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Mkms_0099 Mkms_0099 pckG pckG Mkms_0206 Mkms_0206 Mkms_0227 Mkms_0227 Mkms_0251 Mkms_0251 Mkms_0317 Mkms_0317 Mkms_0391 Mkms_0391 Mkms_0392 Mkms_0392 Mkms_0549 Mkms_0549 ackA ackA Mkms_0640 Mkms_0640 Mkms_0644 Mkms_0644 Mkms_1019 Mkms_1019 pdhA pdhA Mkms_1109 Mkms_1109 Mkms_1110 Mkms_1110 Mkms_1287 Mkms_1287 Mkms_1306 Mkms_1306 Mkms_1399 Mkms_1399 Mkms_1535 Mkms_1535 Mkms_1540 Mkms_1540 Mkms_1805 Mkms_1805 Mkms_1826 Mkms_1826 Mkms_1828 Mkms_1828 Mkms_1989 Mkms_1989 acyP acyP Mkms_2035 Mkms_2035 Mkms_2054 Mkms_2054 mqo mqo Mkms_2331 Mkms_2331 ppc ppc Mkms_2587 Mkms_2587 Mkms_2752 Mkms_2752 Mkms_2836 Mkms_2836 glcB glcB Mkms_3101 Mkms_3101 Mkms_3159 Mkms_3159 Mkms_3286 Mkms_3286 Mkms_3424 Mkms_3424 Mkms_3430 Mkms_3430 Mkms_3469 Mkms_3469 Mkms_3639 Mkms_3639 Mkms_3640 Mkms_3640 Mkms_3697 Mkms_3697 Mkms_3698 Mkms_3698 Mkms_3699 Mkms_3699 Mkms_3703 Mkms_3703 Mkms_3749 Mkms_3749 Mkms_3938 Mkms_3938 Mkms_4051 Mkms_4051 Mkms_4088 Mkms_4088 fumC fumC Mkms_4227 Mkms_4227 Mkms_4393 Mkms_4393 Mkms_4411 Mkms_4411 Mkms_4426 Mkms_4426 Mkms_4482 Mkms_4482 Mkms_4525 Mkms_4525 Mkms_4580 Mkms_4580 Mkms_4666 Mkms_4666 Mkms_4724 Mkms_4724 Mkms_4748 Mkms_4748 Mkms_4764 Mkms_4764 Mkms_4776 Mkms_4776 acsA acsA Mkms_4954 Mkms_4954 leuA leuA Mkms_5019 Mkms_5019 Mkms_5401 Mkms_5401
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
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Mkms_0099PFAM: aldehyde dehydrogenase; KEGG: mmc:Mmcs_0090 aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (470 aa)
pckGPhosphoenolpyruvate carboxykinase (GTP); Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (609 aa)
Mkms_0206PFAM: aldehyde dehydrogenase; KEGG: mmc:Mmcs_0197 aldehyde dehydrogenase. (525 aa)
Mkms_0227PFAM: aldehyde dehydrogenase; KEGG: mmc:Mmcs_0217 aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (491 aa)
Mkms_0251KEGG: mmc:Mmcs_0241 acetyl-CoA C-acyltransferase; TIGRFAM: acetyl-CoA acetyltransferases; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (433 aa)
Mkms_0317PFAM: aldehyde dehydrogenase; KEGG: mmc:Mmcs_0307 betaine-aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (472 aa)
Mkms_0391PFAM: Lactate/malate dehydrogenase; KEGG: mmc:Mmcs_0382 lactate/malate dehydrogenase; Belongs to the LDH/MDH superfamily. (329 aa)
Mkms_0392PFAM: pyruvate kinase; KEGG: mmc:Mmcs_0383 pyruvate kinase. (615 aa)
Mkms_0549Phosphotransacetylase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (704 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (399 aa)
Mkms_0640PFAM: aldehyde dehydrogenase; KEGG: mmc:Mmcs_0627 aldehyde dehydrogenase (NAD+); Belongs to the aldehyde dehydrogenase family. (507 aa)
Mkms_0644TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; glucose-inhibited division protein A; pyridine nucleotide-disulphide oxidoreductase dimerisation region; HI0933 family protein; KEGG: mmc:Mmcs_0631 dihydrolipoamide dehydrogenase. (466 aa)
Mkms_1019(S)-2-hydroxy-acid oxidase; PFAM: FMN-dependent alpha-hydroxy acid dehydrogenase; KEGG: mmc:Mmcs_1002 (S)-2-hydroxy-acid oxidase. (397 aa)
pdhAPyruvate dehydrogenase (acetyl-transferring); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (325 aa)
Mkms_1109Transketolase, central region; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (325 aa)
Mkms_1110PFAM: biotin/lipoyl attachment domain-containing protein; catalytic domain of components of various dehydrogenase complexes; E3 binding domain protein; KEGG: mmc:Mmcs_1093 catalytic domain of components of various dehydrogenase complexes. (399 aa)
Mkms_1287PFAM: aldehyde dehydrogenase; KEGG: mmc:Mmcs_1270 aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (529 aa)
