 aa)
MTH_1106Ferredoxin; Function Code:2.08 - Electron transport; similar to, sp:LN:YOG6_CAEEL AC:P34615, p()=6.7e-12, pid=55%. (84 aa)
mvhBPolyferredoxin (MvhB); Function Code:2.08 - Energy Metabolism, Electron transport; similar to, gp:GI:g149734, p()=4.1E-227, pid=117%. (412 aa)
mvhAMethyl viologen-reducing hydrogenase, alpha subunit; Part of a complex that provides reducing equivalents for heterodisulfide reductase. (472 aa)
mvhGMethyl viologen-reducing hydrogenase, gamma subunit; Part of a complex that provides reducing equivalents for heterodisulfide reductase; Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family. (308 aa)
MTH_399Polyferredoxin; Function Code:2.08 - Energy Metabolism, Electron transport; similar to, gp:GI:e286616:g1747410, p()=4.8E-17, pid=13%. (341 aa)
MTH_401Polyferredoxin; Function Code:2.08 - Energy Metabolism, Electron transport; similar to, pir:LN:C37777 AC:C37777, p()=1.1E-24, pid=165%. (337 aa)
MTH_405Polyferredoxin; Function Code:2.08 - Energy Metabolism, Electron transport; similar to, pir:LN:B64364 AC:B64364, p()=3.9E-55, pid=92%. (261 aa)
MTH_417Homoserine dehydrogenase homolog; Function Code:5.02 - L-Amino Acid Metabolism, Glycine--serine and threonine metabolism; similar to, pir:LN:A64500 AC:A64500, p()=2.1E-79, pid=49%. (340 aa)
fniConserved protein; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP). (349 aa)
msrAPeptide methionine sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity). (169 aa)
MTH_5362-oxoacid:ferredoxin oxidoreductase, alpha subunit; Function Code:2.08 - Energy Metabolism, Electron transport; similar to, pir:LN:JC4919, p()=2.7E-67, pid=53%. (512 aa)
hmgA3-hydroxy-3-methylglutaryl CoA reductase; Converts HMG-CoA to mevalonate. (397 aa)
MTH_574Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, gp_new:GI:e311284:g1929333 LN:BSZ93767, p()=1.4E-13, pid=19%. (212 aa)
aroBConserved protein; Catalyzes the oxidative deamination and cyclization of 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis; Belongs to the archaeal-type DHQ synthase family. (378 aa)
egsAGlycerol 1-phosphate dehydrogenase; Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1- phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea. Is also able to catalyze the reverse reaction, i.e. the NAD(P)(+)-dependent oxidation of G1P but not of G3P. Is not active toward glycerol, dihydroxyacetone, glyceraldehyde-3-phosphate, glyceraldehyde and glycerol-2-phosphate; Belongs to the glycerol-1-phosphate dehydrogenase family. (347 aa)
MTH_63Function Code:14.01 - Conserved protein; similar to, sp:LN:YCO4_PARDE AC:P08304, p()=0.00014, pid=18%. (114 aa)
nifH2Nitrogenase NifH subunit; The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein. (265 aa)
MTH_652Ribonucleotide reductase, large subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (703 aa)
MTH_691Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:F64392 AC:F64392, p()=1.2E-30, pid=47%. (124 aa)
vorC2-oxoisovalerate oxidoreductase, gamma subunit; Function Code:2.08 - Energy Metabolism, Electron transport; similar to, sp:LN:FER3_METJA AC:Q57610, p()=0.000015, pid=39%. (79 aa)
vorB2-oxoisovalerate oxidoreductase, beta subunit; Function Code:2.08 - Energy Metabolism, Electron transport; similar to, pir:LN:E64334 AC:E64334, p()=1E-51, pid=34%. (348 aa)
vorA2-oxoisovalerate oxidoreductase, alpha subunit; Function Code:2.08 - Energy Metabolism, Electron transport; similar to, pir:LN:A64367 AC:A64367, p()=5E-28, pid=16%. (477 aa)
MTH_708Thioredoxin reductase; Function Code:4.02 - Nucleotide Metabolism, Pyrimidine metabolism; similar to, gp_new:GI:e313024:g1945648 LN:BSZ94043, p()=3.8E-57, pid=42%. (303 aa)
msrBTranscriptional regulator; Function Code:10.02 - Metabolism of Macromolecules, Transcription--mRNA synthesis and modification (includes regulators); similar to, gp:GI:e266415:g1550715, p()=5.8E-38, pid=49%; Belongs to the MsrB Met sulfoxide reductase family. (151 aa)
MTH_725Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:G64489 AC:G64489, p()=1.7E-28, pid=31%. (375 aa)
MTH_745Unknown (contains ferredoxin domain); Function Code:14.00 - Unknown; similar to, sp:LN:FER_MEGEL AC:P00201, p()=0.017, pid=09%. (273 aa)
MTH_756Rubrerythrin; Function Code:13.07 - Other, Unclassified; similar to, pir:LN:F64391 AC:F64391, p()=7.9E-73, pid=68%. (197 aa)
