STRINGSTRING
W5S_2497 W5S_2497 W5S_0970 W5S_0970 tssK tssK W5S_0968 W5S_0968 tssG tssG vasA vasA tssE tssE tssC tssC tssB tssB bamE bamE W5S_0786 W5S_0786 W5S_0706 W5S_0706 W5S_0552 W5S_0552 W5S_0444 W5S_0444 W5S_0399 W5S_0399 W5S_0398 W5S_0398 W5S_0364 W5S_0364 W5S_2763 W5S_2763 lolD lolD W5S_2765 W5S_2765 W5S_2891 W5S_2891 W5S_2892 W5S_2892 yidC yidC W5S_4762 W5S_4762 secB secB W5S_4483 W5S_4483 W5S_4482 W5S_4482 W5S_4481 W5S_4481 W5S_4461 W5S_4461 W5S_4427 W5S_4427 W5S_4426 W5S_4426 tatA tatA tatB tatB tatC tatC W5S_4298 W5S_4298 W5S_4271 W5S_4271 W5S_4220 W5S_4220 secY secY W5S_3975 W5S_3975 W5S_3958 W5S_3958 W5S_3957 W5S_3957 secA secA W5S_3904 W5S_3904 W5S_3903 W5S_3903 W5S_3902 W5S_3902 W5S_3712 W5S_3712 W5S_3711 W5S_3711 W5S_3674 W5S_3674 W5S_3624 W5S_3624 W5S_3590 W5S_3590 W5S_3586 W5S_3586 W5S_3538 W5S_3538 W5S_3535 W5S_3535 W5S_3534 W5S_3534 W5S_3530 W5S_3530 W5S_3519 W5S_3519 W5S_3518 W5S_3518 W5S_3515 W5S_3515 W5S_3500 W5S_3500 W5S_3397 W5S_3397 W5S_3396 W5S_3396 W5S_3394 W5S_3394 bamA bamA W5S_3350 W5S_3350 W5S_3317 W5S_3317 yajC yajC secD secD secF secF tig tig W5S_3190 W5S_3190 bamC bamC tolB tolB tatE tatE tolR tolR W5S_0045 W5S_0045 ftsY ftsY W5S_0140 W5S_0140 secE secE W5S_0359 W5S_0359 W5S_2676 W5S_2676 W5S_2587 W5S_2587 W5S_2563 W5S_2563 W5S_2440 W5S_2440 tssK-2 tssK-2 W5S_2438 W5S_2438 W5S_2437 W5S_2437 tssA tssA tssB-2 tssB-2 W5S_2433 W5S_2433 W5S_2424 W5S_2424 tssG-2 tssG-2 W5S_2420 W5S_2420 W5S_2419 W5S_2419 W5S_2415 W5S_2415 W5S_2414 W5S_2414 W5S_2413 W5S_2413 W5S_2412 W5S_2412 W5S_2409 W5S_2409 lolB lolB W5S_2337 W5S_2337 W5S_2323 W5S_2323 W5S_2310 W5S_2310 dtpA dtpA W5S_2240 W5S_2240 W5S_2222 W5S_2222 W5S_2133 W5S_2133 W5S_1960 W5S_1960 lolA lolA fliI fliI fliJ fliJ fliP fliP fliQ fliQ fliR fliR flhA flhA flhB flhB W5S_1719 W5S_1719 W5S_1718 W5S_1718 W5S_1624 W5S_1624 W5S_1621 W5S_1621 W5S_1619 W5S_1619 W5S_1617 W5S_1617 W5S_1613 W5S_1613 W5S_1566 W5S_1566 W5S_1564 W5S_1564 W5S_1563 W5S_1563 W5S_1558 W5S_1558 W5S_1557 W5S_1557 W5S_1556 W5S_1556 W5S_1555 W5S_1555 W5S_1512 W5S_1512 W5S_1511 W5S_1511 W5S_1505 W5S_1505 W5S_2735 W5S_2735 W5S_1490 W5S_1490 W5S_1468 W5S_1468 W5S_1304 W5S_1304 W5S_1303 W5S_1303 W5S_1302 W5S_1302 W5S_1301 W5S_1301 gspI gspI gspH gspH gspG gspG W5S_1297 W5S_1297 gspE gspE W5S_1295 W5S_1295 W5S_1294 W5S_1294 W5S_1291 W5S_1291 bamB bamB W5S_1122 W5S_1122 bamD bamD ffh ffh W5S_1002 W5S_1002 W5S_0976 W5S_0976 W5S_0975 W5S_0975 W5S_0974 W5S_0974
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
W5S_2497Uncharacterized protein. (86 aa)
W5S_0970ImpK/VasF outer membrane protein. (258 aa)
tssKType VI secretion system baseplate subunit TssK. (445 aa)
W5S_0968Type VI secretion lipoprotein, VC_A0113 family. (174 aa)
tssGType VI secretion system baseplate subunit TssG. (332 aa)
vasAType VI secretion system baseplate subunit TssF. (588 aa)
tssEType VI secretion system baseplate subunit TssE. (143 aa)
tssCType VI secretion system contractile sheath large subunit. (492 aa)
tssBType VI secretion system contractile sheath small subunit. (167 aa)
bamEOuter membrane protein assembly factor BamE; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (111 aa)
W5S_0786Type II/IV secretion system secretin RcpA/CpaC associated with Flp pilus assembly; Belongs to the bacterial secretin family. (475 aa)
W5S_0706Protein-export membrane protein SecG; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. (110 aa)
W5S_0552Uropathogenic specific protein. (88 aa)
W5S_0444Hemolysin activator protein. (592 aa)
W5S_0399TonB system transport protein ExbD. (141 aa)
