(6 nodes) Histidine biosynthesis network (Caulobacter vibrioides CB15)

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second shell of interactors

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protein homology

Your Input:
	hisI	phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (139 aa)
	hisB	Imidazoleglycerol-phosphate dehydratase; Identified by match to PFAM protein family HMM PF00475. (196 aa)
	hisH	Amidotransferase HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity). (213 aa)
	hisA	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to TIGR protein family HMM TIGR00007. (241 aa)
	hisF	hisF protein (cyclase); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). (260 aa)
	hisE	phosphoribosyl-ATP pyrophosphatase; Identified by match to PFAM protein family HMM PF01503. (107 aa)

Your Current Organism:

Caulobacter vibrioides CB15

NCBI taxonomy Id: 190650
Other names: C. vibrioides CB15, Caulobacter crescentus CB15, Caulobacter vibrioides ATCC 19089

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
hisA	hisB	CC_3736	CC_3734	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to TIGR protein family HMM TIGR00007.	Imidazoleglycerol-phosphate dehydratase; Identified by match to PFAM protein family HMM PF00475.	0.999
hisA	hisE	CC_3736	CC_3738	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to TIGR protein family HMM TIGR00007.	phosphoribosyl-ATP pyrophosphatase; Identified by match to PFAM protein family HMM PF01503.	0.998
hisA	hisF	CC_3736	CC_3737	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to TIGR protein family HMM TIGR00007.	hisF protein (cyclase); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity).	0.999
hisA	hisH	CC_3736	CC_3735	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to TIGR protein family HMM TIGR00007.	Amidotransferase HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity).	0.999
hisA	hisI	CC_3736	CC_0457	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to TIGR protein family HMM TIGR00007.	phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.	0.999
hisB	hisA	CC_3734	CC_3736	Imidazoleglycerol-phosphate dehydratase; Identified by match to PFAM protein family HMM PF00475.	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to TIGR protein family HMM TIGR00007.	0.999
hisB	hisE	CC_3734	CC_3738	Imidazoleglycerol-phosphate dehydratase; Identified by match to PFAM protein family HMM PF00475.	phosphoribosyl-ATP pyrophosphatase; Identified by match to PFAM protein family HMM PF01503.	0.998
hisB	hisF	CC_3734	CC_3737	Imidazoleglycerol-phosphate dehydratase; Identified by match to PFAM protein family HMM PF00475.	hisF protein (cyclase); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity).	0.999
hisB	hisH	CC_3734	CC_3735	Imidazoleglycerol-phosphate dehydratase; Identified by match to PFAM protein family HMM PF00475.	Amidotransferase HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity).	0.999
hisB	hisI	CC_3734	CC_0457	Imidazoleglycerol-phosphate dehydratase; Identified by match to PFAM protein family HMM PF00475.	phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.	0.995
hisE	hisA	CC_3738	CC_3736	phosphoribosyl-ATP pyrophosphatase; Identified by match to PFAM protein family HMM PF01503.	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to TIGR protein family HMM TIGR00007.	0.998
hisE	hisB	CC_3738	CC_3734	phosphoribosyl-ATP pyrophosphatase; Identified by match to PFAM protein family HMM PF01503.	Imidazoleglycerol-phosphate dehydratase; Identified by match to PFAM protein family HMM PF00475.	0.998
hisE	hisF	CC_3738	CC_3737	phosphoribosyl-ATP pyrophosphatase; Identified by match to PFAM protein family HMM PF01503.	hisF protein (cyclase); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity).	0.998
hisE	hisH	CC_3738	CC_3735	phosphoribosyl-ATP pyrophosphatase; Identified by match to PFAM protein family HMM PF01503.	Amidotransferase HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity).	0.998
hisE	hisI	CC_3738	CC_0457	phosphoribosyl-ATP pyrophosphatase; Identified by match to PFAM protein family HMM PF01503.	phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.	0.999
hisF	hisA	CC_3737	CC_3736	hisF protein (cyclase); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity).	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to TIGR protein family HMM TIGR00007.	0.999
hisF	hisB	CC_3737	CC_3734	hisF protein (cyclase); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity).	Imidazoleglycerol-phosphate dehydratase; Identified by match to PFAM protein family HMM PF00475.	0.999
hisF	hisE	CC_3737	CC_3738	hisF protein (cyclase); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity).	phosphoribosyl-ATP pyrophosphatase; Identified by match to PFAM protein family HMM PF01503.	0.998
hisF	hisH	CC_3737	CC_3735	hisF protein (cyclase); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity).	Amidotransferase HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity).	0.999
hisF	hisI	CC_3737	CC_0457	hisF protein (cyclase); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity).	phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.	0.999