(32 nodes) Oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor network (Sulfolobus sp. A20)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	AOL16505.1	Thiamine pyrophosphate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. (555 aa)
	AOL15486.1	Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (468 aa)
	AOL15492.1	Thiamine pyrophosphate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. (491 aa)
	AOL15496.1	Pyruvate ferredoxin oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (415 aa)
	AOL15497.1	Pyruvate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (338 aa)
	AOL15684.1	Aspartate-semialdehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (336 aa)
	AOL15879.1	Acetolactate synthase, large subunit, biosynthetic type; Derived by automated computational analysis using gene prediction method: Protein Homology. (572 aa)
	AOL16076.1	Transketolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (312 aa)
	AOL16077.1	Transketolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (274 aa)
	gap	Glyceraldehyde-3-phosphate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (341 aa)
	AOL16177.1	Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (541 aa)
	hemA	glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (432 aa)
	lysY	N-acetyl-gamma-glutamyl-phosphate reductase; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily. (352 aa)
	AOL16332.1	Acetolactate synthase catalytic subunit; Catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (536 aa)
	AOL16345.1	Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (509 aa)
	AOL16385.1	Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. (528 aa)
	AOL16387.1	2-ketoisovalerate ferredoxin oxidoreductase; Catalyzes the coenzyme A-dependent oxidation of 3-methyl-2-oxobutanoate coupled to the reduction of ferredoxin producing S-(2-methylpropanoyl)-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology. (296 aa)
	AOL16388.1	Pyruvate ferredoxin oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (399 aa)
	AOL17713.1	Pyruvate dehydrogenase; Catalyzes the formation of acetate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. (549 aa)
	AOL16574.1	Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (477 aa)
	AOL16700.1	Indolepyruvate ferredoxin oxidoreductase subunit alpha; Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates. (612 aa)
	AOL17035.1	Aspartate-semialdehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (356 aa)
	AOL17128.1	1-pyrroline-5-carboxylate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (522 aa)
	AOL17834.1	2-oxoacid:ferredoxin oxidoreductase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (632 aa)
	AOL17169.1	2-oxoacid:ferredoxin oxidoreductase subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. (305 aa)
	AOL17836.1	Formate dehydrogenase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (954 aa)
	AOL17239.1	Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (333 aa)
	AOL17240.1	Pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (345 aa)
	BFU36_12315	ATP-NAD kinase; Incomplete; partial on complete genome; missing start; Derived by automated computational analysis using gene prediction method: Protein Homology. (326 aa)
	AOL17364.1	Pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (332 aa)
	AOL17880.1	Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (480 aa)
	AOL17517.1	Methylmalonate-semialdehyde dehydrogenase (acylating); Derived by automated computational analysis using gene prediction method: Protein Homology. (489 aa)

Your Current Organism:

Sulfolobus sp. A20

NCBI taxonomy Id: 1891280
Other names: S. sp. A20

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AOL15486.1	AOL15492.1	BFU36_00640	BFU36_00670	Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Thiamine pyrophosphate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family.	0.443
AOL15486.1	AOL15496.1	BFU36_00640	BFU36_00695	Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Pyruvate ferredoxin oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.484
AOL15486.1	AOL15497.1	BFU36_00640	BFU36_00700	Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Pyruvate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.418
AOL15486.1	AOL15879.1	BFU36_00640	BFU36_03125	Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Acetolactate synthase, large subunit, biosynthetic type; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.443
AOL15486.1	AOL16177.1	BFU36_00640	BFU36_04990	Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.443
AOL15486.1	AOL16332.1	BFU36_00640	BFU36_06020	Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Acetolactate synthase catalytic subunit; Catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.443
AOL15486.1	AOL16385.1	BFU36_00640	BFU36_06365	Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family.	0.443
AOL15486.1	AOL16387.1	BFU36_00640	BFU36_06380	Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	2-ketoisovalerate ferredoxin oxidoreductase; Catalyzes the coenzyme A-dependent oxidation of 3-methyl-2-oxobutanoate coupled to the reduction of ferredoxin producing S-(2-methylpropanoyl)-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.418
AOL15486.1	AOL16388.1	BFU36_00640	BFU36_06385	Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Pyruvate ferredoxin oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.484
AOL15486.1	AOL16505.1	BFU36_00640	BFU36_07125	Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Thiamine pyrophosphate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family.	0.443
AOL15486.1	AOL17035.1	BFU36_00640	BFU36_10310	Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Aspartate-semialdehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.915
AOL15486.1	AOL17169.1	BFU36_00640	BFU36_11135	Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	2-oxoacid:ferredoxin oxidoreductase subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.939
AOL15486.1	AOL17713.1	BFU36_00640	BFU36_06485	Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Pyruvate dehydrogenase; Catalyzes the formation of acetate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family.	0.443
AOL15486.1	AOL17834.1	BFU36_00640	BFU36_11130	Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	2-oxoacid:ferredoxin oxidoreductase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.947
AOL15492.1	AOL15486.1	BFU36_00670	BFU36_00640	Thiamine pyrophosphate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family.	Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.443
AOL15492.1	AOL15496.1	BFU36_00670	BFU36_00695	Thiamine pyrophosphate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family.	Pyruvate ferredoxin oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.441
AOL15492.1	AOL15497.1	BFU36_00670	BFU36_00700	Thiamine pyrophosphate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family.	Pyruvate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.442
AOL15492.1	AOL16177.1	BFU36_00670	BFU36_04990	Thiamine pyrophosphate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family.	Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.740
AOL15492.1	AOL16345.1	BFU36_00670	BFU36_06100	Thiamine pyrophosphate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family.	Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.443
AOL15492.1	AOL16387.1	BFU36_00670	BFU36_06380	Thiamine pyrophosphate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family.	2-ketoisovalerate ferredoxin oxidoreductase; Catalyzes the coenzyme A-dependent oxidation of 3-methyl-2-oxobutanoate coupled to the reduction of ferredoxin producing S-(2-methylpropanoyl)-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.442