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tadA tadA hisH hisH CC_3648 CC_3648 CC_3631 CC_3631 purU purU nadE nadE CC_3578 CC_3578 cobB cobB CC_3460 CC_3460 CC_3239 CC_3239 CC_3180 CC_3180 CC_3133 CC_3133 CC_3125 CC_3125 CC_3012 CC_3012 rutD rutD rutB rutB CC_2672 CC_2672 CC_2620 CC_2620 CC_2616 CC_2616 CC_2611 CC_2611 CC_2605 CC_2605 CC_2603 CC_2603 cheL cheL CC_2567 CC_2567 purQ purQ CC_2477 CC_2477 CC_2444 CC_2444 CC_2433 CC_2433 hfsH hfsH CC_2369 CC_2369 CC_2359 CC_2359 CC_2237 CC_2237 CC_2153 CC_2153 CC_2072 CC_2072 CC_2039 CC_2039 CC_2032 CC_2032 lpxC lpxC CC_1973 CC_1973 CC_1972 CC_1972 CC_1876 CC_1876 pyrG pyrG astB2 astB2 CC_1475 CC_1475 folD folD CC_1170 CC_1170 CC_1122 CC_1122 CC_1025 CC_1025 CC_0961 CC_0961 hutI hutI CC_0958 CC_0958 CC_0885 CC_0885 CC_0864 CC_0864 CC_0736 CC_0736 CC_0658 CC_0658 cheB2 cheB2 astB1 astB1 CC_0576 CC_0576 CC_0534 CC_0534 CC_0490 CC_0490 folE folE hisI hisI CC_0443 CC_0443 cheD cheD cheB1 cheB1 CC_0401 CC_0401 CC_0388 CC_0388 CC_0300 CC_0300 glsA glsA dapE dapE def def CC_0212 CC_0212 CC_0211 CC_0211 CC_0116 CC_0116 CC_0097 CC_0097 purH purH
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
tadACytidine and deoxycytidylate deaminase family protein; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. (161 aa)
hisHAmidotransferase HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity). (213 aa)
CC_3648Identified by match to PFAM protein family HMM PF00850. (304 aa)
CC_3631Acetylornithine deacetylase; Identified by match to protein family HMM. (391 aa)
purUFormyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (280 aa)
nadENAD(+) synthetase, putative; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (678 aa)
CC_3578Conserved hypothetical protein; Identified by Glimmer2; putative. (251 aa)
cobBTranscriptional regulator, Sir2 family; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form; Belongs to the sirtuin family. Class III subfamily. (238 aa)
CC_3460Hypothetical protein; Identified by Glimmer2; putative. (581 aa)
CC_3239Peptidase, M20/M25/M40 family; Identified by match to protein family HMM. (474 aa)
CC_3180Adenosine deaminase; Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism. (344 aa)
CC_3133Conserved hypothetical protein; Identified by Glimmer2; putative. (226 aa)
CC_3125Xaa-Pro dipeptidase, putative; Identified by match to protein family HMM. (431 aa)
CC_3012Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (140 aa)
rutDHydrolase, alpha/beta hydrolase fold family; May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation. Belongs to the AB hydrolase superfamily. Hydrolase RutD family. (269 aa)
rutBIsochorismatase family protein; In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity); Belongs to the isochorismatase family. RutB subfamily. (225 aa)
CC_2672Xaa-Pro dipeptidase, putative; Identified by match to protein family HMM. (429 aa)
CC_2620Conserved hypothetical protein; Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo- 4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily. (115 aa)
CC_2616Chlorohydrolase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family. (428 aa)
CC_2611Identified by match to protein family HMM. (304 aa)
CC_2605Conserved hypothetical protein; Identified by Glimmer2; putative. (304 aa)
CC_2603N-carbamyl-L-amino acid amidohydrolase; Identified by match to protein family HMM. (427 aa)
cheLChemotactic signal-response protein CheL; Similar to GB:M91448 SP:P33980 PID:144242; identified by sequence similarity; putative. (111 aa)
CC_2567N-acetylmuramoyl-L-alanine amidase; Identified by match to PFAM protein family HMM PF01510. (242 aa)
purQPhosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (220 aa)
CC_2477Hypothetical protein; Identified by Glimmer2; putative. (533 aa)
CC_2444Aspartate transcarbamoylase, pyrC' subunit; Identified by match to PFAM protein family HMM PF00744. (433 aa)
CC_2433Hypothetical protein; Identified by Glimmer2; putative. (92 aa)
hfsHHfsH; Identified by match to PFAM protein family HMM PF01522. (257 aa)
CC_2369Hydantoinase/oxoprolinase; Identified by match to protein family HMM. (1196 aa)
CC_2359N4-(beta-N-acetylglucosaminyl)-L-asparaginase, putative; Identified by match to PFAM protein family HMM PF01112. (327 aa)
CC_2237Hypothetical protein; Identified by Glimmer2; putative. (365 aa)
