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| | rplO | 50S ribosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (144 aa) |
| | topB | DNA topoisomerase 3; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (641 aa) |
| | nth | Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (211 aa) |
| | rnfC | Ion-translocating oxidoreductase complex subunit C; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily. (737 aa) |
| | W5S_2405 | Phospholipase A accessory protein. (247 aa) |
| | W5S_2406 | Fibronectin type 3 and ankyrin repeat domains 1 protein. (224 aa) |
| | asr | Acid shock protein; Required for growth and/or survival at acidic conditions. (120 aa) |
| | W5S_2596 | Urocanate reductase. (957 aa) |
| | edd | Phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. (611 aa) |
| | cobB | NAD-dependent protein deacylase; Belongs to the sirtuin family. Class III subfamily. (276 aa) |
| | rpmF | 50S ribosomal protein L32; Belongs to the bacterial ribosomal protein bL32 family. (56 aa) |
| | W5S_2838 | DNA transformation protein TfoX. (206 aa) |
| | dnaA | Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. (465 aa) |
| | W5S_3015 | N-acetylneuraminate synthase. (349 aa) |
| | recF | DNA replication and repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP; Belongs to the RecF family. (361 aa) |
| | priA | Primosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (732 aa) |
| | rpmE | 50S ribosomal protein L31; Binds the 23S rRNA. (71 aa) |
| | rplK | 50S ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. (142 aa) |
| | rplA | 50S ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (234 aa) |
| | rplJ | 50S ribosomal protein L10; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (165 aa) |
| | rplL | 50S ribosomal protein L7/L12; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family. (121 aa) |
| | W5S_0237 | DNA-binding protein HU-alpha; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. (90 aa) |
| | fis | DNA-binding protein Fis; Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters; Belongs to the transcriptional regulatory Fis family. (98 aa) |
| | W5S_0277 | Rod shape-determining protein MreB. (347 aa) |
| | W5S_0281 | Ribonuclease G. (489 aa) |
| | rplM | 50S ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (142 aa) |
| | W5S_3078 | Cell envelope integrity protein TolA. (386 aa) |
| | rpsI | 30S ribosomal protein S9; Belongs to the universal ribosomal protein uS9 family. (130 aa) |
| | W5S_0316 | ClpXP protease specificity-enhancing factor. (167 aa) |
| | diaA | DnaA initiator-associating protein DiaA; Required for the timely initiation of chromosomal replication via direct interactions with the DnaA initiator protein. Belongs to the SIS family. DiaA subfamily. (196 aa) |
| | W5S_0463 | P4 alpha zinc-binding domain protein. (678 aa) |
| | dnaG | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (584 aa) |
| | rpsU | 30S ribosomal protein S21; Belongs to the bacterial ribosomal protein bS21 family. (71 aa) |
| | rplU | 50S ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. (103 aa) |
| | rpmA | 50S ribosomal protein L27; Belongs to the bacterial ribosomal protein bL27 family. (85 aa) |
| | rpsO | 30S ribosomal protein S15; Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome. (89 aa) |
| | hda | DnaA regulatory inactivator Hda; Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA; Belongs to the DnaA family. HdA subfamily. (235 aa) |
| | recR | Recombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (201 aa) |
| | W5S_3231 | Nucleoid-associated protein W5S_3231; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection. (109 aa) |
| | W5S_3235 | Primosomal replication protein N. (178 aa) |
| | rpmE2 | 50S ribosomal protein L31 type B. (82 aa) |
| | rpmJ | 50S ribosomal protein L36; Belongs to the bacterial ribosomal protein bL36 family. (47 aa) |
| | W5S_3258 | DNA-binding protein HU-beta; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. (90 aa) |
| | W5S_3306 | ADP-ribosylglycohydrolase family protein. (333 aa) |
