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asd asd Mkms_0367 Mkms_0367 cysC cysC Mkms_0397 Mkms_0397 Mkms_0398 Mkms_0398 metZ metZ Mkms_0549 Mkms_0549 ackA ackA thiE thiE Mkms_0557 Mkms_0557 Mkms_0558 Mkms_0558 thiG thiG Mkms_0576 Mkms_0576 mshA mshA mtnP mtnP Mkms_0889 Mkms_0889 pdhA pdhA folD folD metXA metXA Mkms_1225 Mkms_1225 Mkms_1235 Mkms_1235 Mkms_1327 Mkms_1327 Mkms_1417 Mkms_1417 Mkms_1462 Mkms_1462 Mkms_1654 Mkms_1654 Mkms_1734 Mkms_1734 Mkms_1750 Mkms_1750 Mkms_1784 Mkms_1784 Mkms_1924 Mkms_1924 Mkms_1974 Mkms_1974 thiL thiL dxs dxs metK metK Mkms_2441 Mkms_2441 Mkms_2534 Mkms_2534 Mkms_2990 Mkms_2990 Mkms_3105 Mkms_3105 bioB bioB bioD bioD Mkms_3137 Mkms_3137 bioA bioA Mkms_3203 Mkms_3203 Mkms_3211 Mkms_3211 mshC mshC lipA lipA Mkms_3398 Mkms_3398 Mkms_3538 Mkms_3538 Mkms_3699 Mkms_3699 Mkms_3922 Mkms_3922 Mkms_3923 Mkms_3923 Mkms_3924 Mkms_3924 Mkms_3970 Mkms_3970 cysC-2 cysC-2 cysD cysD Mkms_4027 Mkms_4027 mshB mshB Mkms_4221 Mkms_4221 Mkms_4222 Mkms_4222 Mkms_4224 Mkms_4224 Mkms_4263 Mkms_4263 Mkms_4297 Mkms_4297 Mkms_4525 Mkms_4525 Mkms_4548 Mkms_4548 mshD mshD Mkms_4786 Mkms_4786 acsA acsA Mkms_4913 Mkms_4913 Mkms_4965 Mkms_4965 egtE egtE egtD egtD egtC egtC egtB egtB egtA egtA
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proteins of unknown 3D structure
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asdAspartate semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (344 aa)
Mkms_03674-amino-5-aminomethyl-2-methylpyrimidine deaminase / thiaminase; Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway; Belongs to the TenA family. (229 aa)
cysCSulfate adenylyltransferase subunit 1 / adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. Belongs to the APS kinase family. (619 aa)
Mkms_0397KEGG: mmc:Mmcs_0388 sulfate adenylyltransferase, small subunit; TIGRFAM: sulfate adenylyltransferase, small subunit; PFAM: phosphoadenosine phosphosulfate reductase. (306 aa)
Mkms_0398Conserved hypothetical protein; Catalyzes the sulfuryl group transfer from 3'- phosphoadenosine-5'-phosphosulfate (PAPS) to trehalose, leading to trehalose-2-sulfate (T2S). (267 aa)
metZO-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. (412 aa)
Mkms_0549Phosphotransacetylase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (704 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (399 aa)
thiEThiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (226 aa)
Mkms_0557TIGRFAM: glycine oxidase ThiO; PFAM: FAD dependent oxidoreductase; KEGG: mmc:Mmcs_0545 glycine oxidase ThiO. (338 aa)
Mkms_0558TIGRFAM: thiamine biosynthesis protein ThiS; PFAM: thiamineS protein; KEGG: mmc:Mmcs_0546 thiamine biosynthesis protein ThiS. (65 aa)
thiGThiazole-phosphate synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (253 aa)
Mkms_0576KEGG: mmc:Mmcs_0564 phosphomethylpyrimidine kinase type-2; TIGRFAM: phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1. (282 aa)
mshAGlycosyl transferase, group 1; Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2- deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway. (439 aa)
mtnPMethylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. (258 aa)
Mkms_0889Gamma-glutamyltransferase 2, Threonine peptidase, MEROPS family T03; PFAM: gamma-glutamyltranspeptidase; KEGG: mmc:Mmcs_0872 gamma-glutamyltransferase. (530 aa)
pdhAPyruvate dehydrogenase (acetyl-transferring); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (325 aa)
folDMethenyltetrahydrofolate cyclohydrolase / 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (288 aa)
metXAHomoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (373 aa)
Mkms_1225KEGG: mmc:Mmcs_1208 O-acetylhomoserine/O-acetylserine sulfhydrylase; TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; aromatic amino acid beta-eliminating lyase/threonine aldolase. (435 aa)