MTH_757Rubredoxin oxidoreductase; Function Code:2.08 - Energy Metabolism, Electron transport; similar to, gp:GI:e258466:g1491677, p()=1.4E-34, pid=51%; Belongs to the desulfoferrodoxin family. (124 aa)
MTH_772Conserved protein (contains ferredoxin domain); Function Code:14.01 - Unknown, Conserved protein; similar to, gp:GI:g1652823 LN:D90908, p()=2.5E-44, pid=30%. (375 aa)
asd-2Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (347 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. (273 aa)
MTH_807Thioredoxin; Acts to maintain redox homeostasis; functions as a protein disulfide reductase; Belongs to the glutaredoxin family. (85 aa)
MTH_822Rubrerythrin; Function Code:13.07 - Other, Unclassified; similar to, gp:GI:g1616801 LN:DVU71215, p()=3.6E-22, pid=37%. (163 aa)
MTH_836UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase; Function Code:11.04 - Cell envelope, Murein sacculus and peptidoglycan; similar to, gp:GI:g1773354 LN:SAU81973, p()=6.7E-76, pid=38%; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (431 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (382 aa)
MTH_847Unknown; Function Code:14.00 - Unknown; similar to, sp:LN:Y298_METJA AC:Q57746, p()=0.00019, pid=18%. (172 aa)
MTH_853Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:A64481 AC:A64481, p()=4.5E-38, pid=31%. (391 aa)
MTH_854Ferredoxin; Function Code:2.08 - Energy Metabolism, Electron transport; similar to, sp:LN:FER2_METJA AC:Q57563, p()=6.7E-21, pid=29%. (128 aa)
MTH_8753-chlorobenzoate-3,4-dioxygenase dyhydrogenase related protein; Function Code:13.07 - Other, Unclassified; similar to, gp:GI:g1001423, p()=5.8E-38, pid=31%. (318 aa)
MTH_895Conserved protein; Does not function as a glutathione-disulfide oxidoreductase in the presence of glutathione and glutathione reductase. Has low thioredoxin activity in vitro. (77 aa)
MTH_897Pyrroline-5-carboxylate reductase; Function Code:5.09 - L-Amino Acid Metabolism, Arginine and proline metabolism; similar to, sp:LN:PROC_ECOLI AC:P00373, p()=3.1E-16, pid=21%. (253 aa)
fmdCMolybdenum formylmethanofuran dehydrogenase, subunit C; Catalyzes the reversible oxidation of CO(2) and methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). Can only oxidize formylmethanofuran. This enzyme is oxygen-labile. In the N-terminal section; belongs to the FwdC/FmdC family. (400 aa)
MTH_919Molybdenum formylmethanofuran dehydrogenase, subunit B; Function Code:2.02 - Energy Metabolism, Methane metabolism; similar to, gp:GI:e244928:g1702947, p()=7.4E-228, pid=94%. (436 aa)
MTH_926Tungsten formylmethanofuran dehydrogenase, subunit F homolog; Function Code:2.02 - Energy Metabolism, Methane metabolism; similar to, pir:LN:S57453 AC:S57453, p()=3.8E-66, pid=41%. (332 aa)
MTH_927Ferredoxin; Function Code:2.08 - Energy Metabolism, Electron transport; similar to, pir:LN:H64377 AC:H64377, p()=0.0000011, pid=24%. (77 aa)
MTH_933Unknown; Function Code:14.00 - Unknown; similar to, pir:LN:B64114 AC:B64114, p()=0.49, pid=07%. (243 aa)
MTH_935Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:E64165 AC:E64165, p()=0.0000058, pid=18%. (96 aa)
serAPhosphoglycerate dehydrogenase; Function Code:5.02 - L-Amino Acid Metabolism, Glycine--serine and threonine metabolism; similar to, pir:LN:A64427 AC:A64427, p()=2E-140, pid=52%; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (525 aa)
nadXConserved protein; Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate. (257 aa)
MTH_978NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Function Code:1.01 - Carbohydrate Metabolism, Glycolysis--Gluconeogenesis; similar to, pir:LN:B64476 AC:B64476, p()=7.5E-77, pid=37%; Belongs to the aldehyde dehydrogenase family. (455 aa)
MTH_9841,3-propanediol dehydrogenase; Function Code:13.07 - Other, Unclassified; similar to, sp:LN:YIAY_ECOLI AC:P37686, p()=4.5E-70, pid=42%. (341 aa)
mvhDMethyl viologen-reducing hydrogenase, delta subunit; Part of a complex that provides reducing equivalents for heterodisulfide reductase. MvhD may form the contact site to heterodisulfide reductase (By similarity). (141 aa)
MTH_1138Methyl viologen-reducing hydrogenase, delta subunit homolog FlpD; Function Code:2.02 - Energy Metabolism, Methane metabolism; similar to, gp:GI:g726066 LN:MTU19363, p()=1.3E-74, pid=97%. (136 aa)
