STRINGSTRING
W5S_0970 W5S_0970 W5S_0060 W5S_0060 ftsY ftsY W5S_0140 W5S_0140 secE secE lptC lptC W5S_0330 W5S_0330 W5S_0968 W5S_0968 W5S_0337 W5S_0337 W5S_0358 W5S_0358 W5S_0359 W5S_0359 W5S_0444 W5S_0444 W5S_0493 W5S_0493 W5S_0504 W5S_0504 W5S_0553 W5S_0553 W5S_0556 W5S_0556 W5S_0706 W5S_0706 W5S_0784 W5S_0784 W5S_0950 W5S_0950 tagH tagH clpV clpV W5S_0975 W5S_0975 ffh ffh clpB clpB W5S_1044 W5S_1044 W5S_1291 W5S_1291 W5S_1294 W5S_1294 W5S_1295 W5S_1295 gspE gspE W5S_1297 W5S_1297 gspG gspG gspH gspH gspI gspI W5S_1301 W5S_1301 W5S_1302 W5S_1302 W5S_1303 W5S_1303 W5S_1304 W5S_1304 W5S_1305 W5S_1305 W5S_1467 W5S_1467 W5S_1468 W5S_1468 W5S_1505 W5S_1505 W5S_1507 W5S_1507 W5S_1511 W5S_1511 W5S_1512 W5S_1512 W5S_1554 W5S_1554 W5S_1555 W5S_1555 W5S_1556 W5S_1556 W5S_1557 W5S_1557 W5S_1558 W5S_1558 W5S_1563 W5S_1563 W5S_1564 W5S_1564 W5S_1565 W5S_1565 W5S_1566 W5S_1566 W5S_1613 W5S_1613 W5S_1616 W5S_1616 W5S_1618 W5S_1618 W5S_1619 W5S_1619 W5S_1621 W5S_1621 W5S_1623 W5S_1623 W5S_1624 W5S_1624 W5S_1625 W5S_1625 W5S_1626 W5S_1626 W5S_1674 W5S_1674 W5S_1718 W5S_1718 W5S_1719 W5S_1719 W5S_1842 W5S_1842 W5S_1923 W5S_1923 W5S_1960 W5S_1960 W5S_2213 W5S_2213 W5S_2222 W5S_2222 W5S_2310 W5S_2310 W5S_2323 W5S_2323 W5S_2337 W5S_2337 W5S_2409 W5S_2409 W5S_2419 W5S_2419 W5S_2420 W5S_2420 W5S_2422 W5S_2422 W5S_2428 W5S_2428 W5S_2429 W5S_2429 W5S_2432 W5S_2432 W5S_2437 W5S_2437 W5S_2438 W5S_2438 W5S_2440 W5S_2440 W5S_2497 W5S_2497 W5S_2676 W5S_2676 W5S_2677 W5S_2677 W5S_2735 W5S_2735 W5S_2875 W5S_2875 W5S_2876 W5S_2876 W5S_2890 W5S_2890 W5S_2891 W5S_2891 tatE tatE secF secF secD secD yajC yajC W5S_3394 W5S_3394 W5S_3396 W5S_3396 W5S_3397 W5S_3397 mltC mltC W5S_3515 W5S_3515 W5S_3516 W5S_3516 W5S_3518 W5S_3518 W5S_3519 W5S_3519 W5S_3522 W5S_3522 W5S_3530 W5S_3530 W5S_3532 W5S_3532 W5S_3535 W5S_3535 W5S_3538 W5S_3538 W5S_3590 W5S_3590 ftsB ftsB W5S_3674 W5S_3674 W5S_3784 W5S_3784 W5S_3903 W5S_3903 W5S_3904 W5S_3904 secA secA secM secM W5S_3956 W5S_3956 W5S_3957 W5S_3957 W5S_4018 W5S_4018 secY secY W5S_4220 W5S_4220 W5S_4224 W5S_4224 W5S_4225 W5S_4225 tatC tatC tatB tatB tatA tatA W5S_4425 W5S_4425 W5S_4426 W5S_4426 secB secB W5S_4577 W5S_4577 W5S_4579 W5S_4579 W5S_4787 W5S_4787 yidC yidC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
W5S_0970ImpK/VasF outer membrane protein. (258 aa)
W5S_0060Hcp protein. (172 aa)
ftsYSignal recognition particle receptor FtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components. (471 aa)
W5S_0140VgrG protein. (615 aa)
secEProtein translocase subunit SecE; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation; Belongs to the SecE/SEC61-gamma family. (127 aa)
lptCLipopolysaccharide export system protein LptC; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA. Belongs to the LptC family. (188 aa)
W5S_0330Uncharacterized protein. (219 aa)
W5S_0968Type VI secretion lipoprotein, VC_A0113 family. (174 aa)
W5S_0337Outer membrane protein TolC. (463 aa)
W5S_0358Type VI secretion system tube protein Hcp. (172 aa)
W5S_0359VgrG protein. (655 aa)
W5S_0444Hemolysin activator protein. (592 aa)
W5S_0493PpkA like protein. (659 aa)
W5S_0504Outer membrane efflux protein. (471 aa)
W5S_0553Hcp protein. (124 aa)
W5S_0556Uncharacterized protein. (84 aa)
W5S_0706Protein-export membrane protein SecG; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. (110 aa)
W5S_0784Peptidase A24A prepilin type IV. (183 aa)
W5S_0950DUF2569 domain-containing protein. (163 aa)
tagHType VI secretion system-associated FHA domain protein TagH. (406 aa)
clpVType VI secretion ATPase, ClpV1 family; Belongs to the ClpA/ClpB family. (865 aa)
W5S_0975Type VI secretion protein IcmF. (1165 aa)