W5S_0398Biopolymer transporter ExbB. (332 aa)
W5S_0364Uropathogenic specific protein. (88 aa)
W5S_2763Lipoprotein releasing system, transmembrane protein LolE. (415 aa)
lolDLipoprotein-releasing system ATP-binding protein LolD; Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner. (235 aa)
W5S_2765Lipoprotein-releasing system transmembrane protein LolC. (400 aa)
W5S_2891Membrane fusion protein (MFP) family protein. (442 aa)
W5S_2892Type I secretion system ATPase. (575 aa)
yidCMembrane protein insertase YidC; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. (543 aa)
W5S_4762Outer-membrane lipoprotein carrier protein; Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane). (201 aa)
secBProtein-export protein SecB; One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA. (158 aa)
W5S_4483Biopolymer transport protein ExbD/TolR. (133 aa)
W5S_4482Transporter, MotA/TolQ/ExbB proton channel family. (238 aa)
W5S_4481Protein TonB; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Belongs to the TonB family. (288 aa)
W5S_4461SMI1_KNR4 domain-containing protein. (169 aa)
W5S_4427Propable Phospholipase A1. (456 aa)
W5S_4426VgrG protein. (678 aa)
tatASec-independent protein translocase protein TatA; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. (86 aa)
tatBSec-independent protein translocase protein TatB; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation. (203 aa)
tatCSec-independent protein translocase protein TatC; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides. (249 aa)
W5S_4298UPF0056 inner membrane protein. (197 aa)
W5S_4271Putative ABC transporter ATP-binding protein ybbA. (230 aa)
W5S_4220Protein transporter HofQ. (424 aa)
secYProtein translocase subunit SecY; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. (443 aa)
W5S_3975PAAR repeat-containing protein. (99 aa)
W5S_3958Paar domain-containing protein family. (174 aa)
W5S_3957VgrG protein. (610 aa)
secAProtein translocase subunit SecA; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. (916 aa)
W5S_3904Assembly protein in type IV pilin biogenesis, transmembrane protein. (401 aa)
W5S_3903Type IV-A pilus assembly ATPase PilB. (490 aa)
W5S_3902Prepilin peptidase dependent protein D. (148 aa)
W5S_3712POTRA domain-containing protein. (620 aa)
W5S_3711Uncharacterized protein. (1342 aa)
W5S_3674VgrG protein. (725 aa)
W5S_3624DUF3574 domain-containing protein. (149 aa)
W5S_3590VgrG protein. (560 aa)
W5S_3586Uropathogenic specific protein. (88 aa)
W5S_3538Type IVB pilus formation outer membrane protein, R64 PilN family. (554 aa)
W5S_3535General secretion pathway protein E. (521 aa)
W5S_3534PilR. (388 aa)
W5S_3530Shufflon protein A. (451 aa)
W5S_3519Uncharacterized protein. (394 aa)
W5S_3518TraG-D_C domain-containing protein. (312 aa)
W5S_3515VgrG protein. (609 aa)
W5S_3500Type IV secretory protein VirB4 component. (941 aa)
W5S_3397Prepilin-type N-terminal cleavage/methylation domain-containing protein. (167 aa)
W5S_3396Prepilin peptidase dependent protein B. (169 aa)
W5S_3394Prepilin-type N-terminal cleavage/methylation domain-containing protein. (130 aa)
bamAOuter membrane protein assembly factor BamA; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamD, the core component of the assembly machinery. (810 aa)
W5S_3350Molecular chaperone Skp; Belongs to the skp family. (165 aa)
W5S_3317Membrane fusion protein (MFP) family protein. (389 aa)
yajCSec translocon accessory complex subunit YajC; The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions. (109 aa)
