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BB341_23540 BB341_23540 ANW21019.1 ANW21019.1 pdxT pdxT aroQ aroQ ANW21128.1 ANW21128.1 ANW21142.1 ANW21142.1 ANW21163.1 ANW21163.1 ANW21188.1 ANW21188.1 gcsP gcsP nagB nagB ANW21590.1 ANW21590.1 ANW21591.1 ANW21591.1 ANW21628.1 ANW21628.1 hutH1 hutH1 pckG pckG ANW18397.1 ANW18397.1 ANW18282.1 ANW18282.1 ANW18176.1 ANW18176.1 ORF12 ORF12 glyA-3 glyA-3 ANW18039.1 ANW18039.1 glyA-2 glyA-2 gcvH gcvH gcvT gcvT ANW17927.1 ANW17927.1 ANW17883.1 ANW17883.1 ANW17609.1 ANW17609.1 arcA arcA ANW17573.1 ANW17573.1 ANW17572.1 ANW17572.1 ANW17419.1 ANW17419.1 ANW17361.1 ANW17361.1 ANW17251.1 ANW17251.1 ANW17250.1 ANW17250.1 tdh tdh ANW16906.1 ANW16906.1 ANW16950.1 ANW16950.1 hutH2 hutH2 ANW17037.1 ANW17037.1 ANW17060.1 ANW17060.1 ANW17192.1 ANW17192.1 ANW17249.1 ANW17249.1 ANW18683.1 ANW18683.1 ANW21897.1 ANW21897.1 ANW18807.1 ANW18807.1 ANW18845.1 ANW18845.1 dtd dtd ANW19071.1 ANW19071.1 ANW19084.1 ANW19084.1 paaA paaA paaB paaB ANW19205.1 ANW19205.1 ANW19338.1 ANW19338.1 ANW19374.1 ANW19374.1 kynA kynA kynU kynU gadB gadB ANW19862.1 ANW19862.1 hutU hutU hutI hutI ANW19953.1 ANW19953.1 ANW19992.1 ANW19992.1 glyA glyA hpcE hpcE ANW20127.1 ANW20127.1 ANW20401.1 ANW20401.1 ltp ltp ANW20434.1 ANW20434.1 ANW20480.1 ANW20480.1 ANW20670.1 ANW20670.1 ANW20681.1 ANW20681.1 kdgD kdgD ectD ectD ANW20809.1 ANW20809.1 ANW22068.1 ANW22068.1 ANW20931.1 ANW20931.1 hmgA hmgA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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BB341_23540Carboxylate--amine ligase; Incomplete; partial on complete genome; missing stop; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the mandelate racemase/muconate lactonizing enzyme family. (439 aa)
ANW21019.1Alanine racemase; Derived by automated computational analysis using gene prediction method: Protein Homology. (400 aa)
pdxTGlutamine amidotransferase subunit PdxT; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (197 aa)
aroQ3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (146 aa)
ANW21128.1Phosphopantothenoylcysteine decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (400 aa)
ANW21142.1Amine oxidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (563 aa)
ANW21163.1Amidohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (545 aa)
ANW21188.1Lipid-transfer protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (405 aa)
gcsPGlycine dehydrogenase (aminomethyl-transferring); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (961 aa)
nagBGlucosamine-6-phosphate deaminase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion; Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily. (260 aa)
ANW21590.1Lipid-transfer protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (354 aa)
ANW21591.1acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology. (388 aa)
ANW21628.1phytanoyl-CoA dioxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (341 aa)
hutH1Histidine ammonia-lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (515 aa)
pckGPhosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (621 aa)
ANW18397.1Amino acid deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. (424 aa)
ANW18282.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (259 aa)
ANW18176.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (311 aa)
ORF12MBL fold metallo-hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (338 aa)
glyA-3Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (453 aa)
ANW18039.1acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (401 aa)
glyA-2Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (419 aa)
gcvHGlycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (125 aa)
gcvTGlycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. (371 aa)
ANW17927.1Proline dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (308 aa)
ANW17883.12-hydroxyhepta-2,4-diene-1,7-dioate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (258 aa)
ANW17609.15-carboxymethyl-2-hydroxymuconate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (274 aa)
arcAArginine deiminase; Catalyzes the degradation of arginine to citruline and ammonia; Derived by automated computational analysis using gene prediction method: Protein Homology. (410 aa)
ANW17573.13-hydroxyacyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (709 aa)
ANW17572.1acetyl-CoA acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (406 aa)
ANW17419.1MBL fold metallo-hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (208 aa)
ANW17361.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (256 aa)
ANW17251.1Carnitine dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CoA-transferase III family. (394 aa)