Mkms_1306PFAM: biotin/lipoyl attachment domain-containing protein; ATP-dependent carboxylate-amine ligase domain protein, ATP-grasp; Carbamoyl-phosphate synthase L chain, ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; biotin carboxylase domain protein; KEGG: mmc:Mmcs_1289 carbamoyl-phosphate synthase L chain, ATP-binding protein. (602 aa)
Mkms_1399PFAM: biotin/lipoyl attachment domain-containing protein; KEGG: mmc:Mmcs_1381 biotin/lipoyl attachment. (71 aa)
Mkms_1535PFAM: CoA-binding domain protein; KEGG: mmc:Mmcs_1512 CoA-binding protein. (703 aa)
Mkms_1540KEGG: mmc:Mmcs_1517 acetyl-CoA C-acyltransferase; TIGRFAM: acetyl-CoA acetyltransferases; PFAM: Thiolase; 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal domain protein; Belongs to the thiolase-like superfamily. Thiolase family. (403 aa)
Mkms_1805KEGG: mmc:Mmcs_1758 acetyl-CoA C-acetyltransferase; TIGRFAM: acetyl-CoA acetyltransferases; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (404 aa)
Mkms_1826PFAM: Thiolase; KEGG: mmc:Mmcs_1779 thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (381 aa)
Mkms_1828PFAM: aldehyde dehydrogenase; KEGG: mmc:Mmcs_1781 aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (513 aa)
Mkms_1989Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1131 aa)
acyPPFAM: acylphosphatase; KEGG: mmc:Mmcs_1952 acylphosphatase. (94 aa)
Mkms_2035PFAM: FMN-dependent alpha-hydroxy acid dehydrogenase; KEGG: mmc:Mmcs_1989 FMN-dependent alpha-hydroxy acid dehydrogenase. (386 aa)
Mkms_2054PFAM: aldehyde dehydrogenase; KEGG: mmc:Mmcs_2008 aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (494 aa)
mqoMalate--quinone oxidoreductase; KEGG: mmc:Mmcs_2069 malate dehydrogenase (acceptor); TIGRFAM: malate--quinone oxidoreductase; PFAM: FAD dependent oxidoreductase; Malate:quinone-oxidoreductase. (516 aa)
Mkms_2331PFAM: beta-lactamase domain protein; KEGG: mmc:Mmcs_2284 beta-lactamase-like protein. (222 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (946 aa)
Mkms_2587PFAM: aldehyde dehydrogenase; KEGG: mmc:Mmcs_2542 aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (500 aa)
Mkms_2752KEGG: mmc:Mmcs_2708 hypothetical protein. (223 aa)
Mkms_2836KEGG: mmc:Mmcs_2792 acetyl-CoA acetyltransferase. (492 aa)
glcBMalate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (731 aa)
Mkms_3101PFAM: pyruvate kinase; KEGG: mmc:Mmcs_3042 pyruvate kinase; Belongs to the pyruvate kinase family. (472 aa)
Mkms_3159KEGG: mmc:Mmcs_3099 acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (410 aa)
Mkms_3286KEGG: mmc:Mmcs_3224 acetyl-CoA acetyltransferase. (474 aa)
Mkms_34242-oxo-acid dehydrogenase E1 subunit, homodimeric type; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (929 aa)
Mkms_3430Propionyl-CoA carboxylase; PFAM: carboxyl transferase; KEGG: mmc:Mmcs_3368 propionyl-CoA carboxylase. (473 aa)
Mkms_3469Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (798 aa)
Mkms_3639PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; KEGG: mmc:Mmcs_3566 thiamine pyrophosphate enzyme-like TPP-binding protein. (368 aa)
Mkms_3640PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: mmc:Mmcs_3567 pyruvate flavodoxin/ferredoxin oxidoreductase-like protein. (643 aa)
Mkms_3697PFAM: biotin/lipoyl attachment domain-containing protein; catalytic domain of components of various dehydrogenase complexes; E3 binding domain protein; KEGG: mmc:Mmcs_3624 catalytic domain of components of various dehydrogenase complexes. (384 aa)
Mkms_3698PFAM: Transketolase, central region; Transketolase domain protein; KEGG: mmc:Mmcs_3625 transketolase, central region. (349 aa)
