(61 nodes) AMP-binding enzyme network (Kitasatospora aureofaciens)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	KOG79759.1	acetoacetyl-CoA synthetase; AcsA; in Sinorhizobium meliloti this enzyme is required for acetoacetate activation; similar to acetyl-CoA synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (676 aa)
	KOG78275.1	Acyl transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1737 aa)
	KOG77820.1	Peptide synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (2531 aa)
	KOG76173.1	Long-chain fatty acid--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (598 aa)
	KOG75675.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (2506 aa)
	KOG75552.1	2,3-dihydroxybenzoate--AMP ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (570 aa)
	KOG75697.1	Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1172 aa)
	KOG75055.1	acyl--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (644 aa)
	KOG69788.1	acetyl-CoA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (132 aa)
	KOG70186.1	AMP-dependent synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (572 aa)
	KOG70293.1	Amino acid adenylation domain-containing protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (1383 aa)
	acsA	acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (654 aa)
	KOG70696.1	fatty-acid--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (529 aa)
	entE	Enterobactin synthase subunit E; Bifunctional 2,3-dihydroxybenzoate-AMP ligase/S-dihydroxybenzoyltransferase; activates the carboxylate group of 2,3-dihydroxy-benzoate forming (2,3-dihydroxybenzoyl)adenylate then catalyzes the acylation of holo-entB with 2,3-dihydroxy-benzoate adenylate; Derived by automated computational analysis using gene prediction method: Protein Homology. (553 aa)
	KOG70665.1	Peptide synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1532 aa)
	KOG70971.1	Peptide synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (3099 aa)
	KOG70995.1	Peptide synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1290 aa)
	KOG70970.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (1005 aa)
	KOG71138.1	Long-chain fatty acid--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (664 aa)
	KOG71200.1	Thioester reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1053 aa)
	KOG71372.1	Long-chain fatty acid--CoA ligase; Activates fatty acids by binding to coenzyme A; Derived by automated computational analysis using gene prediction method: Protein Homology. (516 aa)
	KOG71318.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (198 aa)
	KOG71297.1	AMP-dependent synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (517 aa)
	KOG71450.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (872 aa)
	KOG71854.1	AMP-dependent synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (496 aa)
	KOG72064.1	phenylacetate--CoA ligase; Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA). (427 aa)
	KOG72059.1	acyl-CoA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (544 aa)
	KOG72412.1	acyl-CoA synthetase; Activates fatty acids by binding to coenzyme A; Derived by automated computational analysis using gene prediction method: Protein Homology. (533 aa)
	KOG72427.1	acyl-CoA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (517 aa)
	KOG72499.1	AMP-dependent synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (530 aa)
	KOG73315.1	Peptide synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (2400 aa)
	KOG73180.1	prolyl-AMP ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (508 aa)
	KOG73177.1	Thioester reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (840 aa)
	KOG73294.1	Non-ribosomal peptide synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (4126 aa)
	KOG73404.1	Fatty acid--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (521 aa)
	KOG73394.1	Thioester reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1096 aa)
	KOG73385.1	Peptide synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1060 aa)
	KOG73726.1	2-aminobenzoate-CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (541 aa)
	KOG74327.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (623 aa)
	KOG74291.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (3348 aa)
	KOG84275.1	Fatty acid--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (514 aa)
	KOG83205.1	Long-chain fatty acid--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (600 aa)
	KOG82242.1	Peptide synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (2394 aa)
	KOG80057.1	Nonribosomal peptide synthetase anabaenopeptin synthetase AptA1; Derived by automated computational analysis using gene prediction method: Protein Homology. (1053 aa)
	KOG80059.1	NRPS/PKS hybrid; Derived by automated computational analysis using gene prediction method: Protein Homology. (634 aa)
	KOG80060.1	Non-ribosomal peptide synthetase module; Derived by automated computational analysis using gene prediction method: Protein Homology. (607 aa)
	KOG80146.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (1030 aa)
	KOG79763.1	AMP-dependent synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (629 aa)
	KOG78286.1	Thioester reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1296 aa)
	KOG67099.1	Long-chain fatty acid--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (550 aa)
	KOG67498.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (3120 aa)
	KOG67497.1	Amino acid adenylation protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (2185 aa)
	KOG67471.1	Fatty acid--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (524 aa)
	KOG67588.1	Amino acid adenylation domain-containing protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (528 aa)
	KOG68266.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (448 aa)
	KOG68630.1	acyl-CoA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (551 aa)
	KOG68739.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (2389 aa)
	KOG69190.1	cyclohex-1-ene-1-carboxylate:CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (525 aa)
	KOG69188.1	Fatty acid--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (558 aa)
	KOG69481.1	acyl-CoA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (250 aa)
	KOG69630.1	acyl-CoA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (485 aa)