secDProtein translocase subunit SecD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. (604 aa)
secFProtein-export membrane protein SecF; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. (322 aa)
tigTrigger factor; Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase; Belongs to the FKBP-type PPIase family. Tig subfamily. (434 aa)
W5S_3190Putative ABC transporter ATP-binding protein ybbA. (243 aa)
bamCOuter membrane protein assembly factor BamC; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (345 aa)
tolBTol-Pal system protein TolB; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. TolB occupies a key intermediary position in the Tol-Pal system because it communicates directly with both membrane-embedded components, Pal in the outer membrane and TolA in the inner membrane. (430 aa)
tatEProbable Sec-independent protein translocase protein TatE; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA; Belongs to the TatA/E family. TatE subfamily. (65 aa)
tolRTol-Pal system protein TolR; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. Required, with TolQ, for the proton motive force-dependent activation of TolA and for TolA-Pal interaction. (141 aa)
W5S_0045Uncharacterized protein. (297 aa)
ftsYSignal recognition particle receptor FtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components. (471 aa)
W5S_0140VgrG protein. (615 aa)
secEProtein translocase subunit SecE; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation; Belongs to the SecE/SEC61-gamma family. (127 aa)
W5S_0359VgrG protein. (655 aa)
W5S_2676annotation not available (615 aa)
W5S_2587Peptide transport system ATP-binding protein SapF. (271 aa)
W5S_2563DctA-YdbH domain-containing protein. (855 aa)
W5S_2440Type VI secretion lipoprotein/VasD. (163 aa)
tssK-2Type VI secretion system baseplate subunit TssK. (446 aa)
W5S_2438Type IV / VI secretion system protein, DotU family. (413 aa)
W5S_2437Type VI secretion protein IcmF. (1198 aa)
tssAType VI secretion-associated protein, ImpA family. (339 aa)
tssB-2Type VI secretion system contractile sheath small subunit. (176 aa)
W5S_2433Type VI secretion protein, EvpB/VC_A0108 family. (499 aa)
W5S_2424Type VI secretion protein, VC_A0110 family. (624 aa)
tssG-2Type VI secretion system baseplate subunit TssG. (349 aa)
W5S_2420Rhs element Vgr protein. (587 aa)
W5S_2419Uncharacterized protein. (156 aa)
W5S_2415Pentapeptide repeat-containing protein. (455 aa)
W5S_2414Pentapeptide repeat protein. (273 aa)
W5S_2413Uncharacterized protein. (140 aa)
W5S_2412QnrD. (228 aa)
W5S_2409Type VI secretion system Vgr family protein. (712 aa)
lolBOuter-membrane lipoprotein LolB; Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein. (207 aa)
W5S_2337Phage like secreted protein; Belongs to the bacterial secretin family. (386 aa)
W5S_2323Transport secretion system IV protein, VirB6. (321 aa)
W5S_2310Phage like secreted protein; Belongs to the bacterial secretin family. (385 aa)
dtpADipeptide and tripeptide permease A; Proton-dependent permease that transports di- and tripeptides; Belongs to the PTR2/POT transporter (TC 2.A.17) family. DtpA subfamily. (506 aa)
W5S_2240Protein TonB; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Belongs to the TonB family. (251 aa)
W5S_2222UPF0225 protein W5S_2222; Belongs to the UPF0225 family. (155 aa)
W5S_2133Osmotically-inducible lipoprotein E. (110 aa)
W5S_1960Rhs element Vgr protein. (689 aa)
lolAOuter-membrane lipoprotein carrier protein; Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane). (203 aa)
fliIFlagellum-specific ATP synthase FliI. (456 aa)