CC_2153Polysaccharide deacetylase; Identified by match to PFAM protein family HMM PF01522. (301 aa)
CC_2072Identified by match to PFAM protein family HMM PF00850. (296 aa)
CC_2039Conserved hypothetical protein; Identified by Glimmer2; putative. (330 aa)
CC_20321-aminocyclopropane-1-carboxylate deaminase; Identified by match to protein family HMM. (333 aa)
lpxCUDP-3-O-3-hydroxymyristoyl N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. (267 aa)
CC_1973Conserved hypothetical protein; Identified by Glimmer2; putative. (450 aa)
CC_1972Conserved hypothetical protein; Identified by Glimmer2; putative. (483 aa)
CC_1876N-acetylmuramoyl-L-alanine amidase; Identified by match to PFAM protein family HMM PF01520. (395 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (550 aa)
astB2Succinylarginine dihydrolase; Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)- succinylornithine, ammonia and CO(2). (446 aa)
CC_1475Hypothetical protein; Identified by Glimmer2; putative. (756 aa)
folDFolD bifunctional protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (344 aa)
CC_1170Identified by match to PFAM protein family HMM PF00857. (209 aa)
CC_1122Identified by match to PFAM protein family HMM PF01804. (725 aa)
CC_1025Identified by match to PFAM protein family HMM PF01804. (689 aa)
CC_0961Chlorohydrolase; Identified by match to PFAM protein family HMM PF01685. (459 aa)
hutIImidazolonepropionase; Identified by match to protein family HMM; Belongs to the metallo-dependent hydrolases superfamily. HutI family. (401 aa)
CC_0958Formiminoglutamase; Similar to GP:2642341; identified by sequence similarity; putative. (271 aa)
CC_0885Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (331 aa)
CC_0864Hypothetical protein; Identified by Glimmer2; putative. (242 aa)
CC_0736M20/M25/M40 family peptidase; Identified by match to protein family HMM. (471 aa)
CC_0658Conserved hypothetical protein; Identified by Glimmer2; putative. (544 aa)
cheB2Protein-glutamate methylesterase; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family. (347 aa)
astB1Succinylarginine dihydrolase; Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)- succinylornithine, ammonia and CO(2). (426 aa)
CC_0576Identified by match to PFAM protein family HMM PF01112. (294 aa)
CC_0534N-acetylglucosamine-6-phosphate deacetylase; Identified by match to TIGR protein family HMM TIGR00221. (387 aa)
CC_0490Conserved hypothetical protein; Identified by Glimmer2; putative; Belongs to the multicopper oxidase YfiH/RL5 family. (261 aa)
folEGTP cyclohydrolase I; Identified by match to TIGR protein family HMM TIGR00063. (212 aa)
hisIphosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (139 aa)
CC_0443N-acetylglucosamine-6-phosphate deacetylase; Identified by match to TIGR protein family HMM TIGR00221. (378 aa)
cheDChemotaxis protein CheD; Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis; Belongs to the CheD family. (187 aa)
cheB1Protein-glutamate methylesterase; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family. (344 aa)
CC_0401Hypothetical protein; Identified by Glimmer2; putative. (127 aa)
CC_0388Dihydroorotase; Identified by match to PFAM protein family HMM PF00744. (444 aa)
CC_0300Xaa-Pro dipeptidase, putative; Identified by match to protein family HMM. (428 aa)
glsASimilar to GP:3746520; identified by sequence similarity; putative; Belongs to the glutaminase family. (306 aa)
dapESuccinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (386 aa)
defPolypeptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. (173 aa)
CC_0212Hydrolase, carbon-nitrogen family; Identified by match to PFAM protein family HMM PF00795. (292 aa)
CC_0211Conserved hypothetical protein; Identified by Glimmer2; putative; Belongs to the agmatine deiminase family. (370 aa)
CC_0116Hypothetical protein; Identified by Glimmer2; putative. (1096 aa)
CC_0097Identified by match to PFAM protein family HMM PF01112. (292 aa)
purHPhosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Identified by match to TIGR protein family HMM TIGR00355. (529 aa)
Your Current Organism:
Caulobacter vibrioides CB15
NCBI taxonomy Id: 190650
Other names: C. vibrioides CB15, Caulobacter crescentus CB15, Caulobacter vibrioides ATCC 19089
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