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ANW20315.1 ANW20315.1 ANW20182.1 ANW20182.1 ANW20126.1 ANW20126.1 ANW20102.1 ANW20102.1 ANW20048.1 ANW20048.1 kdpC kdpC ANW21999.1 ANW21999.1 ANW19979.1 ANW19979.1 ANW19956.1 ANW19956.1 secA secA ANW19779.1 ANW19779.1 nuoD nuoD amfB amfB amfA amfA ANW17416.1 ANW17416.1 ANW17330.1 ANW17330.1 atkA atkA atkB atkB atkC atkC ANW17281.1 ANW17281.1 atpA1 atpA1 ANW18204.1 ANW18204.1 dasB dasB nuoN2 nuoN2 nuoM2 nuoM2 nuoL2 nuoL2 nuoK nuoK ANW17229.1 ANW17229.1 ANW21681.1 ANW21681.1 ANW21606.1 ANW21606.1 secF-2 secF-2 ANW21479.1 ANW21479.1 ANW21383.1 ANW21383.1 ANW21382.1 ANW21382.1 ANW21349.1 ANW21349.1 ANW21309.1 ANW21309.1 nuoJ2 nuoJ2 ANW18664.1 ANW18664.1 nuoB2 nuoB2 nuoA2 nuoA2 ANW21886.1 ANW21886.1 nuoN1 nuoN1 nuoM1 nuoM1 nuoL1 nuoL1 nuoK1 nuoK1 nuoJ1 nuoJ1 nuoG1 nuoG1 nuoF1 nuoF1 nuoD1 nuoD1 nuoC1 nuoC1 nuoB1 nuoB1 nuoA1 nuoA1 ANW18936.1 ANW18936.1 ANW18982.1 ANW18982.1 pstB pstB ANW19303.1 ANW19303.1 ANW19308.1 ANW19308.1 ANW21938.1 ANW21938.1 ANW19326.1 ANW19326.1 ANW19432.1 ANW19432.1 hppA hppA ANW19659.1 ANW19659.1 ANW21765.1 ANW21765.1 kdpA kdpA ANW21308.1 ANW21308.1 secF secF secD secD metN metN ANW20974.1 ANW20974.1 ctaD ctaD ANW20856.1 ANW20856.1 cobD cobD cobQ cobQ secG secG ANW20739.1 ANW20739.1 ANW20563.1 ANW20563.1 qcrC qcrC cox cox ANW20557.1 ANW20557.1 coxa coxa ANW20555.1 ANW20555.1 ANW20543.1 ANW20543.1 ANW20493.1 ANW20493.1 ANW22032.1 ANW22032.1 ANW20316.1 ANW20316.1 atpB atpB ANW18016.1 ANW18016.1 ANW17991.1 ANW17991.1 ANW17990.1 ANW17990.1 fbpC-2 fbpC-2 ANW17814.1 ANW17814.1 ANW17813.1 ANW17813.1 ANW17735.1 ANW17735.1 ANW17580.1 ANW17580.1 ANW17539.1 ANW17539.1 fbpC fbpC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ANW20315.1Multidrug ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (644 aa)
ANW20182.1Sugar ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (313 aa)
ANW20126.1ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (286 aa)
ANW20102.1ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (1275 aa)
ANW20048.1Ectoine/hydroxyectoine ABC transporter ATP-binding protein EhuA; Derived by automated computational analysis using gene prediction method: Protein Homology. (257 aa)
kdpCK+-transporting ATPase subunit B; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex. (206 aa)
ANW21999.1Preprotein translocase subunit SecA; Derived by automated computational analysis using gene prediction method: Protein Homology. (337 aa)
ANW19979.1Sugar transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (344 aa)
ANW19956.1ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (469 aa)
secAPreprotein translocase subunit SecA; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. (935 aa)
ANW19779.1Cobalt ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (255 aa)
nuoDNADH-quinone oxidoreductase subunit D; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I 49 kDa subunit family. (380 aa)
amfBHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (885 aa)
amfAABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (585 aa)
ANW17416.1Glutamate ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (248 aa)
ANW17330.1Sugar ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (509 aa)
atkAK+-transporting ATPase subunit A; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane. (554 aa)
atkBK+-transporting ATPase subunit B; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily. (701 aa)
atkCPotassium-transporting ATPase subunit C; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex. (226 aa)
ANW17281.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0225 family. (153 aa)
atpA1F0F1 ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. (532 aa)
ANW18204.1Ectoine/hydroxyectoine ABC transporter ATP-binding protein EhuA; Derived by automated computational analysis using gene prediction method: Protein Homology. (255 aa)
dasBSugar ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (338 aa)
nuoN2NADH-quinone oxidoreductase subunit N; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 2 family. (548 aa)
nuoM2NADH-quinone oxidoreductase subunit M; Derived by automated computational analysis using gene prediction method: Protein Homology. (544 aa)
nuoL2NADH dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (669 aa)
nuoKNADH-quinone oxidoreductase subunit K; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 4L family. (129 aa)
ANW17229.1Teichoic acid ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (261 aa)
ANW21681.1ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (633 aa)
ANW21606.1ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (275 aa)
secF-2Protein translocase subunit SecDF; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA; Belongs to the SecD/SecF family. SecD subfamily. (763 aa)
ANW21479.1ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (332 aa)
ANW21383.1ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (549 aa)
ANW21382.1ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (537 aa)
ANW21349.1Multidrug ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (604 aa)
ANW21309.1ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (625 aa)
nuoJ2NADH dehydrogenase; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (218 aa)
ANW18664.1Dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (413 aa)
nuoB2NADH-quinone oxidoreductase subunit B; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (239 aa)
nuoA2NADH-quinone oxidoreductase subunit A; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 3 family. (157 aa)
ANW21886.1ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (309 aa)
nuoN1NADH-quinone oxidoreductase subunit N; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 2 family. (549 aa)
nuoM1NADH-quinone oxidoreductase subunit M; Derived by automated computational analysis using gene prediction method: Protein Homology. (523 aa)