ffhSignal recognition particle protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual componen [...] (453 aa)
clpBChaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. (858 aa)
W5S_1044Membrane-bound lytic murein transglycosylase D. (457 aa)
W5S_1291General secretion pathway lipoprotein. (137 aa)
W5S_1294General secretion pathway protein C. (290 aa)
W5S_1295General secretion pathway protein D. (695 aa)
gspEType II secretion system protein E; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. (498 aa)
W5S_1297General secretion pathway protein F. (408 aa)
gspGType II secretion system protein GspG. (146 aa)
gspHType II secretion system protein GspH. (188 aa)
gspIType II secretion system protein GspI. (121 aa)
W5S_1301General secretion pathway protein J. (216 aa)
W5S_1302Type II secretion system protein K. (328 aa)
W5S_1303Type II secretion system protein L; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. (425 aa)
W5S_1304Type II secretion system protein M; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. (164 aa)
W5S_1305Type 4 prepilin-like proteins leader peptide-processing enzyme; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue. (282 aa)
W5S_1467Type VI secretion system tube protein Hcp. (172 aa)
W5S_1468VgrG protein. (616 aa)
W5S_1505Conjugative coupling factor TraD. (719 aa)
W5S_1507Lytic transglycosylase catalytic. (197 aa)
W5S_1511Uncharacterized protein. (147 aa)
W5S_1512SecA like protein. (590 aa)
W5S_1554Type 4 prepilin-like proteins leader peptide-processing enzyme; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue. (248 aa)
W5S_1555Uncharacterized protein. (163 aa)
W5S_1556General secretion pathway protein G. (119 aa)
W5S_1557General secretion pathway GspG like transmembrane protein. (157 aa)
W5S_1558Type IV pilus biogenesis protein PilQ. (627 aa)
W5S_1563General secretion pathway protein E. (547 aa)
W5S_1564Type II secretion system protein. (389 aa)
W5S_1565Lytic transglycosylase PilT. (151 aa)
W5S_1566General secretion pathway protein G. (139 aa)
W5S_1613TriK protein. (620 aa)
W5S_1616Type IV secretion system protein; Part of the Type IV secretion system. Belongs to the GSP E family. (338 aa)
W5S_1618Type IV secretion system protein virB9. (296 aa)
W5S_1619Type IV secretion system protein virB8. (227 aa)
W5S_1621TriE protein. (346 aa)
W5S_1623Pilx5 protein. (238 aa)
W5S_1624Type IV secretion system protein virB4. (915 aa)
W5S_1625CmgB2. (91 aa)
W5S_1626X polypeptide. (221 aa)
W5S_1674Hcp protein. (161 aa)
W5S_1718Type VI secretion system Vgr family protein. (402 aa)
W5S_1719Uncharacterized protein. (160 aa)
W5S_1842annotation not available (161 aa)
W5S_1923ATP-dependent Clp protease ATP-binding subunit ClpA; Belongs to the ClpA/ClpB family. (757 aa)
W5S_1960Rhs element Vgr protein. (689 aa)
W5S_2213Type VI secretion system tube protein Hcp. (159 aa)
W5S_2222UPF0225 protein W5S_2222; Belongs to the UPF0225 family. (155 aa)
W5S_2310Phage like secreted protein; Belongs to the bacterial secretin family. (385 aa)
W5S_2323Transport secretion system IV protein, VirB6. (321 aa)
W5S_2337Phage like secreted protein; Belongs to the bacterial secretin family. (386 aa)
W5S_2409Type VI secretion system Vgr family protein. (712 aa)
W5S_2419Uncharacterized protein. (156 aa)
W5S_2420Rhs element Vgr protein. (587 aa)
W5S_2422Type VI secretion ATPase, ClpV1 family; Belongs to the ClpA/ClpB family. (869 aa)
W5S_2428Protein serine/threonine phosphatase. (263 aa)
W5S_2429Forkhead-associated (FHA) protein. (604 aa)
W5S_2432Type VI secretion system effector, Hcp1 family. (160 aa)
W5S_2437Type VI secretion protein IcmF. (1198 aa)
W5S_2438Type IV / VI secretion system protein, DotU family. (413 aa)
W5S_2440Type VI secretion lipoprotein/VasD. (163 aa)
