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| | W5S_0028 | DUF1471 domain-containing protein. (85 aa) |
| | zapB | Cell division protein ZapB; Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA. (79 aa) |
| | rnk | Regulator of nucleoside diphosphate kinase; May act as an anti-Gre factor; Belongs to the Rnk family. (136 aa) |
| | rapZ | RNase adapter protein RapZ; Modulates the synthesis of GlmS, by affecting the processing and stability of the regulatory small RNA GlmZ. When glucosamine-6- phosphate (GlcN6P) concentrations are high in the cell, RapZ binds GlmZ and targets it to cleavage by RNase E. Consequently, GlmZ is inactivated and unable to activate GlmS synthesis. Under low GlcN6P concentrations, RapZ is sequestered and inactivated by an other regulatory small RNA, GlmY, preventing GlmZ degradation and leading to synthesis of GlmS; Belongs to the RapZ-like family. RapZ subfamily. (285 aa) |
| | W5S_0296 | Lipopolysaccharide ABC transporter ATP-binding protein LptB. (241 aa) |
| | lptA | Lipopolysaccharide export system protein LptA; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm. (190 aa) |
| | lptC | Lipopolysaccharide export system protein LptC; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA. Belongs to the LptC family. (188 aa) |
| | kdsC | 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC; Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8- phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate; Belongs to the KdsC family. (188 aa) |
| | W5S_0300 | Arabinose 5-phosphate isomerase. (345 aa) |
| | W5S_0302 | Phospholipid ABC transporter ATP-binding protein MlaF. (270 aa) |
| | W5S_0303 | Toluene ABC transporter, permease protein. (260 aa) |
| | mlaD | Outer membrane lipid asymmetry maintenance protein MlaD. (188 aa) |
| | W5S_0305 | Phospholipid-binding protein MlaC. (209 aa) |
| | W5S_0306 | YrbB. (96 aa) |
| | W5S_0307 | Protein YrbA; Belongs to the BolA/IbaG family. (84 aa) |
| | murA | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (420 aa) |
| | W5S_0309 | Periplasmic serine peptidase DegS. (365 aa) |
| | W5S_0310 | Periplasmic serine endoprotease DegP-like; Belongs to the peptidase S1C family. (456 aa) |
| | W5S_0311 | Cytochrome D Ubiquinol oxidase subunit III. (134 aa) |
| | W5S_0398 | Biopolymer transporter ExbB. (332 aa) |
| | W5S_0399 | TonB system transport protein ExbD. (141 aa) |
| | W5S_0456 | Lipopolysaccharide export system permease protein lptF. (370 aa) |
| | W5S_0457 | LPS export ABC transporter permease LptG. (358 aa) |
| | W5S_0566 | Protein smp. (230 aa) |
| | dsbD | Thiol:disulfide interchange protein DsbD; Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps. Belongs to the thioredoxin family. DsbD subfamily. (583 aa) |
| | W5S_0769 | Thiol:disulfide interchange protein; Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process; Belongs to the thioredoxin family. DsbC subfamily. (227 aa) |
| | lpxP | Lipid A biosynthesis palmitoleoyltransferase; Catalyzes the transfer of palmitoleate from palmitoleoyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)- (palmitoleoyl)-lipid IV(A); Belongs to the LpxL/LpxM/LpxP family. LpxP subfamily. (319 aa) |
| | W5S_0802 | Transposase YhgA family protein. (298 aa) |
| | W5S_1085 | Periplasmic serine endoprotease DegP-like; Belongs to the peptidase S1C family. (487 aa) |
| | lpxH | UDP-2,3-diacylglucosamine hydrolase; Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (240 aa) |
| | W5S_1249 | Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (164 aa) |
| | W5S_1321 | Phospholipid-binding lipoprotein MlaA. (253 aa) |
| | W5S_1430 | Transposase YhgA family protein. (288 aa) |
| | W5S_1591 | Thiol:disulfide interchange protein. (208 aa) |
| | W5S_1697 | Iron permease, FTR1 family. (634 aa) |
