(56 nodes) Catalytic step 2 spliceosome network (Egretta garzetta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	EIF4A3	Eukaryotic initiation factor 4A-III; Belongs to the DEAD box helicase family. (350 aa)
	CWC22	Pre-mRNA-splicing factor CWC22. (868 aa)
	BUD31	Protein BUD31. (144 aa)
	SF3A2	Splicing factor 3A subunit 2. (205 aa)
	SF3B3	Splicing factor 3B subunit 3. (1230 aa)
	PNN	Pinin. (653 aa)
	SNW1	SNW domain-containing protein 1. (538 aa)
	PPWD1	Peptidylprolyl isomerase domain and WD repeat-containing protein 1. (581 aa)
	SNRPG	Small nuclear ribonucleoprotein G. (62 aa)
	GPATCH1	G patch domain-containing protein 1. (903 aa)
	SNRNP40	U5 small nuclear ribonucleoprotein 40 kDa protein. (310 aa)
	SNRPF	Small nuclear ribonucleoprotein F. (53 aa)
	Z169_08697	RNA-binding protein 8A; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. (152 aa)
	SNRNP200	U5 small nuclear ribonucleoprotein 200 kDa helicase. (1616 aa)
	HNRNPR	Heterogeneous nuclear ribonucleoprotein R. (451 aa)
	CWC15	Protein CWC15 A. (230 aa)
	DGCR14	Protein DGCR14. (432 aa)
	Z169_10182	Uncharacterized protein. (111 aa)
	CDC40	Pre-mRNA-processing factor 17. (520 aa)
	MAGOH	Protein mago nashi 2. (97 aa)
	SF3B1	Splicing factor 3B subunit 1. (1292 aa)
	SNRPD3	Small nuclear ribonucleoprotein Sm D3. (126 aa)
	Z169_03922	Crooked neck-like 1. (685 aa)
	PPIL3	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (161 aa)
	SF3B6	Pre-mRNA branch site protein p14. (125 aa)
	FRG1	Protein FRG1. (236 aa)
	Z169_08664	Small nuclear ribonucleoprotein-associated protein B. (236 aa)
	PRPF4B	Serine/threonine-protein kinase PRP4. (992 aa)
	RBM22	Pre-mRNA-splicing factor RBM22. (402 aa)
	PPIL2	Peptidyl-prolyl cis-trans isomerase-like 2. (479 aa)
	LSM3	U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (95 aa)
	LSM7	U6 snRNA-associated Sm-like LSm7. (101 aa)
	SNRPE	Small nuclear ribonucleoprotein E; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family. (74 aa)
	AQR	Intron-binding protein aquarius. (1370 aa)
	Z169_05338	Pre-mRNA-splicing factor SPF27. (128 aa)
	EFTUD2	116 kDa U5 small nuclear ribonucleoprotein component. (972 aa)
	HNRNPM	Heterogeneous nuclear ribonucleoprotein M. (670 aa)
	PLRG1	Pleiotropic regulator 1. (513 aa)
	Z169_12907	Cactin. (606 aa)
	DDX5	Putative ATP-dependent RNA helicase DDX5; Belongs to the DEAD box helicase family. (592 aa)
	SNRPD1	Small nuclear ribonucleoprotein Sm D1; Essential for pre-mRNA splicing. Implicated in the formation of stable, biologically active snRNP structures. Belongs to the snRNP core protein family. (119 aa)
	WDR25	WD repeat-containing protein 25. (327 aa)
	ISY1	Pre-mRNA-splicing factor ISY1. (219 aa)
	SNRPA1	U2 small nuclear ribonucleoprotein A. (227 aa)
	PRPF6	Pre-mRNA-processing factor 6. (917 aa)
	TFIP11	Tuftelin-interacting protein 11. (761 aa)
	RBM44	RNA-binding protein 44. (80 aa)
	EIF4A2	Eukaryotic initiation factor 4A-II; Belongs to the DEAD box helicase family. (407 aa)
	DDX41	Putative ATP-dependent RNA helicase DDX41. (592 aa)
	ZCCHC8	Zinc finger CCHC domain-containing protein 8. (647 aa)
	PPIE	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (166 aa)
	SYF2	Pre-mRNA-splicing factor syf2. (199 aa)
	SKIV2L2	Superkiller viralicidic activity 2-like 2. (1034 aa)
	SYNCRIP	Heterogeneous nuclear ribonucleoprotein Q. (426 aa)
	DDX23	Putative ATP-dependent RNA helicase DDX23; Belongs to the DEAD box helicase family. (688 aa)
	Z169_13360	Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16. (1127 aa)