| | rpsB | 30S ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family. (241 aa) |
| | W5S_3430 | SIR2_2 domain-containing protein. (1025 aa) |
| | W5S_3438 | DNA repair protein RadC; Belongs to the UPF0758 family. (158 aa) |
| | W5S_3541 | Uncharacterized protein. (145 aa) |
| | W5S_3553 | Type IV secretion-like conjugative transfer system protein TraR. (79 aa) |
| | W5S_3555 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (405 aa) |
| | W5S_3556 | Replicative DNA helicase. (49 aa) |
| | W5S_3571 | Ankyrin domain protein. (716 aa) |
| | W5S_3572 | Ankyrin domain protein. (679 aa) |
| | rplI | 50S ribosomal protein L9; Binds to the 23S rRNA. (150 aa) |
| | rpsR | 30S ribosomal protein S18; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (75 aa) |
| | priB | Primosomal replication protein N; Binds single-stranded DNA at the primosome assembly site (PAS); Belongs to the PriB family. (106 aa) |
| | rpsF | 30S ribosomal protein S6; Binds together with S18 to 16S ribosomal RNA. (130 aa) |
| | W5S_3777 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (468 aa) |
| | W5S_3830 | PELOTA_1 domain-containing protein. (360 aa) |
| | rpsT | 30S ribosomal protein S20; Binds directly to 16S ribosomal RNA. (87 aa) |
| | W5S_4116 | Uncharacterized protein. (123 aa) |
| | W5S_4126 | Topoisomerase DNA-binding C4 zinc finger domain protein. (185 aa) |
| | rplQ | 50S ribosomal protein L17. (130 aa) |
| | rpsD | 30S ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (206 aa) |
| | rpsK | 30S ribosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (129 aa) |
| | rpsM | 30S ribosomal protein S13; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. Belongs to the universal ribosomal protein uS13 family. (118 aa) |
| | rpmJ-2 | 50S ribosomal protein L36; Belongs to the bacterial ribosomal protein bL36 family. (38 aa) |
| | rpsE | 30S ribosomal protein S5; Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body. Belongs to the universal ribosomal protein uS5 family. (166 aa) |
| | rplR | 50S ribosomal protein L18; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (117 aa) |
| | rplF | 50S ribosomal protein L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (177 aa) |
| | rpsH | 30S ribosomal protein S8; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (130 aa) |
| | rpsN | 30S ribosomal protein S14; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site; Belongs to the universal ribosomal protein uS14 family. (101 aa) |
| | rplE | 50S ribosomal protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (179 aa) |
| | rplX | 50S ribosomal protein L24; One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit. (104 aa) |
| | rplN | 50S ribosomal protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (123 aa) |
| | rpsQ | 30S ribosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (84 aa) |
| | rpmC | 50S ribosomal protein L29; Belongs to the universal ribosomal protein uL29 family. (63 aa) |
| | rplP | 50S ribosomal protein L16; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. (136 aa) |
| | rpsC | 30S ribosomal protein S3; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. (233 aa) |
| | rplV | 50S ribosomal protein L22; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome. (110 aa) |
| | rpsS | 30S ribosomal protein S19; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (92 aa) |
| | rplB | 50S ribosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (273 aa) |
| | rplW | 50S ribosomal protein L23; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family. (100 aa) |
| | rplD | 50S ribosomal protein L4; Forms part of the polypeptide exit tunnel. (201 aa) |
| | rplC | 50S ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. (209 aa) |
| | rpsJ | 30S ribosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (103 aa) |
| | rpsG | 30S ribosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (156 aa) |
| | rpsL | 30S ribosomal protein S12; Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit. (124 aa) |
| | W5S_4248 | Propanediol utilization protein: polyhedral bodies PduK. (191 aa) |