MTH_1139Formate dehydrogenase, beta subunit related protein FlpB; Function Code:2.02 - Energy Metabolism, Methane metabolism; similar to, gp:GI:g726065 LN:MTU19363, p()=2.2E-203, pid=89%. (383 aa)
MTH_114Arylsulfatase regulatory protein; Function Code:2.07 - Energy Metabolism, Sulfur metabolism; similar to, gp:GI:g1787774 LN:ECAE000247, p()=1.4E-16, pid=19%. (262 aa)
MTH_1140Formate dehydrogenase, alpha subunit related protein FlpC; Function Code:2.02 - Energy Metabolism, Methane metabolism; similar to, gp:GI:g726064 LN:MTU19363, p()=3.6E-171, pid=93%. (343 aa)
hmdH(2)-dependent N5,N10-methylenetetrahydromethanopterin dehydrogenase; Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT. (347 aa)
MTH_116Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:G64472 AC:G64472, p()=2.8E-22, pid=25%. (247 aa)
MTH_1173Cell division inhibitor related protein; Function Code:12.07 - Cell Processes, Cell division; similar to, pir:LN:C64372 AC:C64372, p()=4.9E-25, pid=23%. (298 aa)
MTH_120NADPH-oxidoreductase; Function Code:13.07 - Other, Unclassified; similar to, sp:LN:MDAA_ECOLI AC:P17117, p()=3.7E-11, pid=24%. (191 aa)
comCMalate dehydrogenase; Catalyzes the reduction of sulfopyruvate to (R)-sulfolactate. Involved in the biosynthesis of both coenzyme M (with (R)-sulfolactate) and methanopterin (with alpha-ketoglutarate) (By similarity). (341 aa)
pyrKCytochrome-c3 hydrogenase, gamma subunit; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). (266 aa)
pyrDDihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. (303 aa)
MTH_1232Homoserine dehydrogenase; Function Code:5.02 - L-Amino Acid Metabolism, Glycine--serine and threonine metabolism; similar to, sp:LN:DHOM_SYNY3 AC:P52986, p()=8.8E-90, pid=46%. (423 aa)
MTH_1238Formate hydrogenlyase, subunit 5; Function Code:2.02 - Energy Metabolism, Methane metabolism; similar to, pir:LN:B64428 AC:B64428, p()=2E-99, pid=47%. (381 aa)
MTH_1240Ferredoxin-like protein; Function Code:2.08 - Energy Metabolism, Electron transport; similar to, pir:LN:E64462 AC:E64462, p()=1.2E-30, pid=38%. (173 aa)
MTH_1241Polyferredoxin; Function Code:2.08 - Energy Metabolism, Electron transport; similar to, pir:LN:F64462 AC:F64462, p()=6.3E-80, pid=134%. (448 aa)
frhBCoenzyme F420-reducing hydrogenase, beta subunit; Reduces the physiological low-potential two-electron acceptor coenzyme F420, and the artificial one-electron acceptor methylviologen; Belongs to the FrhB family. (281 aa)
frhGCoenzyme F420-reducing hydrogenase, gamma subunit; Reduces the physiological low-potential two-electron acceptor coenzyme F420, and the artificial one-electron acceptor methylviologen; Belongs to the FrhG family. (275 aa)
frhACoenzyme F420-reducing hydrogenase, alpha subunit; Reduces the physiological low-potential two-electron acceptor coenzyme F420, and the artificial one-electron acceptor methylviologen; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (408 aa)
MTH_135Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:B64435 AC:B64435, p()=3E-50, pid=47%. (202 aa)
fpaAFlavoprotein AI; Probably functions as an electron acceptor for a hydrogenase; however there is an uncharacterized intermediate between the hydrogenase and flavoprotein A. (409 aa)
MTH_1351Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:B64393 AC:B64393, p()=8E-25, pid=29%. (137 aa)
MTH_1354NADH oxidase; Function Code:9.04 - Metabolism of Cofactors and Vitamins, Nicotinate and nicotinamide metabolism (NADP); similar to, pir:LN:A64381 AC:A64381, p()=5E-126, pid=54%. (450 aa)
MTH_1379Conserved protein (contains ferredoxin domain); Function Code:14.01 - Unknown, Conserved protein; similar to, sp:LN:Y208_METJA AC:Q57661, p()=1.2E-51, pid=48%. (236 aa)
hdrAHeterodisulfide reductase, subunit A; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B); Belongs to the HdrA family. (669 aa)
cbiJCobalamin biosynthesis protein J; Catalyzes the reduction of the macrocycle of cobalt- precorrin-6A to cobalt-precorrin-6B. (302 aa)
Your Current Organism:
Methanothermobacter thermautotrophicus
NCBI taxonomy Id: 187420
Other names: M. thermautotrophicus str. Delta H, Methanobacterium thermoautotrophicum str. Delta H, Methanobacterium thermoautotrophicum str. deltaH, Methanothermobacter thermautotrophicus str. Delta H, Methanothermobacter thermautotrophicus str. deltaH
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