Mkms_3699PFAM: dehydrogenase, E1 component; KEGG: mmc:Mmcs_3626 pyruvate dehydrogenase (lipoamide). (356 aa)
Mkms_3703PFAM: biotin/lipoyl attachment domain-containing protein; Carbamoyl-phosphate synthase L chain, ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; biotin carboxylase domain protein; KEGG: mmc:Mmcs_3630 carbamoyl-phosphate synthase L chain, ATP-binding protein. (662 aa)
Mkms_3749PFAM: aldehyde dehydrogenase; KEGG: mmc:Mmcs_3676 aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (501 aa)
Mkms_3938KEGG: mmc:Mmcs_3864 acetyl-CoA C-acetyltransferase; TIGRFAM: acetyl-CoA acetyltransferases; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (393 aa)
Mkms_4051PFAM: malic enzyme domain protein; malic enzyme, NAD-binding; KEGG: mmc:Mmcs_3977 malate dehydrogenase (oxaloacetate decarboxylating). (391 aa)
Mkms_4088PFAM: beta-lactamase domain protein; Rhodanese domain protein; KEGG: mmc:Mmcs_4014 beta-lactamase-like protein. (453 aa)
fumCFumarase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (473 aa)
Mkms_4227KEGG: mmc:Mmcs_4152 acetyl-CoA C-acyltransferase; TIGRFAM: acetyl-CoA acetyltransferases; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (405 aa)
Mkms_4393Pyruvate carboxylase; PFAM: biotin/lipoyl attachment domain-containing protein; Carbamoyl-phosphate synthase L chain, ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; biotin carboxylase domain protein; KEGG: mmc:Mmcs_4307 pyruvate carboxylase. (645 aa)
Mkms_4411KEGG: mmc:Mmcs_4325 acetyl-CoA acetyltransferase. (509 aa)
Mkms_4426PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: mmc:Mmcs_4340 thiamine pyrophosphate enzyme-like TPP binding region; Belongs to the TPP enzyme family. (574 aa)
Mkms_4482PFAM: aldehyde dehydrogenase; KEGG: mmc:Mmcs_4395 aldehyde dehydrogenase. (478 aa)
Mkms_4525PFAM: AMP-dependent synthetase and ligase; KEGG: mmc:Mmcs_4438 AMP-dependent synthetase and ligase. (565 aa)
Mkms_4580KEGG: mmc:Mmcs_4493 acetyl-CoA C-acyltransferase; TIGRFAM: acetyl-CoA acetyltransferases; PFAM: Thiolase; 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal domain protein; Belongs to the thiolase-like superfamily. Thiolase family. (403 aa)
Mkms_4666PFAM: aldehyde dehydrogenase; KEGG: mmc:Mmcs_4578 aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (489 aa)
Mkms_4724KEGG: mmc:Mmcs_4636 acetyl-CoA acyltransferase. (392 aa)
Mkms_4748Acetaldehyde dehydrogenase; Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds. (310 aa)
Mkms_4764KEGG: mmc:Mmcs_4678 acetyl-CoA C-acyltransferase; TIGRFAM: acetyl-CoA acetyltransferases; PFAM: Thiolase; 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal domain protein; Belongs to the thiolase-like superfamily. Thiolase family. (387 aa)
Mkms_4776KEGG: mmc:Mmcs_4690 acetyl-CoA C-acyltransferase; TIGRFAM: acetyl-CoA acetyltransferases; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (386 aa)
acsAAcetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (660 aa)
Mkms_4954PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; pyruvate ferredoxin/flavodoxin oxidoreductase; pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: mmc:Mmcs_4865 pyruvate:ferredoxin (flavodoxin) oxidoreductase. (1191 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (601 aa)
Mkms_5019PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: mmc:Mmcs_4931 glyoxalase/bleomycin resistance protein/dioxygenase. (145 aa)
Mkms_5401PFAM: beta-lactamase domain protein; Rhodanese domain protein; KEGG: mmc:Mmcs_5312 beta-lactamase-like protein. (459 aa)
Your Current Organism:
Mycobacterium sp. KMS
NCBI taxonomy Id: 189918
Other names: M. sp. KMS
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