(32 nodes) DNA replication preinitiation complex, and G1/S DNA Damage Checkpoints network (Testicularia cyperi)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Predicted Interactions

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Your Input:
	A0A317XH29	Pkinase-domain-containing protein. (842 aa)
	A0A317XI68	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (1021 aa)
	A0A317XIB8	AAA domain-containing protein. (668 aa)
	A0A317XIW6	Pkinase-domain-containing protein. (698 aa)
	A0A317XK97	P-loop containing nucleoside triphosphate hydrolase protein. (800 aa)
	A0A317XKG2	Uncharacterized protein. (118 aa)
	A0A317XLQ2	DNA helicase; Belongs to the MCM family. (731 aa)
	A0A317XLT9	Uncharacterized protein. (843 aa)
	A0A317XM84	Uncharacterized protein. (218 aa)
	A0A317XMB5	SLD5_C domain-containing protein. (245 aa)
	A0A317XMD9	Timeless-domain-containing protein. (1270 aa)
	A0A317XPR7	Uncharacterized protein. (855 aa)
	A0A317XQI9	DNA helicase. (928 aa)
	MCM7	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (850 aa)
	A0A317XS49	DNA helicase; Belongs to the MCM family. (1025 aa)
	A0A317XS85	Pkinase-domain-containing protein. (799 aa)
	A0A317XSN4	Rhodanese-like protein. (151 aa)
	A0A317XSP6	ORC_WH_C domain-containing protein. (985 aa)
	A0A317XT48	Zf-primase domain-containing protein. (987 aa)
	A0A317XTY5	DNA helicase; Belongs to the MCM family. (956 aa)
	A0A317XUP0	Putative TSD2 protein required for DNA replication. (813 aa)
	A0A317XVJ5	Uncharacterized protein. (1126 aa)
	A0A317XW25	Pkinase-domain-containing protein. (1156 aa)
	A0A317XXI3	DBF4-type domain-containing protein. (789 aa)
	A0A317XXZ9	Psf2-domain-containing protein. (329 aa)
	A0A317XY54	Sld5 domain-containing protein. (223 aa)
	A0A317XYA9	Rhodanese domain-containing protein. (783 aa)
	A0A317XYH6	Kinase-like protein. (591 aa)
	A0A317XZ17	Uncharacterized protein. (638 aa)
	A0A317XZD3	DNA helicase; Belongs to the MCM family. (992 aa)
	A0A317XZH6	Uncharacterized protein. (554 aa)
	A0A317Y0D1	WD_REPEATS_REGION domain-containing protein. (1205 aa)

Your Current Organism:

Testicularia cyperi

NCBI taxonomy Id: 1882483
Other names: T. cyperi

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A317XH29	A0A317XI68	A0A317XH29	A0A317XI68	Pkinase-domain-containing protein.	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	0.776
A0A317XH29	A0A317XIB8	A0A317XH29	A0A317XIB8	Pkinase-domain-containing protein.	AAA domain-containing protein.	0.554
A0A317XH29	A0A317XK97	A0A317XH29	A0A317XK97	Pkinase-domain-containing protein.	P-loop containing nucleoside triphosphate hydrolase protein.	0.729
A0A317XH29	A0A317XKG2	A0A317XH29	A0A317XKG2	Pkinase-domain-containing protein.	Uncharacterized protein.	0.788
A0A317XH29	A0A317XLQ2	A0A317XH29	A0A317XLQ2	Pkinase-domain-containing protein.	DNA helicase; Belongs to the MCM family.	0.677
A0A317XH29	A0A317XLT9	A0A317XH29	A0A317XLT9	Pkinase-domain-containing protein.	Uncharacterized protein.	0.729
A0A317XH29	A0A317XMD9	A0A317XH29	A0A317XMD9	Pkinase-domain-containing protein.	Timeless-domain-containing protein.	0.748
A0A317XH29	A0A317XQI9	A0A317XH29	A0A317XQI9	Pkinase-domain-containing protein.	DNA helicase.	0.726
A0A317XH29	A0A317XS49	A0A317XH29	A0A317XS49	Pkinase-domain-containing protein.	DNA helicase; Belongs to the MCM family.	0.876
A0A317XH29	A0A317XSN4	A0A317XH29	A0A317XSN4	Pkinase-domain-containing protein.	Rhodanese-like protein.	0.788
A0A317XH29	A0A317XSP6	A0A317XH29	A0A317XSP6	Pkinase-domain-containing protein.	ORC_WH_C domain-containing protein.	0.572
A0A317XH29	A0A317XT48	A0A317XH29	A0A317XT48	Pkinase-domain-containing protein.	Zf-primase domain-containing protein.	0.765
A0A317XH29	A0A317XTY5	A0A317XH29	A0A317XTY5	Pkinase-domain-containing protein.	DNA helicase; Belongs to the MCM family.	0.697
A0A317XH29	A0A317XUP0	A0A317XH29	A0A317XUP0	Pkinase-domain-containing protein.	Putative TSD2 protein required for DNA replication.	0.871
A0A317XH29	A0A317XVJ5	A0A317XH29	A0A317XVJ5	Pkinase-domain-containing protein.	Uncharacterized protein.	0.568
A0A317XH29	A0A317XXI3	A0A317XH29	A0A317XXI3	Pkinase-domain-containing protein.	DBF4-type domain-containing protein.	0.717
A0A317XH29	A0A317XYA9	A0A317XH29	A0A317XYA9	Pkinase-domain-containing protein.	Rhodanese domain-containing protein.	0.788
A0A317XH29	A0A317XYH6	A0A317XH29	A0A317XYH6	Pkinase-domain-containing protein.	Kinase-like protein.	0.705
A0A317XH29	A0A317XZ17	A0A317XH29	A0A317XZ17	Pkinase-domain-containing protein.	Uncharacterized protein.	0.606
A0A317XH29	A0A317XZD3	A0A317XH29	A0A317XZD3	Pkinase-domain-containing protein.	DNA helicase; Belongs to the MCM family.	0.658