ANW17250.1acetyl-CoA acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (404 aa)
tdhL-threonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family. (342 aa)
ANW16906.1Catalyzes the thiolytic cleavage of beta-ketoadipyl-CoA to succinate and acetyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (394 aa)
ANW16950.1Histidine ammonia-lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (559 aa)
hutH2Histidine ammonia-lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (495 aa)
ANW17037.1Dimethylhistidine N-methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (325 aa)
ANW17060.1Amidohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (283 aa)
ANW17192.1Flavoprotein; Derived by automated computational analysis using gene prediction method: Protein Homology. (201 aa)
ANW17249.13-hydroxyacyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (749 aa)
ANW18683.1Fumarylacetoacetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (409 aa)
ANW21897.1acetyl-CoA acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (389 aa)
ANW18807.1Cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology. (308 aa)
ANW18845.1Lipid-transfer protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (382 aa)
dtdD-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. (138 aa)
ANW19071.12-hydroxyhepta-2,4-diene-1,7-dioate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (258 aa)
ANW19084.1Valine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (363 aa)
paaA1,2-phenylacetyl-CoA epoxidase subunit A; Derived by automated computational analysis using gene prediction method: Protein Homology. (324 aa)
paaB1,2-phenylacetyl-CoA epoxidase subunit B; Derived by automated computational analysis using gene prediction method: Protein Homology. (96 aa)
ANW19205.1phenylacetate-CoA oxygenase subunit PaaI; Derived by automated computational analysis using gene prediction method: Protein Homology. (238 aa)
ANW19338.1Lipid-transfer protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (388 aa)
ANW19374.1Amidohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (665 aa)
kynATryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. (275 aa)
kynUHydrolase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. (464 aa)
gadBGlutamate decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the group II decarboxylase family. (474 aa)
ANW19862.1acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (406 aa)
hutUUrocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate. (555 aa)
hutIImidazolonepropionase; Derived by automated computational analysis using gene prediction method: Protein Homology. (390 aa)
ANW19953.1NAD-glutamate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1651 aa)
ANW19992.14-hydroxyphenylpyruvate dioxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (381 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (430 aa)
hpcE2-hydroxyhepta-2,4-diene-1,7-dioate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (292 aa)
ANW20127.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (306 aa)
ANW20401.1acetyl-CoA acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (389 aa)
ltpNonspecific lipid-transfer protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (397 aa)
ANW20434.1Alcohol dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (329 aa)
ANW20480.1Amidohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (526 aa)
ANW20670.1acyl-CoA transferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CoA-transferase III family. (434 aa)
ANW20681.1acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (385 aa)
kdgD5-dehydro-4-deoxyglucarate dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the DapA family. (314 aa)
ectDEctoine hydroxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (297 aa)
ANW20809.1Amidohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (363 aa)
ANW22068.1Alanine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (371 aa)
ANW20931.1formyl-CoA transferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CoA-transferase III family. (414 aa)
hmgAHomogentisate 1,2-dioxygenase; Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate. (452 aa)
Your Current Organism:
Streptomyces clavuligerus
NCBI taxonomy Id: 1901
Other names: ATCC 27064, BCRC 11518, CBS 226.75, CCRC 11518, CCRC:11518, CECT 3125, DSM 40751, DSM 738, IFO 13307, IMET 43657, JCM 4710, KCTC 9095, NBRC 13307, NCIMB 12785, NCIMB 14335, NRRL 3585, S. clavuligerus, Streptomyces clavuligerus ATCC 27064, Streptomyces clavuligerus NRRL 3585, VKM Ac-602
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