STRINGSTRING
purN purN purM purM BEN71_07435 BEN71_07435 guaB guaB pyrE pyrE rdgB rdgB pyrF pyrF BEN71_00915 BEN71_00915 carA carA carB carB xpt xpt purU purU ppnP ppnP upp upp BEN71_18835 BEN71_18835 purK purK purE purE guaD guaD hpt hpt BEN71_08250 BEN71_08250 purA purA pyrB pyrB BEN71_08445 BEN71_08445 ppnP-2 ppnP-2 purH purH purD purD pyrD pyrD BEN71_08595 BEN71_08595 purF purF purT purT BEN71_08820 BEN71_08820 BEN71_09250 BEN71_09250 BEN71_09255 BEN71_09255 BEN71_09265 BEN71_09265 BEN71_13880 BEN71_13880 folD folD purC purC guaA guaA glyA glyA BEN71_09860 BEN71_09860 purL purL surE surE BEN71_11940 BEN71_11940
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
purNUnannotated protein; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (210 aa)
purMUnannotated protein. (356 aa)
BEN71_07435Unannotated protein; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (462 aa)
guaBUnannotated protein; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (488 aa)
pyrEUnannotated protein; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (216 aa)
rdgBUnannotated protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (208 aa)
pyrFUnannotated protein; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (231 aa)
BEN71_00915Unannotated protein. (434 aa)
carAUnannotated protein; Belongs to the CarA family. (380 aa)
carBUnannotated protein; Belongs to the CarB family. (1077 aa)
xptUnannotated protein; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. (191 aa)
purUUnannotated protein; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (288 aa)
ppnPUnannotated protein; Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions. (107 aa)
uppUnannotated protein; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (211 aa)
BEN71_18835Unannotated protein; Belongs to the 5'-nucleotidase family. (630 aa)
purKUnannotated protein; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (373 aa)
purEUnannotated protein; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (170 aa)
guaDUnannotated protein; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family. (438 aa)
hptUnannotated protein; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (175 aa)
BEN71_08250Unannotated protein; Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism. (333 aa)
purAUnannotated protein; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (439 aa)
pyrBUnannotated protein; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (338 aa)
BEN71_08445Unannotated protein. (414 aa)
ppnP-2Unannotated protein; Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions. (105 aa)
purHUnannotated protein. (524 aa)
purDUnannotated protein; Belongs to the GARS family. (428 aa)
pyrDUnannotated protein; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (334 aa)
BEN71_08595Unannotated protein. (197 aa)
purFUnannotated protein; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (514 aa)
purTUnannotated protein; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (399 aa)
BEN71_08820Unannotated protein. (154 aa)
BEN71_09250Unannotated protein; Belongs to the HSP15 family. (146 aa)
BEN71_09255Unannotated protein. (228 aa)
BEN71_09265Unannotated protein. (245 aa)
BEN71_13880Unannotated protein. (180 aa)
folDUnannotated protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (282 aa)
purCUnannotated protein; Belongs to the SAICAR synthetase family. (239 aa)
guaAUnannotated protein; Catalyzes the synthesis of GMP from XMP. (522 aa)
glyAUnannotated protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (417 aa)
BEN71_09860Unannotated protein. (164 aa)
purLUnannotated protein; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1278 aa)
surEUnannotated protein; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (261 aa)
BEN71_11940Unannotated protein. (238 aa)
Your Current Organism:
Acinetobacter wuhouensis
NCBI taxonomy Id: 1879050
Other names: A. wuhouensis, Acinetobacter sp. WCHA60, Acinetobacter sp. WCHA62, Acinetobacter wuhouensis Hu et al. 2018, CCTCC AB 2016204, CCTCC:AB:2016204, KCTC 52505, strain WCHA60
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