Your Current Organism:

Egretta garzetta

NCBI taxonomy Id: 188379
Other names: E. garzetta, little egret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AQR	BUD31	A0A091J6C7	A0A091KDE5	Intron-binding protein aquarius.	Protein BUD31.	0.978
AQR	CDC40	A0A091J6C7	A0A091JJV6	Intron-binding protein aquarius.	Pre-mRNA-processing factor 17.	0.975
AQR	CWC15	A0A091J6C7	A0A091JM97	Intron-binding protein aquarius.	Protein CWC15 A.	0.891
AQR	CWC22	A0A091J6C7	A0A091KDJ7	Intron-binding protein aquarius.	Pre-mRNA-splicing factor CWC22.	0.810
AQR	EFTUD2	A0A091J6C7	A0A091J4Y2	Intron-binding protein aquarius.	116 kDa U5 small nuclear ribonucleoprotein component.	0.987
AQR	EIF4A3	A0A091J6C7	A0A091IMY3	Intron-binding protein aquarius.	Eukaryotic initiation factor 4A-III; Belongs to the DEAD box helicase family.	0.915
AQR	FRG1	A0A091J6C7	A0A091JD71	Intron-binding protein aquarius.	Protein FRG1.	0.501
AQR	ISY1	A0A091J6C7	A0A091IZJ9	Intron-binding protein aquarius.	Pre-mRNA-splicing factor ISY1.	0.983
AQR	MAGOH	A0A091J6C7	A0A091JJL5	Intron-binding protein aquarius.	Protein mago nashi 2.	0.571
AQR	PLRG1	A0A091J6C7	A0A091J2W7	Intron-binding protein aquarius.	Pleiotropic regulator 1.	0.907
AQR	PPIE	A0A091J6C7	A0A091ITH1	Intron-binding protein aquarius.	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.	0.980
AQR	PPIL2	A0A091J6C7	A0A091JAS9	Intron-binding protein aquarius.	Peptidyl-prolyl cis-trans isomerase-like 2.	0.658
AQR	PPIL3	A0A091J6C7	A0A091JFP7	Intron-binding protein aquarius.	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.	0.515
AQR	PPWD1	A0A091J6C7	A0A091JPW7	Intron-binding protein aquarius.	Peptidylprolyl isomerase domain and WD repeat-containing protein 1.	0.511
AQR	RBM22	A0A091J6C7	A0A091JBK8	Intron-binding protein aquarius.	Pre-mRNA-splicing factor RBM22.	0.983
AQR	SF3A2	A0A091J6C7	A0A091K9N8	Intron-binding protein aquarius.	Splicing factor 3A subunit 2.	0.576
AQR	SF3B1	A0A091J6C7	A0A091JIW6	Intron-binding protein aquarius.	Splicing factor 3B subunit 1.	0.573
AQR	SF3B3	A0A091J6C7	A0A091K789	Intron-binding protein aquarius.	Splicing factor 3B subunit 3.	0.677
AQR	SF3B6	A0A091J6C7	A0A091JEU7	Intron-binding protein aquarius.	Pre-mRNA branch site protein p14.	0.552
AQR	SNRNP200	A0A091J6C7	A0A091JNC7	Intron-binding protein aquarius.	U5 small nuclear ribonucleoprotein 200 kDa helicase.	0.843