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pckG pckG Mkms_0391 Mkms_0391 Mkms_0392 Mkms_0392 zwf zwf Mkms_0514 Mkms_0514 Mkms_0644 Mkms_0644 deoC deoC gpmA gpmA pdhA pdhA Mkms_1109 Mkms_1109 Mkms_1110 Mkms_1110 Mkms_1266 Mkms_1266 pfkA pfkA Mkms_1989 Mkms_1989 Mkms_2022 Mkms_2022 Mkms_2450 Mkms_2450 pgk pgk tpiA tpiA ppc ppc tal tal Mkms_2460 Mkms_2460 Mkms_2748 Mkms_2748 Mkms_3101 Mkms_3101 Mkms_3375 Mkms_3375 Mkms_3424 Mkms_3424 Mkms_3469 Mkms_3469 rbsK rbsK Mkms_3639 Mkms_3639 Mkms_3640 Mkms_3640 Mkms_3697 Mkms_3697 Mkms_3698 Mkms_3698 Mkms_3699 Mkms_3699 Mkms_4051 Mkms_4051 Mkms_4196 Mkms_4196 eno eno pgi pgi Mkms_4954 Mkms_4954 zwf-3 zwf-3
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
experimentally determined
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pckGPhosphoenolpyruvate carboxykinase (GTP); Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (609 aa)
Mkms_0391PFAM: Lactate/malate dehydrogenase; KEGG: mmc:Mmcs_0382 lactate/malate dehydrogenase; Belongs to the LDH/MDH superfamily. (329 aa)
Mkms_0392PFAM: pyruvate kinase; KEGG: mmc:Mmcs_0383 pyruvate kinase. (615 aa)
zwfGlucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (471 aa)
Mkms_0514Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (345 aa)
Mkms_0644TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; glucose-inhibited division protein A; pyridine nucleotide-disulphide oxidoreductase dimerisation region; HI0933 family protein; KEGG: mmc:Mmcs_0631 dihydrolipoamide dehydrogenase. (466 aa)
deoCDeoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (226 aa)
gpmAPhosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (248 aa)
pdhAPyruvate dehydrogenase (acetyl-transferring); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (325 aa)
Mkms_1109Transketolase, central region; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (325 aa)
Mkms_1110PFAM: biotin/lipoyl attachment domain-containing protein; catalytic domain of components of various dehydrogenase complexes; E3 binding domain protein; KEGG: mmc:Mmcs_1093 catalytic domain of components of various dehydrogenase complexes. (399 aa)
Mkms_1266Pyridine nucleotide-disulfide oxidoreductase dimerization region; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; HI0933 family protein; KEGG: mmc:Mmcs_1249 pyridine nucleotide-disulphide oxidoreductase dimerisation region. (470 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (343 aa)
Mkms_1989Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1131 aa)
Mkms_2022PFAM: dehydrogenase, E1 component; Transketolase, central region; Transketolase domain protein; KEGG: mmc:Mmcs_1976 transketolase, central region. (721 aa)
Mkms_2450KEGG: mmc:Mmcs_2404 glyceraldehyde-3-phosphate dehydrogenase, type I; TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I; PFAM: glyceraldehyde 3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (340 aa)
pgkPFAM: phosphoglycerate kinase; KEGG: mmc:Mmcs_2405 phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (407 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (261 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (946 aa)
talTransaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily. (372 aa)
Mkms_2460Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (697 aa)
Mkms_2748PFAM: fructose-bisphosphate aldolase, class-I; KEGG: mmc:Mmcs_2704 fructose-bisphosphate aldolase. (297 aa)
Mkms_3101PFAM: pyruvate kinase; KEGG: mmc:Mmcs_3042 pyruvate kinase; Belongs to the pyruvate kinase family. (472 aa)
Mkms_33752-oxoglutarate dehydrogenase E2 component; PFAM: biotin/lipoyl attachment domain-containing protein; catalytic domain of components of various dehydrogenase complexes; E3 binding domain protein; KEGG: mmc:Mmcs_3313 catalytic domain of components of various dehydrogenase complexes. (629 aa)
Mkms_34242-oxo-acid dehydrogenase E1 subunit, homodimeric type; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (929 aa)
Mkms_3469Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (798 aa)
rbsKPfkB domain protein; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (285 aa)
Mkms_3639PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; KEGG: mmc:Mmcs_3566 thiamine pyrophosphate enzyme-like TPP-binding protein. (368 aa)
Mkms_3640PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: mmc:Mmcs_3567 pyruvate flavodoxin/ferredoxin oxidoreductase-like protein. (643 aa)
Mkms_3697PFAM: biotin/lipoyl attachment domain-containing protein; catalytic domain of components of various dehydrogenase complexes; E3 binding domain protein; KEGG: mmc:Mmcs_3624 catalytic domain of components of various dehydrogenase complexes. (384 aa)
Mkms_3698PFAM: Transketolase, central region; Transketolase domain protein; KEGG: mmc:Mmcs_3625 transketolase, central region. (349 aa)
Mkms_3699PFAM: dehydrogenase, E1 component; KEGG: mmc:Mmcs_3626 pyruvate dehydrogenase (lipoamide). (356 aa)
Mkms_4051PFAM: malic enzyme domain protein; malic enzyme, NAD-binding; KEGG: mmc:Mmcs_3977 malate dehydrogenase (oxaloacetate decarboxylating). (391 aa)
Mkms_4196TIGRFAM: fructose-1,6-bisphosphatase, class II; PFAM: GlpX family protein; KEGG: mmc:Mmcs_4121 fructose-1,6-bisphosphatase, class II. (353 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (429 aa)
pgiPFAM: phosphoglucose isomerase (PGI); KEGG: mmc:Mmcs_4334 glucose-6-phosphate isomerase; Belongs to the GPI family. (554 aa)
Mkms_4954PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; pyruvate ferredoxin/flavodoxin oxidoreductase; pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: mmc:Mmcs_4865 pyruvate:ferredoxin (flavodoxin) oxidoreductase. (1191 aa)
zwf-3Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (505 aa)
Your Current Organism:
Mycobacterium sp. KMS
NCBI taxonomy Id: 189918
Other names: M. sp. KMS
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