STRINGSTRING
AMM06924.1 AMM06924.1 AMM07733.1 AMM07733.1 pyrH pyrH purE purE purK purK AMM08906.1 AMM08906.1 purU purU purM purM purF purF purL purL purQ purQ purS purS purC purC purD purD pyrE pyrE purN purN folD folD AMM11968.1 AMM11968.1 pyrR pyrR pyrB pyrB pyrC pyrC AMM12070.1 AMM12070.1 carA carA carB carB pyrD pyrD AMM12074.1 AMM12074.1 fmt fmt AMM12103.1 AMM12103.1 AMM12251.1 AMM12251.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AMM06924.1Xanthine/uracil permease. (465 aa)
AMM07733.1Xanthine permease. (476 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (254 aa)
purEPhosphoribosylaminoimidazole carboxylase catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (180 aa)
purKPhosphoribosylaminoimidazole carboxylase ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (363 aa)
AMM08906.15-formyltetrahydrofolate cyclo-ligase. (203 aa)
purUFormyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (299 aa)
purMPhosphoribosylformylglycinamidine cyclo-ligase. (356 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (505 aa)
purLPhosphoribosylformylglycinamidine synthase 2; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (749 aa)
purQPhosphoribosylformylglycinamidine synthase subunit I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...] (236 aa)
purSPhosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] (83 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (300 aa)
purDPhosphoribosylamine--glycine ligase; Belongs to the GARS family. (424 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (182 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (218 aa)
folDBifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (287 aa)
AMM11968.1Bifunctional protein FolD 2. (286 aa)
pyrRBifunctional protein pyrR; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant. (198 aa)
pyrBAspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (332 aa)
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (431 aa)
AMM12070.1Integral membrane protein. (199 aa)
carACarbamoyl-phosphate synthase small chain; Belongs to the CarA family. (380 aa)
carBCarbamoyl-phosphate synthase large chain; Belongs to the CarB family. (1101 aa)
pyrDDihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (370 aa)
AMM12074.1Orotidine 5'-phosphate decarboxylase. (284 aa)
fmtMethionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. (314 aa)
AMM12103.1Uracil-xanthine permease. (470 aa)
AMM12251.1Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (477 aa)
Your Current Organism:
Streptomyces albus
NCBI taxonomy Id: 1888
Other names: AS 4.164, ATCC 25426, ATCC 25427 [[Streptomyces almquistii]], ATCC 25453 [[Streptomyces flocculus]], ATCC 25490 [[Streptomyces rangoonensis]], ATCC 3004, ATCC 618 [[Streptomyces almquistii]], ATCC 6852 [[Streptomyces gibsonii]], ATCC 6860 [[Streptomyces rangoonensis]], Actinomyces Gibsoni, Actinomyces Gibsonii, Actinomyces almquisti, Actinomyces flocculus, Actinomyces rangoon, BCRC 10802, BCRC 12068 [[Streptomyces flocculus]], BCRC 12098 [[Streptomyces almquistii]], CBS 118.60 [[Streptomyces gibsonii]], CBS 119.60 [[Streptomyces gibsonii]], CBS 410.63, CBS 686.69 [[Streptomyces flocculus]], CBS 918.69 [[Streptomyces rangoonensis]], CBS 924.69, CBS 925.69 [[Streptomyces almquistii]], CCRC 10802, CCRC 12068 [[Streptomyces flocculus]], CCRC 12098 [[Streptomyces almquistii]], CCRC:10802, CCRC:12068 [[Streptomyces flocculus]], CCRC:12098 [[Streptomyces almquistii]], CCUG 33990, CECT 3077, CIP 104432, DSM 40313, DSM 40327 [[Streptomyces flocculus]], DSM 40447 [[Streptomyces almquistii]], DSM 40452 [[Streptomyces rangoonensis]], DSM 40933 [[Streptomyces griseus subsp. solvifaciens]], DSM 43284 [[Streptomyces gibsonii]], HAMBI 50 [[Streptomyces almquistii]], HUT 6613, HUT 6614 [[Streptomyces almquistii]], HUT 6615 [[Streptomyces flocculus]], HUT 6616 [[Streptomyces rangoonensis]], HUT 6617 [[Streptomyces gibsonii]], IFO 13014, IFO 13015 [[Streptomyces almquistii]], IFO 13041 [[Streptomyces flocculus]], IFO 13078 [[Streptomyces rangoonensis]], IFO 15415 [[Streptomyces gibsonii]], IFO 3710, IMET 40241, IMET 41357 [[Streptomyces rangoonensis]], IMET 43380 [[Streptomyces almquistii]], IMET 43522 [[Streptomyces flocculus]], IMET 7023 [[Streptomyces gibsonii]], IMRU 3004, ISP 5313, ISP 5327 [[Streptomyces flocculus]], ISP 5447 [[Streptomyces almquistii]], ISP 5452 [[Streptomyces rangoonensis]], JCM 4177, JCM 4450, JCM 4451 [[Streptomyces almquistii]], JCM 4476 [[Streptomyces flocculus]], JCM 4510 [[Streptomyces rangoonensis]], JCM 5061 [[Streptomyces gibsonii]], JCM 5079 [[Streptomyces griseus subsp. solvifaciens]], KCTC 9672 [[Streptomyces almquistii]], LMG 19912 [[Streptomyces gibsonii]], LMG:19912 [[Streptomyces gibsonii]], NBRC 13014, NBRC 13015 [[Streptomyces almquistii]], NBRC 13041 [[Streptomyces flocculus]], NBRC 13078 [[Streptomyces rangoonensis]], NBRC 15415 [[Streptomyces gibsonii]], NBRC 3710, NCIMB 9558, NCTC 4575 [[Streptomyces gibsonii]], NRRL 2960 [[Streptomyces flocculus]], NRRL B-12378 [[Streptomyces rangoonensis]], NRRL B-16595 [[Streptomyces rangoonensis]], NRRL B-2208, NRRL B-2465 [[Streptomyces flocculus]], NRRL B-2843 [[Streptomyces flocculus]], NRRL-ISP 5313, NRRL-ISP 5327 [[Streptomyces flocculus]], NRRL-ISP 5447 [[Streptomyces almquistii]], NRRL-ISP 5452 [[Streptomyces rangoonensis]], Nocardia gibsonii, Nocardia rangoonensis, Streptomyces almquistii, Streptomyces flocculus, Streptomyces gibsonii, Streptomyces griseus solvifaciens, Streptomyces griseus subsp. solvifaciens, Streptomyces rangoon, Streptomyces rangoonensis, Streptomyces sp. USC057, Streptotrix alba, VKM Ac-35
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.