STRINGSTRING
ANW16915.1 ANW16915.1 ANW16989.1 ANW16989.1 ANW16990.1 ANW16990.1 ANW17041.1 ANW17041.1 ANW17091.1 ANW17091.1 ANW17119.1 ANW17119.1 ANW17120.1 ANW17120.1 ANW17147.1 ANW17147.1 ANW17156.1 ANW17156.1 ANW17166.1 ANW17166.1 ANW17222.1 ANW17222.1 ANW17223.1 ANW17223.1 whmD whmD ANW17312.1 ANW17312.1 ANW17335.1 ANW17335.1 pqqE pqqE ANW17379.1 ANW17379.1 ANW17460.1 ANW17460.1 ANW17488.1 ANW17488.1 ANW17495.1 ANW17495.1 ANW17526.1 ANW17526.1 ANW17528.1 ANW17528.1 acnA acnA ANW17639.1 ANW17639.1 miaB miaB rimO rimO ispG ispG rlmN rlmN leuC leuC ANW21837.1 ANW21837.1 sdhL sdhL ANW18059.1 ANW18059.1 fd fd wblE wblE whiB whiB ANW18296.1 ANW18296.1 ANW18312.1 ANW18312.1 ANW18336.1 ANW18336.1 ispH ispH wblI wblI ANW21860.1 ANW21860.1 ANW18514.1 ANW18514.1 nuoI2 nuoI2 nuoB2 nuoB2 nuoI1 nuoI1 nuoG1 nuoG1 nuoF1 nuoF1 nuoE1 nuoE1 nuoB1 nuoB1 mqnC mqnC mqnE mqnE ANW18743.1 ANW18743.1 fbiC fbiC ANW18875.1 ANW18875.1 purF purF ANW19125.1 ANW19125.1 ANW19137.1 ANW19137.1 ANW19144.1 ANW19144.1 ANW21931.1 ANW21931.1 ANW19206.1 ANW19206.1 thiA thiA ANW19462.1 ANW19462.1 ANW19469.1 ANW19469.1 wblA wblA nth nth ANW19592.1 ANW19592.1 whiB-2 whiB-2 ANW19710.1 ANW19710.1 ilvD ilvD whiB-3 whiB-3 ANW19982.1 ANW19982.1 ANW21992.1 ANW21992.1 ANW20158.1 ANW20158.1 ANW22009.1 ANW22009.1 ANW20233.1 ANW20233.1 ANW20234.1 ANW20234.1 ANW20261.1 ANW20261.1 ANW20409.1 ANW20409.1 lipA lipA nadA nadA ANW22041.1 ANW22041.1 ANW20554.1 ANW20554.1 ANW20562.1 ANW20562.1 ANW20592.1 ANW20592.1 ANW20675.1 ANW20675.1 gltD gltD ANW20710.1 ANW20710.1 ANW20739.1 ANW20739.1 hcaC hcaC ANW20771.1 ANW20771.1 ANW22061.1 ANW22061.1 ANW20795.1 ANW20795.1 moaA1 moaA1 ANW20915.1 ANW20915.1 ANW20990.1 ANW20990.1 ANW21222.1 ANW21222.1 bioB bioB BB341_25550 BB341_25550 ANW21436.1 ANW21436.1 ANW21438.1 ANW21438.1 whiB-4 whiB-4 ANW21538.1 ANW21538.1 ANW21539.1 ANW21539.1 ANW21550.1 ANW21550.1 ANW21638.1 ANW21638.1 ANW21712.1 ANW21712.1 ANW16736.1 ANW16736.1 ANW16786.1 ANW16786.1 fdxA fdxA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ANW16915.1Radical SAM/SPASM domain-containing protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (492 aa)
ANW16989.1Coproporphyrinogen III oxidase; Catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; Derived by automated computational analysis using gene prediction method: Protein Homology. (468 aa)
ANW16990.1Radical SAM protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (286 aa)
ANW17041.1Succinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (248 aa)
ANW17091.1Radical SAM protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (367 aa)
ANW17119.1Iron-sulfur cluster-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (475 aa)
ANW17120.1Fe-S oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (272 aa)
ANW17147.1B12-binding domain-containing radical SAM protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (554 aa)
ANW17156.1stearoyl-CoA 9-desaturase; Derived by automated computational analysis using gene prediction method: Protein Homology. (353 aa)
ANW17166.1Radical SAM protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (688 aa)
ANW17222.1Hopanoid biosynthesis associated radical SAM protein HpnH; Derived by automated computational analysis using gene prediction method: Protein Homology. (340 aa)
ANW17223.11-hydroxy-2-methyl-2-butenyl 4-diphosphate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (245 aa)
whmDTranscriptional regulator; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA. (82 aa)
ANW17312.1Radical SAM protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (264 aa)
ANW17335.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (131 aa)
pqqEPyrroloquinoline quinone biosynthesis protein PqqE; Catalyzes the cross-linking of a glutamate residue and a tyrosine residue in the PqqA protein as part of the biosynthesis of pyrroloquinoline quinone (PQQ). (433 aa)
ANW17379.1Radical SAM protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (348 aa)
ANW17460.1Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (832 aa)
ANW17488.1(2Fe-2S)-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (190 aa)
ANW17495.1Iron-sulfur protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (281 aa)
ANW17526.1Sulfite reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (565 aa)
ANW17528.1Phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. (232 aa)
acnAAconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (908 aa)
ANW17639.1RNA methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (448 aa)
miaBtRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase MiaB; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine. (506 aa)
rimORibosomal protein S12 methylthiotransferase RimO; Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12; Belongs to the methylthiotransferase family. RimO subfamily. (499 aa)
ispG4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (384 aa)
rlmN23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs; Belongs to the radical SAM superfamily. RlmN family. (368 aa)
leuC3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (475 aa)
ANW21837.1Cysteine desulfurase; Derived by automated computational analysis using gene prediction method: Protein Homology. (387 aa)
sdhLL-serine ammonia-lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (455 aa)
ANW18059.1Radical SAM protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (338 aa)
fdFerredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (65 aa)
wblEWhiB family transcriptional regulator; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA. (85 aa)
whiBDNA-binding protein; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA. (122 aa)
ANW18296.1Sodium:proton antiporter; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family. (377 aa)
ANW18312.1Ferredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. (105 aa)
ANW18336.1Succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (255 aa)
ispH4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (346 aa)
wblIWhiB family transcriptional regulator; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA. (117 aa)
ANW21860.1Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (562 aa)
ANW18514.1Succinate dehydrogenase iron-sulfur subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (252 aa)
nuoI2NADH-quinone oxidoreductase subunit I; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (212 aa)
nuoB2NADH-quinone oxidoreductase subunit B; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (239 aa)
nuoI1NADH-quinone oxidoreductase subunit I; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (206 aa)
nuoG1NADH-quinone oxidoreductase subunit G; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. Belongs to the complex I 75 kDa subunit family. (839 aa)
nuoF1NADH oxidoreductase (quinone) subunit F; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Belongs to the complex I 51 kDa subunit family. (458 aa)
nuoE1NADH-quinone oxidoreductase subunit E; Derived by automated computational analysis using gene prediction method: Protein Homology. (282 aa)
nuoB1NADH dehydrogenase; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (184 aa)
mqnCDehypoxanthine futalosine cyclase; Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2). (399 aa)
mqnEAminofutalosine synthase MqnE; Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate. (387 aa)
ANW18743.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (60 aa)
fbiCHypothetical protein; Incomplete; partial on complete genome; missing stop; Derived by automated computational analysis using gene prediction method: Protein Homology. (864 aa)
ANW18875.1Dimethylmenaquinone methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1001 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (505 aa)
ANW19125.1Radical activating enzyme; Derived by automated computational analysis using gene prediction method: Protein Homology. (291 aa)
ANW19137.1Fe-S cluster assembly protein HesB; Derived by automated computational analysis using gene prediction method: Protein Homology. (198 aa)
ANW19144.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (219 aa)
ANW21931.1phenylacetate-CoA oxygenase subunit PaaJ; Derived by automated computational analysis using gene prediction method: Protein Homology. (158 aa)
ANW19206.1Phenylacetic acid degradation protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (351 aa)
thiAPhosphomethylpyrimidine synthase ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (592 aa)
ANW19462.1Fe-S oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (773 aa)
ANW19469.1(2Fe-2S)-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (106 aa)
wblATranscriptional regulator; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA. (114 aa)
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (284 aa)
ANW19592.1Aminotransferase class V; Derived by automated computational analysis using gene prediction method: Protein Homology. (439 aa)
whiB-2Transcription factor WhiB; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA. (190 aa)