Mkms_1235PFAM: aminotransferase class-III; KEGG: mmc:Mmcs_1218 aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (461 aa)
Mkms_1327PFAM: glycosyl transferase, group 1; KEGG: mmc:Mmcs_1310 glycosyl transferase, group 1. (354 aa)
Mkms_1417PFAM: UBA/THIF-type NAD/FAD binding protein; Rhodanese domain protein; MoeZ/MoeB domain protein; KEGG: mmc:Mmcs_1399 UBA/ThiF-type NAD/FAD binding fold. (400 aa)
Mkms_1462PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: mmc:Mmcs_1444 pyridoxal-5'-phosphate-dependent enzyme, beta subunit. (371 aa)
Mkms_16541-hydroxy-2-naphthoate dioxygenase / gentisate 1,2-dioxygenase; PFAM: Cupin 2, conserved barrel domain protein; KEGG: mmc:Mmcs_1628 cupin 2, conserved barrel. (361 aa)
Mkms_1734PFAM: Cupin 2, conserved barrel domain protein; KEGG: mmc:Mmcs_1706 cupin 2, conserved barrel. (162 aa)
Mkms_1750PFAM: Cupin 2, conserved barrel domain protein; KEGG: mmc:Mmcs_1706 cupin 2, conserved barrel. (162 aa)
Mkms_1784PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: mmc:Mmcs_1737 glyoxalase/bleomycin resistance protein/dioxygenase. (136 aa)
Mkms_1924PFAM: Methionine synthase, vitamin-B12 independent; KEGG: mmc:Mmcs_1878 methionine synthase, vitamin-B12 independent. (336 aa)
Mkms_1974PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; KEGG: mmc:Mmcs_1928 Cys/Met metabolism pyridoxal-phosphate-dependent enzymes. (367 aa)
thiLThiamine-phosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (318 aa)
dxs1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (638 aa)
metKMethionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (402 aa)
Mkms_2441Gamma-glutamyltransferase 1, Threonine peptidase, MEROPS family T03; KEGG: mmc:Mmcs_2394 gamma-glutamyltransferase; TIGRFAM: gamma-glutamyltransferase; PFAM: gamma-glutamyltranspeptidase. (634 aa)
Mkms_2534TIGRFAM: precorrin-3B synthase; PFAM: nitrite/sulfite reductase, hemoprotein beta-component, ferrodoxin domain protein; KEGG: mmc:Mmcs_2489 precorrin-3B synthase. (373 aa)
Mkms_2990KEGG: mmc:Mmcs_2946 hypothetical protein. (394 aa)
Mkms_3105PFAM: TM2 domain containing protein+B7201; KEGG: mmc:Mmcs_3046 TM2 domain containing protein. (127 aa)
bioBBiotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (331 aa)
bioDDethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (229 aa)
Mkms_31378-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. (382 aa)
bioAAdenosylmethionine-8-amino-7-oxononanoate aminotransferase apoenzyme; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. (436 aa)
Mkms_3203PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: mmc:Mmcs_3141 glyoxalase/bleomycin resistance protein/dioxygenase. (124 aa)
Mkms_3211Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1264 aa)
mshCcysteinyl-tRNA synthetase; Catalyzes the ATP-dependent condensation of GlcN-Ins and L- cysteine to form L-Cys-GlcN-Ins; Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily. (415 aa)
lipALipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (325 aa)
Mkms_3398Lyase; KEGG: mmc:Mmcs_3336 lyase. (117 aa)
Mkms_3538Phosphoadenylylsulfate reductase (thioredoxin); Reduction of activated sulfate into sulfite. (231 aa)
Mkms_3699PFAM: dehydrogenase, E1 component; KEGG: mmc:Mmcs_3626 pyruvate dehydrogenase (lipoamide). (356 aa)
Mkms_3922KEGG: mmc:Mmcs_3848 cysteine synthases; TIGRFAM: cysteine synthases; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit. (323 aa)
Mkms_3923Molybdopterin synthase subunit MoaD; PFAM: thiamineS protein; KEGG: mmc:Mmcs_3849 thiamineS. (93 aa)
Mkms_3924PFAM: Mov34/MPN/PAD-1 family protein; KEGG: mmc:Mmcs_3850 Mov34/MPN/PAD-1. (137 aa)
