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purA purA guaB guaB Mkms_1185 Mkms_1185 guaA guaA Mkms_2857 Mkms_2857 Mkms_4654 Mkms_4654
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (431 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (517 aa)
Mkms_1185TIGRFAM: IMP dehydrogenase family protein; KEGG: mmc:Mmcs_1168 IMP dehydrogenase related 2. (378 aa)
guaAGMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (519 aa)
Mkms_2857KEGG: mmc:Mmcs_2813 IMP dehydrogenase related 1; TIGRFAM: IMP dehydrogenase family protein; PFAM: CBS domain containing protein; IMP dehydrogenase/GMP reductase. (478 aa)
Mkms_4654KEGG: mmc:Mmcs_4566 adenylosuccinate lyase; TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (475 aa)
Your Current Organism:
Mycobacterium sp. KMS
NCBI taxonomy Id: 189918
Other names: M. sp. KMS
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