W5S_2497Uncharacterized protein. (86 aa)
W5S_2676annotation not available (615 aa)
W5S_2677Hcp protein. (172 aa)
W5S_2735Uncharacterized protein. (133 aa)
W5S_2875Phage baseplate assembly protein V. (193 aa)
W5S_2876Late control D family protein. (384 aa)
W5S_2890Type I secretion outer membrane protein, TolC family. (455 aa)
W5S_2891Membrane fusion protein (MFP) family protein. (442 aa)
tatEProbable Sec-independent protein translocase protein TatE; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA; Belongs to the TatA/E family. TatE subfamily. (65 aa)
secFProtein-export membrane protein SecF; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. (322 aa)
secDProtein translocase subunit SecD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. (604 aa)
yajCSec translocon accessory complex subunit YajC; The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions. (109 aa)
W5S_3394Prepilin-type N-terminal cleavage/methylation domain-containing protein. (130 aa)
W5S_3396Prepilin peptidase dependent protein B. (169 aa)
W5S_3397Prepilin-type N-terminal cleavage/methylation domain-containing protein. (167 aa)
mltCMembrane-bound lytic murein transglycosylase C; Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. (374 aa)
W5S_3515VgrG protein. (609 aa)
W5S_3516Hcp protein. (172 aa)
W5S_3518TraG-D_C domain-containing protein. (312 aa)
W5S_3519Uncharacterized protein. (394 aa)
W5S_3522Lytic transglycosylase catalytic. (216 aa)
W5S_3530Shufflon protein A. (451 aa)
W5S_3532Lytic transglycosylase PilT. (172 aa)
W5S_3535General secretion pathway protein E. (521 aa)
W5S_3538Type IVB pilus formation outer membrane protein, R64 PilN family. (554 aa)
W5S_3590VgrG protein. (560 aa)
ftsBCell division protein FtsB; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. (111 aa)
W5S_3674VgrG protein. (725 aa)
W5S_3784Hcp protein. (159 aa)
W5S_3903Type IV-A pilus assembly ATPase PilB. (490 aa)
W5S_3904Assembly protein in type IV pilin biogenesis, transmembrane protein. (401 aa)
secAProtein translocase subunit SecA; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. (916 aa)
secMSecretion monitor; Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation. Belongs to the SecM family. (174 aa)
W5S_3956annotation not available (172 aa)
W5S_3957VgrG protein. (610 aa)
W5S_4018Soluble lytic murein transglycosylase. (644 aa)
secYProtein translocase subunit SecY; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. (443 aa)
W5S_4220Protein transporter HofQ. (424 aa)
W5S_4224Fimbrial assembly family protein. (189 aa)
W5S_4225HofM protein. (283 aa)
tatCSec-independent protein translocase protein TatC; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides. (249 aa)
tatBSec-independent protein translocase protein TatB; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation. (203 aa)
tatASec-independent protein translocase protein TatA; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. (86 aa)
W5S_4425Type VI secretion system tube protein Hcp. (172 aa)
W5S_4426VgrG protein. (678 aa)
secBProtein-export protein SecB; One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA. (158 aa)
W5S_4577SLT domain-containing protein. (566 aa)
W5S_4579Gp59 putative baseplate protein. (221 aa)
W5S_4787DUF4810 domain-containing protein. (119 aa)
yidCMembrane protein insertase YidC; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. (543 aa)
Your Current Organism:
Pectobacterium parmentieri
NCBI taxonomy Id: 1905730
Other names: CFBP 8475, LMG 29774, LMG:29774, P. parmentieri, Pectobacterium parmentieri Khayi et al. 2016, Pectobacterium sp. SCC3193, strain RNS 08-42-1A, strain RNS 08.42.1A
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