STRINGSTRING
AIQ66384.1 AIQ66384.1 AIQ66385.1 AIQ66385.1 AIQ66386.1 AIQ66386.1 ldh ldh AIQ66701.1 AIQ66701.1 ilvA ilvA AIQ67016.1 AIQ67016.1 AIQ67143.1 AIQ67143.1 AIQ67217.1 AIQ67217.1 AIQ67495.1 AIQ67495.1 AIQ67496.1 AIQ67496.1 ilvC ilvC leuA leuA leuB leuB ilvD ilvD AIQ68157.1 AIQ68157.1 AIQ68261.1 AIQ68261.1 AIQ68317.1 AIQ68317.1 AIQ68379.1 AIQ68379.1 AIQ68381.1 AIQ68381.1 AIQ68486.1 AIQ68486.1 AIQ68792.1 AIQ68792.1 AIQ68794.1 AIQ68794.1 AIQ69026.1 AIQ69026.1 ldh-2 ldh-2 AIQ69279.1 AIQ69279.1 AIQ69280.1 AIQ69280.1 AIQ69348.1 AIQ69348.1 leuD leuD leuC leuC ackA ackA AIQ69846.1 AIQ69846.1 AIQ70014.1 AIQ70014.1 AIQ70015.1 AIQ70015.1 AIQ70016.1 AIQ70016.1 AIQ70167.1 AIQ70167.1 AIQ70511.1 AIQ70511.1 AIQ70512.1 AIQ70512.1 ilvE ilvE AIQ70757.1 AIQ70757.1 iolA iolA AIQ71512.1 AIQ71512.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AIQ66384.1Acetaldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (875 aa)
AIQ66385.1Formate acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (742 aa)
AIQ66386.1Pyruvate formate lyase-activating protein; Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family. (246 aa)
ldhLactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. (320 aa)
AIQ66701.1Aminotransferase class III; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (433 aa)
ilvAThreonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (420 aa)
AIQ67016.1acyl--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (530 aa)
AIQ67143.1Leucine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (364 aa)
AIQ67217.12-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate). Belongs to the alpha-IPM synthase/homocitrate synthase family. (518 aa)
AIQ67495.1Acetolactate synthase catalytic subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (582 aa)
AIQ67496.1Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (162 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (330 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (513 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (360 aa)
ilvDDihydroxy-acid dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family. (561 aa)
AIQ68157.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (422 aa)
AIQ68261.1Transferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the alpha-IPM synthase/homocitrate synthase family. (539 aa)
AIQ68317.1Malate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (395 aa)
AIQ68379.1Quinone oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (330 aa)
AIQ68381.1Malate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (469 aa)
AIQ68486.1acetyl-CoA synthetase; Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology. (574 aa)
AIQ68792.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (218 aa)
AIQ68794.1Dihydroxy-acid dehydratase; Catalyzes the formation of 3-methyl-2-oxobutanoate from 2,3,-dihydroxy-3-methylbutanoate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family. (569 aa)
AIQ69026.1Acetolactate synthase catalytic subunit; Catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (557 aa)
ldh-2Lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (308 aa)
AIQ69279.1Pyruvate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (768 aa)
AIQ69280.1Ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (336 aa)
AIQ69348.1Propanediol utilization protein; Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate. (190 aa)
leuDIsopropylmalate isomerase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (200 aa)
leuCIsopropylmalate isomerase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (474 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (402 aa)
AIQ69846.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. (544 aa)
AIQ70014.1Pyruvate formate lyase-activating protein; Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family. (245 aa)
AIQ70015.1Formate acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (753 aa)
AIQ70016.1Acetaldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (873 aa)
AIQ70167.1Aldehyde dehydrogenase; NAD-linked; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (476 aa)
AIQ70511.1Catalyzes the formation of 2-acetolactate from pyruvate in stationary phase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. (562 aa)
AIQ70512.1Alpha-acetolactate decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the alpha-acetolactate decarboxylase family. (238 aa)
ilvEBranched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (293 aa)
AIQ70757.1Homocysteine methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the alpha-IPM synthase/homocitrate synthase family. (380 aa)
iolAMethylmalonate-semialdehyde dehydrogenase; Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively. (487 aa)
AIQ71512.1Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (463 aa)
Your Current Organism:
Paenibacillus graminis
NCBI taxonomy Id: 189425
Other names: ATCC BAA-95, DSM 15220, LMG 19080, LMG:19080, P. graminis, Paenibacillus graminis Berge et al. 2002, Paenibacillus sp. RSA19, strain RSA19
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