STRINGSTRING
purB purB cpdA cpdA ANB04555.1 ANB04555.1 pgm pgm add add ANB05022.1 ANB05022.1 yagS yagS ANB05024.1 ANB05024.1 ureC ureC ureB ureB ureA ureA ANB05140.1 ANB05140.1 guaB guaB gmk gmk relA relA apt apt ANB05367.1 ANB05367.1 pyk pyk ANB05869.1 ANB05869.1 adoK adoK ANB06279.1 ANB06279.1 ANB06340.1 ANB06340.1 ndk ndk ANB06649.1 ANB06649.1 purE purE purK purK ANB06824.1 ANB06824.1 ANB06831.1 ANB06831.1 prsA prsA ANB07168.1 ANB07168.1 purM purM purF purF purS purS purC purC purD purD purA purA hpt hpt ANB07740.1 ANB07740.1 ANB07973.1 ANB07973.1 adk adk guaB-2 guaB-2 ANB08072.1 ANB08072.1 guaA guaA purN purN purH purH ANB08160.1 ANB08160.1 add-2 add-2 punA punA cya cya nrdB nrdB ANB08475.1 ANB08475.1 pyk-2 pyk-2 ureAB ureAB ureC-2 ureC-2 ANB08944.1 ANB08944.1 nrdJ nrdJ cysN cysN cysD cysD cysC cysC ANB09380.1 ANB09380.1 ANB09381.1 ANB09381.1 uox uox allB allB alc alc ANB10023.1 ANB10023.1 ANB10057.1 ANB10057.1 ANB10130.1 ANB10130.1 yagS-2 yagS-2 ANB10132.1 ANB10132.1 ANB10201.1 ANB10201.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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purBAdenylosuccinate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (419 aa)
cpdAMetallophosphoesterase; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. (245 aa)
ANB04555.1Asp/Glu/hydantoin racemase; Derived by automated computational analysis using gene prediction method: Protein Homology. (241 aa)
pgmPhosphoglucomutase; Catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (546 aa)
addAdenosine deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily. (359 aa)
ANB05022.1Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (716 aa)
yagSMolybdopterin dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (330 aa)
ANB05024.1(2Fe-2S)-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (199 aa)
ureCUrease subunit alpha; Ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits; Derived by automated computational analysis using gene prediction method: Protein Homology. (573 aa)
ureBUrease subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the urease beta subunit family. (103 aa)
ureAUrease subunit gamma; UreA, with UreB and UreC catalyzes the hydrolysis of urea into ammonia and carbon dioxide; nickel metalloenzyme; accessory proteins UreD, UreE, UreF, and UreG are necessary for assembly of the metallocenter; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the urease gamma subunit family. (100 aa)
ANB05140.1Adenylosuccinate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (480 aa)
guaBInosine-5-monophosphate dehydrogenase; Catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (480 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (197 aa)
relAGTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (847 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (182 aa)
ANB05367.1HIT family hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (183 aa)
pykPyruvate kinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. (478 aa)
ANB05869.1Multifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/5'-nucleotidase/3'-nucleotidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 5'-nucleotidase family. (600 aa)
adoKRibokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (324 aa)
ANB06279.1Deoxyguanosinetriphosphate triphosphohydrolase; dGTPase family type 2 subfamily; presumably hydrolyzes dGTP to deoxyguanosine and triphosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (424 aa)
ANB06340.1Adenosine deaminase; Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism. (330 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (137 aa)
ANB06649.1dITP/XTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (200 aa)
purEN5-carboxyaminoimidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (180 aa)
purKPhosphoribosylaminoimidazole carboxylase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (411 aa)
ANB06824.1Exopolyphosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (313 aa)
ANB06831.1Nucleoside triphosphate hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (328 aa)
prsARibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (324 aa)
ANB07168.15'-nucleotidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 5'-nucleotidase family. (605 aa)
purMPhosphoribosylaminoimidazole synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (355 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (508 aa)
purSPhosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] (90 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the SAICAR synthetase family. (299 aa)
purDPhosphoribosylamine--glycine ligase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GARS family. (421 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (427 aa)
hptHypoxanthine phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (186 aa)
ANB07740.1Exopolyphosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (310 aa)
ANB07973.1Adenosine deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. (360 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (217 aa)
guaB-2Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (502 aa)
ANB08072.1Inosine-5-monophosphate dehydrogenase; Catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (374 aa)
guaAGMP synthetase; Catalyzes the synthesis of GMP from XMP. (526 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (212 aa)
purHPhosphoribosylaminoimidazolecarboxamide formyltransferase; Involved in de novo purine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (521 aa)
ANB08160.1OHCU decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (191 aa)
add-2Adenosine deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily. (389 aa)
punAPurine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (274 aa)
cyaAdenylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology. (380 aa)
nrdBRibonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (335 aa)
ANB08475.1Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (790 aa)
pyk-2Pyruvate kinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. (476 aa)
ureABUrease subunit gamma; Derived by automated computational analysis using gene prediction method: Protein Homology; In the C-terminal section; belongs to the urease beta subunit family. (235 aa)
ureC-2Urease subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (571 aa)
ANB08944.1Kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (723 aa)
nrdJVitamin B12-dependent ribonucleotide reductase; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (967 aa)
cysNSulfate adenylyltransferase; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (451 aa)
cysDSulfate adenylyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (312 aa)
cysCAdenylyl-sulfate kinase; Catalyzes the synthesis of activated sulfate. (178 aa)
ANB09380.1OHCU decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (169 aa)
ANB09381.15-hydroxyisourate hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily. (133 aa)
uoxUrate oxidase; Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin. (311 aa)
allBAllantoinase; Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring; Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family. (445 aa)
alcAllantoicase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the allantoicase family. (376 aa)
ANB10023.1Ribose-phosphate pyrophosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (317 aa)
ANB10057.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (336 aa)
ANB10130.1Xanthine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (709 aa)
yagS-2Molybdopterin dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (330 aa)
ANB10132.1Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (187 aa)
ANB10201.1Aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (232 aa)
Your Current Organism:
Streptomyces ambofaciens
NCBI taxonomy Id: 1889
Other names: ATCC 23877, BCRC 11857, CBS 616.68, CCRC 11857, CCRC:11857, CECT 3101, DSM 40053, IFO 12836, ISP 5053, JCM 4204, JCM 4618, KCTC 9111, NBRC 12836, NRRL 2420, NRRL B-2516, NRRL-ISP 5053, S. ambofaciens
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