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CC_3541 CC_3541 CC_3414 CC_3414 purK purK CC_3245 CC_3245 purC2 purC2 tilS tilS queC queC CC_3138 CC_3138 CC_3130 CC_3130 purA purA carB carB carA carA CC_2711 CC_2711 CC_2613 CC_2613 murE murE murF murF murD murD murC murC ddl ddl purL purL purQ purQ purS purS purC1 purC1 CC_2473 CC_2473 gatC gatC gatA gatA gatB gatB panC panC CC_1969 CC_1969 CC_1936 CC_1936 CC_1884 CC_1884 CC_1830 CC_1830 pyrG pyrG purM purM guaA guaA CC_3732 CC_3732 nadE nadE argG argG gshB gshB purD purD CC_0720 CC_0720 bioD bioD CC_1602 CC_1602
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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CC_3541FolC bifunctional protein; Identified by match to protein family HMM; Belongs to the folylpolyglutamate synthase family. (437 aa)
CC_3414Glutamate-cysteine ligase; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). Belongs to the glutamate--cysteine ligase type 2 family. EgtA subfamily. (453 aa)
purKPhosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (361 aa)
CC_32455-formyltetrahydrofolate cyclo-ligase; Identified by match to protein family HMM; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (214 aa)
purC2Phosphoribosylaminoimidazole-succinocarboxamide synthase; Identified by match to PFAM protein family HMM PF01259; Belongs to the SAICAR synthetase family. (320 aa)
tilSHypothetical protein; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (408 aa)
queCexsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (242 aa)
CC_3138Identified by match to protein family HMM; Belongs to the glutamine synthetase family. (460 aa)
CC_3130Identified by match to protein family HMM; Belongs to the glutamine synthetase family. (465 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (428 aa)
carBCarbamoyl-phosphate synthase, large subunit; Identified by match to PFAM protein family HMM PF00289. (1099 aa)
carACarbamoyl-phosphate synthase, small subunit; Identified by match to protein family HMM; Belongs to the CarA family. (388 aa)
CC_2711Hypothetical protein; Identified by Glimmer2; putative. (585 aa)
CC_2613Pyrazinamidase/nicotinamidase; Identified by match to PFAM protein family HMM PF01425. (464 aa)
murEUDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (486 aa)
murFUDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanyl ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (462 aa)
murDUDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (471 aa)
murCUDP-N-acetylmuramate--alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (473 aa)
ddlD-alanine--D-alanine ligase B; Cell wall formation. (324 aa)
purLPhosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] (739 aa)
purQPhosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (220 aa)
purSConserved hypothetical protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer [...] (79 aa)
purC1Phosphoribosylaminoimidazole-succinocarboxamide synthase; Identified by match to TIGR protein family HMM TIGR00081; Belongs to the SAICAR synthetase family. (252 aa)
CC_2473Identified by match to PFAM protein family HMM PF01425. (497 aa)
gatCglutamyl-tRNA(Gln) amidotransferase subunit C, putative; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatC family. (95 aa)
gatAglutamyl-tRNA(Gln) amidotransferase subunit A; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). (489 aa)
gatBglutamyl-tRNA(Gln) amidotransferase subunit B; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatB/GatE family. GatB subfamily. (498 aa)
panCPantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (285 aa)
CC_1969Glutamine synthetase, class I; Identified by match to TIGR protein family HMM TIGR00653. (469 aa)
CC_1936Biotin protein ligase; Identified by match to protein family HMM. (250 aa)
CC_1884acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (448 aa)
CC_1830Identified by match to PFAM protein family HMM PF01425. (594 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (550 aa)
purMPhosphoribosylformylglycinamidine cyclo-ligase; Identified by match to PFAM protein family HMM PF00586. (341 aa)
guaAGMP synthase; Catalyzes the synthesis of GMP from XMP. (520 aa)
CC_3732Conserved hypothetical protein; Identified by Glimmer2; putative. (309 aa)
nadENAD(+) synthetase, putative; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (678 aa)
argGArgininosuccinate synthase; Identified by match to TIGR protein family HMM TIGR00032; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (408 aa)
gshBGlutathione synthetase; Identified by match to protein family HMM. (317 aa)
purDPhosphoribosylamine--glycine ligase; Identified by match to PFAM protein family HMM PF01071. (427 aa)
CC_0720asparaginyl-tRNA synthetase, putative; Identified by match to protein family HMM. (352 aa)
bioDDethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (219 aa)
CC_1602Conserved hypothetical protein; Identified by Glimmer2; putative. (545 aa)
Your Current Organism:
Caulobacter vibrioides CB15
NCBI taxonomy Id: 190650
Other names: C. vibrioides CB15, Caulobacter crescentus CB15, Caulobacter vibrioides ATCC 19089
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