Your Current Organism:

Kitasatospora aureofaciens

NCBI taxonomy Id: 1894
Other names: ATCC 10762, ATCC 23884, BCRC 11610, CBS 434.51, CBS 664.68, CCRC 11610, CCRC:11610, CECT 3206, CIP 57.11, DSM 40127, HAMBI 313, HUT 6048, HUT 6097, ICMP 499, IFO 12594, IFO 12843, IFO 3712, ISP 5127, JCM 4008, JCM 4624, K. aureofaciens, KACC 20180, LMG 5968, LMG:5968, NBRC 12594, NBRC 12843, NBRC 3712, NCAIM B.01479, NCIMB 8234, NRRL 2209, NRRL B-5404, NRRL-ISP 5127, NRRL-ISP:5127, NRRL:B:5404, RIA 57, Streptomyces aureifaciens, Streptomyces aureofaciens, Streptomyces aureofaciens subsp. aureofaciens, VKM Ac-771

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KOG67099.1	KOG67497.1	ADK78_41860	ADK78_40565	Long-chain fatty acid--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Amino acid adenylation protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.952
KOG67099.1	KOG67498.1	ADK78_41860	ADK78_40580	Long-chain fatty acid--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.968
KOG67099.1	KOG67588.1	ADK78_41860	ADK78_39825	Long-chain fatty acid--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Amino acid adenylation domain-containing protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.861
KOG67099.1	KOG68739.1	ADK78_41860	ADK78_35285	Long-chain fatty acid--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.952
KOG67099.1	KOG69788.1	ADK78_41860	ADK78_31690	Long-chain fatty acid--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	acetyl-CoA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.884
KOG67099.1	KOG70186.1	ADK78_41860	ADK78_30195	Long-chain fatty acid--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	AMP-dependent synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.941
KOG67099.1	KOG70293.1	ADK78_41860	ADK78_29130	Long-chain fatty acid--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Amino acid adenylation domain-containing protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.952
KOG67099.1	KOG70665.1	ADK78_41860	ADK78_27655	Long-chain fatty acid--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Peptide synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.992
KOG67099.1	KOG70970.1	ADK78_41860	ADK78_26845	Long-chain fatty acid--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.972
KOG67099.1	KOG70971.1	ADK78_41860	ADK78_26855	Long-chain fatty acid--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Peptide synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.989
KOG67099.1	KOG70995.1	ADK78_41860	ADK78_26850	Long-chain fatty acid--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Peptide synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.975
KOG67099.1	KOG71138.1	ADK78_41860	ADK78_26410	Long-chain fatty acid--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Long-chain fatty acid--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.868
KOG67099.1	KOG71200.1	ADK78_41860	ADK78_26030	Long-chain fatty acid--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Thioester reductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.965
KOG67099.1	KOG71318.1	ADK78_41860	ADK78_24835	Long-chain fatty acid--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.667
KOG67099.1	KOG71450.1	ADK78_41860	ADK78_24395	Long-chain fatty acid--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.856
KOG67099.1	KOG72064.1	ADK78_41860	ADK78_22345	Long-chain fatty acid--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	phenylacetate--CoA ligase; Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).	0.821
KOG67099.1	KOG73177.1	ADK78_41860	ADK78_16510	Long-chain fatty acid--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Thioester reductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.960
KOG67099.1	KOG73294.1	ADK78_41860	ADK78_16500	Long-chain fatty acid--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Non-ribosomal peptide synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.996
KOG67099.1	KOG73315.1	ADK78_41860	ADK78_17155	Long-chain fatty acid--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Peptide synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.998
KOG67099.1	KOG73385.1	ADK78_41860	ADK78_16005	Long-chain fatty acid--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Peptide synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.958

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