ANW19710.1Adenine glycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (302 aa)
ilvDDihydroxy-acid dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family. (618 aa)
whiB-3Transcription factor WhiB; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA. (87 aa)
ANW19982.1Dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (298 aa)
ANW21992.1Aldehyde oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (326 aa)
ANW20158.1CRISPR-associated protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (173 aa)
ANW22009.12Fe-2S ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (379 aa)
ANW20233.1B12-binding domain-containing radical SAM protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (651 aa)
ANW20234.1Radical SAM protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (251 aa)
ANW20261.1Coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (410 aa)
ANW20409.1Ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (77 aa)
lipALipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (325 aa)
nadAQuinolinate synthetase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (394 aa)
ANW22041.1Iron-sulfur cluster insertion protein ErpA; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the HesB/IscA family. (118 aa)
ANW20554.1Cysteine desulfurase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the sulfur carrier protein TusA family. (455 aa)
ANW20562.1Ubiquinol-cytochrome C reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (360 aa)
ANW20592.1[Fe-S]-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (84 aa)
ANW20675.1Glutamate synthase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (1526 aa)
gltDGlutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate; Derived by automated computational analysis using gene prediction method: Protein Homology. (486 aa)
ANW20710.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (791 aa)
ANW20739.1FeS-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (143 aa)
hcaCRieske (2Fe-2S) protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (105 aa)
ANW20771.1SUF system NifU family Fe-S cluster assembly protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (154 aa)
ANW22061.1Metal-sulfur cluster biosynthetic enzyme; Derived by automated computational analysis using gene prediction method: Protein Homology. (104 aa)
ANW20795.1Dihydroxy-acid dehydratase; Catalyzes the formation of 3-methyl-2-oxobutanoate from 2,3,-dihydroxy-3-methylbutanoate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family. (642 aa)
moaA1Cyclic pyranopterin phosphate synthase; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (329 aa)
ANW20915.1FxsB family radical SAM/SPASM domain protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (877 aa)
ANW20990.1Ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (103 aa)
ANW21222.1Rieske (2Fe-2S) protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (155 aa)
bioBBiotin synthase BioB; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (428 aa)
BB341_255502-oxoacid:ferredoxin oxidoreductase subunit beta; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. (108 aa)
ANW21436.1Thioredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (157 aa)
ANW21438.1Hydrogenase expression protein HypE; Derived by automated computational analysis using gene prediction method: Protein Homology. (360 aa)
whiB-4Hypothetical protein; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA. (83 aa)
ANW21538.1Radical SAM protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (521 aa)
ANW21539.1Radical SAM protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (420 aa)
ANW21550.1Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (150 aa)
ANW21638.1Ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (72 aa)
ANW21712.1(2Fe-2S)-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (355 aa)
ANW16736.1Iron-sulfur protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (286 aa)
ANW16786.1(2Fe-2S)-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (379 aa)
fdxAFerredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (68 aa)
Your Current Organism:
Streptomyces clavuligerus
NCBI taxonomy Id: 1901
Other names: ATCC 27064, BCRC 11518, CBS 226.75, CCRC 11518, CCRC:11518, CECT 3125, DSM 40751, DSM 738, IFO 13307, IMET 43657, JCM 4710, KCTC 9095, NBRC 13307, NCIMB 12785, NCIMB 14335, NRRL 3585, S. clavuligerus, Streptomyces clavuligerus ATCC 27064, Streptomyces clavuligerus NRRL 3585, VKM Ac-602
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