| | W5S_4253 | Bacterial microcompartments protein. (99 aa) |
| | W5S_4254 | Ethanolamine utilization protein EutE. (502 aa) |
| | W5S_4255 | Propanediol utilization microcompartment protein PduB. (261 aa) |
| | pduA | Propanediol utilization microcompartment protein PduA. (93 aa) |
| | W5S_4259 | Ethanolamine utilization protein EutN/carboxysome structural protein Ccml. (90 aa) |
| | W5S_4261 | Phosphate propanoyltransferase; Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate. (229 aa) |
| | W5S_4311 | ATP-dependent DNA helicase RecQ. (608 aa) |
| | W5S_4428 | Ankyrin repeat protein. (232 aa) |
| | W5S_4429 | Phospholipase A accessory protein. (232 aa) |
| | W5S_4430 | Ankyrin repeat protein. (232 aa) |
| | W5S_4431 | Ankyrin repeat domain-containing protein. (232 aa) |
| | rpmG | 50S ribosomal protein L33; Belongs to the bacterial ribosomal protein bL33 family. (55 aa) |
| | rpmB | 50S ribosomal protein L28; Belongs to the bacterial ribosomal protein bL28 family. (78 aa) |
| | W5S_4542 | UPF0758 protein W5S_4542; Belongs to the UPF0758 family. YicR subfamily. (221 aa) |
| | slmA | Nucleoid occlusion factor SlmA; Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions. (198 aa) |
| | W5S_4570 | Zinc-binding domain of primase-helicase family protein. (894 aa) |
| | W5S_4652 | Heat-shock protein DnaJ-like protein. (909 aa) |
| | dtd | D-aminoacyl-tRNA deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. (145 aa) |
| | rpmH | 50S ribosomal protein L34; Belongs to the bacterial ribosomal protein bL34 family. (46 aa) |
| | W5S_0792 | Tetratricopeptide TPR_2 repeat protein. (283 aa) |
| | W5S_0847 | Uncharacterized protein. (87 aa) |
| | W5S_0849 | Uncharacterized protein. (101 aa) |
| | W5S_0855 | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. (553 aa) |
| | matP | Macrodomain Ter protein; Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain. (153 aa) |
| | W5S_2908 | FMN-binding domain protein. (118 aa) |
| | cyaB | Class IV adenylate cyclase. (180 aa) |
| | W5S_0860 | Uncharacterized protein. (100 aa) |
| | W5S_0924 | FMN-binding domain protein. (134 aa) |
| | W5S_0982 | Integron gene cassette protein. (148 aa) |
| | rpsP | 30S ribosomal protein S16; Belongs to the bacterial ribosomal protein bS16 family. (82 aa) |
| | rplS | 50S ribosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. (115 aa) |
| | raiA | Ribosome-associated translation inhibitor RaiA. (112 aa) |
| | recO | DNA repair protein RecO; Involved in DNA repair and RecF pathway recombination. (245 aa) |
| | W5S_1162 | Enhanced serine sensitivity protein SseB. (264 aa) |
| | W5S_1166 | Type IV pilus biogenesis/stability protein PilW. (261 aa) |
| | W5S_1344 | Thermophilic carboxylesterase Est2. (308 aa) |
| | W5S_1473 | Uncharacterized protein. (298 aa) |
| | W5S_1479 | Transposition helper protein. (259 aa) |
| | W5S_1514 | PXO1-08. (434 aa) |
| | W5S_1515 | Helicase domain-containing protein. (343 aa) |
| | W5S_1594 | S-type Pyocin family. (571 aa) |
| | W5S_1629 | C4-type zinc finger protein, DksA/TraR family. (69 aa) |
| | W5S_1650 | Uncharacterized protein. (71 aa) |
| | rplY | 50S ribosomal protein L25; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. (94 aa) |
| | W5S_1934 | Replication-associated recombination protein A. (447 aa) |
| | W5S_1949 | 30S ribosomal protein S1; Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence. (569 aa) |
| | ihfB | Integration host factor subunit beta; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family. (94 aa) |
| | cutC | Copper homeostasis protein CutC; Participates in the control of copper homeostasis. Belongs to the CutC family. (252 aa) |
| | W5S_2072 | Hepatocellular carcinoma-associated protein p28-II. (121 aa) |
| | rpmI | 50S ribosomal protein L35; Belongs to the bacterial ribosomal protein bL35 family. (65 aa) |
| | rplT | 50S ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. (118 aa) |
| | ihfA | Integration host factor subunit alpha; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family. (98 aa) |
