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Mkms_0363 Mkms_0363 dcd dcd purA purA Mkms_0535 Mkms_0535 adk adk map map Mkms_1102 Mkms_1102 glmM glmM glmS glmS guaB guaB Mkms_1185 Mkms_1185 guaA guaA Mkms_1195 Mkms_1195 folD folD Mkms_1248 Mkms_1248 Mkms_1249 Mkms_1249 add add upp upp Mkms_1261 Mkms_1261 purK purK purE purE Mkms_1364 Mkms_1364 Mkms_1426 Mkms_1426 Mkms_1862 Mkms_1862 nrdI nrdI Mkms_1864 Mkms_1864 Mkms_1875 Mkms_1875 thyA thyA Mkms_2159 Mkms_2159 Mkms_2160 Mkms_2160 thyX thyX rnj rnj Mkms_2164 Mkms_2164 dut dut apt apt Mkms_2407 Mkms_2407 Mkms_2408 Mkms_2408 pyrR pyrR pyrB pyrB pyrC pyrC Mkms_2412 Mkms_2412 carA carA carB carB pyrF pyrF gmk gmk Mkms_2857 Mkms_2857 pyrD pyrD Mkms_3362 Mkms_3362 ndk ndk Mkms_3674 Mkms_3674 glyA glyA Mkms_4280 Mkms_4280 glmU glmU prs prs Mkms_4336 Mkms_4336 Mkms_4337 Mkms_4337 Mkms_4338 Mkms_4338 purH purH purN purN purM purM purF purF purL purL purQ purQ purS purS purC purC Mkms_4654 Mkms_4654 purD purD pyrE pyrE upp-2 upp-2
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Mkms_0363PFAM: Xanthine/uracil/vitamin C permease; KEGG: mmc:Mmcs_0353 xanthine/uracil/vitamin C permease. (471 aa)
dcddCTP deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. (190 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (431 aa)
Mkms_0535Formate-dependent phosphoribosylglycinamide formyltransferase; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate. Belongs to the PurK/PurT family. (428 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (181 aa)
mapMethionine aminopeptidase, type I; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily. (267 aa)
Mkms_1102Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (693 aa)
glmMPhosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. (466 aa)
glmSGlutamine--fructose-6-phosphate transaminase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (621 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (517 aa)
Mkms_1185TIGRFAM: IMP dehydrogenase family protein; KEGG: mmc:Mmcs_1168 IMP dehydrogenase related 2. (378 aa)
guaAGMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (519 aa)
Mkms_1195PFAM: Inosine/uridine-preferring nucleoside hydrolase; KEGG: mmc:Mmcs_1178 inosine/uridine-preferring nucleoside hydrolase. (349 aa)
folDMethenyltetrahydrofolate cyclohydrolase / 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (288 aa)
Mkms_1248TIGRFAM: cytidine deaminase; PFAM: CMP/dCMP deaminase, zinc-binding; KEGG: mmc:Mmcs_1231 cytidine deaminase, homotetrameric. (138 aa)
Mkms_1249Thymidine phosphorylase; KEGG: mmc:Mmcs_1232 pyrimidine-nucleoside phosphorylase; TIGRFAM: pyrimidine-nucleoside phosphorylase; PFAM: glycosyl transferase, family 3; Pyrimidine nucleoside phosphorylase, C-terminal domain. (448 aa)
addKEGG: mmc:Mmcs_1233 adenosine deaminase; TIGRFAM: adenosine deaminase; PFAM: adenosine/AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily. (362 aa)
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (207 aa)
Mkms_1261Purine nucleotide phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (264 aa)
purK5-(carboxyamino)imidazole ribonucleotide synthase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (393 aa)
purE5-(carboxyamino)imidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (170 aa)
Mkms_1364PFAM: thymidylate kinase; KEGG: mmc:Mmcs_1346 thymidylate kinase. (229 aa)
Mkms_1426TIGRFAM: Glutaredoxin-like protein; PFAM: glutaredoxin; glutaredoxin 2; KEGG: mmc:Mmcs_1408 glutaredoxin-like protein GlrX. (82 aa)
Mkms_1862Ribonucleoside-diphosphate reductase class Ib glutaredoxin subunit; TIGRFAM: Glutaredoxin-like protein NrdH; PFAM: glutaredoxin; KEGG: mmc:Mmcs_1815 glutaredoxin-like protein NrdH. (83 aa)
nrdINrdI protein; Probably involved in ribonucleotide reductase function. (152 aa)
Mkms_1864Ribonucleoside-diphosphate reductase class Ib alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (693 aa)
Mkms_1875Ribonucleoside-diphosphate reductase class Ib beta subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (320 aa)
thyAThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (266 aa)
Mkms_2159Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (161 aa)
Mkms_2160PFAM: protein of unknown function DUF1006; KEGG: mmc:Mmcs_2114 protein of unknown function DUF1006. (404 aa)
thyXThymidylate synthase (FAD); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (254 aa)
rnjBeta-lactamase domain protein; An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay. (558 aa)
Mkms_2164KEGG: mmc:Mmcs_2118 hypothetical protein. (141 aa)
dutDeoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (154 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (174 aa)
Mkms_2407PFAM: monooxygenase, FAD-binding; FAD dependent oxidoreductase; KEGG: mmc:Mmcs_2360 monooxygenase, FAD-binding protein. (400 aa)
Mkms_2408PFAM: beta-lactamase; KEGG: mmc:Mmcs_2361 beta-lactamase. (401 aa)
pyrRUracil phosphoribosyltransferase; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant. (191 aa)
pyrBTIGRFAM: aspartate carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase, Asp/Orn-binding region; aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; KEGG: mmc:Mmcs_2363 aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (316 aa)
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (431 aa)
Mkms_2412KEGG: mmc:Mmcs_2365 putative export or membrane protein. (166 aa)
carAKEGG: mmc:Mmcs_2366 carbamoyl-phosphate synthase, small subunit; TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: glutamine amidotransferase class-I; Carbamoyl-phosphate synthase, small chain; Belongs to the CarA family. (387 aa)
carBTIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthase L chain, ATP-binding; Carbamoyl-phosphate synthetase large chain, oligomerisation; Carbamoyl-phosphate synthetase large chain domain protein; MGS domain protein; RimK domain protein ATP-grasp; KEGG: mmc:Mmcs_2367 carbamoyl-phosphate synthase, large subunit. (1112 aa)
pyrFTIGRFAM: orotidine 5'-phosphate decarboxylase; PFAM: Orotidine 5'-phosphate decarboxylase; KEGG: mmc:Mmcs_2368 orotidine 5'-phosphate decarboxylase subfamily 2; Belongs to the OMP decarboxylase family. Type 2 subfamily. (272 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (198 aa)
Mkms_2857KEGG: mmc:Mmcs_2813 IMP dehydrogenase related 1; TIGRFAM: IMP dehydrogenase family protein; PFAM: CBS domain containing protein; IMP dehydrogenase/GMP reductase. (478 aa)
pyrDDihydroorotate oxidase A; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (356 aa)
Mkms_3362Adenosine kinase; PFAM: PfkB domain protein; KEGG: mmc:Mmcs_3300 adenosine kinase. (324 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (149 aa)
Mkms_3674PFAM: CMP/dCMP deaminase, zinc-binding; KEGG: mmc:Mmcs_3601 CMP/dCMP deaminase, zinc-binding protein. (154 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (492 aa)
Mkms_4280Putative ribonucleoside-diphosphate reductase; Probable oxidase that might be involved in lipid metabolism. Belongs to the ribonucleoside diphosphate reductase small chain family. R2-like ligand binding oxidase subfamily. (312 aa)
glmUUDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. (497 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (326 aa)
Mkms_4336TIGRFAM: arsenate reductase; PFAM: arsenate reductase and related; KEGG: mmc:Mmcs_4250 arsenate reductase; Belongs to the ArsC family. (120 aa)
Mkms_4337KEGG: mmc:Mmcs_4251 lipoprotein, putative. (219 aa)
Mkms_4338PFAM: short-chain dehydrogenase/reductase SDR; KEGG: mmc:Mmcs_4252 short-chain dehydrogenase/reductase SDR; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (289 aa)
purHIMP cyclohydrolase; KEGG: mmc:Mmcs_4319 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme, formylation region. (527 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (209 aa)
purMKEGG: mmc:Mmcs_4538 phosphoribosylformylglycinamidine cyclo-ligase; TIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein; AIR synthase related protein domain protein. (357 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (511 aa)
purLPhosphoribosylformylglycinamidine synthase subunit II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...] (768 aa)
purQPhosphoribosylformylglycinamidine synthase subunit I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...] (224 aa)
purSPhosphoribosylformylglycinamidine synthase, purS; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assi [...] (79 aa)
purCKEGG: mmc:Mmcs_4560 phosphoribosylaminoimidazole-succinocarboxamide synthase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase. (297 aa)
Mkms_4654KEGG: mmc:Mmcs_4566 adenylosuccinate lyase; TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (475 aa)
purDKEGG: mmc:Mmcs_4571 phosphoribosylamine--glycine ligase; TIGRFAM: phosphoribosylamine--glycine ligase; PFAM: phosphoribosylglycinamide synthetase; Belongs to the GARS family. (422 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (192 aa)
upp-2Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (209 aa)
Your Current Organism:
Mycobacterium sp. KMS
NCBI taxonomy Id: 189918
Other names: M. sp. KMS
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