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gyrA gyrA pitA pitA ispF ispF trpB trpB gcd-2 gcd-2 trpE trpE trpD trpD trpC trpC atpD atpD ipk ipk rpoA rpoA trpE-2 trpE-2 gapA gapA trpS trpS lytB lytB pstA pstA pstS pstS gcd gcd metE metE
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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gyrADNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (899 aa)
pitATransport protein; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. (375 aa)
ispF2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (163 aa)
trpBTryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (405 aa)
gcd-2Glucose dehydrogenase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. (824 aa)
trpEAnthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (491 aa)
trpDAnthranilate synthase component II; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (345 aa)
trpCIndole-3-glycerol phosphate synthase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark; Belongs to the TrpC family. (265 aa)
atpDATP synthase beta chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (468 aa)
ipk4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (295 aa)
rpoARNA polymerase alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (332 aa)
trpE-2Anthranilate synthase component I; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. (451 aa)
gapAGlyceraldehyde-3-phosphate dehydrogenase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (333 aa)
trpStryptophanyl-tRNA synthetase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. (431 aa)
lytBPenicillin tolerance protein; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (316 aa)
pstAABC transporter phosphate permease; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. (287 aa)
pstSABC transporter phosphate binding protein; Part of the ABC transporter complex PstSACB involved in phosphate import; Belongs to the PstS family. (363 aa)
gcdGlucose dehydrogenase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. (823 aa)
metE5-methyltetrahydropteroyltriglutamate- homocysteine methyltransferase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. (343 aa)
Your Current Organism:
Xanthomonas campestris
NCBI taxonomy Id: 190485
Other names: X. campestris pv. campestris str. ATCC 33913, Xanthomonas campestris pv. campestris str. ATCC 33913
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