fliJFlagellar FliJ protein; Flagellar protein that affects chemotactic events. Belongs to the FliJ family. (148 aa)
fliPFlagellar biosynthetic protein FliP; Plays a role in the flagellum-specific transport system. Belongs to the FliP/MopC/SpaP family. (226 aa)
fliQFlagellar biosynthetic protein FliQ; Role in flagellar biosynthesis. Belongs to the FliQ/MopD/SpaQ family. (89 aa)
fliRFlagellar biosynthetic protein FliR; Role in flagellar biosynthesis. Belongs to the FliR/MopE/SpaR family. (261 aa)
flhAFlagellar biosynthesis protein FlhA; Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin; Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family. (693 aa)
flhBFlagellar biosynthetic protein FlhB; Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin; Belongs to the type III secretion exporter family. (383 aa)
W5S_1719Uncharacterized protein. (160 aa)
W5S_1718Type VI secretion system Vgr family protein. (402 aa)
W5S_1624Type IV secretion system protein virB4. (915 aa)
W5S_1621TriE protein. (346 aa)
W5S_1619Type IV secretion system protein virB8. (227 aa)
W5S_1617Type IV secretion system protein virB10. (405 aa)
W5S_1613TriK protein. (620 aa)
W5S_1566General secretion pathway protein G. (139 aa)
W5S_1564Type II secretion system protein. (389 aa)
W5S_1563General secretion pathway protein E. (547 aa)
W5S_1558Type IV pilus biogenesis protein PilQ. (627 aa)
W5S_1557General secretion pathway GspG like transmembrane protein. (157 aa)
W5S_1556General secretion pathway protein G. (119 aa)
W5S_1555Uncharacterized protein. (163 aa)
W5S_1512SecA like protein. (590 aa)
W5S_1511Uncharacterized protein. (147 aa)
W5S_1505Conjugative coupling factor TraD. (719 aa)
W5S_2735Uncharacterized protein. (133 aa)
W5S_1490Type IV secretory protein VirB4 component. (954 aa)
W5S_1468VgrG protein. (616 aa)
W5S_1304Type II secretion system protein M; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. (164 aa)
W5S_1303Type II secretion system protein L; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. (425 aa)
W5S_1302Type II secretion system protein K. (328 aa)
W5S_1301General secretion pathway protein J. (216 aa)
gspIType II secretion system protein GspI. (121 aa)
gspHType II secretion system protein GspH. (188 aa)
gspGType II secretion system protein GspG. (146 aa)
W5S_1297General secretion pathway protein F. (408 aa)
gspEType II secretion system protein E; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. (498 aa)
W5S_1295General secretion pathway protein D. (695 aa)
W5S_1294General secretion pathway protein C. (290 aa)
W5S_1291General secretion pathway lipoprotein. (137 aa)
bamBOuter membrane protein assembly factor BamB; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (393 aa)
W5S_1122Membrane fusion protein (MFP) family protein. (453 aa)
bamDOuter membrane protein assembly factor BamD; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamA, the core component of the assembly machinery. (244 aa)
ffhSignal recognition particle protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual componen [...] (453 aa)
W5S_1002UPF0056 inner membrane protein. (224 aa)
W5S_0976Uncharacterized protein. (478 aa)
W5S_0975Type VI secretion protein IcmF. (1165 aa)
W5S_0974ImpA_N domain-containing protein. (475 aa)
Your Current Organism:
Pectobacterium parmentieri
NCBI taxonomy Id: 1905730
Other names: CFBP 8475, LMG 29774, LMG:29774, P. parmentieri, Pectobacterium parmentieri Khayi et al. 2016, Pectobacterium sp. SCC3193, strain RNS 08-42-1A, strain RNS 08.42.1A
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