| | W5S_1698 | Periplasmic protein-probably involved in high-affinity Fe2+ transport. (181 aa) |
| | W5S_1699 | YHS domain protein. (465 aa) |
| | W5S_1700 | Permease domain protein. (429 aa) |
| | W5S_1701 | Integral membrane protein-permease component, involved in lipoprotein release. (379 aa) |
| | W5S_1702 | ABC transporter domain-containing protein. (238 aa) |
| | W5S_1703 | Thiol-disulfide oxidoreductase resA. (165 aa) |
| | W5S_1804 | Flagella biosynthesis regulatory protein FliT. (111 aa) |
| | lolA | Outer-membrane lipoprotein carrier protein; Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane). (203 aa) |
| | lpxK | Tetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (333 aa) |
| | kdsB | 3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (249 aa) |
| | W5S_2003 | Outer membrane pore protein E. (368 aa) |
| | lpxM | Lipid A biosynthesis myristoyltransferase; Catalyzes the transfer of myristate from myristoyl-acyl carrier protein (ACP) to Kdo(2)-(lauroyl)-lipid IV(A) to form Kdo(2)- lipid A. (290 aa) |
| | W5S_2076 | DUF1471 domain-containing protein. (75 aa) |
| | W5S_2135 | Inner membrane protein YdjM. (191 aa) |
| | dsbB | Disulfide bond formation protein B; Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein; Belongs to the DsbB family. (176 aa) |
| | W5S_2240 | Protein TonB; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Belongs to the TonB family. (251 aa) |
| | W5S_2283 | Protein YdgA. (516 aa) |
| | kdsA | 2-dehydro-3-deoxyphosphooctonate aldolase; Belongs to the KdsA family. (284 aa) |
| | W5S_2558 | Serine protease; Belongs to the peptidase S1B family. (279 aa) |
| | lapB | Lipopolysaccharide assembly protein B; Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane; Belongs to the LapB family. (389 aa) |
| | lapA | Lipopolysaccharide assembly protein A; Involved in the assembly of lipopolysaccharide (LPS). Belongs to the LapA family. (101 aa) |
| | W5S_2727 | Major outer membrane lipoprotein. (78 aa) |
| | W5S_2763 | Lipoprotein releasing system, transmembrane protein LolE. (415 aa) |
| | lolD | Lipoprotein-releasing system ATP-binding protein LolD; Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner. (235 aa) |
| | W5S_2765 | Lipoprotein-releasing system transmembrane protein LolC. (400 aa) |
| | lpxL | Lipid A biosynthesis lauroyltransferase; Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)-(lauroyl)-lipid IV(A). (306 aa) |
| | W5S_2823 | DNA-binding protein; Belongs to the histone-like protein H-NS family. (133 aa) |
| | W5S_2835 | DNA helicase. (685 aa) |
| | W5S_2840 | Outer membrane protein P5; Belongs to the outer membrane OOP (TC 1.B.6) superfamily. (360 aa) |
| | W5S_2938 | Putative gluconeogenesis factor; Required for morphogenesis under gluconeogenic growth conditions; Belongs to the gluconeogenesis factor family. (302 aa) |
| | W5S_2993 | Peptidase S53 propeptide. (540 aa) |
| | W5S_2994 | Monofunctional chorismate mutase. (185 aa) |
| | W5S_2995 | Group 4 capsule (G4C) polysaccharide, lipoprotein YmcA. (711 aa) |
| | W5S_2996 | Group 4 capsule (G4C) polysaccharide, YmcB. (260 aa) |
| | W5S_2997 | Group 4 capsule (G4C) polysaccharide, lipoprotein YmcC. (225 aa) |
| | W5S_2998 | Uncharacterized protein. (93 aa) |
| | W5S_3029 | Suppressor of ompF assembly mutants. (611 aa) |
| | W5S_3041 | DNA-binding protein; Belongs to the histone-like protein H-NS family. (133 aa) |
| | W5S_3043 | Cof-type HAD-IIB family hydrolase. (273 aa) |
| | cpoB | Cell division coordinator CpoB; Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division; Belongs to the CpoB family. (258 aa) |
| | pal | Peptidoglycan-associated protein; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. (169 aa) |