Mkms_3970PFAM: homoserine dehydrogenase; amino acid-binding ACT domain protein; homoserine dehydrogenase, NAD-binding; KEGG: mmc:Mmcs_3896 homoserine dehydrogenase. (445 aa)
cysC-2Adenylylsulfate kinase / sulfate adenylyltransferase subunit 1; Catalyzes the synthesis of activated sulfate. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (619 aa)
cysDKEGG: mmc:Mmcs_3919 sulfate adenylyltransferase, small subunit; TIGRFAM: sulfate adenylyltransferase, small subunit; PFAM: phosphoadenosine phosphosulfate reductase. (309 aa)
Mkms_4027PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: mmc:Mmcs_3953 glyoxalase/bleomycin resistance protein/dioxygenase. (155 aa)
mshBLmbE family protein; Catalyzes the deacetylation of 1D-myo-inositol 2-acetamido-2- deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway. (308 aa)
Mkms_4221Cystathionine gamma-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; DegT/DnrJ/EryC1/StrS aminotransferase; aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: mmc:Mmcs_4146 cystathionine gamma-synthase. (392 aa)
Mkms_4222PFAM: acyl-CoA dehydrogenase domain protein; Acyl-CoA dehydrogenase, type 2, C-terminal domain; KEGG: mmc:Mmcs_4147 acyl-CoA dehydrogenase-like protein. (389 aa)
Mkms_4224KEGG: mmc:Mmcs_4149 cystathionine beta-synthase; TIGRFAM: cystathionine beta-synthase; PFAM: CBS domain containing protein; Pyridoxal-5'-phosphate-dependent enzyme, beta subunit. (464 aa)
Mkms_4263PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: mmc:Mmcs_4197 pyridoxal-5'-phosphate-dependent enzyme, beta subunit. (369 aa)
Mkms_4297PFAM: AMP-dependent synthetase and ligase; KEGG: mmc:Mmcs_4231 AMP-dependent synthetase and ligase. (625 aa)
Mkms_4525PFAM: AMP-dependent synthetase and ligase; KEGG: mmc:Mmcs_4438 AMP-dependent synthetase and ligase. (565 aa)
Mkms_4548PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: mmc:Mmcs_4461 glyoxalase/bleomycin resistance protein/dioxygenase. (153 aa)
mshDGCN5-related N-acetyltransferase; Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol. (300 aa)
Mkms_4786TIGRFAM: acetoacetyl-CoA synthase; PFAM: AMP-dependent synthetase and ligase; KEGG: mmc:Mmcs_4700 acetoacetyl-CoA synthase. (643 aa)
acsAAcetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (660 aa)
Mkms_4913PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: mmc:Mmcs_4827 pyridoxal-5'-phosphate-dependent enzyme, beta subunit. (368 aa)
Mkms_4965KEGG: mmc:Mmcs_4876 hypothetical protein. (492 aa)
egtEAminotransferase, class V; Probably catalyzes the conversion of hercynylcysteine sulfoxide to ergothioneine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. EgtE subfamily. (375 aa)
egtDConserved hypothetical protein; Catalyzes the SAM-dependent triple methylation of the alpha- amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine; Belongs to the methyltransferase superfamily. EgtD family. (321 aa)
egtCConserved hypothetical protein; Catalyzes the hydrolysis of the gamma-glutamyl amide bond of hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide to produce hercynylcysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine. (235 aa)
egtBProtein of unknown function DUF323; Catalyzes the oxidative sulfurization of hercynine (N- alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma-L- glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine; Belongs to the EgtB family. (436 aa)
egtAGlutamate--cysteine ligase, GCS2; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). This compound is used as substrate for the biosynthesis of the low- molecular thiol compound ergothioneine. (424 aa)
Your Current Organism:
Mycobacterium sp. KMS
NCBI taxonomy Id: 189918
Other names: M. sp. KMS
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