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APV48208.1 APV48208.1 APV48210.1 APV48210.1 nirA nirA APV48212.1 APV48212.1 APV48645.1 APV48645.1 APV48651.1 APV48651.1 ilvD ilvD APV49109.1 APV49109.1 APV49219.1 APV49219.1 APV49245.1 APV49245.1 APV49275.1 APV49275.1 APV49286.1 APV49286.1 APV49858.1 APV49858.1 sucC sucC sucD sucD APV49870.1 APV49870.1 APV49871.1 APV49871.1 gabD gabD APV49950.1 APV49950.1 APV50025.1 APV50025.1 APV52396.1 APV52396.1 APV50321.1 APV50321.1 ilvE ilvE APV50602.1 APV50602.1 APV50603.1 APV50603.1 APV52440.1 APV52440.1 APV51014.1 APV51014.1 APV52486.1 APV52486.1 fumC fumC APV51140.1 APV51140.1 APV52498.1 APV52498.1 leuD leuD leuC leuC APV51161.1 APV51161.1 APV51162.1 APV51162.1 APV51174.1 APV51174.1 APV51322.1 APV51322.1 APV51325.1 APV51325.1 APV51326.1 APV51326.1 APV51327.1 APV51327.1 APV51328.1 APV51328.1 sdhB sdhB APV51330.1 APV51330.1 APV51331.1 APV51331.1 APV51332.1 APV51332.1 APV51341.1 APV51341.1 APV51345.1 APV51345.1 mdh mdh APV51527.1 APV51527.1 APV51565.1 APV51565.1 leuB leuB leuD-2 leuD-2 leuC-2 leuC-2 APV51657.1 APV51657.1 APV51662.1 APV51662.1 APV51726.1 APV51726.1 BWI17_19775 BWI17_19775 APV51810.1 APV51810.1 leuA leuA ilvC ilvC APV51820.1 APV51820.1 APV52568.1 APV52568.1 APV51839.1 APV51839.1 APV52046.1 APV52046.1 APV52596.1 APV52596.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
APV48208.1Nitrate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily. (907 aa)
APV48210.1Assimilatory nitrite reductase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (405 aa)
nirAFerredoxin-dependent assimilatory nitrite reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (587 aa)
APV48212.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (525 aa)
APV48645.1Alpha-hydroxy-acid oxidizing enzyme; Derived by automated computational analysis using gene prediction method: Protein Homology. (382 aa)
APV48651.1Dihydroxy-acid dehydratase; Catalyzes the formation of 3-methyl-2-oxobutanoate from 2,3,-dihydroxy-3-methylbutanoate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family. (568 aa)
ilvDDihydroxy-acid dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family. (557 aa)
APV49109.1Rubredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (65 aa)
APV49219.1Glutamate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (1554 aa)
APV49245.1FAD-linked oxidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1258 aa)
APV49275.1Type I glutamate--ammonia ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (469 aa)
APV49286.1Malate synthase A; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the malate synthase family. (531 aa)
APV49858.1methionyl-tRNA formyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (310 aa)
sucCsuccinate--CoA ligase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (388 aa)
sucDsuccinate--CoA ligase subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (291 aa)
APV49870.1NADH-quinone oxidoreductase subunit F; Derived by automated computational analysis using gene prediction method: Protein Homology. (562 aa)
APV49871.1Formate dehydrogenase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (936 aa)
gabDSuccinate-semialdehyde dehydrogenase (NADP(+)); Catalyzes the formation of succinate from succinate semialdehyde; NADP dependent; Derived by automated computational analysis using gene prediction method: Protein Homology. (495 aa)
APV49950.1Tartrate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (351 aa)
APV50025.1NAD-dependent succinate-semialdehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (486 aa)
APV52396.1Thiamine pyrophosphate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. (554 aa)
APV50321.1Tartrate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (360 aa)
ilvEBranched chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (307 aa)
APV50602.1Formate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (975 aa)
APV50603.1Formate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (206 aa)
APV52440.1Formate dehydrogenase subunit gamma; Derived by automated computational analysis using gene prediction method: Protein Homology. (360 aa)
APV51014.1NAD-dependent malic enzyme; Derived by automated computational analysis using gene prediction method: Protein Homology. (550 aa)
APV52486.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (116 aa)
fumCFumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (463 aa)
APV51140.1Isocitrate dehydrogenase; Catalyzes the formation of 2-oxoglutarate from isocitrate; Derived by automated computational analysis using gene prediction method: Protein Homology. (345 aa)
APV52498.1Acetolactate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. (544 aa)
leuD3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (197 aa)
leuC3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (464 aa)
APV51161.12-oxoglutarate ferredoxin oxidoreductase subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. (351 aa)
APV51162.1Ferredoxin oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (618 aa)
APV51174.1Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (609 aa)
APV51322.1Dihydrolipoyl dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (477 aa)
APV51325.1Dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (417 aa)
APV51326.12-oxoglutarate dehydrogenase E1 component; Derived by automated computational analysis using gene prediction method: Protein Homology. (947 aa)
APV51327.1Citrate (Si)-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. (434 aa)
APV51328.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (79 aa)
sdhBPart of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (231 aa)
APV51330.1Succinate dehydrogenase flavoprotein subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (588 aa)
APV51331.1Succinate dehydrogenase, hydrophobic membrane anchor protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (118 aa)
APV51332.1Succinate dehydrogenase, cytochrome b556 subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (132 aa)
APV51341.1Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (905 aa)
APV51345.1Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (880 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (327 aa)
APV51527.1Dihydroxy-acid dehydratase; Catalyzes the formation of 3-methyl-2-oxobutanoate from 2,3,-dihydroxy-3-methylbutanoate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family. (575 aa)
APV51565.1Dihydrolipoyl dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (469 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (354 aa)
leuD-23-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (212 aa)
leuC-23-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (469 aa)
APV51657.1NADP-dependent malic enzyme; NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate; Derived by automated computational analysis using gene prediction method: Protein Homology. (759 aa)
APV51662.1Indolepyruvate ferredoxin oxidoreductase; Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates; Derived by automated computational analysis using gene prediction method: Protein Homology. (1177 aa)
APV51726.1Pyruvate dehydrogenase (acetyl-transferring), homodimeric type; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (886 aa)
BWI17_19775Dihydrolipoyllysine-residue acetyltransferase; Incomplete; partial on complete genome; missing start; Derived by automated computational analysis using gene prediction method: Protein Homology. (602 aa)
APV51810.1Isocitrate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (404 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (520 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (338 aa)
APV51820.1Acetolactate synthase small subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (163 aa)
APV52568.1Acetolactate synthase, large subunit, biosynthetic type; Derived by automated computational analysis using gene prediction method: Protein Homology. (575 aa)
APV51839.1Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (504 aa)
APV52046.1Derived by automated computational analysis using gene prediction method: Protein Homology. (487 aa)
APV52596.12-nitropropane dioxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (389 aa)
Your Current Organism:
Betaproteobacteria bacterium GR1643
NCBI taxonomy Id: 1904640
Other names: B. bacterium GR16-43, Betaproteobacteria bacterium GR16-43, Nnibrrimonas geomnyongensis
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