nuoL1NADH-quinone oxidoreductase subunit L; Derived by automated computational analysis using gene prediction method: Protein Homology. (634 aa)
nuoK1NADH-quinone oxidoreductase subunit K; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 4L family. (99 aa)
nuoJ1NADH:ubiquinone oxidoreductase subunit J; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (305 aa)
nuoG1NADH-quinone oxidoreductase subunit G; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. Belongs to the complex I 75 kDa subunit family. (839 aa)
nuoF1NADH oxidoreductase (quinone) subunit F; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Belongs to the complex I 51 kDa subunit family. (458 aa)
nuoD1NADH dehydrogenase subunit D; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I 49 kDa subunit family. (448 aa)
nuoC1NADH-quinone oxidoreductase subunit C; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I 30 kDa subunit family. (242 aa)
nuoB1NADH dehydrogenase; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (184 aa)
nuoA1NADH-quinone oxidoreductase subunit A; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 3 family. (119 aa)
ANW18936.1Copper-translocating P-type ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology. (753 aa)
ANW18982.1Sugar ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily. (378 aa)
pstBPhosphate ABC transporter ATP-binding protein; Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family. (258 aa)
ANW19303.1ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (1238 aa)
ANW19308.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (299 aa)
ANW21938.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (239 aa)
ANW19326.1Topoisomerase II; Derived by automated computational analysis using gene prediction method: Protein Homology. (329 aa)
ANW19432.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (156 aa)
hppASodium-translocating pyrophosphatase; Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force. (803 aa)
ANW19659.1ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (766 aa)
ANW21765.1Sugar ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (287 aa)
kdpAK+-transporting ATPase subunit A; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane. (554 aa)
ANW21308.1Multidrug ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (603 aa)
secFProtein-export membrane protein SecF; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. (373 aa)
secDProtein-export membrane protein SecD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. (577 aa)
metNMethionine ABC transporter ATP-binding protein; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. (341 aa)
ANW20974.1Multidrug ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (537 aa)
ctaDCytochrome c oxidase subunit I; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B. (569 aa)
ANW20856.1ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (848 aa)
cobDCobalamin biosynthesis protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (324 aa)
cobQCobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (523 aa)
secGPreprotein translocase subunit SecG; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. (75 aa)
ANW20739.1FeS-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (143 aa)
ANW20563.1Ubiquinol-cytochrome c reductase cytochrome b subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (546 aa)
qcrCCystathionine beta-lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (270 aa)
coxDerived by automated computational analysis using gene prediction method: Protein Homology. (205 aa)
ANW20557.1Cytochrome C oxidase subunit IV; Part of cytochrome c oxidase, its function is unknown. Belongs to the cytochrome c oxidase bacterial subunit CtaF family. (132 aa)
coxaCytochrome c oxidase subunit I; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B. (579 aa)
ANW20555.1Cytochrome c oxidase subunit II; Derived by automated computational analysis using gene prediction method: Protein Homology. (321 aa)
ANW20543.1ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (624 aa)
ANW20493.1ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (313 aa)
ANW22032.1Sugar ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (317 aa)
ANW20316.1Multidrug ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (577 aa)
atpBF0F1 ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. (481 aa)
ANW18016.1Amino acid ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (287 aa)
ANW17991.1ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (643 aa)
ANW17990.1ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (638 aa)
fbpC-2Iron ABC transporter ATP-binding protein; Part of the ABC transporter complex FbpABC involved in Fe(3+) ions import. Responsible for energy coupling to the transport system. (340 aa)
ANW17814.1Spermidine/putrescine ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily. (406 aa)
ANW17813.1ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (311 aa)
ANW17735.1Glutamate ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (261 aa)
ANW17580.1ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (307 aa)
ANW17539.1Transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (321 aa)
fbpCABC transporter; Part of the ABC transporter complex FbpABC involved in Fe(3+) ions import. Responsible for energy coupling to the transport system. (368 aa)
Your Current Organism:
Streptomyces clavuligerus
NCBI taxonomy Id: 1901
Other names: ATCC 27064, BCRC 11518, CBS 226.75, CCRC 11518, CCRC:11518, CECT 3125, DSM 40751, DSM 738, IFO 13307, IMET 43657, JCM 4710, KCTC 9095, NBRC 13307, NCIMB 12785, NCIMB 14335, NRRL 3585, S. clavuligerus, Streptomyces clavuligerus ATCC 27064, Streptomyces clavuligerus NRRL 3585, VKM Ac-602
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