STRINGSTRING
NOS2 NOS2 PDGFB PDGFB AVPR1B AVPR1B Z169_12577 Z169_12577 ADCY8 ADCY8 SLC25A6 SLC25A6 ERBB4 ERBB4 ITPKB ITPKB CHRM2 CHRM2 CD38 CD38 PHKA2 PHKA2 EGF EGF CAMK4 CAMK4 PLCZ1 PLCZ1 VDAC3 VDAC3 SLC8A3 SLC8A3 CALM1 CALM1 MCOLN2 MCOLN2 CAMK1D CAMK1D GRIN2A GRIN2A ADORA2B ADORA2B ADCY9 ADCY9 CCKAR CCKAR PRKACB PRKACB PPP3CA PPP3CA Z169_05133 Z169_05133 CACNA1B CACNA1B MCOLN3 MCOLN3 HTR2C HTR2C PDE1C PDE1C HTR2B HTR2B GNA11 GNA11 PTGER3 PTGER3 PDGFC PDGFC HRH1 HRH1 ATP2B2 ATP2B2 TRHR TRHR PHKB PHKB GNA14 GNA14 GNAQ GNAQ Z169_04456 Z169_04456 ADCY2 ADCY2 CASQ2 CASQ2 CACNA1G CACNA1G Z169_05948 Z169_05948 EDNRB EDNRB ADCY1 ADCY1 Z169_01251 Z169_01251 TACR3 TACR3 CACNA1D CACNA1D TNNC1 TNNC1 Z169_15855 Z169_15855 Z169_00986 Z169_00986 AGTR1 AGTR1 PPP3CC PPP3CC MYLK MYLK GRPR GRPR PDGFRB PDGFRB PLCE1 PLCE1 ADRB3 ADRB3 Z169_04874 Z169_04874 PDGFA PDGFA PPP3CB PPP3CB Z169_16232 Z169_16232 CXCR4 CXCR4 P2RX4 P2RX4 PPIF PPIF TACR1 TACR1 ATP2B1 ATP2B1 P2RX6 P2RX6 LHCGR LHCGR VDAC2 VDAC2 ADORA2A ADORA2A ATP2A2 ATP2A2 PLCD1 PLCD1 P2RX1 P2RX1 GNAS GNAS CHRFAM7A CHRFAM7A HTR2A HTR2A CYSLTR2 CYSLTR2 PHKG1 PHKG1 PTAFR PTAFR PLCB2 PLCB2 PDE1B PDE1B GNAL GNAL CHRM3 CHRM3 ATP2A3 ATP2A3 STIM2 STIM2 PLCB1 PLCB1 HTR6 HTR6 ADRA1A ADRA1A PDE1A PDE1A PLCG2 PLCG2 ADRA1B ADRA1B PLCB4 PLCB4 DRD1 DRD1 SLC25A5 SLC25A5 Z169_13582 Z169_13582 ADRA1D ADRA1D VDAC1 VDAC1 HTR4 HTR4 CAMK1G CAMK1G BDKRB2 BDKRB2 Z169_07829 Z169_07829 Z169_12828 Z169_12828 PPP3R1 PPP3R1 PRKCA PRKCA SLC25A4 SLC25A4 TPCN1 TPCN1 NOS1 NOS1 EDNRA EDNRA ORAI2 ORAI2 PLN PLN PLCG1 PLCG1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NOS2Nitric oxide synthase, inducible. (1141 aa)
PDGFBPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (222 aa)
AVPR1BVasopressin V1b receptor. (428 aa)
Z169_12577Myosin light chain kinase, smooth muscle. (140 aa)
ADCY8Adenylate cyclase type 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (946 aa)
SLC25A6ADP/ATP translocase 3; Belongs to the mitochondrial carrier (TC 2.A.29) family. (261 aa)
ERBB4Receptor protein-tyrosine kinase. (1263 aa)
ITPKBKinase; Belongs to the inositol phosphokinase (IPK) family. (378 aa)
CHRM2Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (466 aa)
CD38ADP-ribosyl cyclase 1. (293 aa)
PHKA2Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family. (1209 aa)
EGFPro-epidermal growth factor. (1254 aa)
CAMK4Calcium/calmodulin-dependent protein kinase type IV. (151 aa)
PLCZ1Phosphoinositide phospholipase C. (610 aa)
VDAC3Voltage-dependent anion-selective channel protein 3. (261 aa)
SLC8A3Sodium/calcium exchanger 3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (915 aa)
CALM1Calmodulin; Belongs to the calmodulin family. (148 aa)
MCOLN2Mucolipin-2. (515 aa)
CAMK1DCalcium/calmodulin-dependent protein kinase type 1D. (298 aa)
GRIN2AGlutamate receptor ionotropic, NMDA 2A. (1317 aa)
ADORA2BAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (340 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (818 aa)
CCKARCholecystokinin receptor type A; Belongs to the G-protein coupled receptor 1 family. (430 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
PPP3CASerine/threonine-protein phosphatase. (436 aa)
Z169_05133D(1C) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (418 aa)
CACNA1BVoltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. (2261 aa)
MCOLN3Mucolipin-3. (553 aa)
HTR2C5-hydroxytryptamine receptor 2C. (463 aa)
PDE1CCalcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C. (62 aa)
HTR2B5-hydroxytryptamine receptor 2B. (430 aa)
GNA11Guanine nucleotide-binding protein subunit alpha-11. (315 aa)
PTGER3Prostaglandin E2 receptor EP3 subtype. (223 aa)
PDGFCPlatelet-derived growth factor C. (306 aa)
HRH1Histamine H1 receptor; Belongs to the G-protein coupled receptor 1 family. (456 aa)
ATP2B2Plasma membrane calcium-transporting ATPase 2; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (1205 aa)
TRHRThyrotropin-releasing hormone receptor; Belongs to the G-protein coupled receptor 1 family. (400 aa)
PHKBPhosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (1060 aa)
GNA14Guanine nucleotide-binding protein subunit alpha-14. (314 aa)
GNAQGuanine nucleotide-binding protein G(Q) subunit alpha. (314 aa)
Z169_04456Thyrotropin-releasing hormone receptor; Belongs to the G-protein coupled receptor 1 family. (337 aa)
ADCY2Adenylate cyclase type 2. (1026 aa)
CASQ2Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (404 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha-1G. (2214 aa)
Z169_059485-hydroxytryptamine receptor 7; Belongs to the G-protein coupled receptor 1 family. (369 aa)
EDNRBG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (354 aa)