| | tolB | Tol-Pal system protein TolB; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. TolB occupies a key intermediary position in the Tol-Pal system because it communicates directly with both membrane-embedded components, Pal in the outer membrane and TolA in the inner membrane. (430 aa) |
| | W5S_3078 | Cell envelope integrity protein TolA. (386 aa) |
| | tolR | Tol-Pal system protein TolR; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. Required, with TolQ, for the proton motive force-dependent activation of TolA and for TolA-Pal interaction. (141 aa) |
| | tolQ | Tol-Pal system protein TolQ; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. Required, with TolR, for the proton motive force-dependent activation of TolA and for TolA-Pal interaction. (228 aa) |
| | W5S_3081 | Tol-pal system-associated acyl-CoA thioesterase. (134 aa) |
| | lptE | LPS-assembly lipoprotein LptE; Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane. (184 aa) |
| | W5S_3249 | Multidrug resistance-like ATP-binding protein mdlB. (601 aa) |
| | W5S_3250 | Multidrug resistance, ATP-binding protein mdlA. (589 aa) |
| | W5S_3257 | Peptidylprolyl isomerase. (627 aa) |
| | lpxB | Lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (383 aa) |
| | lpxA | Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (262 aa) |
| | fabZ | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (151 aa) |
| | lpxD | UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O- (hydroxytetradecanoyl)glucosamine using 3-hydroxytetradecanoyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell; Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (340 aa) |
| | W5S_3350 | Molecular chaperone Skp; Belongs to the skp family. (165 aa) |
| | bamA | Outer membrane protein assembly factor BamA; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamD, the core component of the assembly machinery. (810 aa) |
| | W5S_3352 | Zinc metalloprotease. (451 aa) |
| | W5S_3353 | Phosphatidate cytidylyltransferase; Belongs to the CDS family. (285 aa) |
| | uppS | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific); Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di- trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide. (253 aa) |
| | lpxC | UDP-3-O-acyl-N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. (306 aa) |
| | lptD | LPS-assembly protein LptD; Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. (801 aa) |
| | surA | Chaperone SurA; Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation. (431 aa) |
| | pdxA | 4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). (333 aa) |
| | ksgA | Ribosomal RNA small subunit methyltransferase A; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. (272 aa) |
| | apaG | Protein ApaG. (125 aa) |
| | apaH | Bis(5'-nucleosyl)-tetraphosphatase, symmetrical; Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP; Belongs to the Ap4A hydrolase family. (281 aa) |
| | yjjX | Inosine/xanthosine triphosphatase; Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. (179 aa) |
| | W5S_4018 | Soluble lytic murein transglycosylase. (644 aa) |
| | W5S_4371 | Peptidyl-prolyl cis-trans isomerase C (Rotamase C). (93 aa) |
| | W5S_4481 | Protein TonB; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Belongs to the TonB family. (288 aa) |
| | W5S_4482 | Transporter, MotA/TolQ/ExbB proton channel family. (238 aa) |
| | W5S_4483 | Biopolymer transport protein ExbD/TolR. (133 aa) |
| | W5S_4536 | 3-deoxy-D-manno-octulosonic acid transferase; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. (425 aa) |
| | W5S_4663 | Universal stress protein. (145 aa) |
| | W5S_4680 | AsmA domain-containing protein. (563 aa) |
| | W5S_4700 | Thiol:disulfide interchange protein. (207 aa) |
| | srkA | Stress response kinase A; A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response. (328 aa) |
