STRINGSTRING
W5S_1524 W5S_1524 W5S_1600 W5S_1600 W5S_1716 W5S_1716 rimK rimK serC serC W5S_2002 W5S_2002 W5S_2072 W5S_2072 W5S_2084 W5S_2084 W5S_2106 W5S_2106 W5S_2163 W5S_2163 W5S_2405 W5S_2405 W5S_2406 W5S_2406 W5S_2697 W5S_2697 W5S_2832 W5S_2832 W5S_2911 W5S_2911 W5S_3253 W5S_3253 W5S_3295 W5S_3295 W5S_3571 W5S_3571 W5S_3572 W5S_3572 mtnK mtnK mtnA mtnA mtnD-2 mtnD-2 mtnC mtnC mtnB mtnB W5S_3782 W5S_3782 W5S_3833 W5S_3833 ksgA ksgA W5S_4010 W5S_4010 W5S_4022 W5S_4022 metK metK gshB gshB W5S_4103 W5S_4103 W5S_4107 W5S_4107 metAS metAS W5S_4235 W5S_4235 metK-2 metK-2 asd asd ilvE ilvE W5S_4428 W5S_4428 W5S_4429 W5S_4429 W5S_4430 W5S_4430 W5S_4431 W5S_4431 metE metE W5S_4512 W5S_4512 W5S_4515 W5S_4515 expI expI W5S_0192 W5S_0192 metL metL W5S_0394 W5S_0394 W5S_0442 W5S_0442 W5S_0468 W5S_0468 W5S_0567 W5S_0567 W5S_0613 W5S_0613 mdh mdh W5S_0820 W5S_0820 W5S_0898 W5S_0898 W5S_0906 W5S_0906 W5S_0942 W5S_0942 W5S_0947 W5S_0947 gshA gshA luxS luxS mtnN mtnN W5S_1163 W5S_1163 W5S_1276 W5S_1276 W5S_1290 W5S_1290 W5S_1348 W5S_1348 mtnD mtnD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
W5S_1524Uncharacterized protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (476 aa)
W5S_1600Cytosine-specific methyltransferase. (338 aa)
W5S_1716D-cysteine desulfhydrase. (337 aa)
rimKProbable alpha-L-glutamate ligase; Belongs to the RimK family. (303 aa)
serCPhosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (361 aa)
W5S_2002Aminotransferase. (396 aa)
W5S_2072Hepatocellular carcinoma-associated protein p28-II. (121 aa)
W5S_2084Free methionine-(R)-sulfoxide reductase fRMsr. (168 aa)
W5S_2106Electron transport protein YccM. (368 aa)
W5S_2163L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (454 aa)
W5S_2405Phospholipase A accessory protein. (247 aa)
W5S_2406Fibronectin type 3 and ankyrin repeat domains 1 protein. (224 aa)
W5S_2697Ferredoxin-type protein NapH. (287 aa)
W5S_2832CoA-binding domain protein. (137 aa)
W5S_2911Homocysteine S-methyltransferase. (313 aa)
W5S_3253Putative siderophore biosynthesis protein SbnA. (358 aa)
W5S_3295Methionine synthase vitamin-B12 independent. (368 aa)
W5S_3571Ankyrin domain protein. (716 aa)
W5S_3572Ankyrin domain protein. (679 aa)
mtnKMethylthioribose kinase; Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate. (400 aa)
mtnAMethylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). (342 aa)
mtnD-2Acireductone dioxygenase; Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. (181 aa)
mtnCEnolase-phosphatase E1; Bifunctional enzyme that catalyzes the enolization of 2,3- diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK- MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family. (229 aa)
mtnBMethylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Belongs to the aldolase class II family. MtnB subfamily. (205 aa)
W5S_3782Aromatic-amino-acid transaminase. (397 aa)
W5S_3833ATP-grasp domain family. (347 aa)
ksgARibosomal RNA small subunit methyltransferase A; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. (272 aa)
W5S_4010Bifunctional aspartokinase/homoserine dehydrogenase; In the C-terminal section; belongs to the homoserine dehydrogenase family. (819 aa)
W5S_4022D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (410 aa)
metKS-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (383 aa)
gshBGlutathione synthetase; Belongs to the prokaryotic GSH synthase family. (319 aa)
W5S_4103Aspartokinase; Belongs to the aspartokinase family. (458 aa)
W5S_4107Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1227 aa)
metASHomoserine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family. (309 aa)
W5S_4235Uncharacterized protein. (42 aa)
metK-2S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (392 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (367 aa)
ilvEBranched-chain-amino-acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (308 aa)
W5S_4428Ankyrin repeat protein. (232 aa)
W5S_4429Phospholipase A accessory protein. (232 aa)
W5S_4430Ankyrin repeat protein. (232 aa)
W5S_4431Ankyrin repeat domain-containing protein. (232 aa)
metE5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (754 aa)
W5S_4512Serine acetyltransferase. (273 aa)
W5S_4515Rhodanese-like domain-containing protein. (143 aa)
expIAcyl-homoserine-lactone synthase; Required for the synthesis of OHHL (N-(3-oxohexanoyl)-L- homoserine lactone), an autoinducer molecule which binds to ExpR and thus acts in virulence (soft rot disease) through the activation of genes for plant tissue macerating enzymes. (217 aa)
W5S_0192O-succinylhomoserine (Thiol)-lyase. (386 aa)
metLBifunctional aspartokinase/homoserine dehydrogenase; In the C-terminal section; belongs to the homoserine dehydrogenase family. (811 aa)
W5S_0394Cystathionine beta-lyase. (396 aa)
W5S_0442Homoserine O-acetyltransferase; Belongs to the AB hydrolase superfamily. MetX family. (366 aa)
W5S_0468Helix-turn-helix motif harboring transcription regulator protein. (107 aa)
W5S_0567Putative transcriptional regulator with C-terminal CBS domains. (103 aa)
W5S_0613Serine acetyltransferase. (166 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. (311 aa)
W5S_0820Aminotransferase class V-fold PLP-dependent enzyme. (426 aa)
W5S_0898Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (293 aa)
W5S_0906Cysteine synthase. (203 aa)
W5S_09423-mercaptopyruvate sulfurtransferase. (289 aa)
W5S_0947Cystathionine beta-lyase. (389 aa)
gshAGlutamate--cysteine ligase; Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily. (517 aa)
luxSS-ribosylhomocysteine lyase; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (171 aa)
mtnN5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine. Thus, is required for in vivo function of the radical SAM enzymes biotin synthase and lipoic acid synthase, that are inhibited by 5'-deoxyadenosine accumulatio [...] (232 aa)
W5S_11633-mercaptopyruvate sulfurtransferase. (289 aa)
W5S_1276Putative methylcobalamin:homocysteine methyltransferase. (343 aa)
W5S_1290Putative aminotransferase yfdZ. (413 aa)
W5S_1348Aspartate-semialdehyde dehydrogenase family protein; Belongs to the aspartate-semialdehyde dehydrogenase family. (336 aa)
mtnDAcireductone dioxygenase; Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. (173 aa)
Your Current Organism:
Pectobacterium parmentieri
NCBI taxonomy Id: 1905730
Other names: CFBP 8475, LMG 29774, LMG:29774, P. parmentieri, Pectobacterium parmentieri Khayi et al. 2016, Pectobacterium sp. SCC3193, strain RNS 08-42-1A, strain RNS 08.42.1A
Server load: low (32%) [HD]