ADCY1Adenylate cyclase type 1. (1090 aa)
Z169_01251Ig heavy chain V-III region VH26. (64 aa)
TACR3Neuromedin-K receptor; Belongs to the G-protein coupled receptor 1 family. (422 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2172 aa)
TNNC1Troponin C, slow skeletal and cardiac muscles. (158 aa)
Z169_15855Ig-like domain-containing protein. (108 aa)
Z169_00986Histamine H2 receptor; Belongs to the G-protein coupled receptor 1 family. (298 aa)
AGTR1Type-1 angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family. (357 aa)
PPP3CCSerine/threonine-protein phosphatase. (421 aa)
MYLKMyosin light chain kinase, smooth muscle. (1893 aa)
GRPRGastrin-releasing peptide receptor; Belongs to the G-protein coupled receptor 1 family. (384 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1040 aa)
PLCE1Phosphoinositide phospholipase C. (613 aa)
ADRB3Nucleoplasmin. (60 aa)
Z169_04874G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (432 aa)
PDGFAPlatelet-derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (141 aa)
PPP3CBSerine/threonine-protein phosphatase. (427 aa)
Z169_16232Calcium/calmodulin-dependent protein kinase type IV. (176 aa)
CXCR4C-X-C chemokine receptor type 4; Belongs to the G-protein coupled receptor 1 family. (353 aa)
P2RX4p2X purinoceptor 4. (335 aa)
PPIFPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (143 aa)
TACR1Substance-P receptor; Belongs to the G-protein coupled receptor 1 family. (385 aa)
ATP2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1258 aa)
P2RX6p2X purinoceptor 6. (250 aa)
LHCGRLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (639 aa)
VDAC2Voltage-dependent anion-selective channel protein 2. (284 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (258 aa)
ATP2A2Sarcoplasmic/endoplasmic reticulum calcium ATPase 2; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (993 aa)
PLCD1Phosphoinositide phospholipase C. (745 aa)
P2RX1P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (389 aa)
GNASGuanine nucleotide-binding protein G(S) subunit alpha. (334 aa)
CHRFAM7ANeuronal acetylcholine receptor subunit alpha-7. (484 aa)
HTR2A5-hydroxytryptamine receptor 2A. (471 aa)
CYSLTR2Cysteinyl leukotriene receptor 2. (306 aa)
PHKG1Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform; Belongs to the protein kinase superfamily. (388 aa)
PTAFRPlatelet-activating factor receptor; Belongs to the G-protein coupled receptor 1 family. (338 aa)
PLCB2Phosphoinositide phospholipase C. (777 aa)
PDE1BCalcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B. (75 aa)
GNALGuanine nucleotide-binding protein G(Olf) subunit alpha. (337 aa)
CHRM3Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (610 aa)
ATP2A3Sarcoplasmic/endoplasmic reticulum calcium ATPase 3; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (947 aa)
STIM2Stromal interaction molecule 2. (673 aa)
PLCB1Phosphoinositide phospholipase C. (1064 aa)
HTR65-hydroxytryptamine receptor 6; Belongs to the G-protein coupled receptor 1 family. (355 aa)
ADRA1AAlpha-1A adrenergic receptor. (327 aa)
PDE1APhosphodiesterase. (488 aa)
PLCG2Phosphoinositide phospholipase C. (1262 aa)
ADRA1BAlpha-1B adrenergic receptor. (403 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
DRD1D(1A) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (450 aa)
SLC25A5ADP/ATP translocase 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (262 aa)
Z169_13582Neuronal acetylcholine receptor subunit alpha-7. (481 aa)
ADRA1DAlpha-1D adrenergic receptor. (354 aa)
VDAC1Voltage-dependent anion-selective channel protein 1. (285 aa)
HTR45-hydroxytryptamine receptor 4; Belongs to the G-protein coupled receptor 1 family. (351 aa)
CAMK1GCalcium/calmodulin-dependent protein kinase type 1G. (291 aa)
BDKRB2B2 bradykinin receptor; Belongs to the G-protein coupled receptor 1 family. (381 aa)
Z169_078295-hydroxytryptamine receptor 5A. (320 aa)
Z169_12828D(1C) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (359 aa)
PPP3R1Calcineurin subunit B type 1. (156 aa)
PRKCAProtein kinase C alpha type; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (606 aa)
SLC25A4ADP/ATP translocase 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (263 aa)
TPCN1Two pore calcium channel protein 1. (813 aa)
NOS1Nitric oxide synthase; Produces nitric oxide (NO). (1427 aa)
EDNRAEndothelin-1 receptor; Belongs to the G-protein coupled receptor 1 family. (421 aa)
ORAI2Protein orai-2. (257 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
PLCG1Phosphoinositide phospholipase C. (1216 aa)
Your Current Organism:
Egretta garzetta
NCBI taxonomy Id: 188379
Other names: E. garzetta, little egret
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