STRINGSTRING
thiC thiC AOL94020.1 AOL94020.1 AOL94084.1 AOL94084.1 acsA acsA AOL94216.1 AOL94216.1 AOL94244.1 AOL94244.1 AOL94246.1 AOL94246.1 accA accA AOL93091.1 AOL93091.1 thiL thiL AOL94421.1 AOL94421.1 AOL94461.1 AOL94461.1 AOL94594.1 AOL94594.1 accA-2 accA-2 AOL94690.1 AOL94690.1 thiE thiE AOL94821.1 AOL94821.1 gshB gshB AOL94863.1 AOL94863.1 lipA lipA AOL94898.1 AOL94898.1 pdhA pdhA AOL93169.1 AOL93169.1 asd asd accD accD metZ metZ AOL95339.1 AOL95339.1 AOL93206.1 AOL93206.1 cysN cysN AOL93277.1 AOL93277.1 dxs dxs thiG thiG AOL93486.1 AOL93486.1 AOL93504.1 AOL93504.1 AOL93571.1 AOL93571.1 folD folD mtnP mtnP metXA metXA AOL93772.1 AOL93772.1 AOL93820.1 AOL93820.1 AOL93822.1 AOL93822.1
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
thiCHydroxymethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (623 aa)
AOL94020.1Methionine adenosyltransferase; Belongs to the AdoMet synthase family. (394 aa)
AOL94084.15-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase. (375 aa)
acsAAcetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (639 aa)
AOL94216.1Cysteine synthase A. (342 aa)
AOL94244.1Phosphoadenylylsulfate reductase (thioredoxin); Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. (258 aa)
AOL94246.1Sulfite reductase (NADPH) hemoprotein beta-component. (543 aa)
accAacetyl-CoA carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (308 aa)
AOL93091.1Methionine adenosyltransferase; Belongs to the AdoMet synthase family. (403 aa)
thiLThiamine-phosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (285 aa)
AOL94421.1Glutamate--cysteine ligase; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). Belongs to the glutamate--cysteine ligase type 2 family. EgtA subfamily. (456 aa)
AOL94461.1acetyl-CoA carboxylase, biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (450 aa)
AOL94594.1Protein of unknown function (DUF3137). (327 aa)
accA-2acetyl-CoA carboxylase carboxyltransferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (314 aa)
AOL94690.12-oxoisovalerate dehydrogenase E1 component alpha subunit. (431 aa)
thiEThiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (212 aa)
AOL94821.1Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (306 aa)
gshBGlutathione synthase; Belongs to the prokaryotic GSH synthase family. (326 aa)
AOL94863.1Pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase). (474 aa)
lipALipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (341 aa)
AOL94898.1Pyruvate dehydrogenase E1 component beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (454 aa)
pdhAPyruvate dehydrogenase E1 component alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (355 aa)
AOL93169.1Homoserine dehydrogenase. (440 aa)
asdAspartate semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (341 aa)
accDacetyl-CoA carboxylase carboxyltransferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (284 aa)
metZO-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. (405 aa)
AOL95339.1Serine O-acetyltransferase. (243 aa)
AOL93206.1Sulfate adenylyltransferase subunit 2. (300 aa)
cysNAdenylylsulfate kinase /sulfate adenylyltransferase subunit 1; Catalyzes the synthesis of activated sulfate. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (649 aa)
AOL93277.1Pyruvate dehydrogenase E1 component alpha subunit. (322 aa)
dxs1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (648 aa)
thiGThiazole-phosphate synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (329 aa)
AOL93486.1Etoposide-induced protein 2.4 (EI24). (225 aa)
AOL93504.1Gamma-glutamyltransferase 1 Threonine peptidase.MEROPS family T03. (571 aa)
AOL93571.1Thiamine-phosphate pyrophosphorylase. (178 aa)
folDMethylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (302 aa)
mtnP5'-methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. (288 aa)
metXAHomoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (365 aa)
AOL93772.1Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase. (243 aa)
AOL93820.15,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. (309 aa)
AOL93822.1Methionine synthase (B12-dependent). (864 aa)
Your Current Organism:
Porphyrobacter sp. LM 6
NCBI taxonomy Id: 1896196
Other names: P. sp. LM 6
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