(23 nodes) Pyridoxal phosphate-dependent transferase network (Methanosarcina acetivorans)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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Predicted Interactions

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Your Input:
	tyrB	Aromatic amino acid transferase. (401 aa)
	mfnA	Pyridoxal-dependent decarboxylase; Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis; Belongs to the group II decarboxylase family. MfnA subfamily. (395 aa)
	hisC	Histidinol-phosphate aminotransferase. (367 aa)
	argD-2	Acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (477 aa)
	iscS-2	Cysteine desulphurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. (448 aa)
	glyA	Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (412 aa)
	argD	Acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (405 aa)
	MA_0236	NifS protein. (393 aa)
	hemL	Glutamate-1-semialdehyde 2,1-aminomutase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily. (424 aa)
	aspC	Aspartate aminotransferase. (394 aa)
	MA_0722	Conserved hypothetical protein; Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L- cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)); Belongs to the SepCysS family. (386 aa)
	MA_0808	Homocysteine desulfhydrase. (384 aa)
	hisC-2	Histidinol-phosphate aminotransferase. (496 aa)
	MA_1385	Aspartate aminotransferase. (370 aa)
	MA_1712	Aspartate aminotransferase. (389 aa)
	aspC-2	Aspartate aminotransferase. (391 aa)
	aspB	Aspartate aminotransferase. (380 aa)
	MA_1949	Glutamate decarboxylase. (468 aa)
	MA_1950	Hypothetical protein. (519 aa)
	serC	Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (370 aa)
	mgl	Methionine gamma-lyase. (406 aa)
	metY	O-acetylhomoserine (thiol)-lyase. (441 aa)
	iscS	Cysteine desulphurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. (392 aa)

Your Current Organism:

Methanosarcina acetivorans

NCBI taxonomy Id: 188937
Other names: M. acetivorans C2A, Methanosarcina acetivorans C2A, Methanosarcina acetivorans str. C2A

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MA_0236	MA_0808	MA_0236	MA_0808	NifS protein.	Homocysteine desulfhydrase.	0.613
MA_0236	iscS	MA_0236	MA_2718	NifS protein.	Cysteine desulphurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.	0.613
MA_0236	iscS-2	MA_0236	MA_3264	NifS protein.	Cysteine desulphurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.	0.613
MA_0722	serC	MA_0722	MA_2304	Conserved hypothetical protein; Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L- cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)); Belongs to the SepCysS family.	Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.	0.485
MA_0808	MA_0236	MA_0808	MA_0236	Homocysteine desulfhydrase.	NifS protein.	0.613
MA_0808	iscS	MA_0808	MA_2718	Homocysteine desulfhydrase.	Cysteine desulphurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.	0.905
MA_0808	iscS-2	MA_0808	MA_3264	Homocysteine desulfhydrase.	Cysteine desulphurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.	0.905
MA_1385	MA_1949	MA_1385	MA_1949	Aspartate aminotransferase.	Glutamate decarboxylase.	0.837
MA_1385	aspB	MA_1385	MA_1819	Aspartate aminotransferase.	Aspartate aminotransferase.	0.905
MA_1385	aspC-2	MA_1385	MA_1816	Aspartate aminotransferase.	Aspartate aminotransferase.	0.404
MA_1385	hisC	MA_1385	MA_0118	Aspartate aminotransferase.	Histidinol-phosphate aminotransferase.	0.936
MA_1385	mfnA	MA_1385	MA_0006	Aspartate aminotransferase.	Pyridoxal-dependent decarboxylase; Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis; Belongs to the group II decarboxylase family. MfnA subfamily.	0.918
MA_1712	aspC-2	MA_1712	MA_1816	Aspartate aminotransferase.	Aspartate aminotransferase.	0.404
MA_1949	MA_1385	MA_1949	MA_1385	Glutamate decarboxylase.	Aspartate aminotransferase.	0.837
MA_1949	MA_1950	MA_1949	MA_1950	Glutamate decarboxylase.	Hypothetical protein.	0.513
MA_1949	argD-2	MA_1949	MA_2859	Glutamate decarboxylase.	Acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.943
MA_1949	aspB	MA_1949	MA_1819	Glutamate decarboxylase.	Aspartate aminotransferase.	0.837
MA_1949	mfnA	MA_1949	MA_0006	Glutamate decarboxylase.	Pyridoxal-dependent decarboxylase; Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis; Belongs to the group II decarboxylase family. MfnA subfamily.	0.922
MA_1950	MA_1949	MA_1950	MA_1949	Hypothetical protein.	Glutamate decarboxylase.	0.513
argD	argD-2	MA_0119	MA_2859	Acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.	Acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.422