(25 nodes) Glycine, serine and threonine metabolism, and Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL), catalytic domain network (Sulfolobus sp. A20)

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	AOL15535.1	Pyridine nucleotide-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (449 aa)
	AOL15541.1	Ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (344 aa)
	gcvH	Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (140 aa)
	gcvH-2	Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (148 aa)
	AOL15573.1	Ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (367 aa)
	gcvPB	Glycine dehydrogenase (aminomethyl-transferring); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. (508 aa)
	gcvPA	Glycine dehydrogenase (aminomethyl-transferring); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (454 aa)
	AOL15713.1	Glycine cleavage system protein T; Derived by automated computational analysis using gene prediction method: Protein Homology. (346 aa)
	gcvH-3	Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (135 aa)
	AOL15925.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (228 aa)
	AOL16091.1	Serine hydroxymethyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (433 aa)
	AOL16366.1	Ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (267 aa)
	lipA	Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (285 aa)
	BFU36_06255	Biotin attachment protein; Incomplete; partial on complete genome; missing start; Derived by automated computational analysis using gene prediction method: Protein Homology. (251 aa)
	AOL16903.1	Pyridine nucleotide-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (411 aa)
	AOL17178.1	MIase like protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (103 aa)
	AOL17222.1	Dihydrolipoyl dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (464 aa)
	AOL17239.1	Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (333 aa)
	AOL17240.1	Pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (345 aa)
	AOL17362.1	Dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (390 aa)
	BFU36_12315	ATP-NAD kinase; Incomplete; partial on complete genome; missing start; Derived by automated computational analysis using gene prediction method: Protein Homology. (326 aa)
	AOL17364.1	Pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (332 aa)
	AOL17365.1	Pyridine nucleotide-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (410 aa)
	AOL17414.1	Ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (363 aa)
	AOL17428.1	Ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (369 aa)

Your Current Organism:

Sulfolobus sp. A20

NCBI taxonomy Id: 1891280
Other names: S. sp. A20

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AOL15535.1	AOL15541.1	BFU36_00940	BFU36_00985	Pyridine nucleotide-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	Ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.757
AOL15535.1	AOL15573.1	BFU36_00940	BFU36_01175	Pyridine nucleotide-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	Ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.772
AOL15535.1	AOL15713.1	BFU36_00940	BFU36_02045	Pyridine nucleotide-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	Glycine cleavage system protein T; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.968
AOL15535.1	AOL15925.1	BFU36_00940	BFU36_03385	Pyridine nucleotide-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.571
AOL15535.1	AOL16091.1	BFU36_00940	BFU36_04420	Pyridine nucleotide-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	Serine hydroxymethyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.967
AOL15535.1	AOL16366.1	BFU36_00940	BFU36_06240	Pyridine nucleotide-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	Ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.752
AOL15535.1	AOL16903.1	BFU36_00940	BFU36_09505	Pyridine nucleotide-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	Pyridine nucleotide-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	0.919
AOL15535.1	AOL17178.1	BFU36_00940	BFU36_11205	Pyridine nucleotide-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	MIase like protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.582
AOL15535.1	AOL17222.1	BFU36_00940	BFU36_11465	Pyridine nucleotide-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	Dihydrolipoyl dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	0.919
AOL15535.1	AOL17239.1	BFU36_00940	BFU36_11570	Pyridine nucleotide-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.931
AOL15535.1	AOL17240.1	BFU36_00940	BFU36_11575	Pyridine nucleotide-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	Pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.860
AOL15535.1	AOL17362.1	BFU36_00940	BFU36_12305	Pyridine nucleotide-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	Dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
AOL15535.1	AOL17364.1	BFU36_00940	BFU36_12320	Pyridine nucleotide-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	Pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.860
AOL15535.1	AOL17365.1	BFU36_00940	BFU36_12325	Pyridine nucleotide-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	Pyridine nucleotide-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	0.923
AOL15535.1	AOL17414.1	BFU36_00940	BFU36_12600	Pyridine nucleotide-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	Ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.577
AOL15535.1	AOL17428.1	BFU36_00940	BFU36_12700	Pyridine nucleotide-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	Ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.577
AOL15535.1	BFU36_06255	BFU36_00940	BFU36_06255	Pyridine nucleotide-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	Biotin attachment protein; Incomplete; partial on complete genome; missing start; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.779
AOL15535.1	BFU36_12315	BFU36_00940	BFU36_12315	Pyridine nucleotide-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	ATP-NAD kinase; Incomplete; partial on complete genome; missing start; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.933
AOL15535.1	gcvH	BFU36_00940	BFU36_01020	Pyridine nucleotide-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	0.964
AOL15535.1	gcvH-2	BFU36_00940	BFU36_01170	Pyridine nucleotide-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	0.965